• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.413-413
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• 2020

Godunov형 모형을 이용한 홍수모델링에서는 일반적으로 구조적 사각격자나 비구조적 삼각격자가 주로 적용된다. 2차원 수치모형을 이용한 홍수모델링에서 연구유역의 정보가 격자의 노드나 중심에 입력되므로 적용격자의 유형과 생성방법에 따라 모형의 입력자료 오차에 영항을 줄 수 있다. 따라서, 연구유역이 지형 변동성이 심한 지역이거나 흐름형상이나 흐름변동이 심한 구간이라면, 고해상도 격자를 통해 모형의 입력자료 오차를 최소화할 할 수 있다. 본 연구에서는 2가지 유형에 대한 연구를 수행하였다, 첫 번째는 홍수해석을 위한 2차원 모형의 격자형상과 해상도에 따른 홍수위 및 홍수범람범위를 비교·분석하는 연구를 수행하였다. 연구유역은 2000년 10월 29일부터 11월 19일까지 홍수가 발생한 영국의 Severn 강 유역이다. 연구유역의 홍수 모델링을 위한 지형자료는 3m 해상도의 LiDAR(Light Detection And Ranging)를 이용하여 구축하였으며, 격자유형 및 해상도에 따른 2차원 홍수위 및 홍수범람범위를 비교·분석하기 위해서 홍수 발생기간 동안 촬영된 4개(2000년 8월 11, 14, 15, 17일)의 ASAR(Advanced Synthetic Aperture Radar) 영상자료를 활용하였다. 즉, ASAR 영상으로 촬용된 최대범람시기 및 홍수류의 배수기를 활용하여 최대범람범위뿐만 아니라 홍수가 증가하는 시기와 하류단 배수로 인해 홍수가 감소하는 시기를 모두 포함하는 홍수범람범위에 대한 격자유형별 2차원 홍수범람모형의 계산 결과에 대해 비교하였다. 두 번째는 아마존 강 중류유역의 2,500K㎡ 면적에 해당하는 대규모 유역에 대해 SRTM(Shuttle Radar Topography Mission) 지형자료를 이용하여 홍수기와 갈수기에 대해 2차원 모델링을 수행하고 그 결과를 위성자료와 비교하였다.

• Tuberculosis and Respiratory Diseases
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• v.81 no.4
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• pp.281-288
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• 2018

Background: There are limited number of studies that investigate clinical variables instead of chronic obstructive lung disease (COPD) management according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 classification. The aim of the study was to investigate whether there was a difference between GOLD 2017 classification and spirometric stage in clinical variables in patients with COPD. The data of 427 male patients with stable COPD were investigated retrospectively. Methods: Patients were allocated into combined assessment of GOLD 2017 and spirometric stage. Age, amount of smoking, pulmonary function, modified Medical Research Council (mMRC), incremental shuttle walk test (ISWT), Hospital Anxiety-Depression Scale (HADS), St. George's Respiratory Questionnaire (SGRQ), body mass index (BMI), and fat free mass index (FFMI) were recorded. Results: Seventy-three (17%) patients were in group A, 103 (24%) constituted group B, 38 (9%) were included in group C, and 213 (50%) comprised group D according to the combined assessment of GOLD 2017. Twenty-three patients (5%) were in stage 1, 95 (22%) were in stage 2, 149 (35%) were in stage 3, and 160 (38%) were in stage 4 according to spirometric stage. According to GOLD 2017, age, amount of smoking, mMRC, BMI, FFMI, SGRQ, HADS, forced vital capacity, forced expiratory volume in 1 second ($FEV_1$), and ISWT were significantly different between groups. Ages, amount of smoking, FFMI, BMI, HADS of group A were different from B and D. Smiliar values of $FEV_1$ were found in A-C and B-D. A and C had smiliar ISWT. According to spirometric stage, BMI, FFMI of stage 4 were statistically different. mMRC, ISWT, and SGRQ of stages 3 and 4 were different from other stages, amongst themselves. $FEV_1$ was correlated with mMRC, SGRQ, anxiety scores, BMI, FFMI, and ISWT. Conclusion: This study showed that the GOLD ABCD classification might not represent the severity of COPD sufficiently well in terms of lung function or exercise capacity. The combination of both spirometric stage and combined assessment of GOLD 2017 is important, especially for estimating clinical variables.

• Korean Journal of Biological Psychiatry
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• v.10 no.1
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• pp.62-69
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• 2003

Corticotropin-releasing factor(CRF) and neuropeptide Y(NPY) are known to play important roles in mediating stress responses and stress-related behavior. To elucidate the role of neuropeptides in response to the condition that had paired with traumatic event, we observed the changes of CRF and NPY by immunohistochemistry using a conditioned footshock paradigm. Male Sprague-Dawley rats were placed in a shuttle box and exposed to 20 pairings of a tone(< 70dB, 5sec) followed by a footshock(FS, 0.8mA, 1sec) over 60min. A second group was exposed to the tone-footshock pairings, returned to the homecage for 2days, and then reexposed to the test chamber and 20tones alone for 60min, prior to sacrifice. Control groups were : a) sacrificed without exposure to FS ; b) exposed to the tone-footshock pairings and then sacrificed two days later ; or c) exposed to the chamber and tones alone, returned to the homecage for 2days and then reexposed to the chamber and 20tones over 60min prior to sacrifice. CRF was increased in animals exposed to FS or the aversive condition(context and tone) that had paired to FS in bed nucleus of the stria terminalis (BNST) compared to the control. NPY was increased by FS in amygdala and PVN, but the condition previously associated with FS results in slight increase only in amygdala area. These results suggest that the BNST appears to be the mostly involved neural circuit in response to explicit cues previously paired with footshock. Moreover, this study raise the possibility that increased CRF peptide in the BNST in response to re-exposure to the aversive condition may underlie, in part, the experience of conditioned fear-related anxiety behavior.

• The Korean Journal of Food And Nutrition
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• v.15 no.2
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• pp.112-118
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• 2002

Sporulation in the fission yeast Schizosaccharomyces pombe has been regarded as an important model of cellular development and differentiation. S. pombe cells proliferate by mitosis and binary fission on growth medium. Deprivation of nutrients especially nitrogen sources, causes the cessation of mitosis and initiates sexual reproduction by matting between two sexually compatible cell types. Meiosis is then followed in a diploid cell in the absence of nitrogen source. DNA fragment complemented with the mutations of sporulation gene was isolated from the S. pombe gene library constructed in the vector, pDB 248' and designated as pDB(spo5)1. We futher analyzed six recombinant plasmids, pDB(spo5)2, pDB(spo5)3, pDB(spo5)4, pDB(spo5)5, pDB (spo5)6, pDB(spo5)7 and found each of these plasmids is able to rescue the spo5-2, spo5-3, spo5-4, spo5-5, spo5-6, spo5-7 mutations, respectively. Mapping of the integrated plasmid into the homologous site of the S. pombe chromosomes demonstrated that pDB(spo5)1, and pDB(spu5)Rl contained the spo5 gene. Transcripts of spo5 gene were analyzed by Northern hybridization. Two transcripts of 3.2 kb and 2.5kb were detected with 5kb Hind Ⅲ fragment containing a part of the spo5 gene as a probe. The small mRNA(2.5kb) appeared only when a wild-type strain was cultured in the absence of nitrogen source in which condition the large mRNA (3.2kb) was produced constitutively. Appearance of a 2.5kb spo5-mRNA depends upon the function of the meil, mei2 and mei3 genes.