• Journal of Biomedical Engineering Research
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• v.41 no.1
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• pp.62-66
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• 2020

Controlled drug release is important for effective treatment of cancer. Poly(DL-lactide-co-glycolide) acid (PLGA) is a Food and Drug Administration (FDA) approved polymer and have been extensively studied as drug delivery carriers with biodegradable and biocompatible properties. However, PLGA drug delivery carriers are limited due to the initial burst release of drug. Certain drugs require an early rapid release, but in many cases the initial rapid release can be inefficient, reducing therapeutic effects and also increasing side effects. Therefore, sustained release is important for effective treatment. Poly Lactic Acid stereo complex (PLA SC) is resistant to hydrolysis and has high stability in aqueous solutions. Therefore, in this work, PLGA based discoidal polymeric particles are modified by Poly Lactic Acid stereocomplex (PLAsc DPPs). PLAsc DPPs are 3 ㎛ in diameter, also showing a relatively sustained release profile. Fluorescein 5(6)-isothiocyanate (FITC) released from PLAsc DPPs was continuously observed until 38 days, which showed the initial release of FITC from PLAsc DPPs was about 3.9-fold reduced as compared to PLGA based DPPs at 1 hour.

• Proceedings of the Korean Vacuum Society Conference
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• 1999.02a
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• pp.176-176
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• 1999

• Proceedings of the Korean Vacuum Society Conference
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• 1999.02a
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• pp.184-184
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• 1999

• Rapid Communication in Photoscience
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• v.3 no.4
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• pp.73-75
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• 2014

Novel diphenylphenanthrenes (DPPs) were prepared by a photocyclization method, and the substituent effects of the phenyl groups on the photophysical properties of the phenanthrene chromophore were investigated based on measurements of fluorescence yields, lifetimes, and transient absorption. Fluorescence activities in DPPs are increased by introducing phenyl rings that can enhance the transition moment along the short axis of the phenanthrene skeleton. Intersystem crossing from the fluorescent states to the triplet manifolds is shown to be operative through the triplet-triplet absorption spectra obtained by laser photolysis techniques.

• Journal of KIISE:Software and Applications
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• v.30 no.12
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• pp.1149-1157
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• 2003

As an Embedded system combining hardware and software gets more complicated, the importance of the embedded software test increases. Especially, it is mandatory to test the embedded software in the system which has high safety level. In embedded system, it is necessary to develop a test technique to detect faults in interaction between hardware and software. In this paper, we propose a test data selection technique using a fault injection technique for the faults in interaction between hardware and software in embedded system and we apply our technique to the Digital Plant Protection System and analyze effectiveness of the proposed technique through experiments.

• Journal of KIISE:Software and Applications
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• v.32 no.2
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• pp.108-118
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• 2005

The software of the nuclear power plant digital control system is a safety-critical system where many techniques must be applied to it in order to preserve safety in the whole system. Formal specifications especially allow the system to be clearly and completely specified in the early requirements specification phase, therefore making it a trusted method for increasing safety. In this paper, we discuss a systematic method, which generates PLC-based FBD programs from the requirements specification using NuSCR, a formal requirements specification method. This FBD programs takes an important position in design specification. The proposed method can reduce the possible errors occur in the manual design specification, and the software development cost and time. To investigate the usefulness of our proposed method, we introduce the fixed set-point rising trip example, a trip logic of BP in DPPS RPS, which is presently being developed at KNICS.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.4
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• pp.1460-1478
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• 2020

This paper proposes a novel anti-collision protocol for large-scale RFID tags identification, named Bi-response Collision Tree Protocol (BCT). In BCT, two group of tags answer the reader's same query in two response-cycles respectively and independently according to the bi-response pattern. BCT improves the RFID tag identification performance significantly by decreasing the query cycles and the bits transmitted by the reader and tags during the identification. Computation and simulation results indicate that BCT improves the RFID tag identification performance effectively, e.g. the tag identification speed is improved more than 13.0%, 16.9%, and 22.9% compared to that of Collision Tree Protocol (CT), M-ary Collision Tree Protocol (MCT), and Dual Prefix Probe Scheme (DPPS) respectively when tags IDs are distributed uniformly.

• Proceedings of the Korean Information Science Society Conference
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• 2001.04a
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• pp.595-597
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• 2001

오늘날 우리가 사용하고 있는 시스템은 날이 갈수록 규모 면에서 대형화되고, 기능면에서 복잡해지고 있다. 이런 복잡성의 증가로 시스템 에러 발생가능성은 더욱 높아졌다. 특히, safety-critical 시스템의 경우 에러가 발생했을 때 인간과 생태계에 엄청난 영향을 미치기 때문에 더욱 신중한 개발 과정이 필요하다. 따라서 정형기법을 이용한 safety-critical 시스템의 개발방법론이 나오게 되었다. 본 논문에서는 대표적인 safety-critical 시스템인 원자력 발전소 시스템에서 Digital Plant Protection System(DPPS)를 가지고 어떻게 방법론이 적용되는지를 보여준다. Software Cost Reduction(SCR)이라는 정형 명세 도구로 명세를 하였고, SPIN 이라는 정형 검증 도구로 그 특성(property)을 검증하였다.

• Proceedings of the Korean Information Science Society Conference
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• 2001.04a
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• pp.586-588
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• 2001

원전보호계통(RPS: Reactor Protection System)은 사고 시 치명적 피해를 입을 수 있다는 점에서 안전에 대한 중요도가 가장 높은 Safety 1E class로 분류되며, 이러한 보호계통을 디지털 라이즈 하는데 있어서 높은 신뢰도에 대한 보장이 필요하다. 따라서 본 논문에서는 DPPS(Digital Plant Protection System) 내에서 작동하는 내장형 소프트웨어의 높은 신뢰성을 보장하기 위한 테스팅 방법론을 제시하고자 한다. DPPS에서 작동하는 내장형 소프트웨어를 테스트하기 위한 방법은 크게 두 가지로 나누어진다. 첫 번째 단계는 절차중심의 프로그램에서 객체를 추출하고 이를 이용하여 클래스를 추출하는 제공학의 단계이다. 두 번째 단계는 이러한 클래스들을 이용하여 레벨별 테스팅을 수행하기 위한 테스트 아이템을 추출하고, 추출된 테스트 아이템을 이용하여 테스트 케이스를 선정하는 단계이다. 이렇게 각 레벨별로 선정된 테스트 케이스를 이용하여 단위 테스팅, 통합 테스팅, 시스템 테스팅 이렇게 3단계의 레벨별 테스팅을 수행한다.

• Nuclear Engineering and Technology
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• v.36 no.2
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• pp.184-195
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• 2004

The multi-tasking feature of digital I&C equipment could increase risk concentration because the I&C equipment affects the actuation of the safety functions in several ways. Anticipated Transient without Scram (ATWS) is a typical case of safety function failure in nuclear power plants. In a conventional analysis, mechanical failures are treated as the main contributors of the ATWS. This paper quantitatively presents the probability of the ATWS based on a fault tree analysis of a Korea Standard Nuclear Power Plant is also presented. An analysis of the digital equipment in the digital plant protection system. The results show that the digital system severely affects the ATWS frequency. We also present the results of a sensitivity study, which show the effects of the important factors, and discuss the dependency between human operator failure and digital equipment failure.