• Title/Summary/Keyword: D1/D2 domain

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Molecular divergence of the fish somatomedins: the single family of insulin­like growth factor (IGF)-I and -II from the teleost, flounder

  • Kim Dong Soo;Kim Young Tae
    • Fisheries and Aquatic Sciences
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    • v.1 no.2
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    • pp.227-231
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    • 1998
  • The teleosts represent ancient real-bony vertebrates in phylogeny and resemble major genetic patterns to higher vertebrates. In the present study, we have defined the single family of insulin-like growth factors (IGFs) from flounder (Paralichthys olivaceus), compared to the prototype of IGFs observed in the Agnathan hagfish. In flounder, IGFs are clearly diverged into two major types including type I and II, and they are structurally similar by displaying a multidomain structure consisting of five functional regions as previously found in other vertebrates. However, flIGF-I appears to be more basic (pI 8.03) than the flIGF-II (pI 5.34) in the fully processed form for the B to D domain region. The flIGF-I seems to contain an evolutionary conserved Asn-linked glycosylation in E domain, which is not found in flIGF­II. The most interesting feature is that flIGF-II appeared to be structurally close to hagfish IGF in secondary structures, particularly in Band D domains. This could tell us an idea on the molecular divergence of IGFs from the Agnatha to teleosts during the vertebrate phylogeny. It also support, in part, a notion regarding on how IGF-II is appeared as more embryonic during development. Nonetheless, the biologically active B to D domain region of flIGF-II shows significant sequence homology of $65.6\%$ to flIGF-Is and contains the evolutionary conserved insulin-family signature, as well as a reserved recognition site (Lys) in D domain, necessary to generate proteolytic cleavage for E-peptide. A significant structural difference was found in E domain in which flIGF-I possesses two potential alternative splicing donor site at $Val^{17,\;24}$ of E domain. Therefore, it seems so far that IGF-I sorely produces spliced variants due to the spliced E-peptide moiety while IGF-II appears to be maintained in a single type during evolution. IGF-II, however, may be also possible to transcribe unidentified variants, depending on the physiological conditions of tissues in vertebrates in vivo.

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Exploring Concurrent Validity and Item Level Analysis for Two Korean Versions of Health-Related Quality of Life Instrument: EQ-5D vs. WHOQOL-BREF

  • Choi, Bongsam
    • Physical Therapy Korea
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    • v.27 no.4
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    • pp.233-240
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    • 2020
  • Background: Cross-culturally adapted questionnaires may not be comparable to their original version. Objects: To examine concurrent validity of two health-related quality of life (HRQOL) instruments for the Korean versions of EuroQOL-5 Dimension (EQ-5D) and the abbreviated version of the World Health Organization Quality of Life (WHOQOL-BREF) instrument. Methods: A total of 139 cancer survivors from two rehabilitation institutes was recruited. All participants were registered for palliative rehabilitation care. Both instruments were concurrently administered by health care providers following the second bout of the rehabilitation cares. Rasch partial credit model and Spearman's correlation analysis were used to investigate: 1) dimensionality, 2) hierarchical item difficulty, and 3) concurrent validity using correlations between two instruments. Results: For the WHOQOL-BREF, all items except negative feeling, pain, dependence of medical aid, were found to be acceptable, while all items of EQ-5D were acceptable. There was an evidence of negative correlations between EQ-5D and 4 domains of WHOQOL-BREF. Two correlations were strong (EQ-5D vs. physical health domain, ρ = -0.610, 95% CI = -0.716 to -0.475) and moderate (EQ-5D vs. psychosocial domain, ρ = -0.402, 95% CI = -0.546 to -0.236). Other two correlations were weak (EQ-5D vs. social relationship and environmental domains, ρ = -0.242, 95% CI = -0.401 to -0.075 and ρ = -0.364, 95% CI = -0.514 to -0.207, respectively). Item difficulty calibrations of the two measurements were ranged from -0.84 to 0.86 for the EQ-5D and -1.07 to 1.06 for the WHOQOL-BREF. Conclusion: The study provides some supports for the concurrent validity of the two Korean versions of HRQOL instrument, with evidences of weak to strong correlations between the EQ-5D and four domains of the WHOQOL-BREF applied to various cancer survivors. Additionally, the cancer survivors appeared to have more of a tendency to view the EQ-5D items as being slightly more challenging than the WHOQOL-BREF items.

