• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.455-461
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• 2016

Galectins are ${\beta}$-galactoside binding lectins that contain one or more carbohydrate recognition domains. As a consequence of sugar-binding properties, galectins exhibit a variety of interactions with glycoproteins, thus playing important roles in various pathological processes. A number of studies have shown roles of galectins in cancer. Galectin-7 is a prototype member of the galectin family implicated in epithelial stratification and cell migration. It can act as a potent dual regulator in different types of cancer. Galectin-7 may contribute either to neoplastic transformation and tumour progression through regulation of cell growth, cell cycle, angiogenesis, apoptosis and cell migration or may have a protective effect in cancer depending on the tissue type. A perusal of the literature indicates particular roles of galectin-7 in carcinomas and melanomas, while contributions await greater exploration in other types of cancers including sarcomas and leukemia. This review collectively summarizes available literature on expression and roles of galectin-7 in different cancers.

• Agribusiness and Information Management
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• 제12권2호
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• pp.6-23
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• 2021

This study analyzes overall honey consumption and purchasing behavior, and in particular, seeks to identify factors that influence the willingness to pay (WTP) for native honey. A survey of 500 South Korean consumers was conducted to understand their purchasing experiences and perceptions related to honey. A multiple linear regression analysis was carried out to comprehend the effect of the following factors on the willingness to pay for native honey: 1) knowledge of honey, 2) health consciousness, 3) the unhealthy = tasty intuition (UTI), and 4) positive perception of sweetness. As a result, consumers with more knowledge about honey, higher health consciousness and more positive perception of sweetness were more willing to pay for native honey. On the other hand, past honey purchasing or consuming experience had no significant impact on the willingness to pay for native honey. Marketing strategies and implications were derived from the characteristics of native honey consumers identified in this study.

• 한국융합학회논문지
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• 제10권9호
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• pp.47-53
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• 2019

본 논문은 소프트웨어 및 제품의 개발운영 및 개발보안운영에 대한 특성을 검토하고 소프트웨어 코드 관점에서 사용 분석도구를 고찰하였다. 또한 보안 설계규칙을 고려할 때 인적인 요소의 중요성과 이를 강화해야 할 필요성이 강조되었다. 본 논문에서는 개발보안운영을 고려할 때 절차적인 요소의 관점에서 신속하고 정확한 의사결정에 중점을 두고 변화를 관리하는 안전한 프로세스에 대해 분석하였다. 또한 본 논문에서는 개발보안운영 특성과 관련하여 성숙도 모델 분석의 필요성을 논의하였고, 이에 따른 동적인 요소와 정적인 요소의 강도 및 통합 요소에 대한 세부 절차를 통해 분석요소의 의미를 분석하였다. 본 논문에서는 위협모델링 및 컴플라이언스 그리고 통제를 위한 스캔 활동이나 코드 분석과 같은 요소에 대해서도 분석하였다.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2011년도 춘계학술발표대회
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• pp.1356-1359
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• 2011

IT 프로젝트는 많은 불확실성을 내포하고 있다. 이러한 불확실성은 프로젝트의 성공적인 수행에 좋지 않은 영향을 미치게 된다. 이처럼 악영향을 미치는 근본적인 이유는 프로젝트가 가지고 있는 잠재적 위험(Risk)이 중요한 원인이라 할 수 있다. CMMI-DEV(Capability Maturity Model Integration for Development, version 1.2)모델을 기반으로 IT 프로젝트를 수행하는 많은 조직에서 소프트웨어 개발시 실제 CMMI-DEV 모델을 적용하여 IT 프로젝트의 위험관리를 수행하고 있다. 그러나 대다수 기업에서 위험을 관리하기 위한 프로세스의 범위(영역)를 선정하는 것에는 많은 노력을 기울이지만 단위 프로세스별로 어떠한 방법(How)과 도구 및 관리기법을 사용하여 위험을 정량적으로 관리하고 완화시킬지에 대한 구체화된 노력은 미흡한 것이 사실이다. 본 논문에서는 CMMI-DEV 모델의 RSKM(Risk Management) 프로세스와 PMBOK(Project Management Body of Knowledge, 4th Edition)의 위험관리 지식영역(Knowledge Area)을 프로세스의 지속적인 개선을 위하여 PDCA(Plan-Do-Check-Action) Cycle의 각 단계별 목적에 맞게 통합(Integration)시켜 IT 프로젝트를 위한 개선된 위험관리 프로세스를 제안하였다. 제안 프로세스의 개선효과를 검증하고 분석하기 위하여 측정지표를 제시하였으며, 개선 프로세스의 적용 전후 결과를 정량적으로 비교 및 분석함으로써 개선효과를 도출하였다.

