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Subacute Toxicity of HRccine (HFRS-virus vaccine) in Rats (HRccine(HFRS-virus vaccine)의 Rat에서의 아급성독성)

  • 조효진;백영옥;임동문;최재묵;김달현;박관하;조정식;이영순
    • Toxicological Research
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    • v.11 no.1
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    • pp.137-145
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    • 1995
  • HRccine was administered subcutaneously to rats for 4 weeks at dose levels of 300, 60 and 12 times the expected clinical dose to evaluate the subacute toxicity. There were no treatment-related effects in clinical signs, body weight changes, food consumption, water consumption, urinalysis and blood biochemistry in any dose groups. In hematological examinations, increase of leucocyte counts and decrease of hemoglobin concentration were observed in the high dose-treated group. However, no treatment-attributable pathological changes were observed in microscopic examinations. The no-effect dose in subacute toxicity study of rats was considered to be 300 times the expected clinical dose.

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A Consideration on the Characteristics of Electron Beam Dose Distributions for Clinical Applications (임상적용을 위한 전자선의 선량분포 특성에 대한 고찰)

  • Cha, Dong-Soo
    • Korean Journal of Digital Imaging in Medicine
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    • v.12 no.1
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    • pp.65-69
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    • 2010
  • High energy electron beams were to concentrically dose inside a tumor and more energy is a shape decreased of dose. Therefore, it is useful to radiation therapy of a tumor. Also high energy electron beams ionized into collision with a atom in structure material of tissue and it has big changes to dose distribution by multiple scattering. The study had to establish characteristic of electron beams from interaction of electron beams and materials. Experiment method was to measure dependence of electron beam central axis for depth dose curve, field flatness and symmetry and field size dependence. The results were able to evaluate data for a datum pint of electron beam. Also radiotherapy has to be considered for not only energy pencil of lines but characteristic, electron guide and isodose curves distribution.

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Three-Dimensional Dose Distribution for the System of Linear Accelerator-based Stereotactic Radiosurgery (LINAC을 이용한 뇌정위적 방사선 수술에 대한 3 차원 선량분포)

  • Suh, Tae-Suk
    • Progress in Medical Physics
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    • v.2 no.2
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    • pp.121-128
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    • 1991
  • Radiosurgery treatment in the brain requires detailed information on three-dimensional dose distribution. A three-dimensional treatment planning is a prerequisite for treatment plan optimization. It must cover 3-D methods for representing the patient, the dose distributions, and beam settings. Three-dimensional dose models for non-coplanar moving arcs were developed using measured single beam data and efficient 3-D dose algorithms for circular fields. The implementation of three dimensional dose algorithms with stereotactic radiosurgery and the application of the algorithms to several cases are discussed.

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Analysis of Dose Distribution of IORT Cone (IORT CONE의 선량분포에 관한 연구)

  • 김명세;김성규;신세원
    • Progress in Medical Physics
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    • v.2 no.2
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    • pp.141-148
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    • 1991
  • A since authors started IORT for stomach cancer patient on 198, we developed various sized, shaped IORT cones for better clinical application and homogeneous surface and depth dose distribution. Authors concluded as following. 1. The shaping block should be fixed on the tray, not under the tray for homogeneous dose distribution. 2. The straight cone was showed better dose distribution than divergence cone. 3. The acryl cone was superior than the stainless-steel cone. 4. The acryl cover fixed on the end for IORT cone not only improvement of surface dose, but also homogenity of depth dose.

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Radiation Sterilization Dose of Biowastes (방사선을 이용한 생물폐자원의 멸균선량 결정)

  • Lee, Young-Keun;Chang, Hwa-Hyoung;Han, Gab-Jin;Kim, Jin-Kyu;Kim, Jae-Sung
    • Korean Journal of Environmental Agriculture
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    • v.17 no.4
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    • pp.368-370
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    • 1998
  • In order to determine the optimal radiation dose for the sterilization of biowastes, the bioburden, frequencies and radiosensitivities of bacteria, mold and fungi in rice straw, chaff, corn stover and sawdust was observed before and after ${\gamma}-ray$ irradiation. Radiation sterilization dose of rice straw, chaff, com stover and sawdust was calculated as 17.7, 17.6, 15.6 and 20.0kGy, respectively, from the mutual compensation of screening dose and derived dose on the basis of $10^{-3}$ SAL. This method could be acceptable for the sterilization of various biowastes including food, pharmaceuticals, etc.

