• Clinical and Experimental Reproductive Medicine
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• v.48 no.4
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• pp.303-310
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• 2021

Decorin (DCN) is a proteoglycan belonging to the small leucine-rich proteoglycan family. It is composed of a protein core containing leucine repeats with a glycosaminoglycan chain consisting of either chondroitin sulfate or dermatan sulfate. DCN is a structural component of connective tissues that can bind to type I collagen. It plays a role in the assembly of the extracellular matrix (ECM), and it is related to fibrillogenesis. It can interact with fibronectin, thrombospondin, complement component C1, transforming growth factor (TGF), and epidermal growth factor receptor. Normal DCN expression regulates a wide range of cellular processes, including proliferation, migration, apoptosis, and autophagy, through interactions with various molecules. However, its aberrant expression is associated with oocyte maturation, oocyte quality, and poor extravillous trophoblast invasion of the uterus, which underlies the occurrence of preeclampsia and intrauterine growth restriction. Spatiotemporal hormonal control of successful pregnancy should regulate the concentration and activity of specific proteins such as proteoglycan participating in the ECM remodeling of trophoblastic and uterine cells in fetal membranes and uterus. At the human feto-maternal interface, TGF-β and DCN play crucial roles in the regulation of trophoblast invasion of the uterus. This review summarizes the role of the proteoglycan DCN as an important and multifunctional molecule in the physiological regulation of oocyte maturation and trophoblast migration. This review also shows that recombinant DCN proteins might be useful for substantiating diverse functions in both animal and in vitro models of oogenesis and implantation.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.7
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• pp.1610-1623
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• 2013

In-network caching is a key component of information-centric networking (ICN) for reducing content download time, network traffic, and server workload. Data center network (DCN) is an ideal candidate for applying the ICN design principles. In this paper, we have evaluated the effectiveness of caching placement and replacement in DCN with butterfly-topology. We also suggest a new cache placement policy based on the number of routing nodes (i.e., hop counts) through which travels the content. With a probability inversely proportional to the hop counts, the caching placement policy makes each routing node to cache content chunks. Simulation results lead us to conclude (i) cache placement policy is more effective for cache performance than cache replacement, (ii) the suggested cache placement policy has better caching performance for butterfly-type DCNs than the traditional caching placement policies such as ALWASYS and FIX(P), and (iii) high cache hit ratio does not always imply low average hop counts.

• Proceedings of the KIEE Conference
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• 2005.05a
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• pp.75-77
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• 2005

An integrated I&C architecture for nuclear power plants is designed by the systems and devices being developed in a project. Its design reference is the APR1400 that was design certified in Korea. Digital equipment and several kinds of data communication networks (DCN) are used. To confirm the validity of DCN based architecture design, the traffic loads fur each network were calculated assuming the anticipated maximum traffic condition. The analysis showed that the utilizations of all networks satisfied the design requirements.

• Proceedings of the Korean Nuclear Society Conference
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• 2004.10a
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• pp.595-596
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• 2004

Based on the systems and devices which are being developed in the KNICS project, the data communication network (DCN) which is an essential element for the interfaces among the I&C systems. is designed. The traffic load for each network is calculated at the expected maximum traffic condition. The result shows that the utilizations of all networks satisfy the design requirements.

• Proceedings of the Korean Nuclear Society Conference
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• 1997.10a
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• pp.265-270
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• 1997

차세대원자로(II)에서 개발중인 I&C 계통은 기존 아나로그 신호 체계를 가진 한국 표준형이나 웨스팅하우스형의 원전에 비해, 완전 디지탈화 및 소프트웨어에 의한 제어와 보호 기능 수행, 정보 계통의 클라이언트/서버 개념의 도입등 개선된 성능과 신뢰성을 바탕으로한 운전 지원 향상을 주요한 설계 목표로 추진중에 있다. 정보 흐름의 통로 역할을 수행하는 I&C 분야의 Data Communication Network (DCN)의 성능과 신뢰도는 정보 계통의 전체적인 성능과 신뢰도에 매우 중요하며, 특히 Network Architecture가 핵심 기술로써 개발 중에 있다. 본 논문에서는 차세대 원전의 비안전성 정보 계통에 대해 기술하고, Information Network 의 성능 요건을 설정하였다. 또한 Information Network 설계를 위한 Traffic Load 를 간략히 분석한후, 이 결과로부터 Network Performance 증가를 통한 전송 신뢰도 향상을 위한 Information Network Topology 와 Architecture를 개발하였다.

• Journal of the Korean Society of Systems Engineering
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• v.13 no.2
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• pp.9-17
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• 2017

Concept development of a real-time Field Programmable Gate Array (FPGA)-based switched Ethernet data communication network for the Man-Machine Interface System (MMIS) is presented in this paper. The proposed design discussed in this research is based on the systems engineering (SE) approach. The design methodology is effectively developed by defining the concept development stage of the life-cycle model consisting of three successive phases, which are developed and discussed: needs analysis; concept exploration; and concept definition. This life-cycle model is used to develop an FPGA-based time-triggered Ethernet (TTE) switched data communication network for the non-safety division of MMIS system to provide real-time data transfer from the safety control systems to the non-safety division of MMIS and between the non-safety systems including control, monitoring, and information display systems. The original IEEE standard 802.3 Ethernet networks were not typically designed or implemented for providing real-time data transmission, however implementing a network that provides both real-time and on-demand data transmission is achievable using the real-time Ethernet technology. To develop the design effectively, context diagrams are implied. Conformance to the stakeholders needs, system requirements, and relevant codes and standards together with utilizing the TTE technology are used to analyze, synthesize, and develop the MMIS non-safety data communication network of the APR1400 nuclear power plant.