• BMB Reports
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• v.52 no.12
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• pp.679-688
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• 2019

The decrease of metabolism in the brain has been observed as the important lesions of Alzheimer's disease (AD) from the early stages of diagnosis. The cumulative evidence has reported that the failure of mitochondria, an organelle involved in diverse biological processes as well as energy production, maybe the cause or effect of the pathogenesis of AD. Both amyloid and tau pathologies have an impact upon mitochondria through physical interaction or indirect signaling pathways, resulting in the disruption of mitochondrial function and dynamics which can trigger AD. In addition, mitochondria are involved in different biological processes depending on the specific functions of each cell type in the brain. Thus, it is necessary to understand mitochondrial dysfunction as part of the pathological phenotypes of AD according to each cell type. In this review, we summarize that 1) the effects of AD pathology inducing mitochondrial dysfunction and 2) the contribution of mitochondrial dysfunction in each cell type to AD pathogenesis.

• Journal of Communications and Networks
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• v.18 no.1
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• pp.19-26
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• 2016

In this paper, the performance of dual-hop multi-relay maximum ratio transmission (MRT) over Rayleigh flat fading channels is studied with both conventional (all relays participate the transmission) and opportunistic (best relay is selected to maximize the received signal-to-noise ratio (SNR)) relaying. Performance analysis starts with the derivation of the probability density function, cumulative distribution function and moment generating function of the SNR. Then, both approximate and asymptotic expressions of symbol error rate (SER) and outage probability are derived for arbitrary numbers of antennas and relays. With the help of asymptotic SER and outage probability, diversity and array gains are obtained. In addition, impact of imperfect channel estimations is investigated and optimum power allocation factors for source and relay are calculated. Our analytical findings are validated by numerical examples which indicate that multi-relay MRT can be a low complexity and reliable option in cooperative networks.

• Journal of Korean Institute of Industrial Engineers
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• v.35 no.4
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• pp.248-256
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• 2009

In this paper, under saturated traffic condition in a single-hop wireless sensor network, we present an analytic model that evaluates the performance of asynchronous MAC protocol which uses a preamble technique. Our model considers the impact of several important factors such as sleep cycle, the backoff mechanism and the number of contending nodes. After obtaining the cumulative backoff time of a sending node and expected delay of a receiving node, an iterative algorithm is presented for calculating the performance measures such as expected energy consumption usage per packet and latency. Simulation results show that the proposed analytic model can accurately estimate the performance measures under saturated traffic conditions.

• Korean Journal of Metals and Materials
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• v.48 no.6
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• pp.489-497
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• 2010

The remaining life estimation of the level luffing crane component, which has operated for about 20 years is examined carefully, especially on the crane structures. To analyse the crane sructures, the basic load and load combination needed to be considered. We modeled various parts of the level luffing crane to analyse fatigue. Fatigue analysis results showed that the level luffing crane is in the fatigue life so that the crane is in the safe state in fatigue cumulative damage. Analysis results show that the remaining life of a jib upper beam would be about 10 years therefore, the level luffing crane should be stable for fatigue for that period.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.16 no.12
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• pp.1227-1233
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• 2004

Air handling unit (AHU)'s air filter pressure difference is important for energy consumption and indoor air quality. Both energy Performance data and air filter differential pressure of AHU in real office buildings were monitored and analyzed to investigate quantitatively energy impact as dust buildup level on air filter grows. We also modeled and simulated CAV system using HVACSIM＋ program to examine the energy effect of dust buildup on filters. Through analysis of time series pressure drop data, the filter pressure difference rate has been increased due to cumulative supply air flow rate increase. As filter pressure drop increased to 1 inch water column, it is found that the supply air flow rate was decreased by 10%, the chilled water flow rate was increased by 5.9% and the pump energy consumption was increased to 5.9%.

• Nuclear Engineering and Technology
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• v.53 no.9
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• pp.3068-3084
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• 2021

Investigations of large commercial aircraft impact effect on nuclear power plant (NPP) buildings have been drawing extensive attentions, particularly after the 9/11 event, and this paper aims to experimentally assess the damage and vibrations of NPP buildings subjected to aircraft crash. In present Part I, two shots of reduce-scaled model test of aircraft impacting on NPP building were carried out. Firstly, the 1:15 aircraft model (weighs 135 kg) and RC NPP model (weighs about 70 t) are designed and prepared. Then, based on the large rocket sled loading test platform, the aircraft models were accelerated to impact perpendicularly on the two sides of NPP model, i.e., containment and auxiliary buildings, with a velocity of about 170 m/s. The strain-time histories of rebars within the impact area and acceleration-time histories of each floor of NPP model are derived from the pre-arranged twenty-one strain gauges and twenty tri-axial accelerometers, and the whole impact processes were recorded by three high-speed cameras. The local penetration and perforation failure modes occurred respectively in the collision scenarios of containment and auxiliary buildings, and some suggestions for the NPP design are given. The maximum acceleration in the 1:15 scaled tests is 1785.73 g, and thus the corresponding maximum resultant acceleration in a prototype impact might be about 119 g, which poses a potential threat to the nuclear equipment. Furthermore, it was found that the nonlinear decrease of vibrations along the height was well reflected by the variations of both the maximum resultant vibrations and Cumulative Absolute Velocity (CAV). The present experimental work on the damage and dynamic responses of NPP structure under aircraft impact is firstly presented, which could provide a benchmark basis for further safety assessments of prototype NPP structure as well as inner systems and components against aircraft crash.

