• 정보기술응용연구
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• 제3권3호
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• pp.1-24
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• 2001

본 논문은 최소한의 학습데이터를 사용하여 비선형의 응답면을 모델링할 수 있는 방안으로 유전적 프로그래밍을(Genetic Programming, GP)의 사용을 모색하였다. 이때 대두되는 가장 큰 문제는 GP 트리가 부족한 학습 데이터 때문에 심한 Overfilling 현상을 보인다는 점이다.이를 극복하기 위한 방법으로 DDBS (Directional Derivative-Based Smoothering) 기법을 제안하였고, 유용성을 검증하기 위해서 4 가지 응용 예를 보였다.

• Toxicological Research
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• 제16권2호
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• pp.151-161
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• 2000

The Three months subacute toxicity of water soluble dimethyl dimethoxy biphenylate derivative (DDB-S), newly formulated therapeutic agent for hepatitis, was invesgated in SD rats. The body weight and clinical signs were observed after intravenous injection of DDBs at doses of 57, 75 and 100 mg/kg/day for three months. Decrease in motor activity and tremor were observed above 75mg/kg treated groups. Statistically significant changes at serum biochemical analysis were found in some group, how-ever, those changes were within the normal range and had no relationship with dosage. There was no abnormal morphological and pathological findings in relation to DDB-S treatment. The no observable adverse effect level of DDB-S in rats was estimated to be 57 mg/kg/day in this study.