• 제목/요약/키워드: D. Coating

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Stability Improvement of Esomeprazole Magnesium Dihydrate Enteric-Coated Tablet by Adding Alkalizing Agents (에스오메프라졸 마그네슘 이수화물을 함유하는 장용성 제제의 안정성 개선)

  • Cho, Young Ho;Jeon, Hyo Bin;Lee, Jong-Hwa;Lee, Gye Won
    • KSBB Journal
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    • v.32 no.2
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    • pp.108-116
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    • 2017
  • Omeprazole, a benzimidazole derivative, suppresses gastric acid secretion by inhibiting $H^+/K^+$ ATPase in gastric parietals cells, and by reducing $H^+$ concentration. To improve stability of esomeprazole magnesium dihydrate (ESMD), enteric-coated preperation was composed of core tablet, subcoating and enteric coating layer. We were evaluated in vitro dissolution characteristics between test and reference ESMD preparation and stability. We could prepare enteric-coated formulation of ESMD by controlling disintegrating agent and coating ratio which could rapidly dissolved in neutral or alkali medium. The formulation D5 with crospovidone of 1.25% and coating ratio of 16.25% had a similar dissolution behavior compare to reference preparation. Difference factor ($f_1$) and similarity factor ($f_2$) were 0~15 and 50~100 and there was no significant difference in bioequivalence between formulations. The content and dissolution rate of formulation D5 were $96.54{\pm}0.21$ and $78.56{\pm}0.87%$ without change of color in accelerated condition ($40^{\circ}C$, RH 75%, high density polyethylene (HDPE) container) for 6 months. This study concluded that our enteric coated preparation of ESMD could be an useful method to improve stability of unstable drug without direct contact with coating material.

A Evaluation of Corrosion Resistance on the Thermal Sprayed Coating Tube and Cladded Tube of the Open Rack Vaporizer (용사코팅튜브와 클래드튜브 기화기에 대한 내식성 평가)

  • Baek Jong-Hyun;Lee Jae-Ho;Kim Yong-Seog;Shin Dong-Hyuck;Kim Woo-Sik
    • Journal of the Korean Institute of Gas
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    • v.2 no.4
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    • pp.67-72
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    • 1998
  • Due to excellent corrosion resistance, in particular against sea water, Al-2wt.$\%$Zn alloys have been used as the sacrifice anode material for tube of the ORV. Al-2wt.$\%$Zn alloys thermal-sprayed coating, however, were spalled on the lower part of ORV due to the lack of bonding strength between base material and coating layer and the dropping energy of sea water, To overcome the problems of the thermal spray coating, we developed the cladded tube manufacturing process by coextrusion of the clad and base metal. The corrosion resistance of cladded tube was improved by two times at least, compared with that of the present thermal spray coated vaporizer tubes.

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Ce:YAG remote phosphor coating for white LED with silica sol binder (Silica sol 바인더를 적용한 백색 LED용 Ce:YAG remote 형광체 코팅)

  • Gim, Su Jin;Park, Ha Na;Choi, Jae Ho;Jung, Yoon Sung;Kim, Hyeong-Jun
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.31 no.5
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    • pp.212-217
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    • 2021
  • The applicability of the white LED from the blue LED of the coating film as a binder for surface and curved coatings were confirmed. The particle size of YAG is D50: 9~10 ㎛, and the crystal structure is garnet (Y3Al5O12), cubic. The coating film had no cracks, at the same time, the silica sol was uniformly coated with YAG phosphor, and the YAG content and thickness in the coating film showed a tendency to increase up to 40 ㎛ in proportion to the increase in the amount added. Furthermore, as the YAG content increased, the PL emission intensity increased and the color coordinate shift toward the end of the chromatic locus curve was confirmed.

Microencapsulated Ascorbic Acid for Milk Fortification

  • Lee, J.B.;Ahn, J.;Kwak, H.S.
    • Archives of Pharmacal Research
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    • v.26 no.7
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    • pp.575-580
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    • 2003
  • The present study was designed to develop a microencapsulated L-ascorbic acid and iron that could be used to fortify milk and to determine the sensory properties of milk fortified with microencapuslation. Coating material was medium-chain triacylglycerol (MCT), and selected core material was ferric ammonium sulfate and L-ascorbic acid. The highest efficiency of microencapsulation was 95.0% in the ratio of 15:1 as coating to core material. Ascorbic acid release was increased sharply up to 5 d storage as 6.5%. TBA value was the lowest when both capsulated iron and ascorbic acid were added during 12 d storage, compared with other treatments. In sensory analysis, most aspects were not significantly different between control and capsulated ascorbic acid fortified milk at 5 d storage. The present study indicated that the use of microencapsulated ascorbic acid with MCT is effective for fortifying milk. In addition, these results suggest that acceptable milk products can be prepared with microencapsulated ascorbic acid and iron.

