• Journal of the Korean Society of Food Science and Nutrition
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• v.11 no.3
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• pp.21-27
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• 1982

A kinetical approach for the non-enzymatic browning reaction of the dried file-fish was studied. The reaction rates revealed a tend to increase with increasing water activity and showed the maximum at $0.75\;a_w$ The activation energies obtained from the Arrhenius plot ranged 12.5 to 16.5 Kcal/mole. From these energies of activation, the $Q_{10}$ values at $45^{\circ}C$ showed 1.9 to 2.3 and both activation energy and $Q_{10}$ values were reduced with increase in $a_w$ Shelf-lives, the time to reach an 0.15 O.D./g solid at which severe brown color change could be de ectable, decreased rapidly as the temperature and water activity increase. A storage study under a square-wave fluctuating temperature condition (at 35 and $55^{\circ}C$ periodically with 7 days interval), the rate constants at all water activities used in the experiments were higher than those at $45^{\circ}C$, the mean temperature of the cycle which affects other kinetic parameters including activation energies, $Q_{10}$ values and finally the shelf-lives. The data obtained from the fluctuating temperaure storage study will be used in prediction of shelf-life. The shelf lives assessed at $25^{\circ}C$ from the accelerated shelf-life tests ranged from 179 daysat $0.75\;a_w$ to 302 days at $0.44\;a_w$.

• Korean Journal of Construction Engineering and Management
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• v.10 no.4
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• pp.26-37
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• 2009

Ministry of Land, Transportation and Marine Affairs(MLTM) has implemented Construction CALS project for improving productivity of construction industry and for making construction project management efficient by responding to informatization and knowledge base society in 21st century. CALS has beeb applied successfully to projects form MLTM, however, the outcomes of Construction CALS hasn't been recognized. In addition, there is no way to find how high the level of Construction CALS is when it is compared with other SOC informatization projects. This study found out the informatiziation level of Construction CALS by using the evaluation index proposed in the former study, and by comparing with other sectors. The evaluation on the level was implemented in the three parts such as informatization infrastructure(network, hardware, standardization, data, informatization, informatization security), informatization utilization(information usage, IT performance), and informatization support(informatization goal, organization of informatization, informatization investment, informatization education), and then, this evaluation was compared with "Assessment for level of industry information system", "Assessment for level of small and midium sized industry information system", and "IICI(Informatizaion Index for the Construction Industry)". With the result from the comparison, this study produced superior factors and inferior factors for each sector. These results are expected to be useful for prioritizing budget allocation by finding out the informatization level of Construction CALS.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.40 no.5
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• pp.535-546
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• 2020

Land cover maps are derived from satellite and aerial images by the Ministry of Environment for the entire Korea since 1998. Even with their wide application in many sectors, their usage in research community is limited. The main reason for this is the map compilation cycle varies too much over the different regions. The situation requires us a new and quicker methodology for generating land cover maps. This study was conducted to automatically generate land cover map using aerial ortho-images and Landsat 8 satellite images. The input aerial and Landsat 8 image data were trained by Residual U-Net, one of the deep learning-based segmentation techniques. Study was carried out by dividing three groups. First and second group include part of level-II (medium) categories and third uses group level-III (large) classification category defined in land cover map. In the first group, the results using all 7 classes showed 86.6 % of classification accuracy The other two groups, which include level-II class, showed 71 % of classification accuracy. Based on the results of the study, the deep learning-based research for generating automatic level-III classification was presented.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.3
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• pp.170-179
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• 2020

Tidal asymmetry would occur owing to shallow water tides at the Western Coast of macro tidal area. Especially, as ebb dominance of Mokpo coastal zone is known as the most prominent in Korea, it had been studied by domestic researchers. The cause of ebb dominance in Mokpo area is considered due to extensive inter-tidal zone in Muan Bay, and this has been studied based on amplification ratio, relative phase and skewness of tide/tidal flow curves in order to analyze qualitative tidal asymmetry. Furthermore, it was possible to figure out tidal characteristics with the difference of tidal amplitude and phase with Mokpo Harbor by observing the tide for 15 days in Muan Bay, which showed 40 minutes shorter ebbing time than at Mokpo Harbor. In addition, tidal flow prediction data in Mokpo North Harbor and Mokpo-Gu were analyzed. Meanwhile, the basis regarding qualitative interpretation of bed sediment and suspended sediment was provided by examining the qualitative changes in tidal asymmetry for spring-neap tidal cycle through the PCA/SWA indices. In addition, by examining long-term changes of ebb dominance in Mokpo Port, tidal characteristics of the past, present and future in this area, which is related to tidal asymmetry, is also provided.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.41 no.11
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• pp.775-784
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• 2017

