• 한국항공운항학회지
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• 제27권2호
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• pp.26-36
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• 2019

Although the investment size of R&D in Aviation and Aerospace Industries is increasing, R&D performance has not been quite good considering resources invested in it. This study is to find which R&D critical factors affect R&D Performance in aviation and aerospace industries. According to the result of research, a technology provider factor, an organization factor, a system factor and a market environment factor influence positively on financial performance, and a policy factor influences negatively on financial performance. Otherwise, a technology provider factor and an organization factor influence positively on non financial performance, and technology factor influences negatively on non financial performance. Thus, personnel involved in R&D of Aviation and Aerospace Industries should develop policy and system taking positive and negative factors to improve R&D performance. It could lead to take the better performance from R&D in Aviation and Aerospace Industires.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2008년도 춘계 학술발표회 초청강연 및 논문집
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• pp.784-791
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• 2008

In this study, we recognized about application of the load distribution factor for design of tunnel in 3D numerical analysis. Generally, load distribution factor of tunnel is applied to describe 3D arching effect that can not describe when 2D numerical analysis. Through result of 3D numerical analysis, we used to apply in numerical analysis for the load distribution factor that ratio of finally displacement to displacement of construction step. But 3D numerical analysis need to apply to load distribution factor for convenience of numerical analysis. Therefore, we proposed load distribution factor that reduce time and coast. It corrected variable of advanced length in load distribution factor of 3D numerical analysis.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2006년도 학술대회 2부
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• pp.156-162
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• 2006

It was hypothesized that mobile 3D provide the sense of presence in different quantity and quality aspects in virtual reality. And it was supposed that the construction of presence involves various levels and dimensions. The factors of mobile 3D game are divided into 4 super-factors; condition factor, interface factor, attention factor, feedback factor that resulted into 20 sub-factors resulted from the factor analysis. Our primary goal is the development of valid Mobile 3D presence scale, and to find out the factor structure of the scale.

• Animal cells and systems
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• 제2권1호
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• pp.117-122
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• 1998

D-raf, a Drosophila homolog of the human c-raf-1, is known as a signal transducer in cell proliferation and differentiation. A previous study found that the D-raf gene expression is regulated by the DNA replication-related element (DRE)/DRE-binding factor (DREF) system. In this study, we found the sequences homologous to transcription factor C/EBP, MyoD, STAT and Myc recognition sites in the D-raf promoter. We have generated various base substitutional mutations in these recognition sites and subsequently examined their effects on D-raf promoter activity through transient CAT assays in Kc cells with reporter plasmids p5'-878DrafCAT carrying the mutations in these binding sites. Through gel mobility shift assay using nuclear extracts of Kc cells, we detected factors binding to these recognition sites. Our results show that transcription factor C/EBP, STAT and Myc binding sites in D-raf promoter region play a positive role in transcriptional regulation of the D-raf gene and the Myo D binding site plays a negative role.

• Journal of Microbiology and Biotechnology
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• 제28권10호
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• pp.1589-1603
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• 2018

Twenty analogs of $[Orn^6,D-Ala^9]{\alpha}-factor$ were synthesized and assayed for their biological activities: seven analogs of $[Orn^6,X^9]{\alpha}-factor$, seven analogs of $[X^6,D-Ala^9]{\alpha}-factor$, five analogs of $[X^5,X^6,D-Ala^9]{\alpha}-factor$, and native ${\alpha}-factor$ (X = amino acids). Their biological activities (halo, gene induction, and affinity) were measured using S. cerevisiae Y7925 and LM102 and compared with those of native ${\alpha}-factor$ (100%). G protein-coupled receptor was expressed in strain LM102 containing pESC-LEU-STE2 vector. $[Dap^6,D-Ala^9]{\alpha}-factor$ with weak halo activity (10%) showed the highest receptor affinity (> 230%) and the highest gene induction activity (167%). $[Arg^6,D-Ala^9]{\alpha}-factor$ showed the highest halo activity (2,000%). The number of active binding sites per cell (about 20,000 for strain LM102) was determined using a newly-designed fluorescence-based detector, $[Arg^6,D-Ala^9]{\alpha}-factor-Edan$, with high sensitivity (12,500-fold higher than the absorption-based detector $[Orn^6]{\alpha}-factor-[Cys]_3$).

• Reproductive and Developmental Biology
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• 제36권1호
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• pp.13-19
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• 2012

In order to provide the basis for developing practical mouse embryonic stem cells (mESCs) culture method, how the endogenous level of self-renewal-stimulating factor genes was altered in the mESCs by different extracellular signaling was investigated in this study. For different extracellular signaling, mESCs were cultured in 2 dimension (D), 3D and integrin-stimulating 3D culture system in the presence or absence of leukemia inhibitory factor (LIF) and transcriptional level of $Lif$, $Bmp4$ and $Wnt3a$ was evaluated in the mESCs cultured in each system. The expression of three genes was significantly increased in 3D system relative to 2D system under LIF-containing condition, while only $Wnt3a$ expression was increased by 3D culture under LIF-free condition. Stimulation of integrin signaling in mESCs within 3D system with exogenous LIF significantly up-regulated transcriptional level of $Bmp4$, but did not induce transcriptional regulation of $Lif$ and $Wnt3a$. In the absence of LIF inside 3D system, the expression of $Lif$ and $Bmp4$ was significantly increased by integrin signaling, while it significantly decreased $Wnt3a$ expression. Finally, the signal from exogenous LIF significantly caused increased expression of $Lif$ in 2D system, decreased expression of $Bmp4$ in both 2D and 3D system, and decreased expression of $Wnt3a$ in integrin-stimulating 3D system. From these results, we identified that endogenous expression level of self-renewal-stimulating factor genes in mESCs could be effectively regulated through artificial and proper manipulation of extracellular signaling. Moreover, synthetic 3D niche stimulating endogenous secretion of self-renewal-stimulating factors will be able to help develop growth factor-free maintenance system of mESCs.

