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Phytochemical Constituents of Salsola komarovii and Their Effects on NGF Induction

  • Cho, Hyeon Kyung;Suh, Won Se;Kim, Ki Hyun;Kim, Sun Yeou;Lee, Kang Ro
    • Natural Product Sciences
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    • v.20 no.2
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    • pp.95-101
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    • 2014
  • Five lignan glycosides, seven megastigmane glycosides, and seven phenolic compounds were isolated by repeated column chromatography from the MeOH extract of Salsola komarovii. Their structures were determined to be lariciresinol-9-O-${\beta}$-$\small{D}$-glucopyranoside (1), alangilignoside C (2), conicaoside (3), (+)-lyoniresinol 9'-O-${\beta}$-$\small{D}$-glucopyranoside (4), (8S,8'R,7'R)-9'-[(${\beta}$-glucopyranosyl)oxy]lyoniresinol (5), blumenyl B ${\beta}$-$\small{D}$-glucopyranoside (6), blumenyl A ${\beta}$-$\small{D}$-glucopyranoside (7), staphylionoside D (8), icariside $B_2$ (9), (6R,9S)-3-oxo-${\alpha}$-ionol ${\beta}$-$\small{D}$-glucopyranoside (10), 3-oxo-${\alpha}$-ionol 9-O-${\beta}$-$\small{D}$-apiofuranosyl-($1{\rightarrow}6$)-${\beta}$-$\small{D}$-glucopyranoside (11), blumenol B 9-O-${\beta}$-$\small{D}$-apiofuranosyl-($1{\rightarrow}6$)-${\beta}$-$\small{D}$-glucopyranoside (12), benzyl 6-O-${\beta}$-$\small{D}$-apiofuranosyl-${\beta}$-$\small{D}$-glucopyranoside (13), canthoside C (14), tachioside (15), isotachioside (16), biophenol 2 (17), 2-(3,4-dihydroxy)-phenyl-ethyl-${\beta}$-$\small{D}$-glucopyranoside (18), and cuneataside C (19) by spectroscopic methods. All the isolated compounds 1 - 19 were reported from this source for the first time. Compounds 2, 3 and 6 upregulated NGF secretion to $118.8{\pm}3.6%$, $128.2{\pm}9.3%$ and $111.1{\pm}7.1%$ without significant cell toxicity.

1, 25(OH)$_2$-23ene-$D_3$ : Effects on Proliferation and Differentiation of U937 Cells in vitro and on Clcium Metabolism of Rat in vivo (1, 25(OH)$_2$-23ene-$D_3$ : in vitro에서 U937 세포의 증식과 분화 및 in vivo에서 쥐의 칼슘대사에 미치는 영향)

  • 정수자;서명자
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.24 no.1
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    • pp.1-9
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    • 1995
  • 1, 25(OH)2-23ene-D3 is a novel vitamine D3 analog which has a double bond between C-23 and C-24. We describe the effects of this analog on cell differentiation and cell proliferation in vitro using the human histiocytic lymphoma cell line U937, and on calcium metabolism in rats in vivo. In the present investigation 1, 25(OH)2-23ene-D3 was compared to the natural metabolite of vitamin D3, 1$\alpha$, 25-dihydroxycholecalciferol[1, 25(OH)2-23ene-D3 was more potent than 1, 25(OH)2-23ene-D3 for inhibition of proliferation and induction of differentiation of U937 cells. Especially, its effect on induction of differentiation, as measured by superoxide production and nonspecific esterase(NSE) activity, was about 20-fold more potent that 1, 25(OH)2-23ene-D3. This analog morphologically and functionally differentiated U937 cells to monocyte-macrophage phenotype showing a decrease of N/C ratio in Giemsa staining and the increase of adherence ability to surface. Intraperitoneal administration of 1, 25(OH)2-23ene-D3 to rats showed that the compound had at least 50 times less activity than 1, 25(OH)2-23ene-D3 in causing hypercalcemia and hypercalciuria. The strong direct effects of 1, 25(OH)2-23ene-D3 on cell proliferation and cell differentiation, coupled with its decreased activity of calcium metabolism make this compound an interesting candidate for clinical studies including patients with leukemia, as well as several skin disorders, such as psoriasis.

