• Environmental Analysis Health and Toxicology
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• 제19권4호
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• pp.359-366
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• 2004

Iron (Fe) is an essential metal in biological processes, which maintains a homeostasis in the human body. Divalent metal transporter 1 (DMT1) has been known as an iron transporting membrane protein, which is involved in the uptake Fe at the apical portion of intestinal epithelium, and may transport Fe across the membrane of acidified endosome in peripheral tissues. In this study, we studied the tissue distribution of DMT1 in the Fe supplemented (FeS) diet fed rats, and the regulation of DMT1 expression by depleting body Fe. Sprague-Dawley rats were divided into two groups, and fed FeS (120 mg Fe/kg) diet or Fe deficient (FeD, 2∼6 mg Fe/kg) diet for 4 weeks. The evaluation of body Fe status was monitored by measuring sFe, UIBC and tissue Fe concentration. Additionally, DMT1 mRNA levels were analyzed in the peripheral tissues by using the quantitative real time RT-PCR method. In the FeS diet fed rats, the tissue Fe was maintained at a relatively high level, and DMT1 was eventually expressed in all tissues studied. DMT1 was highly expressed in the testis, kidney and spleen, while a moderate levels of DMT1 expression was detected in the brain, liver and heart. In the digestive system, the highest level of DMT1 was found in the duodenum. Feeding the FeD diet caused a reduced body weight gain and depletion of body Fe with finding of decreased sFe, increased UIBC and decreased tissue Fe concentration. The depletion of body Fe upregulated DMT1 expression in the peripheral tissue. The expression of DMT1 was very sensitive to the body Fe depletion in the small intestine, especially in the duodenum, showing dramatically higher levels in the FeD rats than those of the FeS group. In the FeD diet fed animals, the expression of DMT1 was low significantly in other tissues compared with the duodenum. The expression of DMT1, however, was 60∼120% higher in the testis, kidney and spleen, and 30∼50% higher in the lung, liver and heart, compared to the FeS diet fed rats. In summary, DMT1 expression was ubiquitous in mammalian tissue, and the level of expression was the organ-dependent. The expression of DMT1 in peripheral tissues was upregulated by depletion of body Fe. Duodenum was the most sensitive tissue among organs studied during Fe depletion, and expressed the greatest level of DMT1, while other tissues were less higher than in duodenum. This study supports that DMT1 plays a role in maintaining the body Fe level through intestinal uptake as well as homeostasis of Fe in the peripheral tissue.

• 한국지반공학회논문집
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• 제20권5호
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• pp.17-25
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• 2004

DMT 시험은 연약지반의 공학적 특성을 파악하기 위한 현장 시험방법으로, 이 방법으로부터 구한 비배수 전단강도는 가장 신뢰성 있고 유용한 매개변수로 알려져 있다. 그러나 국외 다른 지역의 자료를 토대로 기존에 제안된 상관관계식들은 지역적인 특성에 의존한다. DMT 시험 결과는 3가지 중간 지수 - 재료지수, 수평응력지수, dilatometer modulus를 사용하여 해석이 이루어지며 특히 비배수 전단강도는 수평응력지수만을 이용하여 예측하고 있다. 본 논문에서는 먼저 DMT 시험의 국내 연약지반에서의 적용성을 살펴보았으며 DMT로부터 비배수 전단강도를 추정하기 위하여 $p_0, p_1, p_2, {\sigma '}_v$ 그리고 초기 간극수압을 바탕으로 인공신경망 모델을 개발하였다. 인공신경망 모델은 오차 역전파 알고리즘을 적용하였으며 국내 연약지반에서 수행된 DMT 시험 자료를 이용하여 훈련하였다. 인공신경망 모델의 적용성을 판단하기 위하여 훈련에 이용되지 않은 자료로부터 예측된 결과와 기존에 제안된 상관관계식으로부터 얻은 결과를 서로 비교하였다.

