• Toxicological Research
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• v.13 no.3
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• pp.303-306
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• 1997

Antigenic potential of genetically engineered human granulocyte colony-stimulating factor (CJ-50001) was assessed in guinea pigs and mice. In active systemic anaphylaxis (ASA) test, although CJ-50001 at 50 $\mu\textrm{g}$ /head induced anaphylactic responses, CJ-50001 5 $\mu\textrm{g}$ /head alone or 50 $\mu\textrm{g}$ / head with adjuvant did not induce anaphylactic responses. In passive systemic anaphylaxis test (PCA) or passive hemagglutination test (PHA), CJ-50001 did not induce positive responses. It is concluded that, in light of the fact that CJ-50001 was antigenic only in ASA but not in PCA or PHA and also that CJ-50001 is a foreign human recombinant protein to guinea pigs, CJ-50001 may not induce systemic allergic react-ion in its clinical use in human.

• Journal of the Korea Fashion and Costume Design Association
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• v.21 no.4
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• pp.165-179
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• 2019

This study used 3D body scan data to classify body shapes according to the torso shape of adult males aged 20-75 years. This data will be provided so that the apparel industry can make apparel products corresponding to body characteristics by age. The study used 1,796 adult males between the ages of 20 and 75 and the 3D body shape data of the '5th Research on National Standard Anthropometry'. For data analysis, the program SPSSWIN Ver. 17.0 was used to calculate the mean and frequency allowing for a factor analysis, cluster analysis, analysis of variance, and Duncan test. To classify body shape according to the torso shape of adult males, this study considered nine factors: 'horizontal size of torso,' 'vertical size of body,' 'curve of torso and waist-abdomen flatness ratio,' 'length of torso,' 'shape of neck area,' 'degree of lateral curve,' 'difference between front and back interscye length,' 'shoulder armscye shape,' and 'chest flatness ratio.' Based on the results of the factor analysis, the torso shapes of adult males were classified into five types. Type 1 is "upright body with flat, curvy shape", Type 2 is "curve sway back body type", Type 3 is "flat, abdominally obese body", Type 4 is "obese, crooked body" and Type 5 is "thick sway front body type." named.

• Archives of Pharmacal Research
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• v.21 no.1
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• pp.12-16
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• 1998

The inhibitory effect of 10 lignan constituents isolated from the rhizomes of Coptis japonica var. dissects on tumor necrosis factor (TNF)-${\alpha}$ production in lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW264.7 cells) has been studied. Among them, pinoresinol, woorenoside-V and lariciresinol glycoside showed significant inhibitory activities in the range from 37% to 55% at the concentration of $25{\mu}g/ml.$ The results are first report that the lignans isolated from Coptis japonica inhibit TNF- ${\alpha}$${\alpha}$

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.407-416
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• 2003

In this study, we evaluate the correlation between in vitro and in vivo determination of SPF of sunscreen products containing various ingredients depending on emulsification system. For in vitro approach, we determined SPF by the method of Diffey and Robson using an TransporeTM tape(3M Health care, USA) and SPF 290-analyzer(Optometrics Co. USA). SPF values and standard deviations are calculated and displayed after completion of the run. In vivo SPF values are determined according to KFDA (the Korea Food and Drug Administration) method in panels of Fitzpatrick's skin type II or III. We investigated the difference in SPF data of sunscreen ingredient according to emulsification system. The in vivo SPF data is high in water-in oil(W/O) emulsion than in oil-in water(O/W) emulsion samples. The difference may be due to the particular behavior in each vehicles and its presence on skin surface may produce a different sunscreen film. We obtained the corrlation coefficient between in vitro and in vivo SPF data for O/W (R-squre=0.72 )and W/O emulsion(R-squre=0.77). From these results, we suggest the improvement of methodology using Transpore$^{TM}$ tape as substrate to increase the predictability of in vitro method.d.

• Journal of Sensor Science and Technology
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• v.20 no.2
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• pp.71-76
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• 2011

To characterize the relationship between the stage of hepatic fibrosis and bioimpedance, several electric parameters were estimated in rats with $CCl_4$-induced liver fibrosis. Thirty three Sprague-Dawley rats were intraperitoneally injected with a $CCl_4$-mineral oil mixture (1:1, 0.2 mL/100 g) twice a week for 8 weeks. The resistance(R), reactance(X), impedance(Z), and dissipation factor(D) between 1 kHz and 100 kHz were then evaluated in the livers of the rats under pentobarbital anesthesia using an HP4294A Impedance Analyzer. The rats were killed 2, 4, 6, and 8 weeks later, and their livers were classified in accordance with Ishak's scoring system. R, X, and Z changed in accordance with the progression of hepatic fibrosis and the changes were greater at lower frequencies than at higher frequencies. In comparison, the D spectrum was biphasic; D increased initially then decreased with increasing frequency. All of the parameters(R, X, Z, and D) changed in accordance with the stage of fibrosis in the livers, but D changed specifically with the progression of fibrosis. These results indicate that hepatic fibrosis may be evaluated by determining the changes in D.

