• Nutrition Research and Practice
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• 제17권6호
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• pp.1128-1142
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• 2023

BACKGROUND/OBJECTIVES: Inonotus obliquus has been used as antidiabetic herb around the world, especially in the Russian and Scandinavian countries. Diabetes is widely believed to be a key factor in Alzheimer's disease (AD), which is widely considered to be type III diabetes. To investigate whether I. obliquus can also ameliorate AD, it would be interesting to identify new clues for AD treatment. We tested the anti-AD effects of raw Inonotus obliquus polysaccharide (IOP) in a mouse model of AD (3×Tg-AD transgenic mice). MATERIALS/METHODS: SPF-grade 3×Tg-AD mice were randomly divided into three groups (Control, Metformin, and raw IOP groups, n = 5 per group). β-Amyloid deposition in the brain was analyzed using immunohistochemistry for AD characterization. Gene and protein expression of pertinent factors of the ubiquitin-proteasome system (UPS) was determined using real-time quantitative polymerase chain reaction and Western blotting. RESULTS: Raw IOP significantly reduced the accumulation of amyloid aggregates and facilitated UPS activity, resulting in a significant reduction in AD-related symptoms in an AD mouse model. The presence of raw IOP significantly enhanced the expression of ubiquitin, E1, and Parkin (E3) at both the mRNA and protein levels in the mouse hippocampus. The mRNA level of ubiquitin carboxyl-terminal hydrolase isozyme L1, a key factor involved in UPS activation, also increased by approximately 50%. CONCLUSIONS: Raw IOP could contribute to AD amelioration via the UPS pathway, which could be considered as a new potential strategy for AD treatment, although we could not exclude other mechanisms involved in counteracting AD processing.

• Parasites, Hosts and Diseases
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• 제58권2호
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• pp.153-159
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• 2020

The chigger mite Leptotrombidium sialkotense is one of the 6 main vectors of scrub typhus in China. Before present study, L. sialkotense was found in some parts of Hunan province, China with a narrow geographical distribution. During field investigation 2016-2017, we found L. sialkotense in Jingha, southern Yunnan, China. Of 15 small mammal host species, L. sialkotense were collected from 6 species of the hosts. Rattus brunneusculus was a dominant host of L. sialkotense, from which 98.3% of the mites were collected. The chigger mite showed a relatively high infestation prevalence (P_M =11.7%) and mean abundance (MA=0.5) in comparison with the rest 5 host species. These results reveal a certain host specificity of L. sialkotense to a rat R. brunneusculus. The mite L. sialkotense showed an aggregated distribution on the host (P<0.05). A positive correlation observed between L. sialkotense and the body length of hosts. There was a positive interspecific association between L. sialkotense and 2 other dominant vectors, L. deliense and L. scutellare.

• Parasites, Hosts and Diseases
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• 제54권1호
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• pp.67-70
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• 2016

We report here a human case of Taenia asiatica infection which was confirmed by genetic analyses in Dali, China. A patient was found to have symptoms of taeniasis with discharge of tapeworm proglottids. By sequencing of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene, we observed nucleotide sequence identity of 99% with T. asiatica and 96% with T. saginata. Using the cytochrome b (cytb) gene, 99% identity with T. asiatica and 96% identity with T. saginata were found. Our findings suggest that taeniasis of people in Dali, China may be mainly caused by T. asiatica.

• 대한인간공학회지
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• 제32권2호
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• pp.167-177
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• 2013

