• EDISON SW 활용 경진대회 논문집
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• 제6회(2017년)
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• pp.46-53
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• 2017

알츠하이머병은 치매를 유발하는 가장 주된 원인 질환으로 환자들은 인지장애를 겪게 된다. 현재 치료약으로 사용되는 약으로는 acetylcholinesterase 저해재가 있지만 이 약들의 효과는 미비하다. 그래서 인지기능에 영향을 미친다고 알려진 신경전달물질인 GABA, Glutamate, acetylcholine의 수치를 조절 할 수 있는 $5-HT_6$ receptor antagonist가 현재 개발되고 있다. 현재 여러 antagonist들이 임상실험 되었고, 인지 능력향상에 효과를 보이고 있다. 그러나, $5-HT_6$ receptor의 구조가 밝혀지지 않아 아직 원자적 수준의 결합 분석이 이루어지지 않았으므로 이 부분에 대한 연구가 필요하다. 따라서 본 연구에서는 Homology modeling을 통해 receptor의 구조를 예측하고, 현재 임상실험 중인 antagonist들 중 7개를 docking을 통해 단백질과 리간드의 결합을 예측하였다. Edison에서 Galaxy TBM과 Galaxy Refine을 사용하여 Homology modeling 한 결과 GPCR의 전형적인 모델에 특징적으로 긴 cterminal을 가졌다는 것을 확인 할 수 있었다. 생성된 구조를 가지고 Edison의 Dock 프로그램으로 7개의 antagonist가 어떠한 결합을 하는지 분석하였다. 그 결과, binding pose에 공통적으로 Trp102, Asp106, Val107, Pro177, Phe188, Val189, Ala192, Phe284, Phe285, Asn288, Thr306, Tyr310이 관여하는 것을 docking을 통해 알 수 있었다. 특히, Phe285는 7개의 antagonist 중에 4개와의 interaction을 하고 있는 것을 관찰하였다. 이 연구를 통하여 $5-HT_6$에 효과적으로 결합하여 치료효과를 낼 수 있는 신약을 개발할 수 있다.

• 한국수소및신에너지학회논문집
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• 제19권4호
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• pp.359-366
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• 2008

Hydrogen as a high-quality and clean energy carrier has attracted renewed and ever-increasing attention around the world in recent years, mainly due to developments in fuel cells and environmental pressures including climate change issues. In this processes for hydrogen production from fossil fuels, separation and purification is a critical technology. $(Ni_{60}-Nb_{40})_{95}-Pd_5$ alloy ingots were prepared by arc-melting the mixture of pure metals in an Ar atmosphere. Melt-spun ribbons were produced by the single-roller melt-spinning technique in an Ar atmosphere. Amorphous structure and thermal behavior were characterized by XRD and DSC. The permeability of the $(Ni_{60}-Nb_{40})_{95}-Pd_5$ amorphous alloy membrane was characterized by hydrogen permeation experiments in the temperature range 623 to 773 K and pressure of 2 bars. The maximum hydrogen permeability was $3.54{\times}10^{-9}[mol{\cdot}m^{-1}s^{-1}{\cdot}pa^{-1/2}]$ at 773 K for the $(Ni_{60}-Nb_{40})_{95}-Pd_5$ amorphous alloy.

• 한국수소및신에너지학회논문집
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• 제18권2호
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• pp.182-188
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• 2007

[ $Zr_{50}-Ni_{27}-Nb_{18}-Co_5$ ] amorphous alloys ribbon was prepared by a single-roller melt-spinning technique. In order to improve the hydrogen kinetics Pd-coating were carried out on each side of the amorphous ribbon. Pd prevents oxidation of Zr and catalyses the dissociation of molecular hydrogen to atomic hydrogen. In this work, the hydrogen embrittlement and surface properties on Zr-based amorphous alloys were investigated. The Zr-based amorphous alloys were characterized by X-ray diffractometry(XRD) and differential scanning calorimetry(DSC). The morphology of surface and roughness was observed by using scanning electron microscopy(SEM) and atomic force microscopy (AFM). A lattice parameter of both Pd and Zr-based amorphous alloy was increased after hydrogen permeation at 473 K. After hydrogen permeation at 473 K, some cracks were observed on the surface of Pd, which was the cause for the hydrogen embrittlement. The crystallization temperature of Zr-based amorphous alloy was decreased due to the permeated hydrogen.

• 대한임베디드공학회논문지
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• 제15권2호
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• pp.71-78
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• 2020

This paper proposes vision sensors and deep learning-based around view monitoring system for ship berthing. Ship berthing to the port requires precise relative position and relative speed information between the mooring facility and the ship. For ships of Handysize or higher, the vesselships must be docked with the help of pilots and tugboats. In the case of ships handling dangerous cargo, tug boats push the ship and dock it in the port, using the distance and velocity information receiving from the berthing aid system (BAS). However, the existing BAS is very expensive and there is a limit on the size of the vessel that can be measured. Also, there is a limitation that it is difficult to measure distance and speed when there are obstacles near the port. This paper proposes a relative distance and speed estimation system that can be used as a ship berthing assist system. The proposed system is verified by comparing the performance with the existing laser-based distance and speed measurement system through the field tests at the actual port.

