• 한국공간정보시스템학회:학술대회논문집
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• 2000.06a
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• pp.93-105
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• 2000

GIS is a powerful toolbox in managing spatial data associated with attribute data. However GIS is short of spatial analysis function and graphic user interface(GUI) function in dealing with dynamic planning problems. Decision Support Systems(DSS) make up for the shortage of GIS by providing GUI function, modeling function and database function. Spatial Decision Support Systems(SDSS), a new kind of DSS, incorporate display function, basic spatial analysis function and manipulation function of spatial data and attribute data of GIS and GUI function, modeling function and database function of DSS in dealing with spatial planning problems. Planning Support Systems(PSS) add more advanced spatial analysis function and intertemporal function to the functions of SDSS. This study focuses on the modeling of a PSS for capacity expansion of water-distribution network depending upon land use planning by using GIS, value engineering(VE) and life cycle costing(LCC). The PSS shows a guideline about the investment of water-distribution networks related to urban growth management through generating certain numbers of dynamic alternatives to supply the amount of water caused by land use planning.

• Korean Journal of Construction Engineering and Management
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• v.13 no.1
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• pp.129-139
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• 2012

It is one of the most important decision making problems to select the adequate foundation practice for the downtown construction project. However the foundation practice has not been selected systematically yet by considering various construction field conditions in many projects. The foundation practice is often informally selected on the basis of only past experiences and skilled engineer's opinion. For making the selection process systematically, in this study, we propose a decision support system (DSS) for selecting foundation practices based on the Analytic Hierarchy Process (AHP) and the Preference Function (PF). In the proposed DSS, the AHP is used for making the selection process more reasonable and the PF is used for considering the decision maker's preference. To validate the proposed DSS, we apply the proposed DSS to the pre-performed construction projects. The application results show that the proposed DSS gives the same foundation practices with the implemented foundation practices that the skilled foundation engineers select after carefully analyzing construction field conditions. The proposed DSS can be used as a useful tool for making decisions to select the foundation practice in the construction fields.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2235-2245
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• 2016

Ulcerative colitis (UC) results from colonic epithelial barrier defects and impaired mucosal immune responses. In this study, we aimed to investigate the modifying effects of a Spirogyra neglecta extract (SNE), a polysaccharide extract (PE) and a chloroform fraction (CF) on dextran sodium sulfate (DSS)-induced colitis in mice and to determine the mechanisms. To induce colitis, ICR mice received 3% DSS in their drinking water for 7 days. Seven days preceding the DSS treatment, oral administration of SNE, PE and CF at doses of 50, 25 and 0.25 mg/kg body weight (low dose), 200, 100 and 1 mg/kg body weight (high dose) and vehicle was started and continued for 14 days. Histologic findings showed that DSS-induced damage of colonic epithelial structure and inflammation was attenuated in mice pre-treated with SNE, PE and CF. Furthermore, SNE and PE significantly protected colonic epithelial cells from DSS-induced cell cycle arrest, while SNE, PE and CF significantly diminished apoptosis. Proteome analysis demonstrated that SNE and PE might ameliorate DSS-induced colitis by inducing antioxidant enzymes, restoring impaired mitochondria function, and regulating inflammatory cytokines, proliferation and apoptosis. These results suggest that SNE and PE could prevent DSS-induced colitis in ICR mice by protection against and/or aiding recovery from damage to the colonic epithelium, reducing ROS and maintaining normal mitochondrial function and apoptosis.

• The Research Journal of the Costume Culture
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• v.17 no.4
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• pp.723-732
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• 2009

The quick response(QR) system is very popular in Korean apparel companies. However, the usage of QR system was not known well. The purpose of this study is to identify the usage of the quick response decision support system(QR DSS) and postponement manufacturing in the Korean apparel company. The researched company was the only one which used the QR DSS. The researchers carried out the depth interview with the QR decision makers of the company. This company had 14 brands, and had used the QR DSS since January, 2008. The results are as follows: The QR DSS was supportive computer software program, and it helped the staffs to make agile decision about QR repeat production of clothing. The QR DSS automatically calculated the related data, and suggested the expected sales volume and the proper supply amounts of the styles. There were four functions in QR DSS : 'QR Alert', 'Proper Supply Amount Simulation', 'Sensible QR', and 'Supply/Sales Simulation by Item'. The men's clothing brands effectively used 'Supply/Sales Simulation by Item' function. And the women's clothing brands effectively used 'QR Alert' function. This company also used the postponement production system for QR repeat production. The postponement production was conducted with four methods : the yarn stocking, the grey fabric stocking, the dyed fabric stocking, and the fabric sourcing. The men's clothing brands usually used of the yarn stocking methods and the dyed fabric stocking methods. The women's clothing brands usually used the grey fabric stocking methods. By using QR DSS and postponement production system the company was able to shorten the lead time for QR decision making.