• 한국지반공학회논문집
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• 제23권1호
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• pp.67-76
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• 2007

대변형을 고려한 유한요소법을 이용하여 flat DMT의 3차원 관입을 모사하였다. 상용 프로그램으로 널리 알려진 ABAQUS/Explicit를 이용하여 flat DMT의 3차원 관입 해석을 수행하였으며 관입 도중에 발생되는 큰 요소 변형을 해결하기 위하여 adaptive meshing 기법을 도입하였다. 해석 결과를 바탕으로, flat DMT 시험방법으로부터 얻어지는 3가지 지수 중에 하나인 수평응력지수($K_{D}$)와 지반 설계 정수인 비배수 전단강도 간의 관계를 살펴보았다. 그 결과 $K_{D}=2$ 정규압밀지반에서는 Marchetti(1980)가 제안한 경험적 상관관계식과, $K_{D}$가 2이상으로 모사되는 과압밀지반에서는 Kamei & Iwasaki(1995)가 제안한 경험적 상관관계식과 잘 일치하는 결과를 제공하였다.

• Biomolecules & Therapeutics
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• 제13권1호
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• pp.1-6
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• 2005

Lead and cadmium are potent environmental toxicants that affect populations living in Europe. Americas, and Asia. Identifying transporters for lead and cadmium could potentially 1 help us better understand possible risk factors. The iron transporter, divalent metal transporter 1 (DMT1), mediates intestinal transport of cadmium, and lead in yeast and fobroblasts overexpressing DMT1. In human intestinal cells knocking down expression of DMT1 attenuated uptake of cadmium and iron but not lead. A possible explanation is the expression of a second transporter for lead in intestine. In astrocytes, however, DMT1 appears to transport lead in an extracellular buffer at pH value. At neutral pH, transport was not mediated by DMT1 but rather by a transporter that is stimulated by bicarbonate and inhibited by 4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonic acid. The identity of this lead transporter will beverified by future study.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2004년도 Annual Meeting of the Korean Society ofApplied Pharmacology
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• pp.50-61
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• 2004

Lead and cadmium are potent environmental toxicants that affect populations living in Europe, Americas, and Asia. Identifying transporters for lead and cadmium could potentially 1 help us better understand possible risk factors. The iron transporter divalent metal transporter 1(DMT1) mediates intestinal transport of cadmium, and lead in yeast and fibroblasts overexpressing DMT1. In human intestinal cells knocking down expression of DMT1 attenuated uptake of cadmium and iron but not lead. A possible explanation is the expression of a second transporter for lead in intestine. In astrocytes, however, DMT1 appears to transport lead in an extracellular buffer at pH value. At neutral pH, transport was not mediated by DMT1 but rather by a transporter that is stimulated by bicarbonate and inhibited by 4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonic acid. The identity of this lead transporter is under study.

• Journal of Communications and Networks
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• 제12권1호
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• pp.11-18
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• 2010

Diversity-multiplexing tradeoff (DMT) is an efficient tool to measure the performance of multiple-input and multiple-output (MIMO) systems and cooperative systems. Recently, cooperative multicast system with wireless network coding stretched tremendous interesting due to that it can drastically enhance the throughput of the wireless networks. It is desirable to apply DMT to the performance analysis on the multicast system with wireless network coding. In this paper, DMT is performed at the three proposed wireless network coding protocols, i.e., non-regenerative network coding (NRNC), regenerative complex field network coding (RCNC) and regenerative Galois field network coding (RGNC). The DMT analysis shows that under the same system performance, i.e., the same diversity gain, all the three network coding protocols outperform the traditional transmission scheme without network coding in terms of multiplexing gain. Our DMT analysis also exhibits the trends of the three network coding protocols' performance when multiplexing gain is changing from the lower region to the higher region. Monte-Carlo simulations verify the prediction of DMT.

• 전자공학회논문지 IE
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• 제45권1호
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• pp.24-30
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• 2008

DMT 변조 방식은 VDSL에 적용된 다중 반송파 변조 방식이다. DMT 변조 방식의 문제는 송수신 반송파 주파수들 사이의 주파수 오프셋(Offset)에 민감하다는 것이다. 이러한 주파수 오프셋은 DMT 심볼에서 반송파간 간섭을 야기한다. 본 논문에서는 칼만(Kalman) 필터링을 이용하여 ICI를 감소하는 방법을 제안한다. 제안한 방식은 다른 방식과의 성능과 대역폭 그리고 계산상 복잡도를 비교한다. 시뮬레이션 결과는 제안한 방식의 성능이 주파수 오프셋이 높은 경우와 높은 차수의 변조 방식에 대해서 다른 방식에 대해서 칼만 필터링을 이용한 방식이 더 좋은 성능을 나타내었다.

