• Title/Summary/Keyword: Damage Evaluation

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Protective Effect of Water Extract of Leonurus japonicus Houttuyn against HCl/EtOH-induced Gastric Mucosal Damage and Genotoxicity Evaluation using Micronucleus Test (익모초 물 추출물의 위염 예방효과 및 소핵시험을 이용한 유전독성 평가)

  • Nho, Jong Hyun;Lee, Hyun Joo;Jang, Ji Hun;Yang, Beo Dul;Woo, Kyeong Wan;Kim, A Hyeon;Seo, Jae Wan;Kim, Sun Young;Cho, Hyun Woo;Jung, Ho Kyung
    • Korean Journal of Plant Resources
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    • v.32 no.4
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    • pp.282-289
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    • 2019
  • Gastritis is an inflammatory disease involving the stomach and is caused by several factors, including stress, non-steroidal anti-inflammatory drugs such as aspirin, liquor, and Helicobacter pylori. In Korea, Leonurus japonicus Houttuyn (LJW) has been used as traditional medicine for vaginal bleeding, hematuria, and bruise. Previous studies have reported that LJW exhibited hepatoprotective, cardioprotective, and anti-hyperlipidemic effect. However, the effect of the water extract of LJW on gastritis was not elucidated. Thus, we evaluated the anti-gastric effect and genotoxicity of LJW. LJW effectively prevented the degeneration of surface mucous cells and glandular epithelial cells and vascular congestion induced by HCl/EtOH. Micronucleus assay indicated that the rate of micronucleated polychromatic erythrocytes/polychromatic erythrocytes was not significantly different compared that of the control. Further experiments are required to determine the role of LJW in the gastric injury process such as cyclooxygenase signaling pathway and the secretion of mucus in the stomach.

Construction of Precise Mine Geospatial Information and Ore Modeling for Smart Mining (스마트마이닝을 위한 정밀 광산공간정보 구축 및 광체 모델링)

  • Park, Joon Kyu;Jung, Kap Yong
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.38 no.6
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    • pp.725-731
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    • 2020
  • In mineral resource development, resource exploration is a task to find economical minerals on the surface and underground, and the success rate is low compared to the development and production stages, and it is necessary to collect a lot of data through exploration and accurately analyze the collected information. In this study, mine spatial information was constructed using a 3D (Three-dimensional) laser scanner, and accuracy evaluation was performed to obtain a maximum deviation of 0.140 m and an average of 0.095 m in the X, Y and Z directions, and the possibility of utilizing the construction of mine geospatial information through a 3D laser scanner could be presented. In addition, the ore body modeling was performed by applying the interpolation method of the ore body section using the resource exploration results. The ore body modeling result was superimposed with the modeling result of the mine geospatial information built through the 3D laser scanner to construct the ore body modeling result based on the precise mine geospatial information. The results of ore body modeling based on mine geospatial information built through research can increase the ease of data interpretation and the accuracy of the calculated data, which will greatly increase the efficiency of work related to mineral resource development and mine damage prevention in the future.

A Study on the Evaluation of Expanded Metal Characteristics for Application Rockfall Facilities (낙석방지시설 적용을 위한 팽창메탈의 특성 연구)

  • Lee, Jong-In;Jung, Chun-Gyo;Kim, Sung-Ho;Hwang, Yeong-Cheol;Lee, Seung-Ho
    • Journal of the Korean GEO-environmental Society
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    • v.12 no.9
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    • pp.13-20
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    • 2011
  • There are many mountains in Korean Peninsula, and those used for the construction of roads and railways sectors are forming slopes. Slope collapse occurs with falling rocks and landslide because of the relaxation of the thawing rocks. The heavy rain in summer can also significantly contribute to the process, and abnormal climate change is much more influential than before. Therefore, rockfall-related accidents in rainy season are easily accessible in media every year. There has been a lot of research on application of strengthening compensation of the sections in order to minimize casualties and property damage. Rockfall Protection Net, however, has not been focused on much in the field yet. This study highlights the need of Rockfall Protection Net, since it can segregate the falling rocks inside the net relatively safely. Although there has been a little doubt about the effectiveness of rockfall protection facilities, it is obvious that relevant studies dealing with the solidity of the net are necessary for the rockfall protection net to be capable of supporting rockfall energies. As a result, Expanded metal strength is much more durable compared to the PVC coating net, and it is regarded as an excellent alternative material for the Rockfall Protection Net. In this study, the applicability of Expanded Metal as the alternative of Rockfall Protection Net is verified experimentally.

