• Radiation Oncology Journal
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• 제35권1호
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• pp.32-38
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• 2017

Purpose: Several accelerated partial breast radiation (APBR) techniques have been investigated in patients with early-stage breast cancer (BC); however, the optimal treatment delivery techniques remain unclear. We evaluated the feasibility and toxicity of APBR delivered using intensity-modulated radiation therapy (IMRT) in elderly patients with stage I BC, using a novel fractionation schedule. Materials and Methods: Forty-two patients aged ${\geq}65$ years, with stage I BC who underwent breast conserving surgery were enrolled in a phase I/II study evaluating APBR using IMRT. Forty eligible patients received 40 Gy in 4 Gy daily fractions. Patients were assessed for treatment related toxicities, and cosmesis, before APBR, during, and after completion of the treatment. Results: The median age was 73 years, median tumor size 0.8 cm and the median follow-up was 54 months. The 5-year locoregional control was 97.5% and overall survival 90%. Erythema and skin pigmentation was the most common acute adverse event, reported by 27 patients (69%). Twenty-six patients (65%) reported mild pain, rated 1-4/10. This improved at last follow-up to only 2 (15%). Overall the patient and physician reported worst late toxicities were lower than the baseline and at last follow-up, patients and physicians rated cosmesis as excellent/good in 93% and 86 %, respectively. Conclusion: In this prospective trial, we observed an excellent rate of tumor control with daily APBR. The acceptable toxicity profile and cosmetic results of this study support the use of IMRT planned APBR with daily schedule in elderly patients with early stage BC.

• 한국보육지원학회지
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• 제10권6호
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• pp.313-332
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• 2014

본 연구는 만 4세 유아를 대상으로 일과를 통한 유아 다문화교육 프로그램의 실시 여부가 유아의 다문화 수용성과 친사회적 행동 증진에 미치는 영향을 검증하고자 하였다. 연구는 경기도 서부 A시의 만 4세반을 각각 1학급씩 편의 표집하여 실험집단, 통제집단으로 구분하였다. 두 집단에 대하여 사전검사를 실시한 후 44회기 동안의 프로그램에 의한 교육을 실행한 후 4세아의 문해능력을 고려하여 상황을 이해할 수 있는 그림 자료와 검사지침에 의해 자료를 수집하였다. 자료의 분석 결과, 유아 다문화교육 프로그램을 경험한 실험집단의 유아가 통제집단의 유아보다 문화 인식, 다문화 공감, 다문화 개방성, 관계형성 능력 등 유의하게 높아 다문화 수용성 증진에 영향을 미쳤다. 또한 지도성, 도움, 의사소통, 주도적 배려, 접근 시도하기, 나누기, 감정이입 및 조절에서도 실험집단의 유아가 유의미하게 높아 통제집단의 유아보다 친사회적 행동 증진에도 긍정적 효과가 있는 것으로 나타났다. 본 연구결과 유치원 누리과정의 생활주제에 맞추어 구성 및 적용한 유아 다문화교육프로그램은 유아의 다문화 수용성, 친사회적 행동의 증진을 도모하는 것으로 확인되었다.

• 한국BIM학회 논문집
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• 제9권2호
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• pp.1-10
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• 2019

In this research, schedule optimization is defined as balancing the number of workers while keeping the demand and needs of the project resources, creating the perfect schedule for each activity. Therefore, when one optimizes a schedule, multiple potentials of schedule changes are assessed to get an instant view of changes that avoid any over and under staffing while maximizing productivity levels for the available labor cost. Optimizing the number of workers in the scheduling process is not a simple task since it usually involves many different factors to be considered such as the development of quantity take-offs, cost estimating, scheduling, direct/indirect costs, and borrowing costs in cash flow while each factor affecting the others simultaneously. That is why the optimization process usually requires complex computational simulations/modeling. This research attempts to find an optimal selection of daily maximum workers in a project while considering the impacts of other factors at the same time through OPEN BIM based multiple computer simulations in resource leveling. This paper integrates several different processes such as quantity take-offs, cost estimating, and scheduling processes through computer aided simulations and prediction in generating/comparing different outcomes of each process. To achieve interoperability among different simulation processes, this research utilized data exchanges supported by building SMART-IFC effort in automating the data extraction and retrieval. Numerous computer simulations were run, which included necessary aspects of construction scheduling, to produce sufficient alternatives for a given project.

