• Journal of Life Science
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• v.31 no.7
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• pp.686-697
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• 2021

Propolis is a resinous substance produced by honeybees, which they use to protect their hives. Honeybees produce propolis by mixing exudates from the various trees and plants with saliva and beeswax. It has been used since around 300 B.C. as a folk medicine to cure wounds. Propolis contains many physiologically active components, such as flavonoids, phenolic compounds, and beeswax. Because of its functional components, propolis has a wide spectrum of biological applications. The compounds in propolis and its biological activity can vary according to the location of nectar source and extraction method. Propolis is most commonly known for its anti-microorganism activity against bacteria, viruses, and fungi. Artepillin C and caffeic acid phenethyl ester (CAPE) have been identified as regulatory compounds that reduce inflammation and exert immunosuppressive reactions on T lymphocytes. Through its anti-inflammatory activity, propolis exhibits anti-tumor activity, including the inhibition of cancer cell proliferation, the blocking of tumor signaling cascades, and antiangiogenesis. However, for the more apply of propolis its analysis of nectar source, identifying of propolis compound, the molecular mechanism of propolis and the investigation of compounds synergistic effects are essential. In this study, we described the physiological activity of propolis isolated from honeybees.

• Journal of Korean Theatre Studies Association
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• no.52
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• pp.359-397
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• 2014

This paper describes dramatherapy with a bulmina nervosa patient. She was in her early 20s and has been under the various psychotherapies for cure of deep depression since 2005. We had 24 sessions and 3 persons - the patient, the therapist, and the assist-therapist- participated in dramatherapy. I found there's a big collision between her important roles in the course of initial interview and diagnosis. Those roles are 'a good daughter of mom' and 'an independent adult'. Therefore I defined her bulmina nervosa as 'an symbolic behavior repeats compulsively the failure of separation from her mother.' And I set the general goals, the separation from her mother, the awareness and expression of negative emotions, and the diminuation of overeating and vomiting. To attain these object, we had many different dramatic experiences in dramatherapy. We made a self-portrait, the mask of bulmina nervosa, family sculpture, figure work, the past I and the present I, psychodramatic scene and several stories. In order to objective assessment, I used behavioral observation and 6PSM(6 Pieces Story Making) analysis. First of all the most noticeable change was a rapid decrease in over-eating and vomiting. Before the dramatherapy she had overeaten 30 times per week. At the closure it has fallen off to 1 time per week. Another behavioral changes were shift of outward appearance, not going church, working for living, and having a date with only one. She made 3 stories on 1th session, 13th session, and 23th session. And I comparatively analysed those stories with both qualitative and quantitative method. For qualitative analysis, I classified 5 structures according to the substantial similrarity. On protagonist structure, there's no difference. Three protagonists are dead things. The type of task structure is changed from an escape, a traveling, to metamorphosis. The type of obstruction structure is changed from the protagonist to an outside object. The type of closure structure is changed from an exaggerated happy ending, sad ending to probable happy ending. To quantitify the aspects of transformation, I developed an assesment tool using likert scale. It is composed of 4 sub-categories-reality testing, imagination, ego-strength, optimism problem-solving. In reality testing category, a shift of score was 9-11-15, imagination 2-5-5, ego strength 3-2-2, optimism 6-3-7, and total score 20-21-29. This change of score reflects the growth of problem solving capacity. Viewed in this light, dramatherapy with this girl was successful on the whole. The thing had significant effect on it was psycho-dynamic approach focused on separation from her mother and defence mechanism to avoid negative emotion. And assessment method used in this case will be full of suggestions to researches to come.

• Journal of the Korean Applied Science and Technology
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• v.35 no.4
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• pp.1413-1420
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• 2018

This study was conducted to provide the information for the promotion of oral health in nursing students. The subjects were 207 in female students for self-administered questionnaires. The percentage of subject to visit dental clinic was 64.3%, to Regular checkup was 25.9%, cure of caries was 23.5% for last one year. The percentage of reasons not treated 'less importance' were 12.6%, 'fear of the dental clinic' was 10.6%. The average number of brushing teeth were 3.1. 56.0% students brush their teeth for two ~ three minutes. But intention of visit to the dentist were 'only when treated' was 51.7%, 'only when there is pain' was 10.1%. The intention of oral education was 54.6%, the content of the desired education 'whitening' were 34.5%, 'prevention of bad breath' was 19.2%. Dental health information acquisition path 'internet' were 42.0%, 'family or friends' was 25.6%. Susceptibility was 2.47 points, severity was 2.00 points, benefit was 4.03 points in oral health belief. Compared to students who needed dental treatment but did not receive treatment, oral health beliefs were higher among those who were treated(p<.001), students with cavities showed a higher level of oral health belief than those without cavities(p<.001). There was significant corelation between 'number of caries' and susceptibility(r=.330, p=.002), severity(r=.25, p=.019). The result should be reflected in the development of effective program for nursing students' oral health care.