• The Journal of Advanced Prosthodontics
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• v.6 no.5
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• pp.325-332
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• 2014

PURPOSE. The aim of this review was to analyze the evaluation criteria on mandibular implant overdentures through a systematic review and suggest standardized evaluation criteria. MATERIALS AND METHODS. A systematic literature search was conducted by PubMed search strategy and hand-searching of relevant journals from included studies considering inclusion and exclusion criteria. Randomized clinical trials (RCT) and clinical trial studies comparing attachment systems on mandibular implant overdentures until December, 2011 were selected. Twenty nine studies were finally selected and the data about evaluation methods were collected. RESULTS. Evaluation criteria could be classified into 4 groups (implant survival, peri-implant tissue evaluation, prosthetic evaluation, and patient satisfaction). Among 29 studies, 21 studies presented implant survival rate, while any studies reporting implant failure did not present cumulative implant survival rate. Seventeen studies evaluating peri-implant tissue status presented following items as evaluation criteria; marginal bone level (14), plaque Index (13), probing depth (8), bleeding index (8), attachment gingiva level (8), gingival index (6), amount of keratinized gingiva (1). Eighteen studies evaluating prosthetic maintenance and complication also presented following items as evaluation criteria; loose matrix (17), female detachment (15), denture fracture (15), denture relining (14), abutment fracture (14), abutment screw loosening (11), and occlusal adjustment (9). Atypical questionnaire (9), Visual analog scales (VAS) (4), and Oral Health Impact Profile (OHIP) (1) were used as the format of criteria to evaluate patients satisfaction in 14 studies. CONCLUSION. For evaluation of implant overdenture, it is necessary to include cumulative survival rate for implant evaluation. It is suggested that peri-implant tissue evaluation criteria include marginal bone level, plaque index, bleeding index, probing depth, and attached gingiva level. It is also suggested that prosthetic evaluation criteria include loose matrix, female detachment, denture fracture, denture relining, abutment fracture, abutment screw loosening, and occlusal adjustment. Finally standardized criteria like OHIP-EDENT or VAS are required for patient satisfaction.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.145-145
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• 2018

Small islands rely heavily on groundwater resources in addition to rainwater as the source of freshwater since surface water bodies are often absent. The groundwater resources are vulnerable to sea level rise, coastal flooding, saltwater intrusion, irregular pattern of precipitation resulting in long droughts and flash floods. Increase in population increases the demand for the limited groundwater resources, thus aggravating the problem. In this study, the effects of climate change on Tongatapu Island, Kingdom of Tonga, a small island in Pacific Ocean, are investigated using a sharp interface transient groundwater flow model. Twenty nine downscaled General Circulation Model(GCM) predictions are input to a water balance model to estimate the groundwater recharge. The temporal variation in recharge is predicted over the period of 2010 to 2099. A set of GCM models are selected to represent the ensemble of 29 models based on cumulative recharge at the end of the century. This set of GCM model predictions are then used to simulate a total of six climate scenarios, three each (2010-2039, 2040-2069, and 2070-2099) under RCP 4.5 and RCP 8.5. The impacts of predicted climate change on groundwater resources is evaluated in terms of freshwater volume changes and saltwater ratios in pumping wells compared to present conditions. Though the cumulative recharge at the end of the century indicates a wetter climate compared to the present conditions the large variability in rainfall pattern results in frequent periods of groundwater drought leading to saltwater intrusion in pumping wells. Thus for sustaining the limited groundwater resources in small islands, implementation of timely assessment and management practices are of utmost importance.

• Composites Research
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• v.35 no.2
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• pp.61-68
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• 2022

Composite materials have been used in aerospace industry and many applications because of many advantages such as specific strength and stiffness and corrosion resistance etc. However, it is vulnerable to impacts, these impact lead to formation of cracks in composite laminate and failure of structures. In this paper, we analyzed Mode I fracture toughness of Carbon/Epoxy laminates using acoustic emission signal. DCB test was carried out to analyze Mode I failure characterization of Carbon/Epoxy laminates, and AE sensor was attached to measure AE signal induced by failure of specimen. Fracture toughness was calculated using cumulative AE energy and measured crack length using camera. The calculated fracture toughness was applied in FE model and the result of FE analysis compared with DCB test results. The results show good agreement with between FEM and DCB test results.

• Advances in Computational Design
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• v.8 no.1
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• pp.13-36
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• 2023

The Puebla-Morelos Earthquake (Mw 7.1) occurred in Mexico in 2017 causing 44 buildings to collapse in Mexico City. This work evaluates the non-linear response of a 6-story reinforced concrete (RC) frame prototype model with masonry infill walls on upper floors. The prototype model was designed using provisions prescribed before 1985 and was subjected to seismic excitations recorded during the earthquakes of 1985 and 2017 in different places in Mexico City. The building response was assessed through a damage index (DI) that considers low-cycle fatigue of the steel reinforcement in columns of the first floor, where the steel was modeled including buckling as was observed in cases after the 2017 earthquake. Isocurves were generated with 72 seismic records in Mexico City representing the level of iso-demand on the structure. These isocurves were compared with the location of 16 collapsed (first-floor column failure) building cases consistent with the prototype model. The isocurves for a value greater than 1 demarcate the location where fatigue failure was expected, which is consistent with the location of 2 of the 16 cases studied. However, a slight increase in axial load (5%) or decrease in column cross-section (5%) had a significant detrimental effect on the cumulated damage, increasing the intensity of the isocurves and achieving congruence with 9 of the 16 cases, and having the other 7 cases less than 2 km away. Including column special detailing (tight stirrup spacing and confined concrete) was the variable with the greatest impact to control the cumulated damage, which was consistent with the absence of severe damage in buildings built in the 70s and 80s.