• Animal Bioscience
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• 제35권3호
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• pp.461-474
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• 2022

Objective: This experiment investigated the effects of supplementing vitamin D₃-fortified sow and progeny diets with 25(OH)D₃ on growth performance, carcass characteristics, immunity, and pork meat quality. Methods: The present study involved the assessment of supplementing the diet of sows and their progeny with or without 25 (OH)D₃ in a 2×2 factorial arrangement on the performance and production characteristics of wean-finish pigs. Forty-eight multiparous sows were assigned to a basal diet containing 2000 IU/kg vitamin D₃ and supplemented without (CON) or with (TRT) 50 ㎍/kg 25 (OH)D₃. At weaning, a total of 80 pigs each from CON and TRT sows were allocated to weaning and growing-finishing basal diets fortified with 2,500 and 1,750 IU/kg vitamin D₃ respectively and supplemented without or with 50 ㎍/kg 25(OH)D₃. Results: Sows fed 25(OH)D₃-supplemented diets improved pre-weaning growth rate of nursing piglets. A significant sow and pig weaning diet effect was observed for growth rate and feed efficiency (p<0.05) during days 1 to 42 post-weaning. Pigs consuming 25(OH)D₃-supplemented diets gained weight faster (p = 0.016), ate more (p = 0.044) and tended to convert feed to gain more efficiently (p = 0.088) than those fed CON diet between days 98 and 140 post-weaning. Supplemental 25(OH)D₃ improved water holding capacity and reduced drip loss of pork meat, increased serum 25(OH)D₃ level, produced higher interleukin-1 and lower interleukin-6 concentrations in blood circulation, downregulated myostatin (MSTN) and upregulated myogenic differentiation (MYOD) and myogenic factor 5 (MYF5) gene expressions (p<0.05). Conclusion: Supplementing vitamin D₃-fortified sow and wean-finish pig diets with 50 ㎍/kg 25(OH)D₃ significantly improved production performance suggesting their current dietary vitamin D₃ levels are insufficient. In fulfilling the total need for vitamin D, it is strongly recommended to add 50 ㎍/kg 25(OH)D₃ "on top" to practical vitamin D₃-fortified sow and wean-finish pig diets deployed under commercial conditions.

• 대한공간정보학회지
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• 제15권4호
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• pp.3-9
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• 2007

최근 인간의 활동에 의해 나타나는 인문 활동의 중요한 요소로써 지리현상을 체계적으로 이해하고 활용하고자하는 노력이 증가하고 있다. 이를 위해 지형을 공간과 연계하여 표현할 필요성이 있으며, 특히 수치표고모형을 활용한 지형분석의 기술은 지형에 대한 정밀한 수치표고모형을 생성하여 고품질의 3차원 지형정보가 필요한 분야에서 신속하고 정확하게 지표면에 대한 표고 및 경사도에 대한 정보의 제공이 가능하게 되었다. 본 연구에서는 라이다측량 데이터를 활용해 대상지역에 대한 좀 더 정밀한 수치표고모형을 만들어 기존의 축척 1:1000인 수치지형도와의 비교를 통한 정량적 분석을 실시하였다. 라이다 데이터에 의해 생성된 수치표고모형 자료를 이용하여 지형경사도를 분석한 결과 대상지역 및 주변의 경사도를 비교적 상세하게 표현할 수 있었으며, 표고 해석 결과도 라이다 데이터를 활용한 분석이 수치지형도를 이용한 분석보다 대상지역 및 주변의 표고를 비교적 상세하게 표현할 수 있었다.

• 대한불안의학회지
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• 제17권2호
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• pp.59-66
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• 2021

Objective : The purpose of this study is to investigate the relationship among the degree of symptoms of posttraumatic stress disorder (PTSD) and social support, stress coping strategies, and self-esteem in patients with PTSD. Methods : A total of 48 patients meeting DSM-5 criteria for PTSD and 48 normal controls were recruited for participation in this study. We evaluated subjects using the Clinician-Administered PTSD Scale (CAPS), Hamilton Anxiety Scale (HAM-A), Hamilton Depression Scale (HAM-D), Rosenberg Self-Esteem Scale (RSES), Multidimensional Scale of Perceived Social Support (MSPSS) and The Ways of Stress Coping Questionnaire (SCQ). We analyzed data using an independent t-test and Pearson's correlation analysis. Results : In PTSD patients, total CAPS scores showed a significant positive correlation with HAM-A and HAM-D scores and a significant negative correlation with MSPSS scores. RSES scores showed a significant positive correlation with MSPSS and SCQ scores. MSPSS scores showed a significant negative correlation with PTSD avoidance and numbing and HAM-D scores. SCQ scores showed a significant negative correlation with PTSD avoidance and numbing. Conclusion : These results revealed that the better the stress coping strategies and social support, the lower the degree of symptoms in patients with PTSD. In addition, it was found that the higher the social support and self-esteem, the lower the degree of depression and anxiety. Therefore, in the treatment process, it seems important to identify and correct the self-esteem, social support system, and stress coping strategies of patients with PTSD.