The purpose of this study was to analyse the basic data of the engine tuning inspection by confirming the working possibility of effective engine tuning and identifying the characteristics of tuned engine that are no problem with the safety operation and environment in a driving gasoline car. The effects of tuned engine on the characteristics of air/fuel ratio and performance at a wide range of engine speeds were experimentally investigated by the actual driving car with a four-cycle, four-cylinder DOHC, turbo-intercooler, water-cooled gasoline engine operating under four types of non-tuning, and tuning 2-1, 2-2 and 2-3. The tuned parts of engine in a driving gasoline car include the intake manifold, intake pipe, air filter, exhaust manifold, exhaust pipe and silencer. In this experiment, the air-fuel ratio and torque of both non-tuned and tuned engines that one person took on board in the car with a five-speed automatic transmission were measured by the chassis dynamometer(Dynojet 224xLC). It was found that the maximum torque of tuned engine in a driving gasoline car was increased by 103.68% on average, while the maximum output was increased by 119.68% on average in comparison to the non-tuned engine.

• Development and Reproduction
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• v.17 no.3
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• pp.207-213
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• 2013

This study was performed to investigate the effect of peroxisome proliferators activated receptor-${\gamma}$ (PPAR-${\gamma}$) ligand, pioglitazone, on production of regulated upon activation normal T-cell expressed and secreted (RANTES) and in vitro fertilization (IVF) outcome in infertile patients with endometriosis. Sixty-four infertile patients with stage III or IV endometriosis undergoing IVF were randomly allocated to the study or the control group. The long protocol of GnRH agonist (GnRH-a) was used for controlled ovarian stimulation (COS) in all patients. Patients in the study group were treated with pioglitazone at a dose of 15 mg/day orally from the starting day of GnRH-a treatment to the day of hCG injection. Blood samples were drawn for serologic assay of RANTES on the first day of GnRH-a treatment and the day of hCG injection. There were no differences between the study and control groups in patient characteristics. There were also no differences between the two groups in COS duration, and the numbers of retrieved oocytes, fertilized oocytes and embryos transferred. The clinical pregnancy rate per cycle was higher in the study group, but this difference was not statistically significant. However, embryo implantation rate was significantly higher in the study group of 12.5% compared with 8.6% in the control group (P<0.05). The serum RANTES levels after pioglitazone treatment were significantly lower than those before pioglitazone treatmen in the study group (P<0.05). Our data suggest that pioglitazone treatment can suppress RANTES production and improve the embryo implantation rate in patients with endometriosis undergoing IVF.

• Economic and Environmental Geology
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• v.40 no.4
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• pp.389-401
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• 2007

The oxygen and hydrogen isotopic composition in precipitation, groundwater and geothermal water were monitored over four-year period from 2001 to 2004 at the Yuseong catchment, Daejeon. By analyzing the long term rainfall pattern, we found out the drought cycle of 6 or 7 year. We fortunately revealed that the oxygen and hydrogen isotopic composition of rain has progressively changed to heavier isotopic ratios from 2001 to 2004. The weighted mean values of ${\delta}^{18}O\;and\;{\delta}D$ of rain are calculated to be $-7.7%o\;and\;-51%o$, respectively. These isotopic values are much heavier than those of groundwater and geothermal water collected at the same period, which indicates that the rain or snow of the study area would not immediately affect the isotopic composition of groundwater or geothermal water. Comparing with the previous data, the groundwater and geothermal water collected at 1990 and 1992 year has the heaviest isotopic composition and afterwards their isotopic composition has been progressively shifted to the direction of lighter composition field.

