• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 1999.10c
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• pp.783-788
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• 1999

In this study, a decision support system (DSS) was developed to calculate optimal wastetreatment cost, treatment level and treatment quantity of various pollutants for applying for in rural basin. The DSS includes a gegraphic informatino system (GIS), relational database system (RDBS), water quality models(Loading function , WASP5), watershed pollution load calculation module(SPLC), optimal water quality management plan to satisfy the water quality regulations. The system can be modified by user to trace the optimal condition for decision. The effort was conducted to apply the developed DSS to select the for optimal water quality management plan small rural basin called Kwanri Stream.

• Korean Journal of Pharmacognosy
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• v.50 no.1
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• pp.37-45
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• 2019

Portulaca oleracea L. (PL) has been used in traditional medicine herb for treatment of various diseases, such as diarrhea, dysentery, and skin inflammation. Previous studies have shown that the PL regulates the inflammation by inhibition of pro-inflammatory cytokines. Although PL might have improvement effects of intestinal function and bioactive effects, there are not enough studies to demonstrate. This study investigated the effects of KDC16-2 on the improvement of intestinal function and anti-inflammatory effects in vivo and in vitro. The improvement effect of intestinal function was measured fecal amount, water content and intestinal transit rate in KDC16-2 treated ICR mice. As results, compared with the control group, the KDC16-2 group showed a significant increase in wet fecal weight, dry fecal weight and fecal water content. The intestinal transit rate of KDC16-2 group was significantly increased. Based on the results, KDC16-2 is considered to have effects on improving intestinal function. The effect of anti-inflammatory demonstrated by using dextran sulfate sodium (DSS)-induced colitis mice. The mice were administered 3% DSS along with KDC16-2 (100, 300 mg/kg) for 14 days. DSS-induced colitis mice were significantly ameliorated in KDC16-2 treated group, including body weight loss, colon length shortening, tight junction protein of colon and histological colon injury. The levels of inflammatory mediators (IgG2a, IgA, C-reactive protein and Myeloperoxidase) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-${\alpha}$, Interleukin (IL)-6) which are involved in inflammatory responses were increased in the DSS-treated group as compared to those in the control group, and the levels were significantly decreased in the KDC16-2 groups. In addition, we investigated the impact of KDC16-2 on lipopolysaccharide (LPS)-induced inflammatory responses in J774A.1 cells. KDC16-2 inhibited production of prostaglandin E2 (PGE2) and reactive oxygen species (ROS). These results suggested that the KDC16-2 could effectively alleviate the dysfunction of intestinal and inflammatory mediators. Thus, these KDC16-2 can be potentially used as health functional food of intestinal.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.1
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• pp.54.3-55
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• 2016

DEEP-South Scheduling and Data reduction System (DS SDS) consists of two separate software subsystems: Headquarters (HQ) at Korea Astronomy and Space Science Institute (KASI), and SDS Data Reduction (DR) at Korea Institute of Science and Technology Information (KISTI). HQ runs the DS Scheduling System (DSS), DS database (DB), and Control and Monitoring (C&M) designed to monitor and manage overall SDS actions. DR hosts the Moving Object Detection Program (MODP), Asteroid Spin Analysis Package (ASAP) and Data Reduction Control & Monitor (DRCM). MODP and ASAP conduct data analysis while DRCM checks if they are working properly. The functions of SDS is three-fold: (1) DSS plans schedules for three KMTNet stations, (2) DR performs data analysis, and (3) C&M checks whether DSS and DR function properly. DSS prepares a list of targets, aids users in deciding observation priority, calculates exposure time, schedules nightly runs, and archives data using Database Management System (DBMS). MODP is designed to discover moving objects on CCD images, while ASAP performs photometry and reconstructs their lightcurves. Based on ASAP lightcurve analysis and/or MODP astrometry, DSS schedules follow-up runs to be conducted with a part of, or three KMTNet telescopes.

