• Childhood Kidney Diseases
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• 제20권2호
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• pp.45-49
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• 2016

Purpose: This study was performed to evaluate the effects of cyclosporine-A (CsA) on linear growth in pediatric patients with steroid-dependent (SDNS) or resistant nephrotic syndrome (SRNS). Methods: Thirty-five pediatric patients with SDNS or SRNS undergoing glucocorticoid (GC) and/or CsA treatment were retrospectively reviewed. Seventeen patients were treated with GC alone and 18 were treated with GC and CsA. The cumulative doses of GC and CsA were quantified (mg/kg/day). Linear growth during the follow-up period was defined as the difference in Z-score between the initial and final height according to the follow-up period (${\Delta}$ height Z score/year). The associations between linear growth and clinical parameters were analyzed. Results: The linear growth of patients in the two groups was not significantly different (P=0.262). The ${\Delta}$ height Z score/year did not show a significant correlation with the cumulative doses of CsA, but was negatively correlated with the cumulative dose of GC and positively correlated with the Z score for height at the time of diagnosis. Conclusion: In children with SDNS or SRNS undergoing GC therapy, added CsA treatment may not have harmful effects on linear growth.

• Journal of Korean Medical Science
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• 제33권50호
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• pp.318.1-318.10
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• 2018

Background: In this prospective cohort study, we investigated the association between fatty acid ethyl esters (FAEEs) in meconium as biomarkers of prenatal ethanol exposure and growth deficits, as birth outcomes, that constitute several of the key cardinal features of fetal alcohol syndrome. Methods: A total of 157 meconium samples were collected from enrolled infants within 24 hours of birth, and nine FAEEs were quantified using liquid chromatography/tandem mass spectrometry. The relationships between cumulative concentrations of nine species of FAEEs in meconium and birth parameters of growth (age-sex-specific centiles of head circumference [HC], weight, and length) and respective and combined birth outcomes of growth deficits (HC ${\leq}10th$ centile, weight ${\leq}10th$ centile, and length ${\leq}10th$ centile) were determined. Results: Multivariate logistic regression analysis demonstrated that higher cumulative concentrations of meconium FAEEs correlated with elevated risks for HC and length, both, 10th percentile or less (adjusted odds ratio [aOR], 2.94; 95% confidence interval [CI], 1.12-7.74; P = 0.029) and HC and weight and length, all of them, 10th percentile or less (aOR, 3.27; 95% CI, 1.12-9.59; P = 0.031). Conclusion: The elevated cumulative FAEEs in meconium were associated with combined growth deficits at birth, specifically HC and length, both, 10th percentile or less, which might be correlated with detrimental alcohol effects on fetal brain and bone development, suggesting a plausible alcohol-specific pattern of intrauterine growth restriction.

• 한국정보처리학회논문지
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• 제6권1호
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• pp.90-95
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• 1999

소프트웨어 시스템이 양도된 이후에 시스템의 크기가 성장하는 과정을 나타내는 수학적 모델인 소프트웨어 성장 모델은 시스템의 크기와 계획된 크기를 달성하기 위해 요구되는 노력을 예측하는데 사용될 수 있다. 본 논문은 먼저 시스템의 크기 변화량이 추가되는 노력에 비례하고 시스템의 복잡도에 반비례한다는 가정하에서 소프트웨어 성장 모델을 유도한다. 이 모델에서는 시스템의 복잡도가 중요한 역할을 하는데, 본 논문에서는 시스템 크기의 멱함수 형태인 복잡도를 제안하고 실제 자료에 적용하여, 그 유용성을 보인다. 멱함수 형태의 시스템 복잡도는 추가로 복잡도 비교할 수 있게 하는 측도를 제공하는데, 이 측도는 시스템 크기에 무관하므로 크기가 다른 소프트웨어 시스템의 복잡도를 비교하는데 유용하게 사용될 수 있다.