• Journal of Plant Biotechnology
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• 제7권4호
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• pp.259-265
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• 2005

Indian citrus ringspot virus (ICRSV)-free plants of Kinnow mandarin (Citrus nobilis Lour x C. deliciosa Tenora) were raised from virus-infected plants using unfertilised ovules as explants. Plants were tested by indirect ELISA and RT-PCR before using their explant. An amplified product of 539 bp was obtained by RT- PCR in ICRSV infected plants. Unfertilized ovules were excised from unopened flower buds of plants tested postive for virus and were cultured on Murashige and Skoog's (MS) basal medium supplemented with various concentrations of kinetin (KN) or malt extract (ME). Maximum induction (31.94%) of embryogenic callus was observed on MS medium supplemented with KN ($9.29\;{\mu}M$). Transfer of embryogenic calli to similar media composition resulted in somatic embryogenesis in all cultures, with an average number of 60.36 globular, 17.39 heart and 7.71 cotyledonary-shaped somatic embryos per culture. All cotyledonary shaped embryos developed into complete plantlets within 60 days on transfer to similar medium. Embryogenic callus induction, somatic embryo formation, maturation, germination and plantlet formation were achieved on MS medium supplemented with KN ($9.29\;{\mu}M$) alone. The plantlets derived from somatic embryos were transferred to sterilized soil, sand and vermiculite (3:1:1) mixture. After acclimatization, the plantlets were transferred to screen house and were indexed for ICRSV employing indirect ELISA and RT-PCR and found free of virus. A distinct feature of this study is the induction of somatic embryogenesis from unfertilised ovules to produce virus-free plants.

• Journal of Animal Science and Technology
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• 제60권7호
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• pp.18.1-18.12
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• 2018

Background: Xanthosine treatment has been previously reported to increase mammary stem cell population and milk production in cattle and goats. However, the underlying molecular mechanisms associated with the increase in stem cell population and milk production remain unclear. Methods: Primiparous Beetal goats were assigned to the study. Five days post-partum, one mammary gland of each goat was infused with xanthosine (TRT) twice daily ($2{\times}$) for 3 days consecutively, and the other gland served as a control (CON). Milk samples from the TRT and CON glands were collected on the 10th day after the last xanthosine infusion and the total RNA was isolated from milk fat globules (MEGs). Total RNA in MFGs was mainly derived from the milk epithelial cells (MECs) as evidenced by expression of milk synthesis genes. Significant differentially expressed genes (DEGs) were subjected to Gene Ontology (GO) terms using PANTHER and gene networks were generated using STRING db. Results: Preliminary analysis indicated that each individual goat responded to xanthosine treatment differently, with this trend being correlated with specific DEGs within the same animal's mammary gland. Several pathways are impacted by these DEGs, including cell communication, cell proliferation and anti-microbials. Conclusions: This study provides valuable insights into transcriptomic changes in milk producing epithelial cells in response to xanthosine treatment. Further characterization of DEGs identified in this study is likely to delineate the molecular mechanisms of increased milk production and stem or progenitor cell population by the xanthosine treatment.

• Asian-Australasian Journal of Animal Sciences
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• 제28권2호
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• pp.252-259
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• 2015

The present study was conducted to investigate the efficacy of sweet potato powder (SPP) and water as a fat replacer in low-fat pork patties. Low-fat pork patties were developed by replacing the added fat with combinations of SPP and chilled water. Three different levels of SPP/chilled water viz. 0.5/9.5% (T-1), 1.0/9.0% (T-2), and 1.5/8.5% (T-3) were compared with a control containing 10% animal fat. The quality of low-fat pork patties was evaluated for physico-chemical (pH, emulsion stability, cooking yield, $a_w$), proximate, instrumental colour and textural profile, and sensory attributes. The cooking yield and emulsion stability improved (p<0.05) in all treatments over the control and were highest in T-2. Instrumental texture profile attributes and hardness decreased, whereas cohesiveness increased compared with control, irrespective of SPP level. Dimensional parameters (% gain in height and % decrease in diameter) were better maintained during cooking in the low-fat product than control. The sensory quality attributes juiciness, texture and overall acceptability of T-2 and T-3 were (p<0.05) higher than control. Results concluded that low-fat pork patties with acceptable sensory attributes, improved cooking yield and textural attributes can be successfully developed with the incorporation of a combination of 1.0% SPP and 9.0% chilled water.