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The Clinical Significance of Antiphospholipid Antibodies in Korean Children with Henoch-$Sch{\ddot{o}}nlein$ Purpura (Henoch-$Sch{\ddot{o}}nlein$ 자반증에서 항인지질 항체의 임상적 의의)

  • Park, Eun-Jung;Baek, Ji-Young;Shin, Jae-Il;Lee, Jae-Seung;Kim, Hyon-Suk
    • Childhood Kidney Diseases
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    • v.13 no.2
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    • pp.146-152
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    • 2009
  • Purpose : We performed this study to evaluate the incidence and clinical significance of antiphospholipid antibodies (aPL Ab) in Korean children with Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP). Methods : The medical records of 62 patients (31 boys and 31 girls) aged $46.0{\pm}3.1$ (1-16) years with a clinical diagnosis of HSP based on the EULAR/PReS criteria were reviewed retrospectively. From the years 2007 to 2009, the sera from children with acute HSP were tested for aPL Ab such as LA, anti-cardiolipin antibody and anti-${\beta}_2$ glycoprotein I antibody. Results : LA was positive in 18 (29%) of the 62 patients with HSP and We divided the patients into the two groups LA positive group (N=18) and LA negative group (N=44). There were no significant differences between the two groups with regard to abdominal pain, arthralgia and renal involvement, but LA positive group had significantly higher C-reactive protein ($4.3{\pm}7.2$ mg/dL vs. $1.3{\pm}1.8$ mg/dL, P=0.035), erythrocyte sedimentation rate ($37.5{\pm}26.2$ mm/hr vs. $25.1{\pm}22.6$ mm/hr, P= 0.039), IgM ($148.1{\pm}48.4$ mg/dL vs. $114.9{\pm}41.5$ mg/dL, P=0.024), C3 ($143.1{\pm}21.9$ mg/dL vs. $129.7{\pm}24.5$ mg/dL, P=0.048) and C4 levels ($30.9{\pm}6.3$ mg/dL vs. $24.9{\pm}7.8$ mg/dL, P=0.002) compared with LA negative group. Conclusion : We found that the incidence of positive aPL Ab tests was relatively higher in Korean children with HSP and the presence of aPL Ab was associated with acute inflammatory process of HSP. These results suggest that the aPL Ab are involved in the pathogenesis of HSP in children.

Evaluation of TOF MR Angiography and Imaging for the Half Scan Factor of Cerebral Artery (유속신호증강효과의 자기공명혈관조영술을 이용한 뇌혈관검사에서 Half Scan Factor 적용한 영상 평가)

  • Choi, Young Jae;Kweon, Dae Cheol
    • Journal of the Korean Magnetics Society
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    • v.26 no.3
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    • pp.92-98
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    • 2016
  • To aim of this study was to assess the full scan and half scan of imaging with half scan factor. Patients without a cerebral vascular disease (n = 30) and were subject to the full scan half scan, and set a region of interest in the cerebral artery from the three regions (C1, C2, C3) in the range of 7 to 8 mm. MIP (maximum intensity projection) to reconstruct the images in signal strength SNR (signal to noise ration), PSNR (peak signal noise to ratio), RMSE (root mean square error), MAE (mean absolute error) and calculated by paired t-test for use by statistics were analyzed. Scan time was half scan (4 minutes 53 seconds), the full scan (6 minutes 04 seconds). The mean measurement range (7.21 mm) of all the ROI in the brain blood vessel, was the SNR of the first C1 is completely scanned (58.66 dB), half-scan (62.10 dB), a positive correlation ($r^2=0.503$), for the second C2 SNR is completely scanned (70.30 dB), half-scan (74.67 dB) the amount of correlation ($r^2=0.575$), third C3 of a complete scan SNR (70.33 dB), half scan SNR (74.64 dB) in the amount of correlation between the It was analyzed with ($r^2=0.523$). Comparative full scan with half of SNR ($4.75{\pm}0.26dB$), PSNR ($21.87{\pm}0.28dB$), RMSE ($48.88{\pm}1.61$), was calculated as MAE ($25.56{\pm}2.2$). SNR is also applied to examine the half-scans are not many differences in the quality of the two scan methods were not statistically significant in the scan (p-value > .05) image takes less time than a full scan was used.