• Clinical Psychopharmacology and Neuroscience
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• v.16 no.4
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• pp.422-433
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• 2018

Objective: Neuropsychiatric manifestations like depression and cognitive dysfunction commonly occur in inflammatory bowel disease (IBD). In the context of the brain-gut axis model, colitis can lead to alteration of brain function in a bottom-up manner. Here, the changes in the response of the hypothalamic-pituitary-adrenal axis and inflammation-related markers in the brain in colitis were studied. Methods: Dextran sodium sulfate (DSS) was used to generate a mouse model of colitis. Mice were treated with DSS for 3 or 7 days and sacrificed. We analyzed the gene expression of brain-derived neurotrophic factor (BDNF), cyclooxygenase 2 (COX-2), and glial fibrillary acidic protein (GFAP), and the expression of GFAP, in the hippocampus, hypothalamus, and amygdala. Additionally, the levels of C-reactive protein (CRP) and serum cortisol/corticosterone were measured. Results: Alteration of inflammatory-related markers varied depending on the brain region and exposure time. In the hippocampus, COX-2 mRNA, GFAP mRNA, and GFAP expression were upregulated during exposure to DSS. However, in the hypothalamus, COX-2 mRNA was upregulated only 3 days after treatment. In the amygdala, BDNF and COX-2 mRNAs were downregulated. CRP and corticosterone expression increased with DSS treatment at day 7. Conclusion: IBD could lead to neuroinflammation in a bottom-up manner, and this effect varied according to brain region. Stress-related hormones and serum inflammatory markers, such as CRP, were upregulated from the third day of DSS treatment. Therefore, early and active intervention is required to prevent psychological and behavioral changes caused by IBD, and region-specific studies can help understand the precise mechanisms by which IBD affects the brain.

• Journal of Microbiology and Biotechnology
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• v.32 no.7
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• pp.877-884
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• 2022

Probiotics are microorganisms that can benefit host health when ingested in a live state, and lactic acid bacteria are the most common type. Among fungi, Saccharomyces boulardii (SB) is the only strain known to have a probiotic function with beneficial effects on colitis; however, information on other probiotic yeast strains is limited. Therefore, this study aimed to discover yeast strains expressing intestinal anti-inflammatory activities by exhibiting probiotic properties in dextran sodium sulfate (DSS)-induced colitis mice model. Nuruk (Korean traditional fermentation starter) containing various microbial strains was used as a source for yeast strains, and S. cerevisiae 28-7 (SC28-7) strain was selected with in vitro and in vivo characteristics to enable survival in the intestines. After 14 days of pretreatment with the yeast strains, DSS was co-administered for six days to induce colitis in mice. The results revealed that the disease activity index score was lowered by SC28-7 treatment compared to the DSS group, and the colon length and weight/length ratio were recovered in a pattern similar to that of the normal group. SC28-7 administration significantly reduced the secretion of pro-inflammatory cytokines in the serum and modified the mRNA expression of inflammatory cytokines (interleukin-1β, transforming growth factor-β, and interferon-γ) and proteins involved in gut barrier functions (mucin 2, mucin 3, zonula occludens-1, and occludin) in colon tissues. These results indicate that SC28-7 attenuates DSS-induced colon damage and inflammation, supporting its future use as a probiotic yeast for treating and preventing intestinal inflammatory diseases such as inflammatory bowel disease.

• Journal of the Korea Safety Management & Science
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• v.5 no.2
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• pp.111-127
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• 2003

In this paper, a new method of product function analysis is presented to categorize various design information generated in product development processes. In order to improve product functions, designers must understand unit functions and modified parts of products. The product function analysis (PFA) is based on the designer's understanding of product functions. The proposed PFA provides the methodology to classify the various functions systematically and understand the relation between functions easily. Using this approach, efficient design support system can be developed and used for designers to support decision-making with design knowledge.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.05a
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• pp.122-124
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• 2022

