• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.1949-1953
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• 2014

Background: CA125 and HE4 are used in calculating Risk of Malignancy Algorithm (ROMA); and Risk of Malignancy Index (RMI). However, studies showed that normal levels of CA125, and HE4 differ among ethnicities such as between Asians and Caucasians, thus affecting the accuracy of the RMI score and ROMA in predicting ovarian malignancy. This study aimed to determine whether new or modified cutoff values for Ca125, HE4, the RMI score, and ROMA resulted in a better prediction of malignancy compared with the previous or standard ones. Materials and Methods: Serum level of CA125 and HE4 from 128 patients with diagnosis of ovarian tumor that had been collected before surgery at Cipto Mangunkusumo General Hospital (CMH) in Jakarta from November 2010 until May 2011 were reviewed and analysed. The standard cutoff values of these biomarkers, RMI, and ROMA were modified by using logistic regression model. The modified cutoff values were compared to the standard cutoff values in terms of sensitivity, specificity, and accuracy. Results: The modified cutoff value of CA125, HE4, RMI score and ROMA were 165.2 U/mL, 103.4 pM, 368.7, 28/54. The sensitivity and specificity of the modified cutoff values CA125, HE 4, RMI score and ROMA in differentiating benign from malignant and borderline were 67% and 75,4%; 73.1% and 85.2%; 73.1% and 80.3%; and 77.6% and 86.9%. While the sensitivity and specificity of the standard cutoff value of CA125; HE4; RMI score; and ROMA were 91% and 24.6%; 83.6% and 65%; 80.6% and 65.6%; and 91.0% and 42.6%. The accuracy of modified cutoff values compared with standard cutoff values were: 71.2% vs 59.3%, 78.9% vs 75% vs, 76.5% vs 73.4%, and 82% vs 67.9%. Conclusions: The new or modified cutoff values of Ca125, HE4, RMI score and ROMA resulted in higher accuracy compared to the previous or standard ones, at the cost of reduced sensitivity.

• 대한물리의학회지
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• 제9권1호
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• pp.101-106
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• 2014

PURPOSE: This study was to provide reference data and examine stroke and healty older differences in sit-to-stand test. This study were to determine utility of the 5 repetition sit to stand for discriminating between fallers and non-fallers, identifying an appropriate cutoff score to delineate between the groups. METHODS: Ninety-five participants were recruited. Seventy-two individuals with stroke and twenty-three healthy older agreed to participate in the study. Falls were recorded using a self-administered questionnaire. The 5 repetition sit to stand test measured the time taken to complete t repetitions of the sit to stand maneuver. The time from the initial seated position to the final seated position after completing five stands was the test measure. A cutoff score regarding 5 repetition sit to stand performance in fallers vs. non-fallers, stroke patients vs. healthy older and <60 vs. $$\geq_-$$ age groups was determined using and ROC curve. RESULTS: Cutoff score of 9.9 seconds were found to be discriminatory between healthy older and subjects with stroke. Cutoff score of 15.5 seconds were found to be discriminatory between fallers and non-fallers. Cutoff score of 18.3 seconds were found to be discriminatory between <60 and $$\geq_-$$ age groups. CONCLUSION: The 5-repetition sit-to stand test is quick, easily administered measure useful for gross determination of fall risk in people with stroke.

• 한국콘텐츠학회논문지
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• 제12권10호
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• pp.385-394
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• 2012

본 연구의 목적은 생애전환기 건강진단 골밀도 검사시 측정도구(DEXA, QUS, RA)에 따른 진단범위의 유효성을 평가하는 것이다. DEXA를 이용한 골밀도 검사 결과 T-score -2.5를 기준으로 할 때 QUS의 cutoff 값은 -1.733이며, 이때 민감도는 70.4%, 특이도는 59.5%이었고 T-score -3.0을 기준으로 할 때 cutoff 값은 -2.323으로 이때 민감도는 70.4%, 특이도는 56.8%이었다. DEXA를 이용한 골밀도 검사 결과 T-score -2.5를 기준으로 할 때 RA의 cutoff 값은 -1.675이며, 이때 민감도는 70.0%, 특이도는 63.7%이었고 T-score -3.0을 기준으로 할 때 cutoff 값은 -2.325로 이때 민감도는 70.0%, 특이도는 42.9%로 QUS와 RA의 측정도구 간에 큰 차이를 보이지 않았다. 골밀도 측정도구의 상관관계와 재현성에 대한 평가에서는 일부 차이를 제외하고는 측정도구 간 및 측정도구의 반복 측정값 간에 유의한 차이를 보이지 않았다. ROC 분석에서 측정도구별 평균골밀도 측정결과는 DEXA를 기준으로 할 때 RA와 QUS는 모두 유효한 것으로 판단된다. 다만, 생애전환기 골다공증 진단에 보다 정확한 결과를 얻기 위해서는 성별이나 연령층, 다양한 측정부위별 정량화된 결과를 진단기준의 보정지표로 고려하는 것이 필요하다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권4호
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• pp.341-349
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• 2019