• Journal of Animal Science and Technology
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• 제60권10호
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• pp.25.1-25.10
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• 2018

The central dogma of gene expression propounds that DNA is transcribed to mRNA and finally gets translated into protein. Only 2-3% of the genomic DNA is transcribed to protein-coding mRNA. Interestingly, only a further minuscule part of genomic DNA encodes for long non-coding RNAs (lncRNAs) which are characteristically more than 200 nucleotides long and can be transcribed from both protein-coding (e.g. H19 and TUG1) as well as non-coding DNA by RNA polymerase II. The lncRNAs do not have open reading frames (with some exceptions), 3`-untranslated regions (3'-UTRs) and necessarily these RNAs lack any translation-termination regions, however, these can be spliced, capped and polyadenylated as mRNA molecules. The flexibility of lncRNAs confers them specific 3D-conformations that eventually enable the lncRNAs to interact with proteins, DNA or other RNA molecules via base pairing or by forming networks. The lncRNAs play a major role in gene regulation, cell differentiation, cancer cell invasion and metastasis and chromatin remodeling. Deregulation of lncRNA is also responsible for numerous diseases in mammals. Various studies have revealed their significance as biomarkers for prognosis and diagnosis of cancer. The aim of this review is to overview the salient features, evolution, biogenesis and biological importance of these molecules in the mammalian system.

• Plant Biotechnology Reports
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• 제2권2호
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• pp.137-143
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• 2008

Production of Indian citrus ringspot virus (ICRSV)-free plants from an infected plant of kinnow mandarin (Citrus nobilis Lour ${\times}$ C. deliciosa Tenora) is reported. The shoot apices of different sizes (0.2-1.0 mm) excised from the ICRSV-infected plant were micrografted onto decapitated rootstock seedlings of rough lemon (C. jambhiri). Micrograft survival depended on the size of shoot apex and the sucrose concentration of the culture medium. Increase in scion size from 0.2 to 0.7 mm resulted in an increase in micrografting success rate from 30.55 to 51.88%. Further, micrograft survival obtained with 0.2 mm was improved from 30.55 to 38.88% by increasing sucrose concentration in the culture media from 5 to 7.5%. The micrografted plants were tested for ICRSV using ELISA and RT-PCR. All plants raised from 0.2-mm scion were found negative with both ELISA and RT-PCR whereas only 20% of the ELISA negative plants raised from 0.3-mm scion were found negative for ICRSV with RT-PCR. The outcome of this research is the successful establishment, acclimatization and virus testing of micrografted plants.

• 한국시뮬레이션학회논문지
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• 제23권2호
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• pp.1-6
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• 2014

CPS는 네트워크로 연결된 다수의 임베디드 시스템들이 물리 시스템과 연동하는 새로운 개념의 시스템 이다. 기존의 시스템은 일반적으로 물리 시스템 부분을 고려하지 않았다. 그러나 CPS에서 우리는 물리 시스템에서의 변화와 움직임을 고려해야 한다. 따라서 CPS의 복잡도가 증가로 시스템에서 잠재적인 문제 발생 역시 증가 한다. 본 논문에서 우리는 CPS의 신뢰성을 위하여 실행 가능한 모델 기반 설계 방법론을 적용하고 이를 검증하기 위한 분산 실시간 시뮬레이션 기법을 사용한다. 이산과 연속 요소를 갖는 하이브리드 시스템의 설계를 위하여 우리는 DEV&DESS 형식론을 적용하고 DDS 미들웨어 기반 분산 시뮬레이션 환경에서 시뮬레이션을 수행한다. 또한 우리는 개발한 모델링 도구를 이용한 CPS 응용분야의 모델링 및 시뮬레이션 수행 결과를 보여준다.