• 대한기계학회논문집A
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• 제27권6호
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• pp.864-870
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• 2003

In recent engineering, the designer has become more and more dependent on the computer simulations such as FEM(Finite Element Method) and BEM(Boundary Element Method). In order to optimize such implicit models more efficiently and reliably, the meta -modeling technique has been developed for solving such a complex problems combined with the DACE(Design and Analysis of Computer Experiments). It is widely used for exploring the engineer's design space and for building approximation models in order to facilitate an effective solution of multi-objective and multi-disciplinary optimization problems. Optimization of a train suspension is performed according to the minimization of forty -six responses that represent ten ride comforts, twelve derailment quotients, twelve unloading ratios, and twelve stabilities by using the Kriging model of a train suspension. After each Kriging model is constructed, multi -objective optimal solutions are achieved by using a nonlinear programming method called SQP(Sequential Quadratic Programming).

• 한국물환경학회지
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• 제21권1호
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• pp.79-83
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• 2005

Foraging behaviour of false dace, Pseudorasbora parva, was investigated in water flowing at various velocities with the existence of a cavity for rest. The pursuit comprised three succeeding processes such as, approaching, chasing and attacking. Angles between the fish body and the water flow direction and swimming speeds increased in the latter stages of approaching, chasing and attacking. All pursuit angles, swimming speeds and distances increased with flow velocity and peaked at the flow velocity of 7 cm/sec. At higher velocities, however, the fish avoided the use of much energy against the large drag force. The probability of capture and the feeding rate steadily decreased with increasing flow velocity. Under the fast flow, the fish adjusted their swimming speed to get the optimum velocity relative to the flowing water for the energetic budget. Fish spent more time in the cavity as flow velocity increased to avoid the energy expenditure necessitated by the high velocity.

• 한국동물위생학회지
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• 제29권1호
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• pp.79-82
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• 2006

A 5 years old gelding (Thoroughbred, Equus caballus) had shown severe abdominal pain, colic, after overeating of hay in the feed storage. following through treatment, it subsequently died. Grossly, the large colon was impacted with firm mass of food and congestion of blood vessel in the intestinal wall. There were mild peritonitis and pleuropneumonia. This case demonstrates typical large colon impaction with hard consistence ingesta due to improper management of horse.

• 한국동물위생학회지
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• 제29권4호
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• pp.507-511
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• 2006

Acanthomatous epulis is a malignant form of gingival tumor. This is a case of epulis affecting a four-year old, intact, female Maltese dog raised as indoor pet in Iksan city. Clinical examination showed an enlarged palpable mass along the rostral maxillary gingiva. Section of the excised mass showed epithelial overgrowth and expansion from the basal portions through the tissue stroma. Post-surgical radio-graph showed displacement of the first and second maxillary incisors. Histochemical staining showed strongly positive reaction to epithelial marker cytokeratin and moderately positive reaction to connective tissue marker vimentin. This case was diagnosed as a form of maxillary gingival acanthomatous epulis. Routine clinical oral examination is suggested.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2005년도 춘계학술대회 논문집
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• pp.385-390
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• 2005

LMTT(Linear Motor-based Transfer Technology)는 항만 자동화를 위한 수평 이송 시스템이며, 셔틀카(shuttle car)와 격자구조의 레일에 부착된 스테이터 모듈(stator module)로 구성된 PLMSL(Permanent Magnetic Linear Synchronous Motor)에 의해 구동된다. 본 논문에서는 LMTT시스템 부품인 이동체(mover)의 경량화를 위하여 직교배열표 및 크리깅 방법을 이용하여 최적설계를 수행한다. 설계변수로는 가로빔, 세로빔, 휠빔의 두께와 높이 방향의 치수를 결정하는 형상변수를 포함시켰다. 목적함수로는 중량, 제한조건 함수로는 안전율이 고려된 응력으로 설정하였다. 본 연구에서 제시된 방법으로 구한 최적해를 민감도기반 최적설계로 구해진 최적해와 비교, 검토하였다.

• Parasites, Hosts and Diseases
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• 제35권4호
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• pp.223-232
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• 1997

Metagonimus miyatai n. sp. (Digenea: Heterophyidae) is described based on adult flukes collected from experimental dogs and hamsters fed with metacercariae encysted in the sweetfish, Plecoglossus altivelis, dace, Tribolodon hakonensis and T. taczanowskii, common fat-minnow. Morocco steindachneri pale chub, Zacco platypus, and dark chub, Zacco temmincki, and on those collected from naturally infected humans. The new species was morphologically compared with M. yokogawai and M. takahashii obtained from experimental animals fed with the sweetflsh and the crucian carp, Cnrossius caressius, respectively. The uterine loops of M. miyatai reached near the posterior end of the body through the space between the two testes, whereas those of M. yokogawai, occupied only the space between the acetabulum and anterior border of two testes. This uterine tubule distribution was similar to that of another closely related species, M. takahashii. However vitellaria of M. miyatai ended in front of the posterior end of the left testis, while those of M. takahcshii reached the posterior end of the left testis and ran it over. By raising M. miyatai as a new species, differentiation of M. yokogawai and M. takahashii became very clear. A key to the species of the genus Metagonimus in the Far East has been proposed.