• Journal of Nutrition and Health
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• 제16권2호
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• pp.97-106
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• 1983

For the purpose of implementing health and nutrition education for college women, we investigated changes in height, weight, and daily living schedule, as well as the relationship between energy intake and expenditure, and food and nutrients intake levels for the six years from 1977 to 1982. A special form of questionaires was prepared and distributed to well-trained subjects (total 213) in order to find out their general characteristics, daily living schedule and dietary intakes. The recovery of questionaires distributed to each subject was 90%. Then the quality of their living, energy balance, nutrient intake and food intake were evaluated and the F-test was used to test the statistical significances. It was found that : 1) The range of weights and heights of subjects were between 48-50 kg, 157-161cm respectively over the 6 year period. 2) In daily living schedule, that is, the average physiological activity time including sleeping ranged from 760 to 801 minutes. Free time decreased gradually, from 318 minutes per day in 1977 to 275 minutes in 1982. Average time for study and for house work was 196-280 minutes and 68 - 157 minutes respectively for 6 years, and study time was significantly varied in each year. 3) The energy intake of the subjects averaged 1762 Kcal, whereas the expended energy was 1892 Kcal. In the energy balance determined by the relationship between energy intake and expendituye, the ratio of subjects who maintained a negative energy balance gradually increased from 53% (1977) to 64%(1982). 4) The average nutrient intake was higher than the recommended dietary allowance except for calorie (1997 - 1982), calcium (1979) and iron (1979, 1980). The total calorie intake was composed of 59-63% carbohydrate, 19 - 24% fat and 15 - 18% protein Of the total protein intake the percentage of animal was 47 -51% for six years, showing acceptable nutritional status. 5) The average total food intake of the subjects increased from 1,080 g (1977) to 1,184g (1982), but this was not a significant difference. Cereal composed the highest proportion among the total food intakes, and rice intake was 58-78% of cereals. Cereal was followed in decreasing order by vegetables, dairy products, fruits, meat and fish products. The option available for the selection of cooking methods as well as the selection of food item was limited, so there were few changes over time.

• 산업기술연구
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• 제27권A호
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• pp.61-67
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• 2007

The construction machine is the composite machine assembled by about 30,000 parts. Excavator, one kind of a construction machine, plays the leading role for export of construction equipment. It is generally impossible to produce all of the items within one company. Especially the supply of hydraulic control valves, one of the core part of the construction equipment, depends on the import heavily. So it is important to make an efficient production plan of hydraulic control valves in the company. The most important thing for the production scheduling of a hydraulic control valve is to make production schedule keeping the start date for assembly line for an excavator and to make minimization of the stock level. The production plan of hydraulic control valve includes the decision of the quantity supplied by subcontractor. This paper presents a scheme for a scheduling system of the hydraulic control valve considering the schedule of the assembly line for excavator production. This paper provides a methodology, which can make a plan of supply and production and generate a detailed schedule for daily production.

• Clinical and Experimental Vaccine Research
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• 제12권2호
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• pp.121-126
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• 2023

Purpose: Sublingual immunotherapy is currently promoted by various companies, with administration schedules variable in the different products even though almost all are standardized immunologically. So, this study was planned to examine the efficacy of simple nondaily dosing of sublingual immunotherapy instead of the widely used daily schedule. Materials and Methods: Fifty-two patients with allergic rhinitis and bronchial asthma were enrolled. Sublingual immunotherapy (manufactured at the allergen immunotherapy preparation unit at Mansoura University) was given in suitable bottles with a dropper mechanism that permits comfortable dosing under the tongue. The physician recommended that the patient put the drops under his/her tongue and leave the drops beneath the tongue for 2 minutes before swallowing. This was repeated every 3 days, with the drop number and concentration gradually rising. Results: After 2 months of follow-up, 65.8% responded partially to the symptom score and 26.3% responded completely to the medication score. There was a significant decline in the symptom and medication scores from the baseline scores (p<0.0001). After 4 months of follow-up, 95.8% responded partially to symptom scores and no one has not responded; 54.2% responded completely to medication scores; and 81% of studied patients had no side effects. However, the most frequent side effect was a sore throat. Conclusion: Our nondaily schedule of sublingual immunotherapy is tolerable, safe, and effective in patients with allergic rhinitis and bronchial asthma.

• 아동학회지
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• 제30권4호
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• pp.223-239
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• 2009

In order toidentify the daily activities of five-year-old children in a daycare center, the 23 children in "Yellow" class at "Yellow" Daycare Center were observed for seven months. Research was informed by a qualitative approach. Findings were that : children were rigidly attached to a time frame built into their daily classroom schedule, arranged by time and classroom space allotted to each unit. The meaning to the children was to be found in their "busyness;" they were very busy finalizing activities imposed by teachers within a short period of time. They spent most of their time moving about from one space to another within the classroom, and they played with their mostly artificial toys under rules set by the teacher.

