• Journal of Technologic Dentistry
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• v.9 no.1
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• pp.5-19
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• 1987

The factors which impact on the productivity of medical organization are technique, manager, raw materials, management style, manpower structure, job construction, and so on. Human resources is the most important factor among them, but the productivity of serice organization can not be measured easily. The purpose of this study was to verify the effect of laboratory status, the degree of job cognition, and stress on the productivity of dantal prosthetic products, and to fine out the factors which impact on the productivity. The results were as follows: 1. The job characteristice of crown bridge laboratory part and porcelain laboratory part similar to each other. Also partial denture laboratory part and complete denture laboratory part were similar to each other. But that of orthodontic laboratory part was different from other. 2. the degree of job cognition made significant difference statisfically according to job characteristics of each dental laboratorise. 3. The correlation coefficient between job cognition of dental laboratory technician and workshop environment was.23, but the correlation between job cognition job stress appeared reversely, its coefficient was-.17. 4. The productivity of technician engaged in dental laboratory was much heigher than that of technician engaged in dental clinical laboratory room, and each were different in the degree of job cognition. 5. the most important factors which impact one the performance productivity of dental laboratory technician were the fact whether he married or not and his status.

• Journal of IKEEE
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• v.15 no.4
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• pp.261-266
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• 2011

In this paper, new efficient lighting control system for light devices is proposed to reduce power consumption and increases LED life-cycle and heat efficiency of LED lighting module. The new proposed lighting control system for light devices divides into 4 stages according to the illuminance surrounding by measuring illuminance and apply to automatic pattern lighting algorithm. And via level check will be light up for set time by applying intersection lighting algorithm of magic square pattern forming a fully symmetrical. Experimental analysis results, shows heating value and power consumption reduced to maximum 30 percent and lifetime of LED improved to maximum 60 percent in comparison with previous lighting system so applying system to LED streetlight, stable and high energy efficiency can be acquired.

• Archives of Pharmacal Research
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• v.27 no.1
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• pp.94-98
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• 2004

Effects of dopaminergic drugs on the degranulation of mast cells (RBL-2H3 cells) and the nitric oxide production from macrophage cells (RAW 264.7) were studied. Among the dopaminergic agonists and antagonists tested, bromocriptine, 7-OH-DPAT, haloperidol, and clozapine showed potent inhibitions of mast cell degranualtion ($IC_{50} value, 5 \mu$ M). However, these dopaminergic agents did not affect the tyrosine phosphorylations of the signaling components of the high affinity IgE receptor ($Fc\varepsilonRI$), such as Syk, $PLC\gamma1$, and $PLC\gamma2$.; This suggested that these signaling components were not involved in the inhibition of the mast cell degranulation by these compounds. On the other hand, dopamine, bromocriptine, 7-OH-DAPT, and haloperidol markedly inhibited the nitric oxide production from RAW 264.7 cells ($IC_{50}$ values, 10-20$\mu$M). Bromocriptine, a dopamine agonist that is routinely used for the treatment of Parkinsons disease, inhibited the expression of the inducible nitric oxide synthase at an early stage of the LPS-induced protein expression in a dose-dependent manner. The results suggested that these dopaminergic agents, when used for the treatment of dopamine receptors-related diseases, such as Schizophrenia or Parkinsons disease, might have additional beneficial effects.

• International Journal of Stem Cells
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• v.16 no.3
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• pp.293-303
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• 2023

Background and Objectives: The physiological oxygen tension in fetal brains (~3%, physioxia) is beneficial for the maintenance of neural stem cells (NSCs). Sensitivity to oxygen varies between NSCs from different fetal brain regions, with midbrain NSCs showing selective susceptibility. Data on Hif-1𝛼/Notch regulatory interactions as well as our observations that Hif-1𝛼 and oxygen affect midbrain NSCs survival and proliferation prompted our investigations on involvement of Notch signalling in physioxia-dependent midbrain NSCs performance. Methods and Results: Here we found that physioxia (3% O₂) compared to normoxia (21% O₂) increased proliferation, maintained stemness by suppression of spontaneous differentiation and supported cell cycle progression. Microarray and qRT-PCR analyses identified significant changes of Notch related genes in midbrain NSCs after long-term (13 days), but not after short-term physioxia (48 hours). Consistently, inhibition of Notch signalling with DAPT increased, but its stimulation with Dll4 decreased spontaneous differentiation into neurons solely under normoxic but not under physioxic conditions. Conclusions: Notch signalling does not influence the fate decision of midbrain NSCs cultured in vitro in physioxia, where other factors like Hif-1𝛼 might be involved. Our findings on how physioxia effects in midbrain NSCs are transduced by alternative signalling might, at least in part, explain their selective susceptibility to oxygen.