• Journal of Industrial Convergence
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• v.21 no.9
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• pp.23-32
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• 2023

Interest in Serious Games for Healthcare (SGHs) that can improve health through games is increasing. Digital Therapeutics (DTx) is a treatment that must be approved for effectiveness and safety, so it should follow the traditional drug distribution method, but SGHs are wellness products that are more flexible in terms of adoption and diffusion than DTx. SGHs are effective because it can provide customized services through continuous monitoring and feedback. When SGHs are applied to cognitive impairment treatment or behavioral correction, malfunctions and side effects are minor. This study developed research model based on the Valence Framework, gathered data from 142 undergraduates, and demonstrated that only the perceived benefits have a statistically significant positive (+) effect on SGHs acceptance intentions. Based on these results, this study suggests that SGHs companies should promote benefits in accepting SGHs for general users and they need for a distribution and analytics platform strategy based on a data-driven approach.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.7
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• pp.926-931
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• 2007

Diarrhetic shellfish poisons (DSP) such as okadaic acid (OA), dinophysistoxin-1 (DTX1), pectenotoxin-1(PTX1), PTX2, PTX6 and yessotoxin (YTX) were determined simultaneously by LC-MS/MS and mouse bioassay in the shellfishes (oyster, mussel, Washington purple clam, ark shell, scallop and short necked clam) collected at Tongyeong, from March to September, 2006. Oyster and mussel were found to contain DSP (0.05${\sim}$0.1 MU/g) in March by mouse bioassay; however, no DSP components were detected on the LC-MS/MS. Also, a small amount of DTX1 (0.05 ${\mu}g/g$) in mussel (June) and OA (0.01${\sim}$0.02 ${\mu}g/g$) in 5 species of shellfishes(August) were determined by LC-MS/MS.

• Korean Journal of Food Science and Technology
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• v.44 no.4
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• pp.390-392
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• 2012

Diarrhetic shellfish poisoning toxins were investigated by liquid chromatography-electrospray ionization mass spectrometry (LC-MS/MS). Okadaic acid (OA), Dinophysistoxin-1 (DTX1), Pectonotoxin2, (PTX2) and Yessotoxin (YTX) in bivalves were quantified. OA were found in four samples; mussel Mytilus edulis (0.001 ${\mu}g/g$), Oyster Crassostrea gigas (0.004 and 0.001 ${\mu}g/g$) and manila clam Ruditapes philippinarum (0.001 ${\mu}g/g$). DTX1, PTX2, and YTX were not detected from all of the samples examined.

• Horticultural Science & Technology
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• v.17 no.4
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• pp.473-475
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• 1999

This study was carried out to restore the fertility by suppression of male sterility-induced gene using an antisense construct. Tobacco (cv. Petit Havana SR1) was transformed with the binary vector containing a GBAN215-6 promoter, an antisense diphtheria toxin (DTx-A) gene (pKDA215b) and a hygromycin resistant gene. Seventy-six confirmed transgenic plants regenerated from leaf disks were designated as the $R_0$ generation and selfed to produce the $R_1$ generation. From the inheritance study, five $R_1$ lines with multiple copies of the antisense construct were selected and selfed to identify homozygosity for the antisense construct. In order to restore fertility and finally to select restore lines, five $R_2$ lines with multiple copies of the antisense construct were crossed with male sterile plants. From these crosses, three different phenotypes have been observed: completely restored, partially restored, and not restored pollens, and otherwise tobacco plants were phenotypically same as normal plants. These plants were scored for the degree of restoration and selected for further study.

• Phonetics and Speech Sciences
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• v.14 no.4
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• pp.57-66
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• 2022

In this study, the definition of "digital therapeutics" was clarified by examining related studies, and the development trend of digital therapeutics at the domestic level was investigated. Further, research data and technologies applied to various communication disorders since 2015 were analyzed. From all these, digital therapeutics can be defined as software that can support evidence-based treatment when used on patients to prevent, manage, and treat disorders With huge investments and research efforts increasingly made in the field of digital therapeutics, 17 of the 22 studies examined were on digital therapeutics applied in the treatment of language disorders. In the research papers examined, the technologies applied were virtual reality and augmented reality, with augmented reality used in most cases. The effects of applying digital treatment were positive, and most studies focused on content development in relation to the development of digital treatment, although one study was conducted for app development. Future studies could examine the application of digital therapeutics to more diverse communication disorder subjects. Active government support is expected in developing more sophisticated software that can be applied using a wider range of technologies in the field of digital therapeutics to treat more communication disorders.