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Measurements of X-Ray and Gamma Ray Dosse Rate by the Silicon P-N Junction Diode (Silicon P-N Junction Diode에 대한 X-Ray 및 Gamma-Ray 의 Dose Ratec 측정)

  • 정만영;김덕진
    • 전기의세계
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    • v.13 no.3
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    • pp.13-20
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    • 1964
  • The measurements of X-ray and Gamma-ray Dose Rate have been successfully made by measuring the short circuit current of the Silicon P-N Junction Diode being irradiated. The short circuit current flows when a silicon P-N Junction Diode is irradiated by X-ray of Gammaray radiations due to photovoltaic effect. A brief analysis is given in order to verify the proportionality of a short circuit current to the Dose Rate. Using this method, measurements of X-ray Dose Rate were carried out in the range of 0.05-1600 r/m successfully. The calibration was made by comparing with Victoreen condenser r-meter. Some advantages in this Dose Rate meter over a condenser r-meter were found. One can measure a continous variation of X-ray Dose Rate with this rate meter at the control console of X-ray device.

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A Study on Gamma Dose Rate in Seoul(I) (서울시내 공간 감마선량률 조사(I))

  • Kim, You-Hyun;Kim, Chang-Kyun;Choi, Jong-Hak;Kim, Jeong-Min
    • Journal of radiological science and technology
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    • v.24 no.1
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    • pp.61-65
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    • 2001
  • This study was conducted to find out gamma dose rate in Seoul, from January to December in 2000, and the following results were achieved ; 1. The annual gamma dose rate in Seoul was $17.24{\mu}R/hr$ as average. 2. The annual gamma dose rate in subway of Seoul was $14.96{\mu}R/hr$ as average. 3. The highest annual gamma dose rate was Dong-daemon ku. 4. Annual gamma dose rate in Seoul was higher autumn than winter.

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PRIMORDIAL RADIONUCLIDES DISTRIBUTION AND DOSE EVALUATION IN UDAGAMANDALAM REGION OF NILGIRIS IN INDIA

  • Manikandan, N.Muguntha;Selvasekarapandian, S.;Sivakumar, R.;Meenakshisundaram, V.;Raghunath, V.M.
    • Journal of Radiation Protection and Research
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    • v.26 no.3
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    • pp.183-190
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    • 2001
  • The activity concentration of primordial radionuclides i.e., $^{238}U$ series, $^{232}Th$ series and $^{40}K$, in soil samples collected from Udagamandalam environment, have been measured by employing NaI (Tl) Gamma ray Spectrometer. The absorbed gamma dose rate has also been simultaneously measured by using both Environmental Radiation Dosimeter at each soil sampling location (ambient gamma dose) as well as from the gamma dose derived from the activity concentration of the primordial radionuclides. The results of activity concentration of each radio nuclides in soil, absorbed dose rate in air due to soil activity and possible cosmic radiation at each location along with human effective dose equivalent for Udagamandalam environment are presented and discussed.

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Recent Development in Low Dose Nuclear Medicine Gamma Camera Imaging (저선량 핵의학 감마카메라 영상장치의 최근 발전)

  • Hwang, Kyung Hoon;Lee, Byeong-il;Kim, Yongkwon;Lee, Haejun;Sun, Yong Han
    • Journal of Biomedical Engineering Research
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    • v.36 no.4
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    • pp.123-127
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    • 2015
  • Recently, new gamma camera systems enabling low radiation dose imaging have been developed. We reviewed the recent development of these low dose gamma camera systems including high sensitivity detectors, device structures, noise reduction filters, efficient image reconstruction algorithms, low dose protocols, and so on. It is expected that further technological advances reduce both radiation dose and imaging time in gamma camera imaging especially for radiation-sensitive patients such as pediatric patients.

Patient Radiation Exposure Dose in Computed Tomography (전산화단층촬영장치에서 환자피폭선량)

  • Cho, Pyong Kon
    • Journal of the Korean Society of Radiology
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    • v.9 no.2
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    • pp.109-115
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    • 2015
  • In case of a CT examinations, there is a difference in the distribution of radiation dose from that of general X-ray equipments, and it has been known to cause a great radiation exposure during the examinations. However, owing to its high reliability on the accuracy of a examinations result, its use has increased continuously. In consideration of such a circumstance, the CT equipment, radiation dose during CT examinations, diagnostic reference level, and solutions to reduce radiation dose were mentioned on the basis of previously reported data.