• 제목/요약/키워드: DTPA

검색결과 273건 처리시간 0.03초

Fe ion과 활성산소 관련 지방산화반응에 미치는 솔잎 추출물의 영향 (Effect of Pine Needle Extract on Fe ion and Active Oxygen Related Lipid Oxidation in Oil Emulsion)

  • 김수민;조영석
    • 한국식품저장유통학회지
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    • 제6권1호
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    • pp.115-120
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    • 1999
  • This study was carried out to investigate the effect of Pine needle extract on lipid oxidation and free radical reaction in iron sources reacted with active oxygen species. The results were summarized as follow; The pine needle extracts didn`t show a distinct effect on reduction of lipid oxidation if the iron ion didn`t exist in oil emulsion. The pine needle extracts played role as a strong chelating agents to bind iron ion if Ferrous iron(Fe\ulcorner) exist in oil emulsion. Ferric iron(Fe) was lower effect than Ferrous iron(Fe) on free radical reaction in oil emulsion. And also, the Fe\ulcorner reacted with pine needle extract did not show distinct effect on free radical reaction, compared to Fe\ulcorner reacted with pine needle extract. And also, Pine needle extracts reacted with H\ulcornerO\ulcorner were tended to show a low oxygen scavenging ability in case of H\ulcornerO\ulcorner only was existed, compared to those of H\ulcornerO\ulcorner + Fe\ulcorner complex. Pine needle extracts were the most powerful Fe\ulcorner binding agents, compared to other strong synthetic antioxidants such as EDTA and DTPA.

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Comparison of Bioavailability and Biological Transfer Factor of Arsenic in Agricultural Soils with Different Crops

  • Oh, Se Jin;Kim, Sung Chul;Ok, Yong Sik;Oh, Seung Min;Ji, Won Hyun;Yang, Jae E.
    • 한국토양비료학회지
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    • 제47권6호
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    • pp.518-524
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    • 2014
  • Heavy metal pollution in agricultural field near at the abandoned metal mines has been a critical issue in Korea. In particular, bioaccumulation in plants can have detrimental effect on human health. Main objective of this research was to examine arsenic (As) concentration in soil with varied extraction methods and to determine bioaccumulation and biological transfer factor in different crops. Results showed that bioaccumulation ratio of As for total contents in soil was ordered leafy and stem vegetables (1.19%) > fruit bearing vegetables (0.79%) > pulses (0.40%) > root vegetables (0.36%) with different crop species. Among 6 different extraction methods, all of extraction methods showed high correlation ($R^2=0.87-0.97$) except DTPA ($R^2=0.25$) when comparing As concentration in soil extracted with different extractants and As concentration in each crops. Calculated biological transfer factor was ranged 0.002-0.018 depending on crop species. Overall, concentration of As in crops can be varied and best management practice for minimizing bioaccumulation of As should be considered depending on crop species.

Z-Score를 이용한 관류영상과 조영전후 감산에 의한 역동영상의 뇌관류 양상의 비교 관찰

  • 최순섭;오종영;남경진;이영일
    • 대한자기공명의과학회:학술대회논문집
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    • 대한자기공명의과학회 2001년도 제6차 학술대회 초록집
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    • pp.171-171
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    • 2001
  • 목적: 뇌 자기공명영상에서 Z-score를 이용한 관류 영상과 조영전후의 감산에 의한 역동 영상의 관류 양상을 비교 관찰 하고자 한다. 대상 및 방법: 뇌 자기공명영상에서 이상 소견이 없는 젊은 환자 1명, Moya moya 환자 1, 중대뇌동맥 폐색 환자 1명, 외상후 증후군 1명, 뇌종양 1예를 대상으로 하여, 뇌의 routine 자기공명 영상과 함께 Gd-DTPA 0.1 mmol/kg를 급속 주사 후 자화율 대조 EPI 영상을 얻었다. 영상 기기는 Magnetom Vision(Siemens Medical Systems, Erlangen, Germany)이며, EPI 영상 지표들은 TR/TE는 0.8/29 msec, slice 두께 6 mm, slice 수 10, 화소수 128 $\times$ 128, FOV 215 $\times$ 215 mm, 영상획득 1 회, 1회 검사시간 1.32 초, 검사수 30 회로서, 총 검사시간은 40 초였다. 검사 후 영상처리(post processing)는 Magnetom Vision의 VB31D 자체 프로그램을 이용하였는데, 2-score를 이용한 관류영상은 조영제 유입전 영상들, 조영제 최대 유입기 영상들, 그리고 조영제 배출기 영상들 4-5 회를 각각 한 군으로 하여, Z-score 1.2에서 2.0 사이에서 여러번 반복하여 영상을 재구성하였다. 감산에 의한 역동영상은 조영제 도달 전의 영상으로부터 조영제 유입 후의 영상을 차례로 빼어서 영상을 재구성하였으며, 이들 영상을 재정리하여 각 단면의 시간 경과에 따른 관류 양상을 연속하여 관찰하였다 두 방법에 의한 영상 재구성은 각각 약 10분 정도가 소요되었다.