• 한국방사선학회논문지
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• 제16권2호
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• pp.115-122
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• 2022

본 연구는 후각망울(Olfactory Bulb) 검사 시 SPACE 3D T2 기법의 Turbo Factor 값을 변화하여 검사 한 후 2D TSE T2와 비교하여 진단능과 화질의 변화를 알아보고자 한다. 연구 결과 정성적, 정량적 분석 결과 SPACE 3D T2 기법이 2D TSE T2 기법과 비교 시 통계적으로 유의한 차이가 있음을 알 수 있었으며, 결론적으로 Turbo Factor값을 적절하게 변화 시킨 SPACE 3D T2 기법은 검사시간을 단축시키면서 2D TSE T2기법과 비교하여 화질이 증가 된 영상을 획득할 수 있으므로 임상적으로 충분한 진단적 가치가 있다고 사료된다.

• 디지털산업정보학회논문지
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• 제14권2호
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• pp.35-47
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• 2018

The 4th industrial revolution, digital image technology has developed beyond the limit of multimedia industry to advanced IT fusion and composite industry. Particularly, application technology related to HCI element algorithm in 3D image object recognition field is actively developed. 3D image object recognition technology evolved into intelligent image sensing and recognition technology through 3D modeling. In particular, image recognition technology has been actively studied in image processing using object recognition recognition processing, face recognition, object recognition, and 3D object recognition. In this paper, we propose a research method of human factor 3D image recognition technology applying human factor algorithm for 3D object recognition. 1. Methods of 3D object recognition using 3D modeling, image system analysis, design and human cognitive technology analysis 2. We propose a 3D object recognition parameter estimation method using FACS algorithm and optimal object recognition measurement method. In this paper, we propose a method to effectively evaluate psychological research techniques using 3D image objects. We studied the 3D 3D recognition and applied the result to the object recognition element to extract and study the characteristic points of the recognition technology.

• 대한기계학회논문집B
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• 제23권6호
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• pp.761-768
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• 1999

This paper is studied to find the optimum condition of double-inlet Sirocco fan installed in an indoor PAC for low noise operation by the Taguchi method. The goal of this study is to obtain the best combination of each control factor which results in a desired flowrate of Sirocco fan with minimum variability. In this study, the parameter design of the Taguchi method is adopted for robust design by the dynamic characteristic analysis using orthogonal arrays and S/N ratios. The flowrate measurements are conducted by using a multiple-nozzle-type fan tester according to the orthogonal array L9($3^4$). The results of this study can be summarized as follows ; (i) The optimum condition of control factor is a set of where A is an inner to outer diameter ratio($D_1/D_2$), B is a width to outer diameter ratio($L/D_2$), C is a blade attachment angle(${\theta}$) and D is a number of blade(Z), (ii) The flowrate under the optimum condition satisfies the equation $y=0.0384{\cdot}M$ where M is a signal factor, namely number of revolution. The flowrate performance improves about 7.3% more largely as compared with the current condition, which results in about 35RPM reduction of number of revolution for the target flowrate $18.5m^3/min$, and (iii) The sensitivity analysis shows that the major factors in contribution to flowrate performance are A, B, and D ; the percentage contributions of each control factor are 44.01%(Z), 26.77%($D_1/D_2$) and 20.42%($L/D_2$).

• Nuclear Engineering and Technology
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• 제53권11호
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• pp.3543-3562
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• 2021

The methods and performance of a 3D pin-by-pin neutronics code based on the 2D/1D decoupling method are presented. The code was newly developed as an effort to achieve enhanced accuracy and high calculation performance that are sufficient for the use in practical nuclear design analyses. From the 3D diffusion-based finite difference method (FDM) formulation, decoupled planar formulations are established by treating pre-determined axial leakage as a source term. The decoupled axial problems are formulated with the radial leakage source term. To accelerate the pin-by-pin calculation, the two-level coarse mesh finite difference (CMFD) formulation, which consists of the multigroup node-wise CMFD and the two-group assembly-wise CMFD is implemented. To enhance the accuracy, both the discontinuity factor method and the super-homogenization (SPH) factor method are examined for pin-wise cross-section homogenization. The parallelization is achieved with the OpenMP package. The accuracy and performance of the pin-by-pin calculations are assessed with the VERA and APR1400 benchmark problems. It is demonstrated that pin-by-pin 2D/1D alternating calculations within the two-level 3D CMFD framework yield accurate solutions in about 30 s for the typical commercial core problems, on a parallel platform employing 32 threads.