• Journal of Korea Multimedia Society
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• v.12 no.9
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• pp.1273-1287
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• 2009

PEGASIS, a chain-based protocol, forms chains from sensor nodes so that each node transmits and receives from a neighbor. In this way, only one node (known as a HEAD) is selected from that chain to transmit to the sink. Although PEGASIS is able to balance the workload among all of the nodes by selecting the HEAD node in turn, a considerable amount of energy may be wasted when nodes which are far away from sink node act as the HEAD. In this study, DERP (Distance-based Energy-efficient Routing Protocol) is proposed to address this problem. DERP is a chain-based protocol that improves the greedy-algorithm in PEGASIS by taking into account the distance from the HEAD to the sink node. The main idea of DERP is to adopt a pre-HEAD (P-HD) to distribute the energy load evenly among sensor nodes. In addition, to scale DERP to a large network, it can be extended to a multi-hop clustering protocol by selecting a "relay node" according to the distance between the P-HD and SINK. Analysis and simulation studies of DERP show that it consumes up to 80% less energy, and has less of a transmission delay compared to PEGASIS.

• Korean Journal of Clinical Laboratory Science
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• v.47 no.4
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• pp.230-236
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• 2015

Dermatophagoides pteronissinus (DP) is one of the house dust mites (HDM) associated with allergic diseases. The cysteine protease Der p 1 from DP is a powerful allergen. The pathogenic mechanism of allergy is involved in cytokine secretion of lymphocytes and spontaneous apoptosis of neutrophils. In this study, we investigated whether Der p 1 induces cytokine secretion of lymphocytes and if the release of cytokines is associated with regulation of neutrophil apoptosis. In normal and allergic subjects, Der p 1 increased IL-6, IL-8, MCP-1, and GM-CSF release in a time-dependent course. Supernatants collected from normal and allergic neutrophils after Der p 1 stimulation suppressed the apoptosis of normal and allergic neutrophils, although Der p 1 alone has no effect on neutrophils. Der p 1 suppressed neutrophil apoptosis in coculture of normal neutrophils with normal lymphocytes. Der p 1 more strongly suppressed apoptosis of allergic neutrophils cocultured with allergic lymphocytes than normal neutrophils cocultured with normal lymphocytes. In summary, Der p 1 increases the secretion of cytokines, which has anti-apoptotic effects on neutrophils of normal and allergic subjects. These results will contribute to elucidate the pathogenic mechanism of allergic diseases.