• Proceedings of the Korea Society of Environmental Toocicology Conference
• /
• 2000.12a
• /
• pp.85-85
• /
• 2000

• Bulletin of the Korean Chemical Society
• /
• v.33 no.10
• /
• pp.3169-3170
• /
• 2012

• Proceedings of the Zoological Society Korea Conference
• /
• 1998.10b
• /
• pp.339.2-339
• /
• 1998

No Abstract, See Full Text

• Proceedings of the Botanical Society of Korea Conference
• /
• 2001.04a
• /
• pp.25-25
• /
• 2001

• Proceedings of the PSK Conference
• /
• 2001.10a
• /
• pp.178.3-179
• /
• 2001

• Bulletin of the Korean Chemical Society
• /
• v.30 no.12
• /
• pp.2869-2870
• /
• 2009

• Proceedings of the Zoological Society Korea Conference
• /
• 1997.10b
• /
• pp.219.2-219
• /
• 1997

No Abstract, See Full Text

• Bulletin of the Korean Chemical Society
• /
• v.31 no.12
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• pp.3515-3516
• /
• 2010

• Proceedings of the Korean Biophysical Society Conference
• /
• 1997.07a
• /
• pp.22-22
• /
• 1997

The physiological activity of tracheal epithelial cells is closely related with the ionic conditions of cytosol, specially the concentration of cytosolic Ca$\^$2＋/. We have prepared microsomes in these cells and the molecular mechanisms of ionic regulations were investigated.(omitted)

• Molecules and Cells
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• v.26 no.5
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• pp.481-485
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• 2008

As an inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC), D609 has been widely used to explain the role of PC-PLC in various signal transduction pathways. This study shows that D609 inhibits group IV cytosolic phospholipase $A_2$ ($cPLA_2$), but neither secretory $PLA_2$ nor a $Ca^{2+}$-dependent $PLA_2$. Dixon plot analysis shows a mixed pattern of noncompetitive and uncompetitive inhibition with $K_i=86.25{\mu}M$ for the $cPLA_2$ purified from bovine spleen. D609 also time- and dose-dependently reduces the release of arachidonic acid from a $Ca^{2+}$- ionophore A23187-stimulated MDCK cells. In the AA release experiment, $IC_{50}$ of D609 was ${\sim375}{\mu}M$, suggesting that this reagent may not enter the cells easily. The present study indicates that the inhibitory effects of D609 on various cellular responses may be partially attributable to the inhibition of $cPLA_2$.