Objective: This study aims to compare the usefulness of subjective measures which are comprised of existing methods like NASA-TLX, Bedford-scale and ZEIS and newly developed method like DALI in measuring drivers' mental workload in terms of validity, sensitivity and diagnosticity. Background: Nowadays, with the development of intelligent vehicle and HMI, mental workload of driver has become more and more important. For this reason, the studies on drivers' mental workload about driving situation and the use of information technology equipment such as mobile phones and navigations were conducted intensively. However, the studies on measuring drivers' mental workload were rarely conducted. Moreover, most of studies on comparison of subjective measures were used with performance based measure. However, performance based measures can cause distraction effect with subjective measures. Method: Participants (N=19) were engaged in a driving simulation experiment in 2 driving contexts (downtown driving and highway driving context). The experiment has 2 sessions according to driving contexts. The level of difficulties by driving contexts were adjusted according to existence of intersections, traffic signs and signals, billboards and the number of doublings. Moreover, as criteria of concurrent validity and sensitivity, the EEG data were recorded before and during the sessions. Results: The results indicated that all subjective methods were correlates with EEG in high-way driving. On the contrary to this, in downtown driving, all subjective methods were not correlates with EEG. In terms of sensitivity, multi-dimensional scales (NASA-TLX, DALI) were the only ones to identify differences between high way and downtown driving. Finally, in terms of diagnosticity, DALI was the most suitable method for evaluating drivers' mental workload in driving context. Conclusion: The DALI as newly developed method dedicated to evaluate driver's mental workload was superior in terms of sensitivity and diagnosticity. However, researchers should consider the characteristics of each subjective method synthetically according to research objective by selecting the method in subjective measures. Application: The results of this study could be applied to the intelligent vehicle and next generation of HMI design to decrease mental workload of driver and for the development of new subjective method in vehicle domain.

• 공연문화연구
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• 제39호
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• pp.835-861
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• 2019

1960년대 울산은 한국 경제개발의 선도적 입지로 공업과 산업도시로 선정되었고, 이에 많은 노동인구가 유입되었다. 이러한 상황에서 사회 환경은 급격하게 변화를 가져오게 되었다. 특히 그 변화는 이 지역의 전통적 풍속에 많은 영향을 주었고, 이와 함께 전래된 무형문화는 사라지거나 소멸되었다. 이러한 급박한 상황에서 울산의 무형문화유산은 타 지역에 비해 긴급으로 보호해야 할 필요성을 가진다. 이 연구는 1930년대에 울산 달리지역에서 이루어진 마을농악을 분석하여, 이를 연행하기 위한 상황과 판제를 고찰하였다. 연구방법은 먼저 문헌연구로 조선시대 울산 최초의 사찬 읍지인 학성지(1749, 영조 25년)와 1936년 울산 달리마을의 농경과 이와 연계한 농악을 분석하였다. 둘째, 현장조사는 현재 울산남구문화원에서 울산달리농악을 복구하는 현황을 토대하였다. 연구의 성과는 급격하게 사라져가는 울산지역 농악의 현황과 판제를 고찰하고, 울산문화원에서 활동했던 농악 전승자인 고 '김달오'에게 계승한 김세주의 울산달리농악에 관한 연행을 밝혔다.

• 공학교육연구
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• 제15권4호
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• pp.53-57
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• 2012

Modern manufacturing needs a great number of advanced engineers. China has the world's second largest equipment manufacturing and electronic information industry, and in 2020, the shortage of talented personnel in key industries will be more than 5 million in China. Universities and colleges are the main places to cultivate engineering talents. In this paper, we will introduce a multi-level engineering talents cultivating system we have applied in Dali University, China for more than 4 years. Under this training system, we have achieved some gratifying results.

• 공학교육연구
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• 제15권5호
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• pp.87-92
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• 2012

Independent study is a major ability of engineering students. In independent study training practice, we need to use different instructional strategies and responds to individual student needs and learning styles. The purpose of this paper is to demonstrate a four-step student independent study training mode we applied to teaching the Biomedical Engineering students in Dali University, China. We developed this teaching mode to fulfill the goals of the first years' undergraduates training and improve the students learning skills. The four-step teaching mode includes both in-class and out-of-class activities. The emphasis is on how to train students to get information from the reading materials, understand the concept, develop critical thinking and eventually become independent learner.