THE MAXIMAL VALUE OF POLYNOMIALS WITH RESTRICTED COEFFICIENTS

  • Dubicks, Arturas;Jankauskas, Jonas
    • Journal of the Korean Mathematical Society
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    • v.46 no.1
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    • pp.41-49
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    • 2009
  • Let $\zeta$ be a fixed complex number. In this paper, we study the quantity $S(\zeta,\;n):=mas_{f{\in}{\Lambda}_n}\;|f(\zeta)|$, where ${\Lambda}_n$ is the set of all real polynomials of degree at most n-1 with coefficients in the interval [0, 1]. We first show how, in principle, for any given ${\zeta}\;{\in}\;{\mathbb{C}}$ and $n\;{\in}\;{\mathbb{N}}$, the quantity S($\zeta$, n) can be calculated. Then we compute the limit $lim_{n{\rightarrow}{\infty}}\;S(\zeta,\;n)/n$ for every ${\zeta}\;{\in}\;{\mathbb{C}}$ of modulus 1. It is equal to 1/$\pi$ if $\zeta$ is not a root of unity. If $\zeta\;=\;\exp(2{\pi}ik/d)$, where $d\;{\in}\;{\mathbb{N}}$ and k $\in$ [1, d-1] is an integer satisfying gcd(k, d) = 1, then the answer depends on the parity of d. More precisely, the limit is 1, 1/(d sin($\pi$/d)) and 1/(2d sin($\pi$/2d)) for d = 1, d even and d > 1 odd, respectively.

Taxonomic Review of Clematis flabellata Nakai

  • Beom Kyun Park;Dong Chan Son;Sung Chul Ko
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2020.08a
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    • pp.26-26
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    • 2020
  • Daphne L. (Thymelaceae) comprises about 95 species distributing worldwide from N Africa, N India, SE Asia to E Asia and the coast of the Mediterranean of Europe. In Korea, five species of this genus have been described. In this study, we included four species (D. genkwa, D. pseudomezereum, D. kiusiana, D. jejudoensis) from Korea, excluding cultivated D. odora. The morphological characters through local surveys and the re-classification of the specimens collected in the Korea National Herbarium (KH) were carried out and distribution maps for each taxon were also prepared. The major characters include habit, trichomes in winter bud, leaf, and twig, phyllotaxis, inflorescence, size of calyx lobe and trichomes in the calyx tube, etc. The distribution map showed that D. genkwa is mainly distributed in the coastal area of Hwanghaenam-do, Pyeongannam-do, Jeollabuk-do and Jeollanam-do, whereas D. pseudomezereum is distributed in the limestone zone of Gangwon-do, Jeollabuk-do, and Gyeongsangbuk-do. Similarly, D. kiusiana is mostly found in Jeollanam-do, Gyeongsangnam-do, and Jeju-do. In addition, D. jejudoensis is known to be distributed in forests of Murueng, Andeok, and Seonheul-ri in Jeju-do, but recently, new habitat is discovered in the island forest areas of Jeollanam-do. However, some of these individuals showed the characteristics of D. kiusiana, thus before come to any conclusion detailed taxonomic review of D. jejudoensis and D. kiusiana is required.

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Quality and Epidermal Changes of Chamaecereus silvestriiafter the Spray of the Mixtures of Diniconazole and D-mannitol, D-sorbitol, Wax before Transportation (수송 전 Diniconazole과 D-mannitol, D-sorbitol, Wax의 혼용 살포에 따른 접목 선인장 산취의 품질과 표피의 변화)

  • Park, Seon-Mi;Nam, Sang-Yong;Lee, Byung-Chul;Yi, Bu-Young
    • Journal of Bio-Environment Control
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    • v.20 no.2
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    • pp.144-149
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    • 2011
  • This research has been carried out to examine the effects of quality promoting agents on global quality and epidermal changes of Chamaecereus silvestrii 'Hee-mang' for quality maintenance of the transportation. D-sorbitol than D-mannitol treatment was effective in a lower reduction of fresh weight in C. silvestrii transportations. Application of diniconazole 200 ppm suppressed growth of C. silvestrii. However, it enabled the possibility of long-tenn plant transportation (up to 50 days) and color formation was also effective. As for epidermis structure of C. silvestrii, hypodermis development was lower compared to Gymnocalycium friedrichii and its long-term transportation became poor quality due to single layered, thin cell wall. Application of diniconazole 200 ppm + D-mannitol 10,000 ppm showed higher growth suppressing effects and diniconazole 200 ppm + wax treatment showed better color formation suitable for quality maintenance and storage purposes for C. silvestrii.