• Journal of Dental Rehabilitation and Applied Science
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• v.34 no.4
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• pp.290-296
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• 2018

Purpose: The aim of this study was to evaluate the polymerization ability of resin-based materials used for teeth splinting according to the thickness of cure. Materials and Methods: For this study, the Light-Fix and G-FIX developed for resinous splinting materials and the G-aenial Universal Flo, the high-flowable composite resin available as restorative and splinting material, were used. Ten specimens of the thickness of 2, 3, 4 and 5 mm and 5 mm in diameter for each composite resin (total 120) were prepared. The microhardness of top and bottom surfaces for each specimen was measured by the Vickers hardness testing machine. The polymerization ability of the composite resin for each thickness was statistically analyzed using independent T-test at a 0.05 level of significance. Results: There was no difference of polymerization ability regardless of the thickness in the Light-Fix and G-FIX. The G-aenial Universal Flo showed significantly low polymerization ability from the thickness of the 3 mm (P < 0.05). Conclusion: The Light-Fix and G-FIX, which are resin-based materials used for teeth splinting, are expected to be suitable for light curing up to 5 mm in thickness.

• Journal of Oriental Neuropsychiatry
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• v.29 no.4
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• pp.267-280
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• 2018

Objectives: The objective of this study was to provide clinical evidence to support the use of a herbal medicine (Cheonwangbosim-Dan/Tianwangbuxin-Pellet (TWBXP)) for insomnia. Methods: Randomized controlled trials that verified effects of Herbal Medicine (Cheonwangbosim-Dan, Tianwangbuxin-Pellet) treating primary insomnia were carried out. A literature search of English, Chinese, Korean databases was also performed. The selected literature were assessed by Risk of Bias (RoB). Results: The total number of selected trials was 13 RCTs. Among the 13 RCTs, 10 were meta-analyzed. The Chinese Classification of Mental Disorders-3 (CCMD-3) was frequently used as the diagnostic criteria for interventions during the analysis of the use of herbal medicine (Cheonwangbosim-Dan/Tianwangbuxin-Pellet) for management of primary insomnia. As for outcome measurement, the effective rate was used. From the Meta-analysis of the studies, it was established that the insomnia cure effective rate in the TWBXP group was higher than that in the Western Medicine (WM) group (RR: 1.15, 95% CI: 1.07 to 1.24, p<0.0001, $I^2=33%$). Also, the effective rate in the TWBXP+ACU group was significantly different compared to the WM group (RR: 1.32, 95% CI: 1.13 to 1.54, p=0.0004, $I^2=0%$). The quality of the selected RCTs was low. Conclusions: Herbal medicine (Cheonwangbosim-Dan/Tianwangbuxin-Pellet) is effective for treating primary insomnia. It is worth noting that this studies were of relatively poor quality. The sample sizes were also small. Therefore, further investigations into the diagnosis and treatment of insomnia are warranted.

• KEPCO Journal on Electric Power and Energy
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• v.5 no.1
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• pp.25-32
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• 2019

K-BEMS System was introduced to reduce peak load and to save total energy of the 200 buildings that KEPCO headquarter and branch offices use. And K-BEMS system is composed of PV, battery, and hybrid PCS. KEPCO research institute has carried out this K-BEMS research project for 3 years since January 2016. In this paper, the results of the project are shown. 9 modes of test results of K-BEMS system and are operational problems were analyzed. And measures to cure the trouble are also suggested. Batteries are operated more than 20% of SOC, and less than 20% of SOC battery protection switches are automatically shutting down the system and the system no longer respond to EMS, ending the supply of PV, and so therefore to continue the PV power supply it was turn out to be necessary that the EMS should automatically change its policy to change PV only supply mode automatically when the Battery Switch automatically operated. To operate the system continuously and automatically, it is necessary to modify the minimum operational SOC value, and in addition to that the EMS computer must remember the last shut-down SOC and Voltage which interrupted the system and add some margin to reflect the measurement error in the system.

