• Bulletin of the Korean Chemical Society
• /
• 제26권11호
• /
• pp.1695-1700
• /
• 2005

Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is an S-adenosylmethionine (SAM, AdoMet) dependent methyltransferase, and is related to the functions of the neurotransmitters in various mental processes, such as Parkinson’s disease. COMT inhibitors represent a new class of antiparkinson drugs, when they are coadministered with levodopa. Based on x-ray structure of rat COMT (rCOMT), the three dimensional structure of human COMT (hCOMT) was constructed by comparative homology modeling using MODELLER. The catalytic site of these two proteins showed subtle differences, but these differences are important to determine the characterization of COMT inhibitor. Ligand docking study is carried out for complex of hCOMT and COMT inhibitors using AutoDock. Among fifteen inhibitors chosen from world patent, nine models were energetically favorable. The average value of heavy atomic RMSD was 1.5 $\AA$. Analysis of ligand-protein binding model implies that Arg201 on hCOMT plays important roles in the interactions with COMT inhibitors. This study may give insight to develop new ways of antiparkinson drug.

• Bulletin of the Korean Chemical Society
• /
• 제33권3호
• /
• pp.848-854
• /
• 2012

We have studied the oligomerization of a fibril-forming segment of ${\alpha}$-Synulcein using a replica exchange molecular dynamics (REMD) simulation. The simulation was performed with trimers and tetramers of a 12 amino acid residue stretch (residues 71-82) of ${\alpha}$-Synulcein. From extensive REMD simulations, we observed the spontaneous formation of both trimer and tetramer, demonstrating the self-aggregating and fibril-forming properties of the peptides. Secondary structure profile and clustering analysis illustrated that antiparallel ${\beta}$-sheet structures are major species corresponding to the global free energy minimum. As the size of the oligomer increases from a dimer to a tetramer, conformational stability is increased. We examined the evolution of simple order parameters and their free energy profiles to identify the process of aggregation. It was found that the degree of aggregation increased as time passed. Tetramer formation was slower than trimer formation and a transition in order parameters was observed, indicating the full development of tetramer conformation which is more stable than that of the trimer. The shape of free energy surface and change of order parameter distributions indicate that the oligomer formation follows a dock-and-lock process.

• 산업공학
• /
• 제15권3호
• /
• pp.230-240
• /
• 2002

Information technologies centered on the internet in the area of shipbuilding and marine engineering further incur the needs to increase the flexibility of the organization, the dispersion of work process, and the use of out sourcing, as well as the globalization of related market. In near future, electronic commerce and concurrent engineering based on CALS/EC and the Internet will be an integral part of the environment and upon these changes, ship design and construction will become a computer supported cooperative work of many dispersed and specialized groups. As the means of active response to these environmental changes, many new concepts such as digital shipbuilding, virtual shipyard, and simulation based design are appearing. In this paper, the concept and current status of digital manufacturing in general manufacturing industry will be reviewed. Then, related technologies, area of application and methods of digital manufacturing in shipbuilding and marine industries are presented. In addition, virtual assembly simulation system for shipbuilding(VASSS), a tool for crane operability and block erection simulation in virtual dock based on 3D product model, will be introduced.

• 한국전산구조공학회논문집
• /
• 제18권1호
• /
• pp.61-69
• /
• 2005

장경간화되고 경량화된 데크 바닥판 구조물은 부재가 유연하기 때문에 거주자의 움직임에 의하여 진동이 크게 발생할 수 있으며, 이러한 바닥판 진동은 건축물의 안전성뿐만 아니라 건축물의 사용성에도 많은 영향을 끼치므로 건축물의 품질 평가기준으로 사용되고 있다. 데크 바닥판 구조물의 올바른 사용성 평가를 위해서는 정확한 진동해석과 응답평가가 수반되어야한다. 본 논문에서는 데크 바닥판 구조물의 직교이방성을 고려한 여러 가지 모형화 방법을 적용하여 진동해석을 수행하였으며 모형화 방법에 따른 진동응답을 비교 분석하였다. 본 논문에서 제시한 데크 골 방향 강성에 대한 등가두께 모형화방법은 간단한 방법으로 데크 바닥판 구조물의 직교이방성을 간단한 방법으로 고려할 수 있으며, 정확한 진동응답을 얻을 수 있으므로 실무에서 실용적으로 활용할 수 있다.

• 한국해양공학회지
• /
• 제17권2호
• /
• pp.72-76
• /
• 2003

This paper presents the design concept and operation results of float-off for FSO (340,000 DWT Class, ELF AMENAM KPONO Project) built on the ground, without dry dock facilities. It was the first attempt to build FSO, completely, on the ground and launch it using DBU (Double Barge Unit, which was connected by rigid frame structure.) The major characteristics of FSO, which are similar to general VLCC type hull, including topside structure, weigh 51,000 metric ton. In order to have sufficient stability during the deck immersion of DBU, while passing through a minimum water plane area zone, proper trim control was completed with LMC (Load Master Computer). The major features of the monitoring system include calculation for transverse bending moment, shear force, local strength check of each connector, based on component stress, and deformation check during the load-out and float-off. Another major concern during the operation was to avoid damages at the bottom and sides of FSO, due to motion & movement after free-floating; therefore, adequate clearances between DBU and FSO were to be provided, and guide posts were installed to prevent side damage of the DBU casings. This paper also presents various measures that indecate the connector bending moment, damage stability analysis, and mooring of DBU during float off.