Design of a Conical Spiral Antenna for Satellite TT&C Applications (위성 TT&C용 원뿔 나선 안테나 설계)

  • Ko Han-Woong;Lee Junwen;Yu Jae-Deok;Kim Se-Yon;Ahn Bierng-Chearl;Park Dong-Hee
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.17 no.1 s.104
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    • pp.24-38
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    • 2006
  • In this paper, we investigate the design and fabrication of a conical spiral antenna suitable for satellite TT&C applications. The shape of the spiral is optimized using a commercial electromagnetic software for good gain and axial ratio performances over $2.0{\sim}2.3\;GHz$ frequencies. A coaxial infinite balun feeding the spiral is designed using experimental methods. A method for precision fabrication of the spiral is presented. Measurements of the fabricated antenna show satisfactory performances over $2.0{\sim}2.3\;GHz$ such as a reflection coefficient less than -18 dB, a maximum gain greater than 4 dB, a gain greater than 0 dB over angles ${\pm}75^{\circ}$ from the antenna boresight, an axial ratio less than 5 dB over angles ${\pm}90^{\circ}$ from the antenna boresight, a front-back ratio greater than 15 dB.

Biosynthesis of New Oligosaccharides via Acceptor Reaction using Fructosyloligosaccharide as an Acceptor (Fructosyloligosaccharide를 Acceptor 반응의 기질로 사용한 새로운 올리고당의 생합성)

  • 이찬용;이충환
    • Korean Journal of Microbiology
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    • v.35 no.2
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    • pp.146-152
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    • 1999
  • Acceplor reaction of glucosyltr~ansferase of Streptococcus ,SO~~-~IZLIS with f ~ ~ t o ~ y l o l i g o ~ a ~ ~ h a r i d e ~ was studied for the biosynthesis of novel olgisaccharides. First, bacilracin resistant mutants were selected by mutagenesis of Streptococcus sobrimis ATCC27351. Among these mutants 4 strains were selected by resistance to bacitracin and increase of glucosyltransferase. Acceptor reaction of maltose was analyzed by TLC and image analysis. There were differences in the specificity of the acceptor reaclion by Ule glucosylumsferase between mother strain (Streptococcus sobrinus ATCC2735) and bacitracin resistant mutants (Streptococcus sobrinus BR24C, Strepfococcus sobrinus CH-5). Molher strain did ilot show an acceptor reaction with fructosyloligosaccharides such as 1-keqtose and nystose. Acceptor reaction products of turailose and 1-kestose with glucosyltransferase (GW-S) of Streptococcus sobrini~s BR24C were TEX>\6^{3}$-$\alpha$-D-glucopyranosyl \3^{2}$-O-$\alpha$-D-fructose (glucose-fructose-glucose) and \6^{4}$-$\alpha$-D-glucopyranosyl \1^{3}$-$\beta$-D-~-h~ctofuranos~~ sucrose (glucose-glucosefructose- fructose). respectively These are novel oligosaccharides which can be produced only by enzymatic reaction.

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D(-) and L(+)-Lactic Acid Determination of Lactobacillus acidophilus during Fermentation and Storage Period (Lactobacillus acidophilus NCFM의 배양 및 저장 중 D(-) 및 L(+)-lactic acid의 변화)

  • Lee, Kyung-Wook;Shin, Yong-Kook;Baick, Seung-Chun
    • Korean Journal of Food Science and Technology
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    • v.30 no.1
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    • pp.168-174
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    • 1998
  • The amount of D(-)-lactic acid in fermented dairy products is very important because the rate of metabolism of D(-)-lactic acid is lower than that of L(+)-lactic acid. The purpose of this study was to investigate the optimum condition during fermentation and storage of yogurt for the formation of isomers of lactic acid by Lactobacillus acidophilus NCFM. The production of acid was excellent at $37^{\circ}C$ of fermentation and the ratio of D(-)-lactic acid was also lower than that of other conditions such as $35^{\circ}C{\;}and{\;}40^{\circ}C$. Among shaking and non-shaking treatment under aerobic condition and anaerobic condition, non-shaking treatment under aerobic condition was the best condition at the production of acid and L(+)-lactic acid during fermentation. During storage at low temperature, a larger amount of L(+)-lactic acid was produced than at higer storage temperature.

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