• Journal of Food Hygiene and Safety
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• v.35 no.6
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• pp.567-573
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• 2020

The persimmon is commonly cultivated in temperate regions of the world, including China, Korea, Japan, Brazil, Turkey, and Italy. In some Asian cultures, consumers are aware of the health claims related to the persimmon and its functional ingredients. The rich phytochemistry of the persimmon has opened new avenues of research on diet-based regimens designed to cure various ailments. This study was conducted to identify the genotoxicity of immature green persimmon (Diospyros kaki THUNB.) extract (DKA). The bacterial reverse mutation assay, the chromosomal aberration assay, and the mammalian micronucleus test were performed to determine the DKA genotoxicity. The result of the bacterial reverse mutation assay revealed that the DKA did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA with or without metabolic activation of S9 mixture. The oral administration of DKA also caused no significant increase in the number of micronucleated polychromatic erythrocytes or in the mean ratio of polychromatic to total erythrocytes. In addition, DKA did not cause a significant chromosome aberration on CHL cells in the presence or absence of S9 activation. In conclusion, DKA could be considered as a reliable and safe functional food since no toxicity was found under the condition of this study.

• Journal of Microbiology and Biotechnology
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• v.32 no.4
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• pp.405-418
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• 2022

Simotang oral liquid (SMT) is a traditional Chinese medicine (TCM) consisting of four natural plants and is used to alleviate gastrointestinal side effects after chemotherapy and functional dyspepsia (FD). However, the mechanism by which SMT helps cure these gastrointestinal diseases is still unknown. Here, we discovered that SMT could alleviate gastrointestinal side effects after chemotherapy by altering gut microbiota. C57BL/6J mice were treated with cisplatin (DDP) and SMT, and biological samples were collected. Pathological changes in the small intestine were observed, and the intestinal injury score was assessed. The expression levels of the inflammatory factors IL-1β and IL-6 and the adhesive factors Occludin and ZO-1 in mouse blood or small intestine tissue were also detected. Moreover, the gut microbiota was analyzed by high-throughput sequencing of 16S rRNA amplicons. SMT was found to effectively reduce gastrointestinal mucositis after DDP injection, which lowered inflammation and tightened the intestinal epithelial cells. Gut microbiota analysis showed that the abundance of the anti-inflammatory microbiota was downregulated and that the inflammatory microbiota was upregulated in DDP-treated mice. SMT upregulated anti-inflammatory and anticancer microbiota abundance, while the inflammatory microbiota was downregulated. An antibiotic cocktail (ABX) was also used to delete mice gut microbiota to test the importance of gut microbiota, and we found that SMT could not alleviate gastrointestinal mucositis after DDP injection, showing that gut microbiota might be an important mediator of SMT treatment. Our study provides evidence that SMT might moderate gastrointestinal mucositis after chemotherapy by altering gut microbiota.

• Korean Journal of Culture and Social Issue
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• v.27 no.1
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• pp.19-34
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• 2021

Many survivors of sexual violence disclose their experience to others. When they receive negative social reactions, this can be a traumatic event for the survivor where their trust towards others is violated and can cause posttraumatic cognitions and depression. Likewise, institutional betrayal, or negative reactions from trusted institutions regarding the disclosure of sexual victimization can be a traumatic event for the survivor and is associated with depression as well. However, studies investigating the mechanism underlying the relationship between institutional betrayal and depression is yet limited. Therefore, based on cognitive behavioral theory (CBT), which is known as the most effective approach to date for understanding and treating posttraumatic symptoms, this study examined if posttraumatic cognitions mediate the relationship between institutional betrayal and depression. Questionnaires were administered to 462 women who had experienced institutional betrayal to their sexual victimization. Results showed that institutional betrayal had an effect on depression only through negative cognitions about the self and world. This suggests the importance of identifying and treating trauma-related cognitions in order to prevent or cure depression of those who had experienced institutional betrayal to their sexual victimization. Limitations and implications of this study are also discussed.

• Journal of Korea Entertainment Industry Association
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• v.14 no.2
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• pp.119-129
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• 2020

Intellectual disability affects all spheres of the lives of people can be who suffer from it. Unfortunately, modern medicine cannot cure intellectual disability. However, the quality of life improved by means of physical exercise. In this study, we compared the health-related physical fitness, metabolic syndrome index and mental health between a game biking group(5 participants) and a brisk walking group(4 participants). This study used a between-subject design and verified by non-parametric test. The participants performed an exercise program with warm up and resistance training for 12 weeks. A game bike was used for the physically impaired, where the individual looked at a screen and pedaled. The fasters he pedaled the faster the object on the screen movies. We measured health-related physical fitness, metabolic syndrome index and mental health. We also measured their perceived exertion and interest during the exercise by a visual analog scale. The results before and after the exercise program showed that health-related physical fitness, metabolic risk factors, mental health level were improved in both groups. As we hypothesized before the study, the game biking group showed a statistically significantly different level on the Rating of Perceived Exertion than the brisk walking group and a higher level on the Rating of Exercise Interest during the exercise program. Our results lead to a conclusion that an exercise program with the use of a game bike improve motivation for exercise participation in intellectually handicapped participants.