• Membrane and Water Treatment
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• v.10 no.2
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• pp.127-137
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• 2019

The D2EHPA/TBP co-extractants immobilized PolyHIPE membrane can be used for the selective separation of Mn (II) from Co (II). By solvent-nonsolvent method, D2EHPA/TBP co-extractants can be effectively immobilized into PolyHIPE membrane. The pore structure of PolyHIPE membrane and the presence of TBP enhance the stability of immobilized co-extractants. The optimal operating conditions for the separation of Mn (II) and Co (II) are feeding phase at pH 5.5, sulfuric acid concentration in the stripping phase of about 50 g/L and stirring speed at 400 rpm. The D2EHPA/TBP co-extractants ratio of 5:1 shows synergetic effect on Mn/Co separation factor about 22.74. The removal rate and recovery rate of Mn (II) is about 98.4 and 97.1%, respectively, while for Co (II) the transport efficiency is insignificant. The kinetic study of Mn (II) transport shows that high initial flux, $J_f^o=80.1({\mu}mol/m^2s)$, and maxima stripping flux, $J_s^{max}=20.8({\mu}mol/m^2s)$, can be achieved with D2EHPA/TBP co-extractants immobilized PolyHIPE membrane. The stability and reusability study shows that the membrane can maintain a long term performance with high efficiency. High purity of Co (II) and Mn (II) can be recovered from the feeding phase and stripping phase, respectively.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.3
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• pp.283-291
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• 2015

In this paper, the two-dimensional(2D) and three-dimensional(3D) analyses have been performed in order to evaluate the structural integrities and compare 2D and 3D results for nozzles attached to cylindrical shells. Three nozzles, which are currently used in the nuclear power plant, are chosen to evaluate the structural integrities, and each nozzle is subjected to internal pressure, temperature variation and external loads. It is found that the 2D analysis for internal pressure should be performed with a factor of more than 1.5 or a stress concentration factor; 2D and 3D analysis results for temperature variation are almost similar to each other regardless of cladding; and the analysis results for external loads by WRC Bulletin 297 are more conservative than the 3D analysis results.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.3
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• pp.475-485
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• 2017

This paper develops a conversion function and method transforming from daily peak load curve used $LOLE_D$ [days/year] to hourly load curve used $LOLE_H$[hours/year]and describes relationship between $LOLE_D$ [days/year] and $LOLE_H$ [hours/year]. The indices can not only be transformed just arithmetically but also have different characteristics physically because of using their different load curves. The conversion function is formulated as variables of capacity and forced outage rate of generator, hourly load daily load factor and daily peak load yearly load factor, etc. Therefore, the conversion function (${\gamma}={\varphi}$(.)) can not be simple. In this study, therefore, the function is formulated as linear times of separated two functions. One is an exponential formed conversion function of daily load factor. Another is formulated with an exponential typed conversion function of daily peak load yearly load factor. Futhermore, this paper presents algorithm and flow chart for transforming from $LOLE_D$[days/year] to $LOLE_H$[hours/year]. The proposed conversion function is applied to sample system and actual KPS(Korea Power System) in 2015. The exponent coefficients of the conversion functions are assessed using proposed method. Finally, assessment errors using conversion function for case studies of sample system and actual system are evaluated to certify the firstly proposed method.

• Food Science of Animal Resources
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• v.44 no.1
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• pp.204-215
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• 2024

This study was designed to examine the effect of Lactilactobacillus curvatus LB-P9 on hair regeneration. The treatment of LB-P9 conditioned medium increased the proliferation of both hair follicle dermal papilla cells and hair germinal matrix cells (hGMCs). Moreover, the expression levels of hair growth factors such as vascular endothelial growth factor (VEGF) and fibroblast growth factor 7 were significantly elevated in hGMCs co-cultured with LB-P9. After time-synchronized depilation, mice were orally administered with either 4×10⁷ colony forming unit (CFU) of LB-P9 (low dose) or 4×10⁸ CFU of LB-P9 (high dose), once daily for 4 weeks. Compared with the vehicle (phosphate-buffered saline)-administrated group, the LB-P9-treated groups exhibited accelerated hair regrowth rate and enhanced hair thickness in a dose-dependent manner. Supporting this observation, both hair follicle numbers and the dermal thickness in skin tissues of the LB-P9-treated groups were increased, compared to those of the vehicle-treated group. These results might be explained by the increased level of β-catenin and number of hair follicle stem cells (CD34⁺ CD49f⁺ cells) in the skin tissues of mice administered with LB-P9, compared to the vehicle-treated mice. Also, increased serum levels of hair growth factors such as VEGF and insulin-like growth factor-1, and superoxide dismutase were found in the LB-P9-treated groups, compared to those of the vehicle-treated group. Taken together, these results might demonstrate that the oral administration of LB-P9 promotes hair regeneration by the enhancement of dermal papilla proliferation through the stimulation of hair growth factor production.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.11
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• pp.89-94
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• 2008

In this paper, a cascade of a wideband amplifier and a high-Q bandpass filter (BPF) has been realized in a 0.18mm CMOS technology for the applications of subsampling direct-conversion receivers. The wideband amplifier is designed to obtain the -3dB bandwidth of 5.4GHz, and the high-Q BPF is designed to select a 2.4GHz RF signal for the Bluetooth specifications. The measured results demonstrate 18.8dB power gain at 2.34GHz with 31MHz bandwidth, corresponding to the quality factor of 75. Also, it shows the noise figure (NF) of 8.6dB, and the broadband input matching (S11) of less than -12dB within the bandwidth. The whole chip dissipates 64.8mW from a single 1.8V supply and occupies the area of $1.0{\times}1.0mm2$.