• 약학회지
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• 제9권1_2호
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• pp.8-13
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• 1965

The sensitivity on microorganisms of ten sulfa-drugs and their Cu-complexes was observed. Ericsson's disc method and modified tube dilution method were applied. Dimethylformamide was used for solvent of sulfa drugs. In general, original sulfa-drugs showed more sensitive patterns than its Cu-complexes except sulfadimethoxine-Cu complex which showed more sensitive patterns than its original drug with disc method.

• Bulletin of the Korean Chemical Society
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• 제28권2호
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• pp.263-270
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• 2007

New mono- and bis-Cu(II)-triazacyclononane(tacn) complex that conjugated with 9-aminoacridine were synthesized, and their binding modes and DNA cleavage activity were investigated in this study. When the classic intercalator, 9-aminoacridine, was conjugated to mono- and bis-Cu(II)-tacn complexes, a significant red-shift and hypochromism in absorption spectrum was apparent in the acridine absorption region upon binding to DNA. Furthermore, the magnitude of the negative reduced linear dichroism signal in the substrate absorption region appeared to be larger than that in the DNA absorption region. These spectral observations indicated that the acridine moiety intercalated when the Cu(II)-tacn complex was conjugated. In contrast, from a close analysis of the circular and linear dichroism spectrum, the aminoacridine-free bis-Cu(II)-tacn complex was concluded to bind at the phosphate groups of DNA. The 9-aminoacridine-free-bis-Cu(II)-tacn complex produces the nicked and linear DNA. On the other hand, 9-aminoacridine conjugated mono-and bis-Cu(II)-tacn complexes showed unspecific binding with negligible DNA cleavage.

• 한국토양비료학회지
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• 제19권4호
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• pp.307-314
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• 1986

Sewage Sludge 를 시용하지 않은 토양(W), 6년간 시용한 토양($WS_6$), Sludge와 토양의 혼합물을 1주일동안 incubation한 토양($WS_1$), 그리고 Sewage Sludge(SS)로 부터 추출한 수용성 유기물(WSOF)이 구리(II) 이온과 어떻게 착화합물을 형성하는지를 전자스핀공명분광법(ESR)과 전위차적정법을 이용하여 규명하였다. Cu(II)-WSOF 착화합물은 ESR spectra 상에서 $g_{\perp}$ 값보다 큰 $g_{\amalg}$ 값을 가짐으로서 늘어난 팔면체(elongated octahedron) 배위결합을 하고 있음을 나타내었다. $77^{\circ}K$에서 Cu(II)-SS착물은 anisotropic ESR spectrum을 보인 반면 Cu(II)-W착물은 anisotropic spectrum을 나타내었다. 이러한 결과는 결국 W의 산소공여 리간드가 Cu(II)와 강한 착화합물을 이루는 반면에 SS의 리간드는 Cu(II)와 거의 Chelate를 이루지 않고 있음을 의미한다. 또한 Cu(II)-SS 착화합물의 ESR spectra는 평면상의 네개의 모서리 리간드(예, $COO^-$, $H_2O$, $Cl^-$ 등등)의 각각이 한자리 리간드로서 독립적으로 행동하고 있음을 암시한다. W에서는 방향족 카복실기 같은 산소공여 리간드가 주로 Cu(II)와 결합하고 있는것 같고 SS에서는 Sulfonate, 지방족 카복실기 그리고 질소를 함유하는 리간드가 주요한 결합 site인 것 같다. Cu(II)-SS착화합물과 비교할때 Cu(II)-W로 부터 Cu(II)를 치환하는데 6배정도의 Pyridine 농도가 요구되었다.