A Study on the Prevention of Print Mottle by Means of the Liquid Absorptivity Controlling in Coated Paper (도공지 흡수성 조절에 따른 인쇄 모틀 개선에 관한 연구)

  • Lee, Se-Hyun;Kim, Young-Sik;Yoo, Sung-Jong;Youn, Jong-Tae
    • Journal of the Korean Graphic Arts Communication Society
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    • v.22 no.2
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    • pp.139-150
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    • 2004
  • Development of the paper coating technologies to prevent print mottle is needed to obtain high quality printing. Printing mottle is recognized as the most common printing problems in using coated paper and which is one of the most difficult problems to solve in offset printing. Print mottle is one of the most important quality properties of printed products and manufacturers strive to improve the paper surface to gain higher and more even print mottle. The prevention of printed mottle requires of coating color formation, especially the minimum of binder migration. The results the uniformity of liquid absorption by paper at very short contact time between paper and testing printing liquids.

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Mechanical Properties & Ablation Mechanism of SiC Coated Carbon/Carbon Composite by Pack-cementation Method

  • Kim, J.I.;Oh, I.S.;Joo, H.J.
    • Carbon letters
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    • v.2 no.1
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    • pp.27-36
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    • 2001
  • The pack-cementation process is the method which is formed SiC coating layer to improve weak oxidation properties of CFRCs (carbon fiber-reinforced carbons). This method develops the anti-oxidation coating layer having no dimensional changes and good wetting properties. In this study to improve the oxidative resistance of the prepared 4D CFRCs, the surface of CFRCs is coated by SiC using pack cementation method. The mechanical properties of SiC-coated 4D CFRCs are measured by the 3-point bending test, and their ablation properties are investigated by the arc torch plasma test. From the results, it is found that both mechanical and ablation properties of SiC-coated 4D CFRCs are much better than bare CFRCs.

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Improvement of Oxidation Resistance and Erosion Resistance Properties of the C/C Composite with the Multilayer Coating (다층코팅을 이용한 C/C 복합재료의 내산화성 및 내마모성 증진)

  • 김옥희;이승윤;윤병일;박종욱
    • Journal of the Korean Ceramic Society
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    • v.32 no.9
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    • pp.1003-1008
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    • 1995
  • CVD-Si3N4/CVD-SiC/pack-SiC/pyro-carbon/(3-D C/C composite) multilayer coating was performed to improve the oxdiation resistance and erosion resistance properteis of the 3-D carbon/carbon composite, and the plasma test was performed to measure the oxidation resistance and erosion resistance properties. The thicknesses of each film layer were about 10${\mu}{\textrm}{m}$ for pack-SiC, 5${\mu}{\textrm}{m}$ for CVD-SiC and 40${\mu}{\textrm}{m}$ for CVD-Si3N4. When the multilayer coated specimen was exposed to the plasma flame with temperature of 500$0^{\circ}C$ for 20 seconds, it showed the weight loss five times less than that of the only pyro-carbon coated specimen.

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The Characteristics of c-BN Thin Films on High Speed Steel by Electron Assisted Hot Filament C.V.D Systems (EACVD법에 의한 고속도강에의 c-BN박막형성 및 특성에 관하여)

  • Lee, Gun-Young;Choe, Jean-Il
    • Journal of the Korean institute of surface engineering
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    • v.39 no.3
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    • pp.87-92
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    • 2006
  • The characteristic of interface layer and the effect of bias voltage on the microstructure of c-BN films were studied in the microwave plasma hot filament C.V.D process. c-BN films were deposited on a high speed steel(SKH-51) substrate by hot filament CVD technique assisted with a microwave plasma to develop a high performance of resistance coating tool. c-BN films were obtained at a gas pressure of 20 Torr, vias voltage of 300 V and substrate temperature of $800^{\circ}C$ in $B_2H_6-NH_3-H_2$ gas system. It was found that a thin layer of hexagonal boron nitride(h-BN) phase exists at the interface between c-BN layer and substrate.

Deposition of $(Ti,Cr)N-MoS_2$ Thin Films by D.C Magnetron Sputtering

  • Kim S.K.;Kim J.H.
    • Journal of the Korean institute of surface engineering
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    • v.39 no.2
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    • pp.70-75
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    • 2006
  • As technology advances, there is a demand for development of hard, solid lubricant coating. (Ti,Cr)N-$MoS_2$, films were deposited on SKD 11 tool steel substrate by co-deposition of $MoS_2$, with (Ti,Cr)N using a D.C. magnetron sputtering process. The influence of the $N_2/Ar$ gas ratio, the deposition temperature, the amount of $MoS_2$ in the films, and the bias voltage on the mechanical and the structural properties of the films were investigated. Wear tests were performed on the films deposited in various conditions.

Validation of Some Protection Guidelines for Neighboring Pipelines against Fault Currents from Power Transmission Tower

  • Lee, Seong-Min;Song, Hong-Seok;Kim, Young Geun
    • Corrosion Science and Technology
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    • v.6 no.2
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    • pp.77-81
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    • 2007
  • Fault current can be discharged from power transmission tower due to lightning or inadvertent contact of crane, etc. Pipelines in proximity to either the source of the ground fault or the substation grounding grid may provide convenient conductive path for the fault current to travel. Inappropriate measures to the neighboring pipelines against the fault current may cause severe damages to the pipes such as coating breakdown, arc burn, puncture, loss in wall thickness, or brittle heat-affected zone. Like inductive and conductive AC coupling, steadily induced fault current right after the coating breakdown can lead to corrosion of the pipeline. In this work, some protection guidelines against fault currents used in the field have been validated through the simulation and analytical method.