• Journal of Food Hygiene and Safety
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• v.38 no.6
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• pp.409-419
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• 2023

Okadaic acid (OA) group toxins, including OA and its analogs, such as dinophysis toxins (DTXs), have been reported to cause diarrheal shellfish poisoning (DSP). These toxins are primarily produced by dinoflagellates and are accumulated in bivalves. Recently, the presence of Dinophysis sp., a causative alga of DSP, has been reported along the coasts of Korea, posing a potential risk of contamination to domestic seafood and exerting an impact on both the production and consumption of marine products. Accordingly, the European Food Safety Authority (EFSA) and the World Health Organization (WHO) have established standards for the permissible levels of OA group toxins in marine products for safety management. Additionally, in line with international initiatives, the domestic inclusion and regulation of DTX2 among the substances falling under the purview of management outlined by the 2022 diarrheal shellfish toxin standard have been implemented. In this study, we reviewed the physicochemical properties of OA group toxins, their various exposure routes (such as acute toxicity, genotoxicity, reproductive and developmental toxicity), and the relative toxicity factors associated with these toxins. We also performed a comparative assessment of the methods employed for toxin analysis across different countries. Furthermore, we aimed to conduct a broad review of human exposure cases and assess the international guideline for risk management of OA group toxins.

• Electronics and Telecommunications Trends
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• v.19 no.4 s.88
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• pp.1-9
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• 2004

본 고에서는 미국식(ATSC) 지상파 디지털 TV 방송을 단일 주파수 망(SFN)을 통해 서비스하기 위해 필요한 기술적인 사항에 대하여 고찰하고, ATSC 방송 방식에서 SFN을 구성하기 위한 방법을 제안한다. SFN구성은 방송 주파수의 이용 효율을 높이고, 방송 구역 내에서 안정적인 전파 세기를 보장한다. 이러한 SFN 구성을 위한 기술은 복수 개의 송신기를 이용하는 방법(DTX)과 복수 개의 디지털 동일 채널 중계기(DOCR)를 이용하는 방법으로 나뉘어진다. ATSC 방식에서는 두 가지 방법 모두 사용하여 SFN 구성이 가능하나, 복수 개의 송신기를 이용하는 방법은 현재의 기술 기준을 변경해야 한다는 제약이 따른다. 반면 다수 개의 DOCR를 이용하는 방법은 기존의 송신기와 함께 SFN 구성이 가능하여 망 구성이 용이하다.

• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.9-12
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• 2001

본 논문에서는 유럽 통신 표준화기구인 ETSI 의 SMGll에서 채택된 GSM Full Rate(FR) 보코더 알고리wma[1]을 Teak DSP Core를 이용하여 실시간 구현하였다. GSM FR 보코더는 유럽에서 사용하는 통신 시스템인 GSM 의 full-rate Traffic Channel(TCH)의 표준 코덱[2]으로서 GSM HR, GSM EFR GSM AMR과 더불어 모뎀칩 내에 장착되는 필수적인 음성 서비스이다. 구현된 GSM FR는 13.05kbps의 비트율을 가지고 있으며, 인코더와 디코더 기능 외에 voice activity detection(VAD)[3]블록과 DTX[4]블록 등의 부가 기능도 구현되어 있다. 구현에 사용된 Teak[5]는 DSP Group 의 16bit고정 소수점 DSP core로서 최대 140MIPS 의 성능을 낼 수 있고 400bits ALU 와 두개의 MAC 이 장착되어 있어 음성 및 채널 부호화기의 실시간 처리에 최적화 되어있다. 구현된 GSM FR 은 인코더와 디코더 부분이 각각 약 235 MIPS 및 1.19MIPS 의 복잡도를 나타내며, 사용된 메모리는 프로그램 ROM 3.9K words, 데이터 ROM(table) 396 words 및 RAM 932words이다.

• Broadcasting and Media Magazine
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• v.27 no.1
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• pp.38-48
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• 2022

해마다 정신 질환의 발병률은 높아지지만, 이를 위한 진단과 치료의 한계는 현재까지도 해결되지 않고 있다. 디지털 치료제(DTx)는 이러한 한계를 극복할 수 있는 새로운 해결법으로 화두되고 있다. 본 연구는 객관적인 ADHD 진단을 위한 Hippo T&C의 디지털 치료 솔루션인 AttnKare-D를 제안한다. AttnKare-D는 정신 질환의 진단 및 통계 편람(DSM-5)에 따라 통제된 환경에서 데이터를 정량화함으로써 진단을 객관화한다. 또한, ADHD의 세부적 증상에 대한 상세한 보고서를 만듦으로써, 넓은 분류보다는 특정한 증상들에 집중하여 치료를 개인화한다. 적절한 샘플 사이즈에 낮은 오류율을 보이므로 임상 환경에서 AttnKare-D는 긍정적인 가능성을 보여준다.

• Journal of Korea Multimedia Society
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• v.25 no.4
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• pp.640-648
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• 2022

Menopausal women have to care for their health. Menopause is a symptom that needs to be managed in the long term, which requires safe and economical treatment even after long term use. This study proposes digital-based exercise therapy. This study also suggests resistance exercise and walking exercise methods according to the proof of previous studies. It provides motivational contents for those who cannot perform regularly. As motivational methods, self-efficacy and narrative-based history methods are accepted. Self-efficacy is improved through voice agents feedback during exercise. Feedback is a type of messages such as encouragement and motivation. The narrative-based history consists of characters of visualization that improves through values, which leveraged by the exercise.