• 터널과지하공간
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• 제19권3호
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• pp.167-173
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• 2009

지하비축기지는 터널의 규모와 건설공정의 복잡성, 지질 및 지반공학적인 문제들로 인해 가장 난해한 지하공간건설 프로젝트로 알려져 있다. 최근 복잡한 지하구조를 3차원으로 가시화하고, 건설 자원과 지반조건 그리고 공정계획을 고려한 4차원 시뮬레이션을 활용하여 건설공정을 최적화하는 기술이 지하비축기지 건설 프로젝트에 적용되었다. 이 사례연구는 지하구조의 3차원 모델링을 통해 작업자가 복잡한 지하 현황을 쉽게 이해하고, 정확한 3차원 공간상에서 지질자료를 분석하고 검토할 수 있도록 도와줄 수 있음을 보여주고 있다. 또한 건설공정과 실제 공기를 고려한 4차원 시뮬레이션을 활용하여 자재와 버력의 반출입에서 나타날 수 있는 bottle neck의 위치와 시점을 판단하거나 일일 공사비의 변동을 검토하고, 작업조와 투입장비의 수, 터널 시공방향 및 굴착 착수 시점, 버력 및 자재의 운반경로를 검토함으로써 공정의 최적화를 달성할 수 있었다.

• 한국항행학회논문지
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• 제2권1호
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• pp.61-67
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• 1998

이 연구에서는 항공기의 주기 문제를 해결하여 주는 스케줄링 시스템과 그 조정을 위한 전문가 시스템(RACES : Ramp Activity Co-ordination Expert System)을 설계 및 개발한 내용을 기술하고 있다. RACES는 공항에서 매일 발생하는 출발편 및 도착편 항공기를 브릿지(bridge)와 스팟(spot)에 배정하기 위해 인간 전문가(human expert)로부터 습득한 해당 분야의 지식(도메인 지식) 및 휴리스틱(heuristic)을 지식 베이스로 갖고 있다. 이 RACES는 브릿지/스팟과 항공기 간에 내적 관계, 예를 들어 승객 및 공항의 그라운드 핸들링(ground handling) 등과 같은 복잡하며 동적인 제약조건 들로부터 발생하는 복잡한 스케줄링 문제를 수반한다. 매일 발생하는 600편 정도의 항공기에 대한 주기장 관리 스케줄링이 인간 전문가에 의해 수행되어졌을 경우에는 약 4~5시간이 소요되는 반면 RACES에 의해 수행되어졌을 경우에는 약 20초 정도의 시간이 소요되었고 RACES로부터 얻어진 스케줄링 결과는 해당 분야의 전문가들로부터 인정되었다. RACES는 또한 예외적인 상황이 발생했을 경우에 스케줄의 부분적인 조정을 처리하도록 설계되었다. 하루의 스케줄링이 완료된 후 항공기의 변경 및 지연 메시지는 도메인 전문가의 지식을 바탕으로 스케줄링에 반영되어 스케줄이 조정되어야 한다. 동적 재스케줄링(reactive scheduling) 단계는 도메인 전문가의 지식 모델 분석을 통해 사용자 그래픽 인터페이스의 규칙과 시나리오로써 효과적으로 나타내어진다. 항공편의 변경 및 취소로 인해 발생되는 항공기 배치의 조정은 현재 스케줄에 반영되어져야 하기 때문에 이러한 항공기 배치의 조정은 동적 재스케줄링을 위해 메인 프레임으로부터 RACES에게 통보되어져야 하며 부분적인 재스케줄링을 처리하는 것에는 불규칙적인 요소들이 많기 때문에 RACES에 의해 스케줄의 조정이 반 자동적으로 수행된다.

• 약학회지
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• 제44권1호
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• pp.16-21
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• 2000

Peptic ulcer is involved with Helicobacter pylori infection and antibiotic regimens are primary treatments. An optimal therapeutic regimen for eradication of Helicobacter pylori remains uncertain due to variable efficacy. The objectives of this study were to evaluate the efficacy of omeprazole based antibiotic regimens in bacterial eradication, healing of peptic ulcer and to identify factors affecting efficacy. Seventy-seven patients were enrolled in the prospective, open-trial from November 1997 to Setember 1998. H. pylori infection was identified with endoscopy, H. pylori stain and rapid urease test. The first group (OAC7) received omeprazole 20 mg twice daily for 4 weeks which were the same schedule for all, amoxicillin and clarithromycin 500 mg three times daily for 1 week; the second group (OAC14), for 2 weeks on the same regimen as the first; and the last group (OACD) has taken bismuth in addition to the OAC7 regimen for 1 week. Eradication of H. pylori and healing of peptic ulcer were evaluated with endoscopy and tests for H. pylori before and after treatments. There were no significant differences in eradication rates; 77% in OAC7, 76% in OAC14, 81% in OACD (p=0.935) and healing rates; 82% in OAC7, 71% in OAC14, 95% in OACD (p=0.179), respectively. Compliance had an relationship with eradication rates significantly among regimens (p=0.049). Twenty three cases (29%) complained of the minor side effects. In conclusion, OAC7 was better in convenience of dosing schedule and showed fewer side effects with shorter duration and lower cost while There were no significant differences in efficacy among regimens.