• Journal of Microbiology and Biotechnology
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• 제31권7호
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• pp.949-955
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• 2021

Previously, our research group isolated Bifidobacterium breve IDCC4401 from infant feces as a potential probiotic. For this study, we evaluated the safety of B. breve IDCC4401 using genomic and phenotypic analyses. Whole genome sequencing was performed to identify genomic characteristics and investigate the potential presence of genes encoding virulence, antibiotic resistance, and mobile genetic elements. Phenotypic analyses including antibiotic susceptibility, enzyme activity, production of biogenic amines (BAs), and proportion of D-/L-lactate were evaluated using E-test, API ZYM test, high-performance liquid chromatography (HPLC), and D-/L-lactic acid assay respectively. The genome of B. breve IDCC4401 consists of 2,426,499 bp with a GC content of 58.70% and 2,016 coding regions. Confirmation of the genome as B. breve was provided by its 98.93% similarity with B. breve DSM20213. Furthermore, B. breve IDCC4401 genes encoding virulence and antibiotic resistance were not identified. Although B. breve IDCC4401 showed antibiotic resistance against vancomycin, we confirmed that this was an intrinsic feature since the antibiotic resistance gene was not present. B. breve IDCC4401 showed leucine arylamidase, cystine arylamidase, α-galactosidase, β-galactosidase, and α-glucosidase activities, whereas it did not show production of harmful enzymes such as β-glucosidase and β-glucuronidase. In addition, B. breve IDCC4401 did not produce any tyramine, histamine, putrescine, cadaverine, or 2-phenethylamine, which are frequently detected BAs during fermentation. B. breve IDCC4401 produced 95.08% of L-lactate and 4.92% of D-lactate. Therefore, our findings demonstrate the safety of B. breve IDCC 4401 as a potential probiotic for use in the food industry.

• 한국측량학회:학술대회논문집
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• 한국측량학회 2004년도 춘계학술발표회논문집
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• pp.15-26
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• 2004

The calibration for systematic error in LiDAR is crucial for the accuracy of airborne laser scanning. The main error is the misalignment of platforms between INS(Inertial Navigation System) and Laser scanner For planimetrical calibration of LiDAR, the building is good feature which has great changes in height and continuous flat area in the top. The planimetry error(pitch, roll) is corrected by adjustment of height which is calculated from comparing ground control points(GCP) of building to laser scanning data. We can know scale correction of laser range by the comparison of LiDAR data and GCP is arranged at the end of scan angle where maximize the height error. The area for scale calibration have to be large flat and have almost same elevation. At 1000m for average flying height, The Accuracy of laser scanning data using LiDAR is within 110cm in height and ${\pm}$50cm in planmetry so we can use laser scanning data for generating 3D terrain surface, expecically digital surface model(DSM) which is difficult to measure by aerial photogrammetry in forest, coast, urban area of high buildings

• 한국정보통신학회논문지
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• 제10권1호
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• pp.104-110
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• 2006

고정도, 저주파용 데이터 변환기로 사용되어온 델타-시그마 변환기는 그 출력 단에 1 bit 혹은 multi-bit 양자화기(ADC)를 사용할 수 있다. 이 중 multi-bit 양자화기를 사용하는 경우 궤환회로에도 multi-bit DAC을 사용하여야 하며 시스템의 데이터 변환 정확도는 DAC의 비선형성에 직접적인 영향을 받는다. 이 영향을 최소화하여 델타-시그마 변환기의 변환 정확도를 높이기 위해서는 DAC에 사용되는 단위 데이터 변환소자 간의 오차가 시스템에 미치는 영향을 최소화 하여야한다. 이 과정 즉 Dynamic Element Matching을 위하여 제안된 4가지 방안(DER, CLA, ILA, DWA)을 비교 설명하였다. 그리고 각 방안을 사용하였을 때 시스템 출력의 잡음 특성을 비교 하였다. 이중 DWA(Data Weighted Averaging) 방안이 가장 우수한 출력 특성을 보였다.