• International Journal of Control, Automation, and Systems
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• 제6권5호
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• pp.731-739
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• 2008

The docking and recharging system for a mobile robot must guarantee the ability to perform its tasks continuously without human intervention. This paper proposes two docking mechanisms with localization error-compensation capability for an auto recharging system. The mechanisms use friction forces or magnetic forces between the docking parts of the robot and those of the docking station. It is a structure to improve the allowance ranges of lateral and directional docking offsets, in which the robot is able to dock into the docking station. In this paper, auto-recharging system and the features of the proposed mechanisms are verified with experimental results using simple homing method.

• 대한조선학회 특별논문집
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• 대한조선학회 2005년도 특별논문집
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• pp.144-150
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• 2005

The size of ship is being larger than the past in the shipping industry thanks to the increased quantity of goods transported by ship. Therefore, HHIC (Hanjin Heavy industries & Construction co., LTD) invented innovative construction method, so called 'DAM', to build a ship which is longer than the length of the HHIC's dry dock. On Erection at the sea by the application of DAM Method, Squeezing & Detachment of A/F film may occur as a result of the wave and the constriction between A/F film pre-applied on the side shell and DAM's Rubber Packing. Thus, the test for finding the minimum curing time of A/F film was performed to protect Squeezing & Detachment of A/F film on the hull. To verify the soundness of paint and to find the optimum condition during the erection period of the DAM, laboratory test was carried out under no immersion condition through the application of various coatings on the Rubber Packing. And two methods were selected from the results of laboratory test for actual MOCK-UP Test. In addition, the test for the film profile per temperature of silicone A/F coat and the film Squeezing was performed.

• 대한조선학회논문집
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• 제44권6호
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• pp.666-674
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• 2007

It is very important to estimate static squeezing pressure distributions for lining material of sterntube after bearing at dry dock stage since the maximum squeezing pressure value can be one of the significant characteristics representing coming navigation performances of the propulsion system. Moderate oil film pressure between lining material and propulsion shaft is also essential for safe ship service. In this paper, Hertz contact theory is explained to derive static squeezing pressure. Reynolds equation simplified from Navier-Stokes equation is centrally differentiated to numerically obtain dynamic oil film pressures. New shaft alignment technology of nonlinear elastic multi-support bearing elements is also used in order to obtain external forces acting on lining material of bearing. For 300K DWT class VLCC with synthetic bush of sterntube after bearing, static squeezing pressures are calculated using derived external forces and Hertz contact theory. Optimum partial slope of the after bush is presented by parametric shaft alignment analyses. Dynamic oil film pressures are comparatively evaluated for partially bored and unbored after bush. Finally it is proved that the partial slope can drastically reduce oil film pressure during engine running.

• 대한조선학회 특별논문집
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• 대한조선학회 2008년도 특별논문집
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• pp.118-125
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• 2008

The deck plates of ship block is made of thin plates in their construction. A main reason of using thin plates is that deck plates don't need to support large structural loads. Therefore, out-of-plane deformations between stiffeners are frequent in deck blocks. Because these are got right by correction heating, they continuously causes quality problems in the final dock-building process. According to preceding research, the lifting process by cranes would offset the effect of correction heating. This study finds out the remained efficiency of correction heating when tensional loads are added by a lifting to corrected parts. We used inherent strains in calculating the efficiency, and established the methodology where the positions for callings are. For getting more accurate positions, besides the structural lifting analysis, welding deformation analysis with upper block and measured data from a serial ship are also referenced.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2009년도 춘계학술대회 논문집
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• pp.28-41
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• 2009

We know the several construction methods for underwater tunnel, but properly submerged concrete box type tunnel was mostly good structure stability and mostly shot length of tunnels. Submerged box type tunnel was buildup the unit segments in dry dock or ship yard by 10 to 20meters. The submerged box was composed with segments was join each together. It was installing the gate and waterproofing the coupling the front hull of a box. The complete submerged box rise up to the surface water, tow in the submerged box by tugboat, going to the destination of tunnel construction site. Beforehand dredge up soil at the bottom of a underwater, sinking the submerged box, connection together complete submerged box in underwater. The research and development ILM tunneling method is receiving careful study. Biggest weakness in submerged concrete box type tunnel was pressure waterproofing, box to box connecting, complete submerged boxes navigation and installation, after operation the submerged tunnel and management concrete box structure. It was positive evidence in submerged concrete box type tunnel. We make a practical application of the principle "the ILM tunneling method in underwater construction methods."

• Corrosion Science and Technology
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• 제11권1호
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• pp.29-36
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• 2012

The resistance spot welding of high strength steel degrades the weldability because of its high strength with rich chemical composition and coating layer to protect from corrosion. During the each resistance welding process the electrodes tip reacts with coating layer, then subsequently deteriorates and shorten electrode life. In this study, the Al-coated HPF (Hot Press Forming) steels and Zn-coated TRIP steels were used to investigate the electrode life for resistance spot welding. Experimental results show that the reactivity of Al-coating on HPF steels to electrode tip surface behaviors different from the conventional Zn-coated high strength steels. The electrode tip diameter and nugget size in electrode life test of Al-coated HPF steels are observed to be constant with respect to weld numbers. For Al-coated HPF steels, the hard aluminum oxide layer being formed during high temperature heat treatment process reduces reactivity with copper electrode during the resistance welding process. Eventually, the electrode life in resistance spot welding of Al-coated HPF steels has the advantage over the galvanized steel sheets.