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경피적 관동맥혈관성형술 후 Re-188을 이용한 혈관 내 방사선조사요법 (Intracoronary Radiation Therapy Using Re-188 after percutaneous Coronary Angioplasty)

  • 채인호;이명묵;이동수
    • 대한핵의학회:학술대회논문집
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    • 대한핵의학회 1999년도 제38차 춘계학술대회
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    • pp.228-241
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    • 1999
  • Percutaneous coronary angioplasty is well established therapeutic modality in the management of coronary artery disease. However, the high restenosis rate of 30 to 50% limits its usefulness. The principal mechanism of restenosis, intimal hyperplasia, is the proliferative response of vessel wall to injury, which consists largely of smooth muscle cells. A large body of animal investigations and a limited number of clinical studies have established the ability of ionizing radiation to reduce neointimal proliferation and restenosis rate significantly. Human studies have been reported that intravascular radiation after first restenosis inhibits a second restenosis. Encouraged by these reports, we are also conducting a double blind, placebo-controlled, randomized trial to evaluate this new therapeutic modality in patients with coronary artery stenosis. The objective of our trial is to determine the safety and efficacy of catheter-based solutional beta emitting radioisotope system in preventing restenosis after angioplasty. This review describes the vascular brachytherapy systems and isotopes that have been utilized in the initial clinical trials performed in this area of post PTCA coronary restenosis. The results of many worldwide ongoing clinical trials will determine whether this new technology will change the future practice of vascular intervention.

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Remodeling of Infarcted Myocardium with Contrast-Enhanced Magnetic Resonance Imaging

  • 최병욱;최규옥;김영진;정남식;임세중
    • 대한자기공명의과학회:학술대회논문집
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    • 대한자기공명의과학회 2003년도 제8차 학술대회 초록집
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    • pp.45-45
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    • 2003
  • To evaluate remodeling of infarcted myocardium with contrast-enhanced MRI (co-MRI) at true end-diastole (ED) MRI was performed with a Gyroscan Intera (1.5 Tesla, Philips, Netherlands) in 13 patients with acute subendocardial myocardial infarction. The First exam was done 0-15 days (mean 5.2days) after symptom onset and the second exam 28-88days (mean 49 days) after the first exam. Ce-MRI encompassing the entire left ventricle was performed with a multi-shot, turbo-field-echo, breath-hold sequence and a non-selective, inversion prepulse 10 minutes after the intravenous injection of Gd-DTPA at a dose of 0.2 mmol/kg body weight. To allow the long TD, ECG synchronization should use two RR-intervals for one acquisition of a segment of k-space by setting the heart rate to half that of the true heart rate. Trigger delay time (TD) was adjusted to the RR-interval for true end-diastolic imaging. The other typical parameters were TR=5.4ms, TE=1.6ms, voxel size=1.37${\times}$1.37${\times}$10mm, k-space data segmented into 8 segments with 32 lines of segment per two cycles over 16 cardiac circles. The thickness of hyperenhanced myocardium and epicardially nonenhanced myocardium were followed.

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Remodeling of Infarcted Myocardium with Contrast-Enhanced Magnetic Resonance Imaging

  • 최병욱;최규옥;김영진;정남식;임세중
    • 대한자기공명의과학회:학술대회논문집
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    • 대한자기공명의과학회 2003년도 제8차 학술대회 초록집
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    • pp.92-92
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    • 2003
  • To evaluate remodeling of infarcted myocardium with contrast-enhanced MRI (co-MRI) at true end-diastole (ED) MRI was performed with a Gyroscan Intera (1.5 Tesla, Philips, Netherlands) in 13 patients with acute subendocardial myocardial infarction. The First exam was done 0-15 days (mean 5.2days) after symptom onset and the second exam 28-88days (mean 49 days) after the first exam. Ce-MRI encompassing the entire left ventricle was peformed with a multi-shot, turbo-field-echo, breath-hold sequence and a non-selective, inversion prepulse 10 minutes after the intravenous injection of Gd-DTPA at a dose of 0.2 mmol/kg body weight. To allow the long TD, ECG synchronization should use two RR-intervals for one acquisition of a segment of k-space by setting the heart rate to half that of the true heart rate. Trigger delay time (TD) was adjusted to the RR-interval for true end-diastolic imaging. The other typical parameters were TR=5.4ms, TE=1.6ms, voxel size=1.37$\times$1.37$\times$10mm, k-space data segmented into 8 segments with 32 lines of segment per two cycles over 16 cardiac cycles. The thickness of hyperenhanced myocardium and epicardially nonenhanced myocardium were followed.

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기관지확장증 환자에서 환기 폐주사의 임상적 의의 (Clinical Significance of $^{99m}Tc-DPTA$ Ventilation Scan in Patient with Bronchiectasis)

  • 박춘식;백승호;어수택;나현;최득린;김기정
    • 대한핵의학회지
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    • 제19권2호
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    • pp.57-63
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    • 1985
  • To evaluate the clinical significance of lung ventilation scan using $^{99m}Tc-DTPA$ in patient with bronchiectasis, we compared the involovement area of bronchogram and lung ventilation scan according to lobar and segmental distribution. There were no correlation between impairment of pulmonary function test and the number of bronchiectatic lobe and segment(p>0.5). Lung ventilation scan showed 66.7% of sensivity, 100% of specificity, ana 91.7% of accuracy according to lobar distribution, and 51.9% of sensivity, 96.9% of specificity, and 88.9% of accuracy according to segmental distribution. These results suggest that lung ventilation scan can be used as diagnostic tool in patient with bronchiectasis in whom bronchogram is not tolerable.