• 한국해양공학회지
• /
• 제30권3호
• /
• pp.208-213
• /
• 2016

This paper proposes a potential field-based guidance law for docking a USV (unmanned surface vehicle). In most cases, a USV without side thrusters is an under-actuated system. Thus, there are undockable regions near docking stations where a USV cannot dock to a docking station without causing a collision or backward motion. This paper suggest a guidance law that prevents a USV from enter such a region by decreasing the lateral error to the docking station at the initial stage of the docking process. A Monte-carlo simulation was performed to validate the performance of the proposed method. The proposed method was compared to conventional guidance laws such as pure pursuit guidance and pure/lead pursuit guidance. As a result, the collision angle and lateral distance error of proposed method tended to have lower values compared to conventional methods.

• 산업공학
• /
• 제13권3호
• /
• pp.471-478
• /
• 2000

One of the most important problems encountered by parcel transportation firms or LTL (Less-than-truckload) firms is the planning of daily linehaul operations. The transportation firm's goal is to determine the most efficient way to move all freight from its originating terminal to its destination terminal after each shipment is picked up from the shipping dock. The purpose of this study is to design a transportation system and develop an efficient scheduling algorithm for linehaul operations carrying small amount of shipment. This paper presents three approaches for efficient linehaul operations. The first approach examines drivers using the roundtrips which start from a terminal, visit several terminals, and return to the starting terminal. The second approach uses a freight assembly center where drivers take freight for a number of destination terminals which they then swap for freight for their starting terminal. The third approach is similar to the second approach in that it uses a transshipment point like a freight assembly terminal for shipment, but it has several transshipment points since each shipment may have a different transshipment point. In this study, we developed a mathematical formulation and algorithm for each approach. The experimental results using data of a LTL firm show that the third approach is more efficient than the other two. Mileage and overnight stays of the third approach are reduced by 10% and 30%, respectively.

• 한국농촌건축학회논문집
• /
• 제14권4호
• /
• pp.37-45
• /
• 2012

The villages in island were established overcoming natural environment through Shamanism and changed by developing various industrials like transportation. Gapa Island located in southern part of Jejudo is flat topography different from the other islands. The purpose of this study is to clarify characteristics on transformation of community space in Gapa Island. For purpose, community spaces in Gapa Island are researched such as establishment, function, change, and use of community space. Spatial components in Gapa Island are like as spaces in faith, residential area, area for production, commercial zone, community space, education facilities, public offices, port, and roads. The methods of this study are literature research and interview survey for residents in Gapa Island. The results are as followings: First, community space is in charge about social, industrial, and religious function. Second, for traditional spaces separated for male and female, demarcation of space does not exist in industrial side but the demarcation has still been exist in religious side. Finally, by development of tourism new community space has been charge in festival function as well as function of space like agora for meeting with people freely, which is relatively various in function of community space in social side. Role of the dock for ship, main transportation of island, is being increasing as square.

• Journal of Advanced Marine Engineering and Technology
• /
• 제36권2호
• /
• pp.250-257
• /
• 2012

오늘날 큰 선박 및 구조물은 블록 형태로 만들어지고 조립된다. 수천 톤의 큰 대형 선박은 도크 또는 육상에서 큰 블록을 조립함으로써 짧은 기간 내에 만들어 진다. 이동 과정에 경사면을 만나게 되면 이동물이 기울어지게 되고 기울어진 상태로 경사면을 통과하는 경우, 블록이 전복하는 사고가 종종 발생한다. 본 연구는 트렌스포터의 이송 중량물의 평면상에서 무게 중심을 구하고, 더불어 3차원 상의 무게 중심을 구한다. 또한, ZMP(Zero Moment Point)를 이용하여 물체가 넘어지는 각도를 예측하는 연구를 수행하였다. 특히 경사면에서 물체의 이송과정 안정성을 시뮬레이션을 통하여 확인하였다.

• 한국산업보건학회지
• /
• 제1권1호
• /
• pp.68-72
• /
• 1991

The present investigation studied the welding fumes produced during the arc welding process at a shipyard. The air at the shipyard was sampled (between February and May, 1990) to determine the total welding fume concentration, its heavy metal content and the concentrations of different sized particles of the welding fumes. The results were as follows : 1. Forty-four out of 50 samples showed welding fume concentrations which exceeding the threshold limit value of $5mg/m^3$. The geometric mean of welding fume concentration was $9.73mg/m^3$ ($2.14-24.86mg/m^3$), and the nighest level was found at the dock assembly shop ($12.0mg/m^3$). 2. The welding fume concentration measured with personal air sampler was 4.2 times greater than that measured with area sampler. 3. Of the heavy metals analyzed, Fe was found to be the most concentrated at $1.29mg/m^3$ ; it constitued 13.3% of the total welding fume concentration. 4. Of the different sized particles that make up the welding fumes, there was a tendency for the smaller particles to be more concentrated. Particles that measured $7{\mu}$ or less in diameter constituted 85.8% of the total welding fume concentration.