Background: A self-assessment questionnaire, the GERD-Questionnaire (GERD-Q) was used to determine the prevalence of GERD in adolescents, describe the related factors, and determine the impact on quality of life (QoL). Methods: The incidence of GERD was evaluated using the GERD-Q in adolescents aged 12-18 years. The Pediatric Gastroesophageal Reflux Disease Symptom Questionnaire and Quality of Life Questionnaire (PGSQ-A) for adolescents were additionally administered. Some factors considered related to GERD were also evaluated. Results: The 520 adolescents were included. The prevalence of suspected GERD, according to a GERD-Q cutoff score of ${\geq}7$ was 32.9%, and those drinking soda were 1.7 times more likely to have GERD (95% confidence interval, 1.3-2.2; p<0.001). However, soda consumption was not a risk factor for development of GERD symptoms. Applying a cutoff score of ${\geq}8$, only 10.9% of the participants had a positive GERD score, but the association with soda consumption persisted. The median PGSQ-A score in subjects suspected of GERD was 8 (range 0-37) on weekends and 1 (range 0-17) during weekdays (p<0.001) compared to those not suspected of GERD, with a median of 2 (range 0-27) during weekends and 0 (range 0-10) during weekdays. Heartburn, regurgitation, and extraesophageal symptoms correlated significantly with QoL (p<0.001). Conclusion: The prevalence of suspected GERD in adolescents was 32.9% or 10.9%, depending on the cutoff score used. There was a statistically significant difference in PGSQ-A scores between the subjects suspected or not of GERD, indicating an impaired QoL.

• 한국전문물리치료학회지
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• 제9권3호
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• pp.47-65
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• 2002

This study examined the correlations among the Berg Balance Scale, which is a clinical tool used to evaluate balance ability, spatiotemporal parameters of gait, and falling; determined the parameters most closely related to falling; and identified a discriminatory parameter and its predictability. Thirty-four subjects aged 72 to 92 years participated in this study. Following a questionnaire survey about falling, the Berg Balance Scale and spatiotemporal parameters of gait were measured. The results revealed that the incidence of falls increased with aging and an accompanying reduction in the flexion range of motion of the hip joint. The gait characteristics of elderly people who fell easily included a slower walking speed, shorter stride, and longer stance time than other elderly. When the cutoff score was set at 45, the Berg Balance Scale was able to identify correctly those individuals who truly have experience of falling than when the cutoff score was set at 39. But when the cutoff score was set at 39, the scale's specificity identifying correctly those individuals who truly have not experience of falling was higher than at the cutoff score of 45. Therefore, the Berg Balance Scale is an appropriate screening method in a clinical setting for the early detection of elderly people at risk of falling. In conclusion, elderly people with a Berg Balance Scale score. below 45 are the most likely to fall owing to their decreased balance ability.

• 한국보건간호학회지
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• 제32권2호
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• pp.304-318
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• 2018

Purpose: This study examined the characteristic of the Injury Severity Score (ISS) of Korean geriatric patients with a traumatic injury in a nationally representative sample to determine the optimal cutoff of ISS of mortality according to age. Methods: The subjects were 3,018 non-elderly patients and 1,584 elderly patients with an ISS and Korean Triage and Acuity Scale (KTAS) in 2016 from the data of the Health Insurance Review and Assessment Service. The traumatic characteristics of the elderly and non-elderly were compared by stratifying the ISS. Receiver Operating Characteristic (ROC) curve analysis was used to find the optimal cutoff of ISS of mortality according to age. Results: The elderly were more prone to severe trauma than the non-elderly were. The distribution of KTAS grades was lower, even though the severity of ISS was as high as that of the non-elderly. The optimal cutoff score of the ISS for mortality in the ROC curve was lower in elderly over 65 years than in the other age group. Conclusion: The elderly are more prone to severe trauma and death than non-elderly, even though their ISS is low. Therefore, a strategy to prevent elderly from experiencing serious trauma and managing their geriatric trauma actively is needed.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제34권1호
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• pp.40-50
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• 2023

Objectives: This study examined the validity of the Childhood Autism Rating Scale, Second Edition (CARS-2) compared with the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) in identifying autism spectrum disorder (ASD). Methods: A total of 237 children were tested using both the CARS-2 and ADOS-2. We examined the correlation using Pearson's correlation analysis. In addition, we used a receiver operating characteristic graph to determine the optimal standard version of the CARS-2 (CARS2-ST) cutoff score for ASD diagnosis using the ADOS-2. Results: The concurrent validity of the CARS2-ST was demonstrated by a significant correlation with the ADOS-2 (r=0.864, p<0.001). The optimal CARS2-ST cutoff scores were 30 and 28.5 for identifying autism and autism spectrum, respectively, based on the ADOS-2. Conclusion: We suggest a newly derived CARS2-ST cutoff score of 28.5 for screening ASD and providing early intervention.