• Journal of Nutrition and Health
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• v.37 no.6
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• pp.431-439
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• 2004

Scutellariae Radix (Scu.), one of the immune-regulatory substances, is recognized to play the role in the metabolic process of inflammation, allergy and immunity. It has been traditionally used in the Oriental medicine to treat inflammatory bowel diseases (IBD). The purpose of this study was to evaluate the effects of water extracts of Scutellariae Radix on the spleen lymphocyte immune function in the Balb/c female mice treated with dextran sodium sulfate (DSS) to induce colitis. Water extract of Scutellariae Radix (100 mg/kg) and sulfasalazine (50 mg/kg) were administrated orally for 2 weeks of experimental period. Mice were divided into three experimental groups randomly: DSS group (5％ DSS was ad libitum for 5 days) as control group, DSS ＋ Scu. (water extracts of Scutellariae Radix for 2 weeks after 5％ DSS was ad libitum for 5 days) as experimental group, and DSS ＋ Sulfasalazine group (Sulfasalazine for 2 weeks after 5％ DSS was ad libitum for 5 days) as positive control group. Levels of Ig A, Ig E, CD4$^{＋}$, CD8$^{＋}$, TNF-$\alpha$ and other cytokines were measured. Treatment of DSS for 5 days induced bowel inflammation and the treatment with Scu. water exteract and sulfasalazine significantly recovered the damage. The length of intestine of DSS group was significantly shorter than that of other groups. The serum and fecal concentration of Ig A of SS ＋ Scu group was higher than those of DSS group. The contents of CD4$^{＋}$ T cells was higher in the DSS ＋ Scu. group than the other groups and CD8$^{＋}$ T cells was the lowest in DSS ＋ Sulfasalazine group. The Ig A level of cultured supernatant of spleen lymphocyte was the highest, while the Ig E level was the lowest in SS ＋ Scu group. The concentration of TNF-$\alpha$, cytokine secreted from the Th1 cell in the supernatant spleen lymphocyte, was the highest in the DSS group and the lowest in the DSS ＋ Scu. group. The concentration of IFN-${\gamma}$ and ll...-12 was lower in the DSS ＋ Scu. group than those of the other groups. The concentration of IL-4 in the supernatant of spleen lymphocyte was the lowest in the DSS ＋ Scu. group but IL-10 was not significantly different. Based on these findings, water extract of Scutellariae Radix exhibited the inhibitory effect via IL-4 production thereby inhibited the production of Ig E and strengthened immune system, and alleviated injury in DSS- induced colitis mice model.

• Korean Journal of Plant Resources
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• v.35 no.3
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• pp.391-398
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• 2022

Ulcerative colitis (UC) is a typical inflammatory colon disorder. Platycodon grandiflorum (PG) is known to exert various beneficial effects including anti-oxidative and anti-bacterial properties and improvements in liver function. However, the improving effect and mechanism of PG on intestinal inflammation are not fully understood. The present research was designed to investigate the effect of PG on the clinical signs of DSS-induced colitis in mice. The ameliorative effects of PG on inflammatory cytokine expression and the activation of hypoxia-inducible-factor (HIF)-1α in DSS-treated colon tissue were also determined. Our results showed that mice treated with DSS displayed the main clinical symptoms of colitis, including weight loss, bloody stools, decrease in colon length and diarrhea and PG treatment significantly improved the clinical features induced by DSS in mice. PG inhibited the increase in the levels of inflammatory cytokines caused by DSS in colon tissues. We also showed that the anti-inflammatory mechanism of PG involved suppressing the activation of HIF-1α in DSS-treated colon tissues. Collectively, the findings of this study indicate the prospect of developing new drugs from PG for UC treatment.

• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.536-542
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• 2016

Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan (Chinese name Mudanpi) is a traditional Chinese medicine using for treating vascular diseases. Danshensu (DSS) is a main effective monomer composition derived from radix Salviae miltiorrhizae and paeonol (Pae) from cortex moutan. Although the two herbs are widely used in traditional Chinese medicine, the pharmacological functions of their active compositions were not reported. Therefore, the research of DSS and Pae in mechanisms and pharmacodynamics interaction can provide scientific evidence to support clinical application. The diabetic nephropathy (DN) rats which were induced by streptozotocin (STZ) were treated with SDO, DSS, Pae, and DSS+Pae for eight weeks. The positive effects on DN animal models were investigated by detection of physiological and biochemical indexes and oxidative stress markers, within five treatments: SDO, DSS, Pae, DSS+Pae and insulin group. Compared with the model group, the DSS+Pae group improved the renal function, blood lipid metabolism and blood viscosity, increased the vitality of T-SOD or T-AOC and decreased the level of MDA or NO after the treatment. The study was successfully showed that the DSS+Pae group could delay the process of DN, especially in the renal injury part of histopathology changes. Our results suggest that the co-administration of DSS and Pae significantly may play a protective role in DN rats through decreasing the oxidative stress and improving the blood lipid metabolism mechanisms.

• Biomedical Science Letters
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• v.19 no.3
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• pp.188-194
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• 2013

Ulcerative colitis (UC) is an inflammatory bowel disease, which is a chronic gastrointestinal disorder. Adenophorae Radix (AR) has been used as a traditional medicine for various diseases including strengthening cardiac function, allaying a fever, and easing pain and cough. However, the regulatory effects of AR in intestinal inflammation are not yet understood. This study attempted to determine the effect of AR in dextran sulfate sodium (DSS) - induced colitis in mice. The colitis mice were induced by drinking water containing 5% DSS for 7 days. The results showed that mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. Administration of AR attenuated weight loss, colon shortening and inhibited the levels of interleukin (IL) - 6 in DSS - treated colon tissues. These results provide experimental evidence that AR might be a useful therapeutic medicine for patients with UC.

• International Journal of Internet, Broadcasting and Communication
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• v.13 no.2
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• pp.145-155
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• 2021

With the recent rapid improvement in the standards of life and westernization of dietary lifestyles, the consumption of high-calorie diets such as high-fat and high-protein red meat and instant foods has increased, while less vegetables containing dietary fiber are consumed. In addition to that, stress, erroneous dietary behaviors, and contaminated environments are linked to the risk of developing ulcerative colitis, which is on the rise. Another cause of ulcerative colitis is that involve laxative abuse, including repeated, frequent use of laxatives, and include such conditions as deteriorated bowel function, irritable bowel syndrome, diarrhea, intestinal inflammation, etc. The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and combination with herbal medicine on dextran sodium sulfate (DSS)-induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): group I-normal group, group II-DSS control group, group III-DSS + sulfasalazine (30 mg/kg), group IV-DSS + sulfasalazine (60 mg/kg), group V-DSS + sulfasalazine (30 mg/kg) + Radish Extract mixture (30 mg /kg) (SRE). DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. SRE supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SRE treatment significantly reduced the expression of pro-inflammatory signaling molecules through suppression both mitogen-activated protein kinases (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways, and prevented the apoptosis of colon. Moreover, SRE administration significantly led to the up-regulation of antioxidant enzyme including SOD and Catalase. This is the first report that Radish extract mixture combined with sulfasalazine protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine.

• Magazine of the Korean Society of Agricultural Engineers
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• v.42 no.5
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• pp.103-113
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• 2000

A decision support system DSS-WQMRA (Decision Support System-Water Quality Management in Rural Area) was developed to help regional planners for the water quality management in a rural basin. The integrated model DSS-WQMRA, written in JAVA, includes four subsystems such as a GIS, a database, water quality simulation models and a decision model. In the system, the GIS deals with landuse and the location of pollutant sources. The database manages each data and supplies input data for various water quality simulation models. the water quality simulation model is composed of the GWLF( Generalized Watershed Loading Function), PCLM(Pollutant Loading Calculation Module) and the WASP5 model. The decision model based on mixed integer programming is designed to determine optimal costs and thus allow the selection of managemental practices to meet the water quality criteria. The methodology was tested with an example application in the Bokha River Basin, Kyunggi Province in Korea. It was proved that the integrated model DSS-WQMRA could be very useful for water quality management including the non-point source pollution in rural areas.