• Bulletin of the Korean Chemical Society
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• v.34 no.12
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• pp.3777-3781
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• 2013

A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid-cis-bis-lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.