• Genomics & Informatics
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• 제14권4호
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• pp.241-254
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• 2016

Environmental microbes like Bordetella petrii has been established as a causative agent for various infectious diseases in human. Again, development of drug resistance in B. petrii challenged to combat against the infection. Identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. In this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of B. petrii DSM 12804 (accession No. PRJNA28135) from genome database of National Centre for Biotechnology information. In this regards, the inhibitory effect of nine natural compounds like ajoene (Allium sativum), allicin (A. sativum), cinnamaldehyde (Cinnamomum cassia), curcumin (Curcuma longa), gallotannin (active component of green tea and red wine), isoorientin (Anthopterus wardii), isovitexin (A. wardii), neral (Melissa officinalis), and vitexin (A. wardii) have been acknowledged with anti-bacterial properties and hence tested against identified drug target of B. petrii by implicating computational approach. The in silico studies revealed the hypothesis that lpxD could be a potential drug target and with recommendation of a strong inhibitory effect of selected natural compounds against infection caused due to B. petrii, would be further validated through in vitro experiments.

• 생물정신의학
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• 제23권2호
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• pp.48-56
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• 2016

Alzheimer's disease (AD) is a neurodegenerative disorder in which neuronal loss causes cognitive decline and other neuropsychiatric problems. It can be diagnosed based on history, examination, and appropriate objective assessments, using standard criteria such as the Diagnostic and Statistical Manual of Mental Disorders or the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Brain imaging and biomarkers are making progress in the differential diagnoses among the different disorders. The cholinesterase inhibitors, donepezil, rivastigmine and galantamine and N-methyl-D-aspartate receptors antagonist memantine are approved by the US Food and Drug Administration for AD. Recently some acetylcholinesterase inhibitors gained approval for the treatment of severe AD and became available in a higher dose formulation or a patch formulation. Optimal care in AD is multifactorial and it should include early diagnosis and multidisciplinary care with pharmacological and nonpharmacological interventions including exercise interventions, cognitive interventions and maintenance of social networks.

• 생물정신의학
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• 제14권1호
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• pp.14-20
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• 2007

Objectives : The diagnosis of depression is based on a highly variable set of symptoms. Therefore, depression should not be viewed as a single disease, but a heterogenous syndrome comprised of different pathophysiologies. There are several subtypes of depression which were already incorporated in DSM-IV. This article provides a systematic review of pharmacological treatments of two recognized subtypes of depression-dysthymic disorder and atypical depression. Methods : Systematic search of relevant literatures on dysthymic disorder and atypical depression was performed by proposed search strategy of the Clinical Research Center for Depression of Korean Health 21 R&D Project. All identified literatures were carefully reviewed and classified according to SIGN grading system and summarized in a narrative manner. Results : For the treatment of dysthymic disorder and atypical depression, selective serotonin reuptake inhibitors( SSRIs) and moclobemide have more evidence than the other antidepressants. SSRIs and moclobemide showed superior tolerability than tricyclic antidepressants. Conclusions : The authors proposed treatment recommendations for dysthymic disorder and atypical depression by the methods of evidence-based medicine(EBM). However, guideline developing methods of EBM also have several inevitable limitations. Therefore, in the absence of clear and significant differences in efficacy, the choice of medication must be individualized for a particular patient based on psychiatrist's own clinical decision.

• 환경영향평가
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• 제22권1호
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• pp.99-107
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• 2013

This study is an impact assessment of building blocks on urban inundation depth and area. LiDAR data is used to generate two original data set in terms of DEM with $5{\times}5$ meter and building block elevation layer of the study drainage area in Cheongju and then the building block elevation layer is modified again to the mesh data with same size to DEM. Two-dimensional inundation analysis is carried out by applying 2D SWMM model. The inundation depth calculated by using the building block elevation layer shows higher reliability than the DEM. This is resulted from the building block interference to surface flow. In addition, the maximum flooded area by DEM is two times wider than the area by building block layer. In the case of the surface velocity, the difference of velocity is negligible in either DEM or building block case in the low building impact zone. However, If the impact of building on the surface velocity was increase, the gap of velocity was significant.