• Journal of Life Science
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• v.28 no.6
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• pp.733-737
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• 2018

Cucurbitacin-I, a natural triterpenoid derived from Cucurbitaceae family plants, exhibits a number of potentially useful pharmacological and biological activities. Indeed, the previous study demonstrated that cucurbitacin-I reduced the proliferation of colon cancer cells by enhancing apoptosis and causing cell cycle arrest at the G2/M phase. CD44, a type I transmembrane protein with the function of adhering to cells, mediates between the extracellular matrix and other cells through hyaluronic acid. Recent studies have demonstrated that an overexpression of the CD44 membrane receptor results in tumor initiation and growth, specific behaviors of cancer stem cells, the development of drug resistance, and metastasis. The aim was to examine the effect of cucurbitacin-I on CD44 expression human ovarian cancer cells because the effect of cucurbitacin-I on CD44 expression has not been reported. The expressions of CD44 mRNA and protein were detected using a quantitative real-time reverse-transcription polymerase chain reaction and a Western blot analysis, respectively. Treatment with cucurbitacin-I inhibited the expression of CD44 mRNA and protein. A subsequent analysis revealed that cucurbitacin-I blocked the phosphorylation of activator protein-1 (AP-1) and nuclear factor kappa-B ($NF-{\kappa}B$), which are key regulators of CD44 expression. Taken together, the data demonstrate that cucurbitacin-I regulates the AP-1 and $NF-{\kappa}B$ signaling pathways, leading to decreased CD44 expression.

• Molecules and Cells
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• v.43 no.5
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• pp.469-478
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• 2020

Hepatitis C virus (HCV) propagation is highly dependent on cellular proteins. To identify the host factors involved in HCV propagation, we previously performed protein microarray assays and identified the LIM and SH3 domain protein 1 (LASP-1) as an HCV NS5A-interacting partner. LASP-1 plays an important role in the regulation of cell proliferation, migration, and protein-protein interactions. Alteration of LASP-1 expression has been implicated in hepatocellular carcinoma. However, the functional involvement of LASP-1 in HCV propagation and HCV-induced pathogenesis has not been elucidated. Here, we first verified the protein interaction of NS5A and LASP-1 by both in vitro pulldown and coimmunoprecipitation assays. We further showed that NS5A and LASP-1 were colocalized in the cytoplasm of HCV infected cells. NS5A interacted with LASP-1 through the proline motif in domain I of NS5A and the tryptophan residue in the SH3 domain of LASP-1. Knockdown of LASP1 increased HCV replication in both HCV-infected cells and HCV subgenomic replicon cells. LASP-1 negatively regulated viral propagation and thereby overexpression of LASP-1 decreased HCV replication. Moreover, HCV propagation was decreased by wild-type LASP-1 but not by an NS5A binding-defective mutant of LASP-1. We further demonstrated that LASP-1 was involved in the replication stage of the HCV life cycle. Importantly, LASP-1 expression levels were increased in persistently infected cells with HCV. These data suggest that HCV modulates LASP-1 via NS5A in order to regulate virion levels and maintain a persistent infection.

• Transactions of the Korean Society of Automotive Engineers
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• v.24 no.2
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• pp.144-151
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• 2016

This study effect of engine oils on regulated fuel economy and emissions including particulate matter (PM) to provide basic data for management of engine oil in vehicles. Three engine oils (Group III base oil, Group III genuine oil with additive package and synthetic oil with poly alpha olefins (PAOs)) were used in one gasoline, one LPG(liquefied petroleum gas) and two diesel vehicles. In the case of diesel vehicles, one is a diesel vehicle without DPF (diesel particulate filter) other is a diesel vehicle with DPF. In this study, the US EPA emission test cycle FTP-75, representing city driving, was used. HORIBA, PIERBURG, and AVL gas analyzers were used to measure the fuel economy and regulated emissions such as CO, NOx, and THC. The number of PM was measured using a PPS (pegasor particle sensor). And, the shape of PMs was analyzed by SEM (scanning electron microscope). The effects of oil type on fuel economy, exhaust gas, and PM were not significant because engine oil consumption by evaporation and combustion in the cylinder is very tiny. Fuel and vehicle type were dominant factors in fuel economy and emissions. HC emission from gasoline vehicles was higher than that from other vehicles and NOx emission from diesel vehicles was higher than that from other vehicles. The number of PM was not affected by the engine oil, but by the driving pattern and fuel. The shapes of the PM, sampled from each vehicle using any test engine oil, were similar.