• 센서학회지
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• 제31권3호
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• pp.180-186
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• 2022

Photosynthetically active radiation flux density (PPFD) and daily light integral (DLI) values related to plant photosynthesis were obtained using the sunlight time and insolation data points in the agricultural weather sensor data for Jinan-gun, Jeollabuk-do, Korea from 2016 to 2020. The objective was to optimize the photo-environmental conditions for cultivating ginseng. The range of average monthly sunshine duration was 395.5-664.1 min, with the longest duration observed in June. The range of average annual accumulated daily insolation was 11.98-17.65 MJ·m^-2. The range of average daily external DLI calculated from the insolation and solar time data was 22.3-36.1 mol·m^-2·d^-1, and the annual cumulative DLI was 8,156-13,175 mol·m^-2·d^-1. Both the insolation and DLI values were the highest in 2016 and lowest in 2020. Based on the PPFD required for ginseng growth (111-185 µmol·m^-2·s^-1), the monthly average daily DLI and monthly cumulative DLI were 3.51-5.87 and 82-228 mol·m^-2·d^-1, respectively. The range of five-year average value for the external monthly cumulative DLI was 298-1,459 mol·m^-2·d^-1, and the monthly cumulative DLI values when a black double shading film and blue-white shading film were applied were 101-496 and 36-175 mol·m^-2·d^-1, respectively. A comparative analysis of DLI values indicated that shading was required to ginseng growth throughout the year under natural light. When the black double shading film was used, shading was required from March to October. When the blue-white shading film was applied from April to August, (i.e., the period with active ginseng growth) the appropriate DLI for ginseng growth could be continuously maintained. Regional weather differences due to climate change are gradually increasing, and even in one region, monthly and cumulative DLI values are different every year. Therefore, in order to implement a precise agricultural environment for ginseng cultivation, precise analysis and continuous research using agricultural weather sensor big data is required.

• Food Science and Biotechnology
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• 제16권6호
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• pp.1046-1050
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• 2007

To investigate the growth promoting effects of an herbal medicine formulation (HM-10), Sprague Dawley (SD) male rats (3 weeks old) were divided into 3 groups (8 rats/group). The control group was given a daily oral administration of saline, and the treatment groups, HM-1 and HM-2, were given daily administrations of HM-10 (500 and 1,000 mg/kg BW, respectively). The cumulative tibial bone growth of the HM-1 and HM-2 groups (22.5 and 20.8 mm, respectively), and their cumulative femur bone growth (19.4 and 18.2 mm, respectively), were significantly different compared to the control group (7.5 mm of tibial growth and 7.7 mm of femur growth) (p<0.05). Lastly, the growth hormone levels of the HM-1 and HM-2 groups (1.70 and 1.79 ng/mL, respectively), as well as their insulin like growth factor 1 (IGF-1) levels (165.1 and 171.7 ng/mL, respectively) showed significant differences compared to the control (0.93 ng/mL of growth hormone and 125.6 ng/mL of IGF-1) (p<0.05).

• Asian-Australasian Journal of Animal Sciences
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• 제14권8호
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• pp.1110-1117
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• 2001

Responses of the rumen fungus, Neocallimastix frontalis RE1, to long chain fatty acid (LCFA) were evaluated by measuring gas production, filter paper (FP) cellulose digestion and polysaccharidase enzyme activities. LCFA (stearic acid, $C_{18:0}$; oleic acid, $C_{18:1}$; linoleic acid, $C_{18:2}$ and linolenic acid, $C_{18:3}$) were emulsitied by ultrasonication under anaerobic condition, and added to the medium. When N frontalis RE1 was grown in culture with stearic, oleic and linoleic acid, the cumulative gas production, gas pool size, FP cellulose digestion and enzymes activities significantly (p<0.05) increased at some incubation times(especially, exponential phases of fungal growth, 48~120 h of incubation) relative to that for control cultures. However, the addition of linolenic acid strongly inhibited all of the investigated parameters up to 120 h incubation, but not after 168 and 216 h of incubation. These results indicated that stearic, oleic and linoleic acids tended to have great stimulatory effects on fungal cellulolysis, whereas linolenic acid caused a significant (p<0.05) inhibitory effects on the cellulolysis by the rumen fungus. These results are the first report of the effect of LCFAs on the ruminal fungi. Further research is needed to identify the mode of action of LCFAs on fungal strains and to verify whether or not ruminal fungi have ability to hydrate unsaturated LCFAs to saturated FAs. There was high correlation between cumulative in vitro gas production and fungal growth (94.78%), FP cellulose degradation (96.34%), CMCase activity(90.86%) or xylanase activity (87.67%). Thus measuring of cumulative gas production could be a useful tool for evaluating fungal growth and/or enzyme production by ruminal fungi.

