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Red Ginseng Ameliorates Place Learning Deficits in Aged Rats Young Rats with Selective Hippocampal Lesions

  • Zhong, Yong-Mei;Hisao Nishijo;Teruko Uwano;Hidetishi Yamaguchi;Taketosho Ono
    • Proceedings of the Ginseng society Conference
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    • 1998.06a
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    • pp.1-11
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    • 1998
  • Ameliorating mechanisms of red ginseng on learning deficits were investigated in the following 3 experiments; its effects on 1) place learning deficits in aged rats and in young rats with selective hippocampal lesions (behavioral study), 2) long-term potentiation in the hippocampal formation (neuro- physiological study), and 3) ChAT (choline acetyl transferase) activity in various brain regions of aged rats (pharmacological study). In the behavioral study, first, performance in the place learning tasks were compared among 3 groups of young and aged rats; control young intact rats (10-12 week old) treated with water, aged rats (28-32 month old) treated with water, and aged rats (28-32 month old) treated with red ginseng (100 mghglday) suspended in water. Second, performance in the place learning tasks was compared among 3 groups of young rats; control intact rats treated with water, rats with bilateral hippocampal lesions treated with water, and rats with bilateral hippocampal lesions treated with red ginseng (100 mg/kg/day). Each rat in these 2 behavioral experiments was tested with the 3 types of the place learning tasks in a circular open field using intracranial self-stimulation (ICSS) as reward. The ICSS reward was delivered if the rat (1) moved distance of 100-160 cm (DMT): (2) entered an experiment-determined reward place within the open field, and this place was randomly varied in sequential trials (RRPST); or (3) entered 2 specific places, and did a shuttle behavior between the 2 places (PLT). Performance of the aged rats in the ginseng group was not significantly different from that of control young rats in ICSS (current intensity, bar press rates), DMT and RRPST. However, treatment with red ginseng significantly ameliorated place-navigation learning deficits in aged rats in the PLT. Similarly, red ginseng ameliorated learning and memory deficits in young rats with hippocampal lesions in the same tasks. In the neurophysiological study using young rats, perfusion of hippocampal slices with non-sapon in fraction of red ginseng significantly enhanced magnitudes of the long-term potentiation (LfP) in the CA3 subfield. In the pharmacological study, treatment with red ginseng did not affect ChAT activity in aged rat brain including the hippocampal formation. These results strongly suggest that red ginseng ameliorates learning and memory deficits in aged rats through actions on the CA3 subfield of the hippocampal formation, which were independent of the presynaptic components of the cholinergic system

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A Study on Factors Influencing to Coefficient of Consolidation in Horizontal Direction (수평압밀계수의 영향인자에 관한 연구)

  • Kim, Chang-Seop;Park, Byung-Soo;Yoo, Nam-Jae
    • Journal of Industrial Technology
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    • v.28 no.B
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    • pp.81-89
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    • 2008
  • This paper is results of investigating the dominant factors influencing to coefficient of consolidation in horizontal direction of Korean marine clays and their correlations through literature review. From the results of analyzing data obtained from field tests such as piezocone penetration and dilatometer tests as well as laboratory tests, coefficient of consolidation in the horizontal direction was found to increase with increase of stiffness index of soil while it decreases with the increase of dissipation time of pore pressure developed during field tests. In general, the coefficient of consolidation in the horizontal direction tends to increase with increase of undrained shear strength and preconsolidation pressure although correlation between them are relatively low. Friction ratio has a high correlation with coefficient of consolidation in the horizontal direction in case of friction ratio being greater than 1.0. For methods of estimating coefficient of consolidation in the horizontal direction with different testing device, values obtained from methods of P2-logt and DMT-A with dilatometer were quite similar to values from piezocone penetration test. Consistency of soil is quite proportional to coefficient of consolidation in the horizontal direction. Clear correlation between coefficients of consolidation in the horizontal and the vertical directions could not be found. coefficient of consolidation in the horizontal direction estimated from the results of field test tends to be 1.13~3.11 times greater than that obtained from laboratory tests.

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Market Prediction Methodology for a Medical 3D Printing Business : Focusing on Dentistry (의료분야 3D프린팅 비즈니스 시장규모 예측 연구 : 치과 분야를 중심으로)

  • Kim, Min Kwan;Lee, Jungwoo;Kim, Young Myung;Lee, Kikwang;Han, Chang Hee
    • Journal of Information Technology Applications and Management
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    • v.23 no.2
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    • pp.263-277
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    • 2016
  • Recently, 3D printing technology has been considered as a core applicable technology because it brings many improvements such as the development of medical technology, medical customization, and reducing production cost and shortening treatment period. This research suggests a market prediction framework for medical 3D printing business. As an immature market situation, it is important to control some uncertainty for market prediction such as a customers' conversion rate. So we adopt decision making tree (DMT) model which used to choose an optimal decision making among diverse pathway. Among medical industries this paper just focuses on dentistry business. For predicting a 5 year period trend expected market size, we identified some replaceable denture procedure by 3D printing, collected related data, controlled uncertain variables. The result shows that medical 3D printing business could be a market of 28.2 billion won at 1st year and in the end of fifth year it could become on a scale of 61.1 billion won market.