• Journal of Korean Neurosurgical Society
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• 제63권5호
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• pp.550-558
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• 2020

To perform a systematic review of the data collected from case-control studies conducted earlier to investigate the correlation between E-selectin S128R polymorphism and ischemic stroke (IS) risk among the Chinese population. The PubMed, Web of Science, Chinese biomedical literature database (CBM), Chinese databases China National Knowledge Infrastructure (CNKI), WanfangData knowledge service platform (Wanfang Data), and information resource integration service platform (VIP) Databases were searched to retrieve case-control studies on the correlation between E-selectin gene S128R polymorphism and IS from the inception of the database till June 2019. The literature was screened, data were extracted, the risk of bias was reviewed, and the studies included were assessed independently by two reviewers. Stata ver. 12.0 software (Stata Corp LLC, College Station, TX, USA) was used to perform the meta-analysis. A total of 2907 cases from eight case-control studies involving 1478 IS patients and 1429 controls were included in this study. The R allele and RS genotype in E-selectin were found to be associated with the risk of IS as per the results of the meta-analysis (R vs. S : odds ratio [OR], 2.75; 95% confidence interval [CI], 2.15-3.51; p<0.00001; RS vs. SS : OR, 2.50; 95% CI, 1.95-3.19; p<0.00001; RR+RS vs. SS : OR, 2.85, 95% CI, 2.21-3.67; p<0.00001). The E-selectin gene S128R polymorphism is likely related to IS based on the results of a meta-analysis in the Chinese population, and the R allele and RS genotype of E-selectin may be IS risk factors.

• Journal of Korean Neurosurgical Society
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• 제65권5호
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• pp.697-709
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• 2022

Objective : The present study aimed to identify the function of ischemic stroke (IS) patients' peripheral blood and its role in IS, explore the pathogenesis, and provide direction for clinical research progress by comprehensive bioinformatics analysis. Methods : Two datasets, including GSE58294 and GSE22255, were downloaded from Gene Expression Omnibus database. GEO2R was utilized to obtain differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed using the database annotation, visualization and integrated discovery database. The protein-protein interaction (PPI) network of DEGs was constructed by search tool of searching interactive gene and visualized by Cytoscape software, and then the Hub gene was identified by degree analysis. The microRNA (miRNA) and miRNA target genes closely related to the onset of stroke were obtained through the miRNA gene regulatory network. Results : In total, 36 DEGs, containing 27 up-regulated and nine down-regulated DEGs, were identified. GO functional analysis showed that these DEGs were involved in regulation of apoptotic process, cytoplasm, protein binding and other biological processes. KEGG enrichment analysis showed that these DEGs mediated signaling pathways, including human T-cell lymphotropic virus (HTLV)-I infection and microRNAs in cancer. The results of PPI network and cytohubba showed that there was a relationship between DEGs, and five hub genes related to stroke were obtained : SOCS3, KRAS, PTGS2, EGR1, and DUSP1. Combined with the visualization of DEG-miRNAs, hsa-mir-16-5p, hsa-mir-181a-5p and hsa-mir-124-3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene. Conclusion : Thirty-six DEGs, five Hub genes, and three miRNA were obtained from bioinformatics analysis of IS microarray data, which might provide potential targets for diagnosis and treatment of IS.

• Journal of Korea Trade
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• 제26권4호
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• pp.23-38
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• 2022

Purpose - This paper empirically explores the RCA of electrical equipment trade between China and Korea from the perspective of gross trade and value-added trade. The goal of this paper is to scan the electrical equipment's RCA, the decomposition of gross exports, and the impacts of an exerted shock. Design/methodology - We applied the domestic value-added method in measuring the RCA, which could be more accurate than traditional RCA since it excludes foreign value-added. Based on the research purpose, this paper follows the framework of Koopman, Wang, and Wei (2014)-as extended by Wang, Wei, and Zhu (2018). It extracts the data from the 2019 Multi-regional Input-Output (MRIO) databases compiled by the Asian Development Bank in January 2021. Findings - After rigorous examination, the main findings are as follows: First, the electrical equipment sector maintains a consistent comparative advantage in either assessing method. Second, China exports more gross goods of electrical equipment to the world than South Korea does, but there is a trade deficit with Korea. Third, South Korea and P.R. China are the most significant bilateral partners of foreign value-added sourcing. Finally, it is surprising that there is a shock on electrical equipment; the partner's service, as well as manufacturing sectors, would be affected. Originality/value - This paper explores the revealed comparative advantage between Korea and China from traditional gross export and value-added perspectives. Second, we apply the information from the 2019 MRIO database compiled by the Asian Development Bank in January 2021, reflecting the current situation. Third, this paper analyzes the electrical equipment and the impacts on other parties' sectors. Finally, we carry out the subjects that deserve to be investigated in the future.