• 대한한방소아과학회지
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• 제38권2호
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• pp.1-10
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• 2024

Objectives This study aimed to assess the reliability and validity of the Five-Visceral Weak Children Questionnaire (FWCQ) in childhood anorexia and to propose optimal cutoff values. Methods We conducted two surveys, spaced one month apart, targeting the parents of 366 children aged 2-9 years who had been diagnosed with anorexia for at least one month. To evaluate the reliability of the FWCQ, we calculated Cronbach's alpha coefficient and employed the test-retest method. Additionally, correlation analysis was performed between the FWCQ and each visceral question, and discriminant validity was assessed by comparing responses from the anorexic and normal groups. Furthermore, we determined the cutoff value of the spleen weak score, which is closely associated with appetite, for the anorexic group. Results The first survey yielded responses from 336 participants, followed by 171 responses in the second survey conducted one month later. The FWCQ demonstrated high internal consistency (Cronbach's alpha = 0.776), and test-retest results were consistent. The correlation coefficients between the FWCQ and each visceral question were all statistically significant. Moreover, significant discriminant validity was observed between the anorexic and normal groups in the FWCQ score and the heart, spleen, and kidney weak scores. The optimal cutoff value for the spleen weak score in the anorexic group was found to be 5.5 points (with a sensitivity of 73.44% and specificity of 66.47%). Conclusions The FWCQ exhibited strong reliability and validity in children with anorexia.

• 기술발표회
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• 통권2006호
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• pp.279-291
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• 2006

This study shows decision-making process for selection of cutoff wall on a wastewater treatment project. There are 10 different cut-off wall methods So, we examine the site to gather information for find appropriate methods. After using that information, 10 cutoff wall methods are reviewed for analysis. Through brainstorming, four alternatives are selected for design VE item. Following the standard VE process, we established performance criteria and evaluated function score(F) using questionnaire. The questionnaires, brainstorming and AHP method for weighting on performance criteria and evaluate function score increased the reliability of this selection process. Water Jet method, one of four methods, has the best function score(F=92.71) and the lease construction cost(as cost index 1,000). The value score also highest as 92.7, so we select the method. The result is value innovation type In addition, the authors try to calculate the environmental burden in selection process using LCA. We cannot conduct the full LCA as defined ISO, so perform Simple LCA In LCA result, the cut-off grouting has the least environmental burden as index 9.09E+01 and Water Jet method has following as the second. To selection best method to specific area and purpose, design VE/LCG process used as useful tool and it is needed to develop integrated method that evaluate VEILCC and LCA as one-set process.

• 한국동물위생학회지
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• 제27권1호
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• pp.95-101
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• 2004

Babesia bovis rap-1 and B equi ema-1 intergenic(IG) nucleotides were analyzed and compared for identifying putative promoter sites using computer programs. The reason to initiate this research was to determine if IG nucleotides of Babesia genes that are predicted to be involved in erythrocyte invasion have functions regulating gene transcription and translation, which can be applied to functional gene knockout. Four IG sequences used included BbIG5(B bovis rap-1 5' IG), BblG3(B bovis rap-1 3' IG), BeIG5(B equi ema-1 5' IG) and BeIG3(B equi ema-1 3' IG). BbIG5 contained a putative promoter at nucleotide 197-246 with a predicted TATA-box and a transcription start site. BbIG3 had a putative promoter at nucleotide 270-320 with two predicted TATA-boxes and a transcription start site. BeIG3 had a putative promoter at nucleotide 155-205 with a predicted TATA-box and a transcription start site. Putative promoter sites in these three sequences mentioned above were identified with score cutoff 0.8, which means detection of about 40% recognized promoters with 0.1-0.4% false positives. In contrast, BeIG5 had a putative promoter at nucleotide 163-213 with score cutoff 0.8, but neither TATA-box nor transcription start site were recognized. However, BeIG5 had a putative promoter at nucleotide 388-438 with a predicted TATA-box and a transcription start site when score cutoff was decreased to 0.18, which means detection of about 70% recognized promoters with 2.2-5.3% false positives. These sequences with putative promoters can be tested if they have functions regulating gene transcription and translation.