Preparation of Polyesteramide from Oligobutylene Terephtahlate and 6-amino Caproic Acid (올리고 부틸렌 테레프탈레이트와 6-아미노 카프론산으로부터 포리에스테르 아미드의 합성)

  • Cho, Soon-Chae;Choi, Doo-Jin;Kim, Seon-Ho;Rhee, Johng-Moon;Pak, Pyong-Ki;Ahn, Jong-Yeol;Kim, Young-Gil
    • Textile Coloration and Finishing
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    • v.3 no.1
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    • pp.17-24
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    • 1991
  • Polyesteramide(PEA) has been synthesized with different molar ratio of 6-aminocaproic acid(ACA) and oligo butylene terephthalate(OBT) prepared from Dimethyl terephthalate(DMT) and 1, 4-butanediol(BD) by the melt polymerization. Oligomer and polymer molecular structure were characterized by IR spectra, H'-NMR spectra. Also the thermal properties were examined by thermogravimetric analysis(TGA) and differential scanning calorimetry(DSC). DSC and TGA results exhibited that the$ T_m$ s were detectable in the vicinity of $170-220^{\circ}C$ and the Ta's were detectable in the vicinity of $380-390^{\circ}C$ . X-ray diffraction analysis results show that the synthesized polyesteramide has high degree of crystallinity.

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Air Temperature And Leaf Growth of Several Woody Plants in Early Gruwing Season (수 종 목본식물의 생육초기 기온과 잎의 생장)

  • 민병미
    • The Korean Journal of Ecology
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    • v.17 no.1
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    • pp.49-58
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    • 1994
  • To investigate the relationship between leaf growth of several woody plants and ait tempera ture in early growing season (from April to June) in deciduous forests, I surveyed the changes of leaf area (LA), leaf weight (LW) and specific leaf area (SLA) of 19 specles, in two areas Namhansansung (NA) and Taegwallyong (TA) area in which that the latitudes are similer ($37^{\circ}28'N$ at NA and $37^{\circ}27'N$ an TA), but annual mean-temperatures were different ($11.8^{\circ}C\;in\;NA, \;6.3^{\circ}C$ in TA) for two years, 1991 and 1992. In the same species, the plants of NA began to grow 10-25 days earlier than those of TA, but the latter grew faster than the former. On 10 June the values of LA and LW per leaf were similar in the two areas but the maximum values of SLA were higher in NA. In the same plant, the values of LA and LW were constant year by year, except for PYIOLUS leveilleana, Quercus mongolica, Symplocos chznensis for. pilosa and S t y a r ubussiu. In N A , the leaves be gan to grow during the first ten days of April, and eariler in 1992 than in 1991, and daily mean temperature (DMT) of the former from 27 March to 6 April were higher than those of thc latter. But the LA increased faster in 1991 than in 1992. and DMT from 10 April to 16 April were higher in 1991 than in 1992.

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An Efficient Discrete Bit Allocation Algorithm for Multi-user Channels (다수 사용자 채널을 위한 효율적인 이산 비트 할당 방법)

  • Choi, Min-Ho;Song, Sang-Seob
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.29 no.9A
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    • pp.998-1004
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    • 2004
  • In this paper we propose a discrete bit-loading algorithm that maximizes the transmit bit rate using the channel information. to optimize the performance of the very high-speed digital subscriber line(VDSL) system under the constraint of a maximum transmit power for each user. When the power level of crosstalk is high, the power allocation of a user changes the crosstalk experienced by the other users in the same binder. In this case, the performance of DSL modems can be improved by jointly considering the bit and power allocation of all users Simulation results shows that the proposed method improves the performance compared With that of iterative water-filling method.

Effect of Hydrofluoric Acid on the Electrochemical Properties of Additive Manufactured Ti and Its Alloy (적층가공된 티타늄 합금의 전기화학적 특성에 미치는 불산의 영향)

  • Kim, K.T.;Cho, H.W.;Chang, H.Y.;Kim, Y.S.
    • Corrosion Science and Technology
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    • v.17 no.4
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    • pp.166-175
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    • 2018
  • In this study, the electrochemical properties of CP-Ti (commercially pure titanium) and Ti-64 (Ti-6Al-4V) were evaluated and the effect of hydrofluoric acid on corrosion resistance and electrochemical properties was elucidated. Additive manufactured materials were made by DMT (Directed Metal Tooling) method. Samples were heat-treated for 1 hour at $760^{\circ}C$ and then air cooled. Surface morphologies were studied by optical microscope and SEM. Electrochemical properties were evaluated by anodic polarization method and AC-impedance measurement. The oxide film formed on the surface was analyzed using an XPS. The addition of HF led to an increase in the passive current density and critical current density and decreased the polarization resistance regardless of the alloys employed. Based on the composition of the oxide film, the compositional difference observed by the addition of HF was little, regardless of the nature of alloys. The Warburg impedance obtained by AC-impedance measurement indicates the dissolution of the constituents of CP-Ti and Ti-64 through a porous oxide film.

