• Investigative Magnetic Resonance Imaging
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• v.2 no.1
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• pp.73-82
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• 1998

Purpose : A precise NMR technique for measuring the rate of water exchange and cell membrane permeability across the hepatocyte membrane using liver-specific MR contrast agent is described. Materials and Methods : The rat hepatocytes isolated by perfusion of the livers were used for the NMR measurements. All experiments were performed on an IBM field cycling relaxometer operating from 0.02MHz to 60 MHz proton Larmor frequency. spin-echo pulse sequence was empolyed to measure spin-lattice relaxation time, T1. The continuous distribution analysis of water proton T1 data from rat hepatocytes containing low concentrations of the liver specific contrast agent, Gd-EOB-DTPA, modeled by a general two compartment exchange model. Results : The mean residence time of water molecule inside the hepatocyte was approximately 250 msec. The lower limit for the permeability of the hepatocyte membrane was $(1.3{\pm}0.1){\;}{\times}{\;}10^{-3}cm/sec$. The CONTIN analysis, which seeks the natural distribution of relaxation times, reveals direct evidence of the effect of diffusive exchange. the diffusive water exchange is not small in the intracellular space in the case of hepatocytes. Conclusions : Gd-EOB-DTPA, when combined with continuous distribution analysis, provides a robust method to study water exchange and membrane permeability in hepatocytes. Water exchange in hepatocyte is much slower thatn that in red blood cells. Therefore, tissue-specific contrast agent may be used as a functional agent to give physiological information such as cell membrane permeability.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2007.05a
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• pp.199-204
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• 2007

Hot embossing, one of Nanoimprint Lithography(NIL) techniques, has been getting attention as an alternative candidate of next generation patterning technologies by the advantages of simplicity and low cost compared to conventional photolithographies. A typical hot embossing usually, however, takes more than ten minutes for one cycle of the process because of a long thermal cycling. Over the last few years a number of studies have been made to reduce the cycle time for hot embossing or similar patterning processes. The target of this research is to develop an induction heating apparatus for heating a metallic micro patterning mold at very high speed with the large-area uniformity of temperature distribution. It was found that a 0.5 mm-thick nickel mold can be heated from $25^{\circ}C$ to $150^{\circ}C$ within 1.5 seconds with the temperature variation of ${\pm}5^{\circ}C$ in 4-inch diameter area, using the induction heating apparatus.

• Journal of the Korean Institute of Navigation
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• v.17 no.3
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• pp.69-76
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• 1993

In harbour the practical shiphandlers should have a expert knowledge of systematically reducing head-way and keeping ship's positions to the final position with confidence and under control. But now in the practical approaches we do not have any special maneuvers of controlling the ship effi-ciently regarding the headway and approaches except some existing reduction of speeds according to the Weight-to-Power Ratio, use of astern power and Rudder Cycling. Consequently this study put Woo's Super Rudder Controlling originally developed by Captain Woo, Ph. D. to practical use as a special maneuvers in the port approaches. The conclusions of this paper are drawn as follows : 1) Optimum standard and desirable controls in combination of three engine speeds with three yaw ang-les were proposed for the practical shiphandlers, 2) According to simulation of the pilotships the Super advances are 10.5 ship lengths for Full full full maneuvers, and 7.9 ship lengths for Full half maneuvers approximately, 3) Approach maneuvers to anchorages by trying Woo's Super Rudder Controlling saved about 30% of total standby time in comparison with the existing Weight-to-Power Ratio maneuvers in the Pusan and Kwang Yang ports.

• BMB Reports
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• v.48 no.12
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• pp.677-684
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• 2015

Cardiovascular function is regulated by the rhythmicity of circadian, infradian and ultradian clocks. Specific time scales of different cell types drive their functions: circadian gene regulation at hours scale, activation-inactivation cycles of ion channels at millisecond scales, the heart's beating rate at hundreds of millisecond scales, and low frequency autonomic signaling at cycles of tens of seconds. Heart rate and rhythm are modulated by a hierarchical clock system: autonomic signaling from the brain releases neurotransmitters from the vagus and sympathetic nerves to the heart's pacemaker cells and activate receptors on the cell. These receptors activating ultradian clock functions embedded within pacemaker cells include sarcoplasmic reticulum rhythmic spontaneous Ca²⁺ cycling, rhythmic ion channel current activation and inactivation, and rhythmic oscillatory mitochondria ATP production. Here we summarize the evidence that intrinsic pacemaker cell mechanisms are the end effector of the hierarchical brain-heart circadian clock system.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.935-938
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• 2004

This paper describes the quantitative analysis on the improvement of equilibrium sensory using virtual bicycle system. We have used a virtual bicycle system that combines virtual reality technology with a bicycle. In this experiment, 10 subjects were tested to investigate the influencing factors on equilibrium sensory. Straight road and curved road driving at several factors including cycling time, number of times of path deviation, and center of pressure(COP) were extracted and evaluated to quantify the extent of control. Also, To improve the effect of balance training, we investigated the usefulness of virtual feedback information by weight shift. The result showed that the system could be effective for equilibrium sensory rehabilitation training device. The analysis method might also have wider applicability to the rehabilitation field.