Evaluation of Reinforcing Performance of Window Protection Device Against Strong Wind (강풍에 대비한 창호보호장치의 보강성능 평가)

  • Park, Won Bin;Kim, Hong Jin
    • Journal of the wind engineering institute of Korea
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    • v.22 no.4
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    • pp.155-161
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    • 2018
  • In modern society, damage caused by strong winds such as typhoons is expected to increase due to urbanization and global warming. In order to test the reinforcement performance of the newly developed window protection device, two-point force test and uniformly distributed load test were carried out on non-reinforced plate glass. It reinforcement performance of the window protection device was evaluated based on the flexural performance improvement. The analytical performance of the window protection device was evaluated by analysis using differential equations of elastic loading method and deflection curve and Midas-Gen. First, the analytical window protection device was evaluated by formulae derived using differential equations of elastic loading and deflection curve. The validity of the derived formulae investigated by comparing the maximum deflection of the central part of the plate with the experimental value and the theoretical value at maximum load. Then the results were compared with those by finite element FE method using Midas-Gen. Under the experimental conditions, with the window protection device, stress reduction effect up to 40% and deflection reduction up to 71.4% under the same load were obtained. It was also found that it is advantageous to perform the FE analysis using the plate element when the performance is evaluated because the error of FE analysis result using plate elements is far less than that using beam elements.

A Study on the Design of Prediction Model for Safety Evaluation of Partial Discharge (부분 방전의 안전도 평가를 위한 예측 모델 설계)

  • Lee, Su-Il;Ko, Dae-Sik
    • Journal of Platform Technology
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    • v.8 no.3
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    • pp.10-21
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    • 2020
  • Partial discharge occurs a lot in high-voltage power equipment such as switchgear, transformers, and switch gears. Partial discharge shortens the life of the insulator and causes insulation breakdown, resulting in large-scale damage such as a power outage. There are several types of partial discharge that occur inside the product and the surface. In this paper, we design a predictive model that can predict the pattern and probability of occurrence of partial discharge. In order to analyze the designed model, learning data for each type of partial discharge was collected through the UHF sensor by using a simulator that generates partial discharge. The predictive model designed in this paper was designed based on CNN during deep learning, and the model was verified through learning. To learn about the designed model, 5000 training data were created, and the form of training data was used as input data for the model by pre-processing the 3D raw data input from the UHF sensor as 2D data. As a result of the experiment, it was found that the accuracy of the model designed through learning has an accuracy of 0.9972. It was found that the accuracy of the proposed model was higher in the case of learning by making the data into a two-dimensional image and learning it in the form of a grayscale image.

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The evaluation of borage oil to use in pet foods (반려견 건강증진을 위한 보라지유 활용 가능성 평가)

  • Kim, Min ji;Seo, Kangmin;Chun, Ju Lan;Jeon, Jung Hwan;Kim, Chan Ho;Jung, Ji Yeon;Kim, Ki Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.12
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    • pp.354-361
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    • 2020
  • The purpose of this study was to investigate the safety and anti-inflammatory effects of borage oil on dogs. Twelve dogs were fed on a commercial diet of 1% or 2% borage oil alone for twelve weeks. To assess safety, the changes in body weight, blood cells, and immune-related cytokines were analyzed. The results showed that there was no significant difference in body weight, complete blood count (CBC), and immunomodulatory cytokines between the dogs fed with diets without or with borage oil. Also, there was no change in transepidermal water loss (TEWL). However, the amount of lactate dehydrogenase (LDH) was reduced significantly in the dogs fed on a borage oil diet. In summary, the addition of borage oil to pet food did not result in any significant health issues. Moreover, borage oil could contribute to a reduction in cell damage in aged dogs although it did not decrease TEWL. Therefore, borage oil could be safe for use in pet foods.

Protective Effect of Curcumin on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Obese Mice (비만마우스에서 Dextran Sulfate Sodium 유도 궤양성 대장염에 대한 커큐민의 보호효과)

  • Park, Ho
    • Korean Journal of Clinical Laboratory Science
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    • v.54 no.1
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    • pp.9-14
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    • 2022
  • Ulcerative colitis is a disease that causes inflammation in the mucosal or submucosal layer of the colon. Previous studies have reported that obesity increases the prevalence of ulcerative colitis and aggravates the progression. This study was therefore undertaken to investigate whether curcumin inhibits the progression of ulcerative colitis caused by obesity. Mice were bred on a high-fat diet to induce obesity, and curcumin was administered with the high-fat diet to confirm the anti-inflammatory effect. To induce ulcerative colitis, dextran sulfate sodium (DSS) was administered orally, and clinical symptoms of colitis were subsequently observed. For histological evaluation of curcumin, the colon, liver and abdominal fat tissue samples were prepared and analyzed by hematoxylin and eosin (H&E) and Alcian blue-periodic acid-Schiff (PAS) staining. Our results confirm that consumption of curcumin resulted in decreasing the score of the disease activity index, and inhibited shortening of the colon length. In addition, inflammatory cell infiltration and mucosal damage were inhibited in the colon tissue of ulcerative colitis exacerbated by obesity. We further confirmed that exposure to curcumin significantly reduced the steatosis area of the liver and adipocytes of abdominal fat. In conclusion, we believe that curcumin can be applied as a therapeutic agent to treat ulcerative colitis, by inhibiting the progression of colitis caused by obesity.

