• 제목/요약/키워드: DA-8159

검색결과 27건 처리시간 0.026초

DA-8159, a New PDE5 Inhibitor, Does Not Influence Fertility Function in Male Rats

  • Kim, Dong-Hwan;Kang, Kyung-Koo;Park, Seul-Min;Sohn, Yong-Sung;Ahn, Byoung-Ok;Kwon, Jong-Won;Kim, Won-Bae
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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    • pp.208-208
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    • 2002
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Oral Efficacy of DA-8159, a Novel Selective PDE 5 Inhibitor, for Inducing Penile Erection in Conscious Rabbits

  • Kang, Kyung-Koo;Oh, Tae-Young;Choi, Seul-Min;Kim, Ju-Mi;Ahn, Byoung-Ok;Kwon, Jong-Won;Kim, Won-Baw
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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    • pp.232-232
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    • 2002
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DA-8159, a Novel Selective PDE 5 Inhibitors Induces Penile Erection in Rabbits with Acute Spinal Injury

  • Kang, Kyung-Koo;Ahn, Gook-Jun;Baek, Dae-Hyun;Sohn, Yong-Sung;Kim, Dong-Hwan;Ahn, Byoung-Ok;Kwon, Jong-Won;Kim, Won-Bae
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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    • pp.223-223
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    • 2002
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Simultaneous determination of sildenafil and its active metabolite in human plasma using LC/MS/MS

  • Ji, Hye-Young;Kim, Sook-Jin;Lee, Hong-Il;Lee, Seung-Seok;Lee, Hye-Sook
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.402.1-402.1
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    • 2002
  • The LC/MS/MS method for the simultaneous determination of sildenafil and its active metabolite N-demethylsildenafil in human plama was developed. Sildenafil. its active metabolite and the internal standard. DA-8159 were extracted form human plasma by liquid-liquid partitioning. A reverse-phase HPLC separation was performed on Luna phenylhexyl column with the mixture of acetonitrile-5 mM ammonium formate (55:45. v/v) as mobile phase. (omitted)

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