• IMMUNE NETWORK
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• v.23 no.6
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• pp.46.1-46.16
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• 2023

Autoimmune hepatitis (AIH) affects all age group and occurs mainly in women. Pyroptosis is a novel programmed cell death featured with cell bursting and release of proinflammatory cytokines. A deeper understanding of AIH pathogenesis will contribute to novel therapy for AIH patients. Here, we aimed to investigate the role of IL-17 in immune-mediated liver injury. The levels of cytokines were measured by ELISA, and mRNA levels of STAT3 and IFN gamma-inducible protein 16 (IFI16) were detected by PCR. Expressions of STAT3, IFI16, gasdermin D and cleaved caspase-1 were measured by western-blotting. Immunohistochemical staining and transmission electron microscopy were applied to evaluate liver histopathological changes of the treated mice. Our results showed that the levels of IFI16 was increased in hepatocytes treated with IL-17 protein, and further elevated after STAT3-overexpressed (STAT3-OE) lentivirus treatment. The levels of IFI16 were reduced in hepatocytes treated with IL-17 neutralizing Ab (nAb), but were significantly increased after STAT3-OE treatment. Pyroptosis was observed in hepatocytes treated with IL-17 protein, and further cell damage was observed after STAT3-OE lentivirus treatment. Liver damage was alleviated in mice treated with IL-17 nAb, however sever damage was experienced after STAT3-OE lentivirus treatment. A binding interaction between IFI16 and STAT3 was detected in IL-17 treated hepatocytes. Glutathione transaminase activity was enhanced in concanavalin A-induced AIH mice compared to the control group (p<0.01). IL-17 plays an important role in activating STAT3 and up-regulating IFI16, which may promote the pyroptosis in AIH-related liver injury through STAT3-IFI16 axis.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.5
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• pp.1139-1144
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• 2012

The ration of payload to weight of industrial robot amounts form 1:10 to 1:30. Compared with man who have a ration of 3:1, it is very low. One of the goals for the next generation of robots will be a ration. This might be possible only by developing lightweight robots. When two-link flexible arm is rotated about an joint axis, transverse vibration may occur. In this paper, vibration dynamics of flexible arm is modeled by using Bernoulli-Euler beam theory and Lagrange equation. Using the fact that matrix $\dot{D}-2C$ is skew symmetric, new controllers which have a simplified structure with less computational burden is proposed by using Lyapunov stability theory. We propose deterministic and adaptive control laws for two link flexible arm, and the validity of the proposed control scheme is shown in computer simulation for two-link flexible arm.

• Bulletin of the Korean Space Science Society
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• 2003.10a
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• pp.63-63
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• 2003

There are many actuators and sensors used for attitude control system for KOMPSAT such as Reaction Wheel Assembly, Magnetic Torque Assembly, Dual Thruster Module, Solar array Drive, Three Axis Magnetometer, Conical Earth Sensor, Fine Sun Sensor Assembly, Coarse Sun Sensor Assembly, Gyro Reference Assembly and so on. For KOMPSA T satellite it has been considered using the Magnetic Torquer (MTQ) generating the magnetic dipole moment. In general, the magnetic dipole moment for satellite attitude control system is used for dumping out the excessive reaction wheel momentum so that the reaction wheel speed is not saturated. The objective of this study is to analyze the magnetic field characteristics generated by the Magnetic Torquer using the Maxwell 2D Field Simulator software. Currently, the developing model (DM) of the MTQ is being developed and manufactured at a company under the supervision of KARL MTQ is an electromagnet consisting of a ferromagnetic cylindrical core on which an excitation coil is wound. A current is passed through the coil to produce a dipole momentum in the ferromagnetic core. The configuration of the MTQ will be introduced in the presentation. The 2 dimensional model of the MTQ is drawn as axisymmetric models in RZ plane, and each corresponding material is assigned to the each MTQ object, the core, coil, and background. After the boundary conditions, current sources, and solution parameters are set up, the magnetic field intensities, directions, and other values specified by users can be calculated by using the finite element analysis. The theoretical magnetic field quantities obtained by the Maxwell 2D Simulator can be used for the basis of the development of the MTQ.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.1
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• pp.254-260
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• 2013

This paper deals with electromagnetic characteristics of IPMSM (Interior Permanent Magnet Synchronous motor) caused by field weakening current control. In order to extend operation speed, field weakening current control is generally used in IPMSM operation. During field weakening, distorted linkage fluxes are resulted by saturation of core material. Therefore, distorted input voltage waveform is required for sinusoidal current input. As the current vector angle increases for field weakening, distortion of linkage flux and back-emf becomes significant. This situation is analyzed by 2-dimensional finite element analysis and verified by experiment. With the results, it is concluded that motor parameters, such as linkage flux by permanent magnet, phase resistance, d-q axis inductance, are insufficient for estimating required voltage for given speed especially in field weakening and additional considerations for increased harmonics of voltage are required.

• Korean Journal of Remote Sensing
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• v.37 no.3
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• pp.567-575
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• 2021

In order to correct the provided RPC and DEM generated from the high-resolution satellite images, the acquisition of the ground control point (GCP) must be preceded. This task is a very complicate that requires field surveys, GPS surveying, and image coordinate reading corresponding to GCPs. In addition, since it is difficult to set up and measure a GCP in areas where access is difficult or impossible (tidal flats, polar regions, volcanic regions, etc.), an alternative method is needed. In this paper, we propose a 3D surface matching technique using only the established ground coordinate package, avoiding the ground-image-location survey of the GCP to correct the DEM produced from WorldView-2 satellite images and the provided RPCs. The location data of the public control points were obtained from the National Geographic Information Institute website, and the DEM was corrected by performing 3D surface matching with this package. The accuracy of 3-axis translation and rotation obtained by the matching was evaluated using pre-measured GPS checkpoints. As a result, it was possible to obtain results within 2 m in the plane location and 1 m in height.