Comparison of Liquefaction Assessment Results with regard to Geotechnical Information DB Construction Method for Geostatistical Analyses (지반 보간을 위한 지반정보DB 구축 방법에 따른 액상화 평가 결과 비교)

  • Kang, Byeong-Ju;Hwang, Bum-Sik;Bang, Tea-Wan;Cho, Wan-Jei
    • Journal of the Korean Geotechnical Society
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    • v.38 no.4
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    • pp.59-70
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    • 2022
  • There is a growing interest in evaluating earthquake damage and determining disaster prevention measures due to the magnitude 5.8 earthquake in Pohang, Korea. Since the liquefaction phenomena occurred extensively in the residential area as a result of the earthquake, there was a demand for research on liquefaction phenomenon evaluation and liquefaction disaster prediction. Liquefaction is defined as a phenomenon where the strength of the ground is completely lost due to a sudden increase in excess pore water pressure caused due to large dynamic stress, such as an earthquake, acting on loose sand particles in a short period of time. The liquefaction potential index, which can identify the occurrence of liquefaction and predict the risk of liquefaction in a targeted area, can be used to create a liquefaction hazard map. However, since liquefaction assessment using existing field testing is predicated on a single borehole liquefaction assessment, there has been a representative issue for the whole targeted area. Spatial interpolation and geographic information systems can help to solve this issue to some extent. Therefore, in order to solve the representative problem of geotechnical information, this research uses the kriging method, one of the geostatistical spatial interpolation techniques, and constructs a geotechnical information database for liquefaction and spatial interpolation. Additionally, the liquefaction hazard map was created for each return period using the constructed geotechnical information database. Cross validation was used to confirm the accuracy of this liquefaction hazard map.

A LiDAR-based Visual Sensor System for Automatic Mooring of a Ship (선박 자동계류를 위한 LiDAR기반 시각센서 시스템 개발)

  • Kim, Jin-Man;Nam, Taek-Kun;Kim, Heon-Hui
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.28 no.6
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    • pp.1036-1043
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    • 2022
  • This paper discusses about the development of a visual sensor that can be installed in an automatic mooring device to detect the berthing condition of a vessel. Despite controlling the ship's speed and confirming its location to prevent accidents while berthing a vessel, ship collision occurs at the pier every year, causing great economic and environmental damage. Therefore, it is important to develop a visual system that can quickly obtain the information on the speed and location of the vessel to ensure safety of the berthing vessel. In this study, a visual sensor was developed to observe a ship through an image while berthing, and to properly check the ship's status according to the surrounding environment. To obtain the adequacy of the visual sensor to be developed, the sensor characteristics were analyzed in terms of information provided from the existing sensors, that is, detection range, real-timeness, accuracy, and precision. Based on these analysis data, we developed a 3D visual module that can acquire information on objects in real time by conducting conceptual designs of LiDAR (Light Detection And Ranging) type 3D visual system, driving mechanism, and position and force controller for motion tilting system. Finally, performance evaluation of the control system and scan speed test were executed, and the effectiveness of the developed system was confirmed through experiments.

Full mouth rehabilitation using various digital tools in a patient with collapsed bite due to severe attrition (심한 마모로 인하여 교합이 붕괴된 환자의 다양한 디지털 도구를 이용한 완전 구강회복증례)

  • Moon, Sooin;Lee, Younghoo;Hong, Seoung-Jin;Noh, Kwantae;Pae, Ahran;Kim, Hyeong-Seob;Kwon, Kung-Rock;Paek, Janghyun
    • The Journal of Korean Academy of Prosthodontics
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    • v.60 no.4
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    • pp.320-329
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    • 2022
  • Physiological wear of occlusal surface is inevitable throughout the lifetime, and considered to be normal. Pathologic wear, however, may cause fatal damage to the occlusal surface and destroy esthetics and proper anterior guidance. In such cases, rehabilitation of occlusal wear should be followed by thorough evaluation and diagnosis. In this present case, severe occlusal wear was found in the labial surfaces of mandibular anterior teeth and palatal surfaces of maxillary anterior teeth. Occlusal vertical dimension was evaluated and decided to be regained due to insufficient amount of restorative space. After determining new occlusal vertical dimension, diagnostic wax-up is usually performed to continue prosthodontic treatment. In this case with collapsed occlusion and loss of occlusal vertical dimension, conventional diagnostic wax-up was replaced with various digital devices. Diagnostic wax-up was digitally performed in the software and provisional prosthesis was fabricated with digital tools. With verification with provisional prosthesis, the entire dentition was rehabilitated with newly set occlusal vertical dimension and proper anterior guidance.