Near-IR Spectroscopic Studies of the Hydrogen Bonding between Thioacetamide and N,N-Dimethylpropionamide in Carbon Tetrachloride (사염화탄소 중에서 Thioacetamide와 N,N-Dimethylpropionamide간의 수소 결합에 관한 분광학적 연구)

  • Byung-Chul Kim;Seok-Kyu Song;Keon Kim;Young-Sang Choi
    • Journal of the Korean Chemical Society
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    • v.29 no.6
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    • pp.599-607
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    • 1985
  • Near-ir spectra have been obtained for the $ν_3$+ Amide II combination thioacetamide(TA) band in CC$l_4$ and TA-DMP in CC$l_4$ in the range of 5 to 55${\circ}C$. Absorbance of the weak bands of the DMP and solvent has been compensated. The spectra are analyzed by the computer resolution into two Lorentzian-Gaussian product bands which have been identified with monomeric TA and 1 : 1 TA-DMP complex. Equilibrium constants and thermodynamic parameters for the hydrogen bonding between TA and DMP have been evaluated by the analysis of the concentration and temperature dependent spectra for the very dilute CC$l_4$ solutions. The $ΔH{\circ} and ΔS{\circ}$ of TA and DMT have been found to be -14.6 kJmo$l^{-1}$ and -16.2 Jmo$l^{-1}$ de$g^{-1}$.

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Effect of Manufacturing Process on Electrochemical Properties of CP-Ti and Ti-6Al-4V Alloys (CP-Ti 및 Ti-6Al-4V 합금의 전기화학적 특성에 미치는 제조공정의 영향)

  • Kim, K.T.;Cho, H.W.;Chang, H.Y.;Kim, Y.S.
    • Corrosion Science and Technology
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    • v.17 no.1
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    • pp.20-29
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    • 2018
  • Ti and its alloys show the excellent corrosion resistance to chloride environments, but they show less corrosion resistance in HCl, $H_2SO_4$, NaOH, $H_3PO_4$, and especially HF environments at high temperature and concentration. In this study, we used the commercially pure titanium and Ti-6Al-4V alloy, and evaluated the effect of the manufacturing process on the electrochemical properties. We used commercial products of rolled and forged materials, and made additive manufactured materials by DMT (Directed Metal Tooling) method. We annealed each specimen at $760^{\circ}C$ for one hour and then air cooled. We performed anodic polarization test, AC impedance measurement, and Mott-Schottky plot to evaluate the electrochemical properties. Despite of the difference of its microstructure of CP-Ti and Ti-6Al-4V alloys by the manufacturing process, the anodic polarization behavior was similar in 20% sulfuric acid. However, the addition of 0.1% hydrofluoric acid degraded the electrochemical properties. Among three kinds of the manufacturing process, the electrochemical properties of additive manufactured CP-Ti, and Ti-6Al-4V alloys were the lowest. It is noted that the test materials showed a Warburg impedance in HF acid environments.

High Resolution Borehole Acoustic Scanner (Televiewer) (고분해능 텔레뷰어 검층기법의 기능)

  • ;Schepers,R
    • The Journal of Engineering Geology
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    • v.5 no.3
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    • pp.277-288
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    • 1995
  • Fracture detection has always been very attractive to the log, because it is important in many of our prospecting activities, e.g. in understanding the underground rock formation and also the fluid flow as a high permeability path. This paper demonstrates the use of high resolution borehole acoustic scanner for the detection of fractures. The tool, known as Televiewer, is the first acoustic borehole imaging system to use a focussed beam. The acoustic beams generated by a single transducer are sent toward the borehole wall, scanning the wall in a tight helix as the tool moves along the borehole. The amplitudes and travel times of the reflected signals are then measured, which produces the corresponding images. The highly resolved amplitude image allows to recognize various size of fractures and in addition to derive the rock strength from the image. Meanwhile, the travel time image itself can be directly converted to a precise caliper image, providing detailed information of deviations of the borehole shape. It also allows correction of and explanations for amplitude variations. Field measurements were carried Out at the Cheongyang study sites in Korea to illustrate the efficiency of the televiewer log.

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