A Time-Domain Comparator for Micro-Powered Successive Approximation ADC (마이크로 전력의 축차근사형 아날로그-디지털 변환기를 위한 시간 도메인 비교기)

  • Eo, Ji-Hun;Kim, Sang-Hun;Jang, Young-Chan
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.16 no.6
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    • pp.1250-1259
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    • 2012
  • In this paper, a time-domain comparator is proposed for a successive approximation (SA) analog-to-digital converter (ADC) with a low power and high resolution. The proposed time-domain comparator consists of a voltage-controlled delay converter with a clock feed-through compensation circuit, a time amplifier, and binary phase detector. It has a small input capacitance and compensates the clock feed-through noise. To analyze the performance of the proposed time-domain comparator, two 1V 10-bit 200-kS/s SA ADCs with a different time-domain comparator are implemented by using 0.18-${\mu}m$ 1-poly 6-metal CMOS process. The measured SNDR of the implemented SA ADC is 56.27 dB for the analog input signal of 11.1 kHz, and the clock feed-through compensation circuit and time amplifier of the proposed time-domain comparator enhance the SNDR of about 6 dB. The power consumption and area of the implemented SA ADC are 10.39 ${\mu}W$ and 0.126 mm2, respectively.

Field Distribution Characteristics of a Reverberation Chamber with 2D Diffuser Sets (2D 확산기를 이용한 전자파 잔향실 내의 필드 분포 특성)

  • Yang Wook;Rhee Joong-Geun
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.16 no.4 s.95
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    • pp.373-379
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    • 2005
  • Papers on improvement of electromagnetic field uniformity in a reverberation chamber with 1D Quadratic Residue Diffuser of Schroeder method has been published several times. In this paper, to obtain improved electromagnetic field characteristics and field uniformity in a reverberation chamber, cubical residue diffuser sets of Schroeder type are designed for a chamber in $2.3\;\cal{GHz}\~3\;\cal{GHz}$. The FDTD(Finite-Difference Time-Domain) technique is used to analyze the field characteristics in a chamber. Cubical residue algorithm and 2D arrangement show more randomness than the previous study results. The characteristics of tolerance, polarity, deviations, as well as power efficency, are improved with cubical residue diffuser sets in a chamber.

Compression Method for Digital Hologram using Motion Prediction Method in Frequency-domain (주파수 영역에서 움직임 예측을 이용한 디지털 홀로그램 압축 기법)

  • Choi, Hyun-Jun;Bae, Yun-Jin;Seo, Young-Ho;Kang, Chang-Soo;Kim, Dong-Wook
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.14 no.9
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    • pp.2091-2098
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    • 2010
  • This paper proposes a hologram data compression scheme that uses the existing image/video compression techniques, in which the existing techniques are modified appropriately to fit to the characteristics of hologram. In this paper we use CGH as the hologram data. The proposed scheme uses the generation characteristics of a CGH to consist of a pre-processing, spatial segmentation of a CGH, frequency-transformation with 2D-DCT (2-dimensional discrete cosine transform), and motion estimation and residual image generation in the frequency-domain. It uses H.264/AVC, the lossless compressor BinHex, and a linear quantizer that we have made. From the experiments the proposed scheme showed the image quality of about 25.4 dB at the compression ratio of 10:1 and about 16.5dB at 90:1 compression ratio.

Indexing Techniques or Nested Attributes of OODB Using a Multidimensional Index Structure (다차원 파일구조를 이용한 객체지향 데이터베이스의 중포속성 색인기법)

  • Lee, Jong-Hak
    • The Transactions of the Korea Information Processing Society
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    • v.7 no.8
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    • pp.2298-2309
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    • 2000
  • This paper proposes the multidimensioa! nested attribute indexing techniques (MD- NAI) in object-oriented databases using a multidimensional index structure. Since most conventional indexing techniques for object oriented databases use a one-dimensional index stnlcture such as the B-tree, they do not often handle complex qUlTies involving both nested attributes and class hierarchies. We extend a tunable two dimensional class hierachy indexing technique(2D-CHI) for nested attributes. The 2D-CHI is an indexing scheme that deals with the problem of clustering ohjects in a two dimensional domain space that consists of a kev attribute dOI11'lin and a class idmtifier domain for a simple attribute in a class hierachy. In our extended scheme, we construct indexes using multidimensional file organizations that include one class identifier domain per class hierarchy on a path expression that defines the indexed nested attribute. This scheme efficiently suppoI1s queries that involve search conditions on the nested attribute represcnted by an extcnded path expression. An extended path expression is a one in which a class hierarchy can be substituted by an indivisual class or a subclass hierarchy in the class hierarchy.