• 한국동물위생학회지
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• 제29권4호
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• pp.493-496
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• 2006

This study investigated cases of progressively necrotizing limbs in Korean indigenous calves. The recent case (Case 1) involved a 3-month old, male calf in Jeonbuk province that presented a visibly dry form of gangrene affecting joints of the forelimbs and the hind limbs. Radiograph revealed osteoarthritis possibly resulting from pressure of disrupted joint skin, fasciae, deeper underlying musculatures and tendon. Histopathology of affected tissue showed necrotizing; severely thrombosed dilated blood vessels with rechanneling microvasculatures. The lack of substantial infectious inflammatory exudates in the vital organs and the inability to respond to antimicrobial treatment bolstered the notion that the observed thromboembolic and vascular lesion was attributed to possible vasoconstrictive effects of ergot alkaloids. Case 2: A previously encountered similar case in a 4-month old, male calf showing gangrene of hind limbs and posterior ataxia was likewise presented. These two cases were impressed as probable ergotism. Ergotism may be uncommon or underreported in Korea. Future isolation of ergot alkaloids in feeds or in pasture is highly suggested.

• 한국동물위생학회지
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• 제28권4호
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• pp.367-373
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• 2005

Coccidiosis of domestic fowl is a parasitic disease that infects poultry drastically and can cost the pastured poultry producer much in the course of a year. Two hundred forty, day-old-broiler chicks were purchased and were randomly divided in eight groups, containing thirty birds in each group. Decoquinate $6\%$, maduramicin ammonium $2\%$, monensin sodium $13.2\%$, salinomycin sodium $12\%$, a live attenuated vaccine, and trivalent live attenuated vaccine, was provided to the day chicks of six groups, respectively. The chicks of last two groups served as infected non-medicated and uninfected non-medicated, respectively. Feed consumption, weight gain, feed conversion ratio, mortality and oocyst count per gram feces were recorded during the conduction of the experiment. Among treated groups, performance of salinomycin group was significantly better (p<0.05) in all aspects. Salinomycin acts against the sporozoites, trophozoites and first generation schizonts and is highly effective against the economically important species of Eimeria. The present study confirms that use of salinomycin, as an anticoccidial, is a drug of choice.

• Journal of Veterinary Science
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• 제21권2호
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• pp.32.1-32.13
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• 2020

Levofloxacin pharmacokinetic profiles were evaluated in 6 healthy female rabbits after intravenous (I/V), intramuscular (I/M), or subcutaneous (S/C) administration routes at a single dose of 5 mg/kg in a 3 × 3 cross-over study. Plasma levofloxacin concentrations were detected using a validated Ultra Performance Liquid Chromatography method with a fluorescence detector. Levofloxacin was quantifiable up to 10 h post-drug administration. Mean AUC_0-last values of 9.03 ± 2.66, 9.07 ± 1.80, and 9.28 ± 1.56 mg/h^*L were obtained via I/V, I/M, and S/C, respectively. Plasma clearance was 0.6 mL/g*h after I/V administration. Peak plasma concentrations using the I/M and S/C routes were 3.33 ± 0.39 and 2.91 ± 0.56 ㎍/mL. Bioavailability values, after extravascular administration were complete, - 105% ± 27% (I/M) and 118% ± 40% (S/C). Average extraction ratio of levofloxacin after I/V administration was 7%. Additionally, levofloxacin administration effects on tear production and osmolarity were evaluated. Tear osmolarity decreased within 48 h post-drug administration. All 3 levofloxacin administration routes produced similar pharmacokinetic profiles. The studied dose is unlikely to be effective in rabbits; however, it was calculated that a daily dose of 29 mg/kg appears effective for I/V administration for pathogens with MIC < 0.5 ㎍/mL.

• 한국어류학회지
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• 제27권1호
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• pp.26-32
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• 2015

참붕어 심장의 조직학적 구조를 광학현미경을 이용하여 관찰하였다. 참붕어의 심장은 정맥동, 심방, 심실 및 동맥구가 연속적으로 배열되어 있었다. 정맥동은 조직학적으로 심내막, 심근층, 심외막층으로 구분되었고, 심방과 심실은 심내막, 심내막하층, 심외막하층 및 심외막으로 구분되었으며, 동맥구는 심내막, 심내막하층, 중간층, 심외막하층 및 심외막으로 구분되었다. 정맥동과 심방, 심방과 심실 및 심실과 동맥구 사이에는 판막이 존재하였다. 정맥동은 대부분 아교질로 구성된 외벽을 가지고 있었으며 정맥동과 심방의 연결부위에는 고리 모양의 조직이 분포하였다. 심방은 얇은 심근층에 의해서 형성된 비연속적인 테두리가 소주들에 의해 형성된 해면성 심근을 둘러싸고 있었고, 심외막하층과 소주에는 아교질이 분포하였다. 심실의 심근층은 해면성 심근으로 이루어져 있고, 심외막하층에는 혈관이 분포하였으며, 심실의 심외막하층과 소주에는 아교질이 분포하였다. 동맥구에서 심내막하층에 의해 형성된 이랑은 직경과 길이가 매우 다양했고, 심내막 세포는 볼록한 모양이었으며, 심내막하층의 세포들은 불규칙한 모양이었으나 무리를 지어 분포하지는 않았다. 중간층의 세포들은 배열방향이 다르게 불규칙한 층을 이루었고, 심외막하층에서는 서로 다른 모양의 세포들이 관찰되었다. 동맥구의 심내막하층, 중간층 및 심외막하층에는 아교질과 탄력소가 풍부하였고, 심외막은 한 층의 편평한 세포들로 이루어져 있었다.