• 한국해양공학회지
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• 제9권2호
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• pp.98-111
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• 1995

High temperature low cycle fatigue shows that cycle-dependent crack growth owing to cyclic plastic deformation occurred simultaneosly with time-dependent crack growth owing to intergranular deformation. Consequently, to estimate crack growth rate uniquely, many to investigators have proposed various kinds of parameters and theories but these could not produce satisfactory results. Therefore the goal of this study is focused on prediction of crack growth rate using predominant damage rule, linear cumulative damage rule and transitional parameter ${\Delta}J_c/{\Delta}J_f$. On the basis of these sinusoidal loading waveform at 600$^{\circ}C$ and 700$^{\circ}C$.

• 품질경영학회지
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• 제50권3호
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• pp.349-371
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• 2022

Purpose: Compared to the rapid growth rate of the domestic automotive LED industry so far, the predictive analysis method for demand forecasting or market outlook was insufficient. Accordingly, product characteristics are analyzed through the life trend of LEDs for automotive exterior lamps and the relative strengths of p and q using the Bass model. Also, future demands are predicted. Methods: We used sales data of a leading company in domestic market of automotive LEDs. Considering the autocorrelation error term of this data, parameters m, p, and q were estimated through the modified estimation method of OLS and the NLS(Nonlinear Least Squares) method, and the optimal method was selected by comparing prediction error performance such as RMSE. Future annual demands and cumulative demands were predicted through the growth curve obtained from Bass-NLS model. In addition, various nonlinear growth curve models were applied to the data to compare the Bass-NLS model with potential market demand, and an optimal model was derived. Results: From the analysis, the parameter estimation results by Bass-NLS obtained m=1338.13, p=0.0026, q=0.3003. If the current trend continues, domestic automotive LED market is predicted to reach its maximum peak in 2021 and the maximum demand is $102.23M. Potential market demand was $1338.13M. In the nonlinear growth curve model analysis, the Gompertz model was selected as the optimal model, and the potential market size was $2864.018M. Conclusion: It is expected that the Bass-NLS method will be applied to LED sales data for automotive to find out the characteristics of the relative strength of q/p of products and to be used to predict current demand and future cumulative demand.

• KSBB Journal
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• 제14권5호
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• pp.543-549
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• 1999

본 연구에서는 미생물의 성장시 수반하는 대사열을 측정할 수 있는 직접 열량계의 기능을 가질 수 있도록 발효조를 개량하였다. 발효조의 온도제어신호의 길이를 측정하고 이 신호를 컴퓨터에서 전달하여 계산하고 발효조에 공급된 누적 열량을 측정할 수 있도록 발효조를 일부 개조하고 온라인 측정 시스템을 구성하였다. 균체 없이 발효조를 운전하면서 여러 조건에서 누적 열량을 측정하여 통기량의 따라 30.9kJ/vvm의 열손실과 공기중으로 전도 및 대류, 복사에 의한 0.5 kJ/L/hr/$^{\circ}C$의 열손실이 발생함을 측정할 수 있었다. 그리고 소형의 가열체를 반응액에 발생함을 측정할 수 있었다. 그리고 소형의 가열체를 반응액에 투입하여 열량측정의 정확도를 확인하였으며 누적열량은 $\pm$0.2%의 오차 범위 내에서 측정되었다. 본 시스템에소 효모와 대장균을 이용하여 대사열량을 성공적으로 측정할 수 있음을 보였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3229-3232
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• 2012

In this study, cancer incidence data were assessed to provide various rates of five year age groups for a given year, lying between two census years. The individual exponential growth rate method is most useful in both population-based and non-population cased cancer registries in India to estimate the population by five yearly age groups and also find the rates of crude rates, age standard rates and cumulative rates. This method has been shown to endure from bias and often results sacrificing the overall growth rate and correction factor must be needful in five year age group population to maintain it. A second method, the difference distribution method is also able to maintain the overall growth rate and overcome the bias in estimation of five yearly age group populations. From this point of view these methods serving a new technique for population estimation by five yearly age groups for inter census years.