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The Normality of Meromorphic Functions with Multiple Zeros and Poles Concerning Sharing Values

  • WANG, YOU-MING
    • Kyungpook Mathematical Journal
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    • v.55 no.3
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    • pp.641-652
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    • 2015
  • In this paper we study the problem of normal families of meromorphic functions concerning shared values. Let F be a family of meromorphic functions in the plane domain $D{\subseteq}{\mathbb{C}}$ and n, k be two positive integers such that $n{\geq}k+1$, and let a, b be two finite complex constants such that $a{\neq}0$. Suppose that (1) $f+a(f^{(k)})^n$ and $g+a(g^{(k)})^n$ share b in D for every pair of functions f, $g{\in}F$; (2) All zeros of f have multiplicity at least k + 2 and all poles of f have multiplicity at least 2 for each $f{\in}F$ in D; (3) Zeros of $f^{(k)}(z)$ are not the b points of f(z) for each $f{\in}F$ in D. Then F is normal in D. And some examples are provided to show the result is sharp.

FINITE ELEMENT ANALYSIS FOR A MIXED LAGRANGIAN FORMULATION OF INCOMPRESSIBLE NAVIER-STOKES EQUATIONS

  • Kim, Hong-Chul
    • Journal of the Korean Mathematical Society
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    • v.34 no.1
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    • pp.87-118
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    • 1997
  • This paper is concerned with a mixed Lagrangian formulation of the wiscous, stationary, incompressible Navier-Stokes equations $$ (1.1) -\nu\Delta u + (u \cdot \nabla)u + \nabla_p = f in \Omega $$ and $$ (1.2) \nubla \cdot u = 0 in \Omega $$ along with inhomogeneous Dirichlet boundary conditions on a portion of the boundary $$ (1.3) u = ^{0 on \Gamma_0 _{g on \Gamma_g, $$ where $\Omega$ is a bounded open domain in $R^d, d = 2 or 3$, or with a boundary $\Gamma = \partial\Omega$, which is composed of two disjoint parts $\Gamma_0$ and $\Gamma_g$.

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Implementation of Co-Channel Radio Relay System and Its Performance Evaluation with Synchronous Digital Hierarchy (동기식 디지틀 계위의 동일채널 무선 전송장치구현 및 성능분석)

  • 서경환
    • Journal of the Korean Institute of Telematics and Electronics D
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    • v.35D no.11
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    • pp.10-22
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    • 1998
  • In this paper, as a way of improving the availability and spectral efficiency of radio relay system, a co-channel radio relay system based upon the synchronous digital hierarchy is developed and its performance measured by 64-QAM with a never-seen multi-purpose ASIC chip is illustrated. This system provides a couple of transmission capacity compared with alternative channel arrangement. By adopting a powerful complex 13-tap adaptive time domain equalizer and cross-pol interference canceller, improvement of more than 1.5 ~ 2.0 dB in signature is obtained in comparison to 9 or 11-tap adaptive time domain equalizer, and about 22.5 dB in improvement factor of cross-pol interference canceller is achieved at C/N of 24.5 dB. In addition, digital filter makes it possible to optimize the occupied bandwidth by selecting an appropriate roll-off factor externally. It is expected that co-channel radio relay system with the powerful multi-purpose ASIC chip plays a key role in creating a value-added product, reliability, and reducing the outage time.

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A Study on Blind Watermarking Technique of Digital Image using 2-Dimensional Empirical Mode Decomposition in Wavelet Domain (웨이블릿 평면에서의 2D-EMD를 이용한 디지털 영상의 블라인드 워터마킹 기술에 관한 연구)

  • Lee, Young-Seock;Kim, Jong-Weon
    • Journal of Internet Computing and Services
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    • v.11 no.2
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    • pp.99-107
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    • 2010
  • In this paper a blind watermarking algorithm for digital image is presented. The proposed method operates in wavelet domain. The watermark is decomposed into 2D-IMFs using BEMD which is the 2-dimensional extension of 1 dimensional empirical mode decomposition. The CDMA based on SS technique is applied to watermark embedding and detection process. In the watermark embedding process, each IMF of watermark is embedded into middle frequency subimages in wavelet domain, so subimages just include partial information about embedded watermark. By characteristics of BEMD, when the partial information of watermark is synthesized, the original watermark is reconstructed. The experimental results show that the proposed watermarking algorithm is imperceptible and moreover is robust against JPEG compression, common image processing distortions.