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Intracranial Plasma Cell Granuloma

  • Kim, Dae-Jin;Choi, Yu-Seok;Song, Young-Jin;Kim, Ki-Uk
    • Journal of Korean Neurosurgical Society
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    • 제46권2호
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    • pp.161-164
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    • 2009
  • Plasma cell granuloma is a tumor-like disease characterized by non-neoplastic polyclonal proliferation of plasma cells and other mononuclear cells. This disease occurs most frequently in the lung and upper respiratory tract, while the involvement of the central nervous system is very rare. A 44-year-old female patient presented with nausea and progressive visual disturbance. Brain magnetic resonance imaging (MRI) revealed the mass along the right tentorium with low signal intensity in the T2 weighted image (T2WI) and fluid-attenuated inversion recovery (FLAIR) sequence, and an isosignal intensity in T1 weighted image (T1WI), the latter of which was enhanced after administration of gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA). The thickest portion of the tentorium was partially excised via the combined suboccipital and infratentorial approach. The histopathological examination indicated a diagnosis of plasma cell granuloma. Postoperative steroid therapy was administered for remnant tumor control. Although a follow up MRI scan taken 20 months after the operation showed a slight decrease in tumor size, the lesion had extended to the falx and left frontal convexity along with parenchymal edema at 32 months after the operation and the clinical status was aggravated. The mass was removed from the left frontal convexity. Radiation therapy was given, together with steroid administration.

Studies on the Bleaching Efficiency in Newsprint Using Formamidine Sulfinic Acid

  • Choi, Won-Jung;Kim, Hyoung-Jin
    • 한국펄프종이공학회:학술대회논문집
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    • 한국펄프종이공학회 2006년도 PAN PACIFIC CONFERENCE vol.2
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    • pp.381-386
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    • 2006
  • Many different types of bleaching chemicals and processes have been globally used for deinked pulp. Besides chlorine-free bleaching chemicals, hydrogen peroxide, and sodium dithionite that could be used without restriction for almost all types of fibers, chlorine-containing chemicals such as chlorine dioxide and sodium hypochlorite have also used throughout the world. Even though hydrogen peroxide is commonly used in newsprint, it could not effectively increase brightness. Experimental evaluation on the possibility of using formamidine sulfinic acid (FAS), a reducing agent, for bleaching a wood-containing deinked pulp has been carried out in this study. The effect of bleaching efficiency for FAS on operational conditions and chemical concentrations compaired to hydrogen peroxide in one and two stages was studied. FAS bleaching showed higher brightness at high temperature and low consistency, and vice versa for peroxide one. Bleaching with sodium silicate and DTPA in FAS and peroxide stage showed better results than cases without them. Sodium silicate and chelant seemed minimize the influence of transition metal ions, including manganese and iron ions, which induce both bleaching agents to decompose. As a result, FAS as a reducing agent seems more effective than hydrogen peroxide for increasing brightness and reducing yellowness. FAS and FAS sequence seemed more efficient than the other two stages of bleaching sequences with regard to the best brightness level obtained. When bleaching was conducted with FAS, COD load was just about one-third compared to peroxide, and brightness stability of the bleached pulp appeared better than peroxide after UV light irradiation.

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Tc-99m 거대응집알부민을 이용한 폐관류 스캔에서 관찰되는 다발성 열소 (Hot Spots on Tc-99m MAA Perfusion Lung Scan)

  • 임석태;손명희
    • 대한핵의학회지
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    • 제35권4호
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    • pp.288-290
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    • 2001
  • A 61 year-old woman underwent perfusion and inhalation lung scan for the evaluation of pulmonary thromboembolism. Tc-99m MAA perfusion lung scan showed multiple round hot spots in both lung fields. Tc-99m DTPA aerosol inhalation lung scan and chest radiography taken at the same time showed normal findings (Fig. 1, 2). A repeated perfusion lung scan taken 24 hours later demonstrated no abnormalities (Fig. 3). Hot spots on perfusion lung scan can be caused by microsphere clumping due to faulty injection technique or by radioactive embolization from upper extremity thrombophlebitis after injection. Focal hot spots can signify zones of atelectasis, where the hot spots probably represent a failure of hypoxic vasoconstriction. Artifactual hot spots due to microsphere clumping usually appear to be round and in peripheral location, and the lesions due to a loss of hypoxic vasoconstriction usually appear to be hot uptakes having linear $borders^{1-3)}$. Although these artifactual hot spots have been well-known, we rarely encounter them. This report presents a case with artifactual hot spots due to microsphere clumping on Tc-99m MAA perfusion lung scan.

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