• 한국응용과학기술학회지
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• 제26권3호
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• pp.317-327
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• 2009

In this study DMT(Dimethylterephthalate), NDC(Dimethyl-2, 6-Naphthalene Dicarboxylate) were used to synthesize polyester polyol which shows enhanced storage stability, improved flame retardancy, and good compressive strength. If DMT and NDC react respectively with DEG(Diethylene Glycol) which is kind of linear diol, the obtained polyester polyols tend to crystallize easily after the reaction. In case of DMT, PA(Phthalic Anhydride) which has asymmetric structure was introduced to retard the crystallization. In case of NDC, DPG(Dipropylene Glycol) which has an methyl side chain was introduced to prevent the crystallization. It was found that to introduce DPG was much more effective method to prevent the crystallization than PA. NDC and DMT were reacted together with DPG for various compositions of NDC:DMT(8:2, 6:4, 4:6 mol ratio). The obtained NDC-DMT-DPG based polyester polyol showed improved flame retardancy, and good compressive strength with increasing the content of NDC.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2001년도 추계학술대회 및 정기총회
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• pp.91-91
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• 2001

Nramp2, also known as DMT1 and DCT1, is a 12-transmembrane domain protein responsible for dietary iron uptake as well as metal ions such as lead, manganese, zinc, copper, nickel, cadmium, and cobalt. High expression of DMT1 increase lead uptake, and DMT1-dependent lead transport was H -dependent and inhibited by iron ions. The molecular mechanism of lead transport in CNS is as yet unknown. although interactions between iron and lead at the level of absorption have been known for some time. The process of lead uptake into astrocytes was not known yet. Nramp2 may mediate transport of heavy metal into astrocytes. We investigated whether Nramp2 mediate transport of lead into astrocytes. And we do whether Nramp2 was expressed highly by deprivation of iron in Astrocytes, and lead uptake into astrocytes was influenced by expression of Nramp2. Immortalized human fetal astrocyte(SV-FHA) cells were cultured in medium containing Dulbecco's modified Eagle's medium and treated with Deferoxamine. Northern blot analysis was done for determining mRNA level of DMT1 and lead uptake assay was done in incubation condition of pH 5.5 and 7.4.

• 한국통신학회논문지
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• 제30권2A호
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• pp.1-11
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• 2005

잡음환경이 열악한 케이블모뎀 상향채널에서 보다 많은 채널과 QoS를 제공할 수 있는 새로운 물리계층 변조기술 중의 하나인 S-DMT방식 성능을, 현재 DOCSIS 2.0에서 채용하고 있는 S-CDMA방식 및 기존의 TDMA방식과 비교 평가하였다. 케이블 모뎀 상향채널모델은 ${\varepsilon}$-복합 임펄스 모델을 적용하였으며, 이를 바탕으로 S-DMT 방식의 비트 에러 확률을 유도하고 변복조 시스템을 시뮬레이션 하였다. 유도한 비트 에러 확률과 시뮬레이션 결과는 잘 일치함을 보인다. 성능 비교 결과, 잡음전력의 크기와 잡음발생 구간에 따라 차이가 있긴 하나, 잡음전력 크기에 따라서는 Eb/No가 $10dB{\sim}26dB$이상에서부터 잡음전력의 분산효과에 의해 S-DMT와 S-CDMA의 성능이 TDMA에 비해 우수해지고, 잡음발생구간에 따라서는 Eb/No가 $16{\sim}19dB$ 이상에서부터 S-DMT와 S-CDMA의 성능이 TDMA에 비해 우수해지는 것을 확인할 수 있었고 실용적 수준에서 어느 정도 데이터 통신이 가능해지기 시작하는 $BER=10^{-3}$ 이하의 임펄스 잡음 채널 환경에서는 S-DMT와 S-CDMA의 성능이 TDMA에 비해 우수함을 확인하였다. 또한 S-DMT방식은 S-CDMA방식과 거의 비슷한 성능을 보였다.