Handling Passenger Traffic is the main challenge for designing an elevator group-control algorithm. Advanced control systems such as Hyundai's Destination Selection System(DSS) lets passengers select the destination by pressing on a selecting screen, and the systems have shown great efficiency. However, the algorithm cannot be applied to the general elevator control system due to the expensive cost of the technology. Often many elevator systems use Nearest Car(NC) algorithms based on the SCAN algorithm, which results in time efficiency problems. In this paper, we designed an elevator group-control algorithm for specific buildings that have approximate timetable data for most of the passengers in the building. In that way, it is possible to predict the destination and the location of passenger calls. The algorithm consists of two parts; the waiting function and the assignment function. They evaluate elevators' actions with respect to the calls and the overall situation. 10 different timetables are created in reference to a real timetable following midday traffic and interfloor traffic. The specific coefficients in the function are set by going through the genetic algorithm process that represents the best algorithm. As result, the average waiting time has shortened by a noticeable amount and the efficiency was close to the known DSS result. Finally, we analyzed the algorithm by evaluating the meaning of each coefficient result from the genetic algorithm.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.25 no.9
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• pp.671-676
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• 2012

In this paper, TCAD assessment of 30-V class n-channel EDMOS (extended drain metal-oxide-semiconductor) transistors with DWFG (dual work function gate) structure are described. Gate of the DWFG EDMOS transistor is composed of both p- and n-type doped region on source and drain side. Additionally, lengths of p- and n-type doped gate region are varied while keeping physical channel length. Two-dimensional device structures are generated trough TSUPREM-4 and their electrical characteristics are investigated with MEDICI. The DWFG EDMOS transistor shows improved electrical characteristics than conventional device - i.e. higher transconductance ($g_m$), better drain output current ($I_{ON}$), reduced specific on-resistances ($R_{ON}$) and higher breakdown characteristics ($BV_{DSS}$).

• Food Science of Animal Resources
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• v.34 no.6
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• pp.829-835
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• 2014

Inflammatory bowel disease (IBD) is caused by dysregulation of colon mucosal immunity and mucosal epithelial barrier function. Recent studies have reported that lipoteichoic acid (LTA) from Lactobacillus plantarum K8 reduces excessive production of pro-inflammatory cytokine. In this study, we investigated the preventive effects of lysate of Lb. plantarum K8 in dextran sulfate sodium (DSS)-induced colitis. Male Sprague-Dawley rats were orally pretreated with lysate of Lb. plantarum K8 (low dose or high dose) or live Lb. plantarum K8 prior to the induction of colitis using 4% DSS. Disease progression was monitored by assessment of disease activity index (DAI). Histological changes of colonic tissues were evaluated by hematoxylin and eosin (HE) staining. Tumor necrosis factor-alpha (TNF-${\alpha}$), interleukin-6 (IL-6) levels were measured using enzyme-linked immunosorbent assay (ELISA). The colon mRNA expressions of TNF-${\alpha}$, IL-6, and toll like receptor-2 (TLR-2) were examined by quantitative real-time-transcription polymerase chain reaction (qPCR). Lysate of Lb. plantarum K8 suppressed colon shortening, edema, mucosal damage, and the loss of DSS-induced crypts. The groups that received lysate of Lb. plantarum K8 exhibited significantly decreased levels of the pro-inflammatory cytokines TNF-${\alpha}$ and IL-6 in the colon. Interestingly, colonic expression of toll like receptor-2 mRNA in the high-dose lysate of Lb. plantarum K8 group increased significantly. Our study demonstrates the protective effects of oral lysate of Lb. plantarum K8 administration on DSS-induced colitis via the modulation of pro-inflammatory mediators of the mucosal immune system.

• Journal of KIISE:Databases
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• v.30 no.4
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• pp.408-419
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• 2003

Data warehouses are usually dedicated to the processing of quires issued by decision support system(DSS). The response time of DSS queries is typically several orders of magnitude higher than the one of OLTP queries. Since DSS queries are often submitted interactively, techniques for reducing their response time are important. The caching of query results is one such technique particularly well suited to the DSS environment. In this paper, we present a cache manager for such an environment. Specifically, we define a canonical form of query. The cache manager looks up a query based on the exact query match or using a suggested query split process if the query is found is non-canonical form or in canonical form, respectively. It dynamically maintains the cache content by employing a profit function which reflects in an integrated manner the query execution cost, the size of query result, the reference rate, the maintenance cost of each result due to updates of their base tables, and the frequency of such updates. We performed the experimental evaluation and it positively shows the performance benefit of our cache manager.