• Journal of the korean society of oceanography
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• v.39 no.1
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• pp.14-19
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• 2004

Difference of Dissolved Inorganic Phosphorus (DIP), Dissolved Inorganic Nitrogen (DIN) and Dissolved Silicate (DSi) budgets in the Bohai Sea between 1982 and 1992 related the decrease of the Yellow River discharge is discussed on the basis of observed data. The estuarine circulation in the Bohai Sea had been weakened from 1982 to 1992 due to the decrease of the Yellow River discharge and the average residence time of fresh water had become longer. DIN concentration increased but DIP and DSi concentrations decreased from 1982 to 1992 in the Bohai Sea. Primary production was regulated mainly by water temperature and DIN concentration in 1982 but it was regulated mainly by DIP concentration in 1992. Primary production was larger than decomposition plus bottom release and nitrogen fixation was larger than denitrification in 1982. However, decomposition plus bottom release was larger than primary production and denitrification was larger than nitrogen fixation in 1992 in the Bohai Sea.

• Journal of Korean Society for Atmospheric Environment
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• v.26 no.2
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• pp.107-117
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• 2010

The atmospheric geochemistry of mercury is generalls represented by gaseous elemental phase that exhibits the high environmental mobility and relatively long atmospheric residence time (c.a., 1 year) with its high chemical stability. In the recognition of the environmental significance of its global cycling, enormous efforts have been devoted to the measurements of Hg exchange across air-soil boundary. To be able to describe the fundamental aspects on this subject, the current development in the measurements of atmospheric exchange rates of mercury has been summarized using the current database reported worldwide. As a first step, different techniques commonly employed in its measurements are introduced with the discussions on their merits and disadvantages. Then, the results derived from various field measurement campaigns are also compared and discussed. The direction for the future study of mercury is presented at last.

• Journal of The Korean Society of Agricultural Engineers
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• v.52 no.2
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• pp.19-25
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• 2010

This study was conducted to determine the resilient modulus (Mr) and the unconfined compressive strength (UCS) of two recycled roadway materials such as recycled pavement material (RPM) and road surface gravel (RSG) with or without cement kiln dust (CKD). The recycled materials were blended with two CKD contents (5, 10 %) and 28 day curing time. Mr and UCS tests were also conducted after 10cycles of freezing and thawing to asses the impact of freeze-thaw cycling. Mr was determined conducting by the laboratory test method described by NCHRP 1-28A. Stabilized RPM and RSG had a modulus and a strength higher than unstabilized RPM and RSG. Mr and UCS of RPM and RSG mixed with CKD increased with increasing CKD content. The results indicated that the addition of CKD could be improved the strength and the stiffness of RPM and RSG. Therefore, RPM, RSG and CKD could be used as an effective materials in the reconstruction of roads.

• Bulletin of the Korean Chemical Society
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• v.32 no.9
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• pp.3333-3337
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• 2011

$ZnMn_2O_4$ has been prepared by a mechanochemical process using a mixture of $Mn_2O_3$ and ZnO as starting materials, and investigated as a possible anode material for lithium-ion batteries. The phase evolution and morphologies of the ball-milled and annealed powders are characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) with energy dispersive microanalysis (EDX), respectively. The solid-state reaction for the formation of $ZnMn_2O_4$, under the given experimental conditions, is achieved in a short time (30 min), and the prepared samples exhibit excellent electrochemical performances including an enhanced initial coulombic efficiency, high reversible capacity, and stable capacity retention with cycling.

• KIEAE Journal
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• v.2 no.2
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• pp.23-31
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• 2002

The purpose of this study is to suggest an environmentally friendly energy system of ecological architecture, with the reference to foreign cases, judge feasibility of it. The ecological architecture is very similar to the natural ecosystem. There is growing international scientific consensus that human activities are having a discernible effect on the global climate. Therefore, with a precise understanding of the concept of ecological approach and concrete perception of the necessity it, an establishment of planning which recognizes the ecological architecture as a organism a same time, ensures diversity, stability and cycling stemmed from the ecosystem to various activities through a ecological structure shall bring the introduction of substantial ecological architecture into domestic realm. As a result, in this Age of industrial science, We are proposing useful materials and suggestion regarding the ecological architecture planning of korean cities, by preestimating the characteristics of a city heading toward the Age of the new ecological environment.