• The Transactions of the Korean Institute of Power Electronics
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• v.11 no.5
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• pp.395-403
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• 2006

This paper has proposed a new dead time compensation method for a voltage-fed PMW inverter. In the voltage-fed PMW inverter, a voltage distortion is generated by the dead time effect and the nonlinear characteristics of the switching devices. Especially, the distorted voltage causes 5th and 7th harmonics in the stationary phase currents, and 6th harmonic in the synchronous phase currents. As a result, the integrator output of the synchronous PI current regulator has the ripple corresponding to six times of the inverter output frequency. In this paper, the signal of the integrator output of the d-axis current regulator is used as the control signal for the dead time compensation. The experimental and simulation results are presented to verify the validity of the proposed method.

• Journal of Advanced Marine Engineering and Technology
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• v.39 no.5
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• pp.570-576
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• 2015

3D visualization of navigation simulation is to visualize the environment conditions (e.g. nearby ships, dynamic characteristics, environment, terrain, etc) for any users on ships at sea. Realistic 3D visualization enables the users to be immersed to it and guarantees the reliability of the simulation. In particular, terrain visualization contains many virtual objects, so it is time and cost-intensive for object modelling. This paper proposes a 3D terrain visualization method that can be realized in a short time and with low cost by using the Unity 3D development tool. The 3D terrain visualization system requires bathymetric and elevation terrains, and Aids to Navigations (AtoNs) to be realized. It also needs to include 3D visualization objects including bridges, buildings and port facilities for more accurate simulation. Bathymetric and AtoN elements are acquired from ENC, and the elevation element is acquired from SRTM v4.1 digital elevation chart database developed by NASA. Then, the bathymetric and elevation terrains are generated, and the satellite images are superposed by using this terrain information. The longitudinal and latitudinal information of the AtoNs are converted to the 3-axis information to position the AtoN locations. The 3D objects such as bridges, buildings and port facilities are generated and the terrain visualization is completed. The proposed method realizes more realistic 3D terrain visualization of Busan Port.

• Journal of Electrical Engineering and Technology
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• v.13 no.6
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• pp.2530-2544
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• 2018

In this paper, we propose an enhanced LiDAR-camera calibration method that extracts the marker plane from 3D point cloud information. In previous work, we estimated the straight line of each board to obtain the vertex. However, the errors in the point information in relation to the z axis were not considered. These errors are caused by the effects of user selection on the board border. Because of the nature of LiDAR, the point information is separated in the horizontal direction, causing the approximated model of the straight line to be erroneous. In the proposed work, we obtain each vertex by estimating a rectangle from a plane rather than obtaining a point from each straight line in order to obtain a vertex more precisely than the previous study. The advantage of using planes is that it is easier to select the area, and the most point information on the board is available. We demonstrated through experiments that the proposed method could be used to obtain more accurate results compared to the performance of the previous method.

• Transactions of the Korean Society of Automotive Engineers
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• v.6 no.1
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• pp.163-181
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• 1998

In this study, the objective is determine the optimal design variable of engine mount system using the rubber mount of bush-type which is usually utilized in passive control to minimize vibrations of vehicle body or transmission from engine into body. The engine model adopted in this study is 4-cylinder, 4-stroke gasoline engine support- ed by 4-points. The system is modelled in 10 d.o.f.-rigid body motion of the engine & transmission in 6 d.o.f., elastic motion of vehicle body in 4 d.o.f.(1st torsional, 1st vertical and 1st & 2nd lateral bending vibration mode). To consider the elastic motion of vehicle body, find the eigenvalues and mode shapes of vehicle body by nodal testing and then determine the modal masses and stiffnesses of the body. The design variables of the engine mount system are locations, stiffness and damping coefficients of the rubber mounts(28 design variables). In case of considering the torque-roll axis for the engine, the design variables of the mount system are reduced to 22 design variables. The objective functions in optimal design process are considered by three cases, that is, 1) transmitted forces through engine mounts, 2) acceleration components of generalized coordinates for the vibration of vehicle body, 3) acceleration of specified location(where gear box) of body. three case are analyzed and compared with each other.

• Transactions of Materials Processing
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• v.17 no.1
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• pp.27-34
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• 2008

In order to manufacture a doubly curved sheet metal, the incremental roll forming process which adopts advantages such as the flexibility of the incremental forming process and continuous bending deformation of the roll forming process has been experimentally investigated. An experimental equipment was developed which was named as unit roll set (URS) consisting of two pairs of support rolls and an upper center roll. The upper roll equipped with the servo control unit is motor-driven and can be positioned in the vertical direction according to the user's commands. Four support rolls are idle, and they freely rotate only along the axis so as to transfer the plate more stably in the tangential direction of the rotation of the driving roll. In the process, the plate is deformed incrementally as deformation proceeds simultaneously in longitudinal and transverse directions. Through the experiments using URS, information regarding to forming schedules is found out to fabricate curved hull plates. This study demonstrates the further application of the incremental roll forming process in shipbuilding industries.