• 대한화학회지
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• 제30권1호
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• pp.51-56
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• 1986

디메틸술폭시드 속에서 카드뮴(II)과 구리(II)의 1,5-diphenylcarbohydrazide 錯物의 性質을 直流 폴라로그래프로 調査한 結果 各 錯物의 電極過程은 다음과 같이 생각된다. Cd(II)${\cdot}$DPH Complex$\frac{e^-}{(E_{\frac{1}{2}}=-0.12V)}$${\to}$Cd(I)${\cdot}$DPH Complex. Cd(I)${\cdot}$DPH Complex$\frac{e^-}{(E_{\frac{1}{2}}=-0.74V)}$${\to}$ Cd(Hg) + nDPH. Cu(II)${\cdot}$DPH Complex$\frac{e^-}{(E_\frac{1}{2}=-0.44V)}$${\to}$Cu(I)${\cdot}$DPH Complex. Cu(I)${\cdot}$DPH Complex$\frac{e^-}{(E_{\frac{1}{2}}=-0.84V)}$${\to}$Cu(Hg) + nDPH. 모든 波는 擴散에만 依存하고, 또 Cd(I)${\cdot}$DPH 착물의 ligand의 자리수는 2이며, 錯物의 解離常數 Kd는 5.12 ${\times}10^{-8}$이었다. 이들 各 錯物의 還元波는 非可逆的이었으며, 디메틸 술폭시드 溶液속에서 錯物들의 還元波는 1電子 2段階임을 알 수 있다.

• 한국세라믹학회지
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• 제26권3호
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• pp.395-401
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• 1989

The concentrations of Cu(II), Y(III) and Ba(II) ionic species in aqueous solution due to the formation of Cu2+-oxalate-complex have been theoretically calculated with respect to pH and their solubility diagrams could be obtained. It was verified from the calculation that the excess of Cu2+ and Ba2+ should be added in order to obtain oxalate coprecipitates with the molar ratio of Y : Ba : Cu=1 : 2 : 3. The exact amount of excess species has been calculated with respect to the initial concentrations of metal ions and pH.

• Bulletin of the Korean Chemical Society
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• 제34권9호
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• pp.2731-2736
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• 2013

We report a new tetrameric supramolecular Cu(II) complex ($Cu_4L_4$ = tetrakis(N,N'-bis(salicylidene)-2,2'-ethylenedianiline)Copper(II)) with a Schiff-base ligand ($H_2L$ = N,N'-bis (salicylaldimine)-1,2-ethylenediamine) containing two N,O-bidentate chelate groups. Though the copper sites of $Cu_4L_4$ are non-coupled, the complex exhibits a unsually high catecholase-like activity ($k_{cat}=935h^{-1}$) when the $Cu_4L_4$ solution is treated with 3,5-di-tert-butylcatechol (3,5-DTBC) at basic condition in the presence of air. Combined information obtained from UV-VIS and EPR measurements could lead the suggestion of the reaction pathway in which the substrate may bind to Cu(II) ions by anti-anti didentate bridging mode.

• 한국자기공명학회논문지
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• 제5권1호
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• pp.1-12
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• 2001

ZSM-5 gallosilicate molecular sieves was synthesized and cupric ion was ion-exchanged into the gallosilicate. The locations of Cu(ll) species in the framework and their interactions with various adsorbates were characterized by combined electron spin resonance(ESR) and electron spin echo modulation(ESEM) methods. It was found that in a fresh hydrated material, Cu(II) is octahedrally coordinated to six water molecules. This species is located in the channel intersections of two sinusoidal channels and rotates rapidly at room temperature. Evacuation removes some of these water molecules, leaving the Cu(II) coordinated to less water molecules and anchored to of oxygens in the channel wall. Dehydration produces two Cu(II) species, both of which are located in sites inaccessible to oxygen as evidenced by non-broadening of its ESR lines by oxygen. Adsorption of adsorbate molecules such as water, alcohols, ammonia, acetonitrile and ethylene on dehydrated CuNaH-ZSM-5 gallosilicate materials causes changes in the ESR spectrum of Cu(II), indicating the migration of Cu(II) into main channels to form complexes with these adsorbates there. Cu(II) forms a complex with two molecules of methanol, ethanol and propanol, respectively as evidenced by ESR parameters and ESEM data. Cu(II) also forms a square planar complex with four molecules of ammonia, based on the resolved nitrogen superhyperfine interactions and their ESEM parameters. Cu(II) forms a complex with two molecules of acetonitrile based on the ESR parameters and ESEM data. Interestingly, however, only part of Cu(II) interacts indirectly with one molecule of nonpolar ethylene based on ESR and ESEM analyses.

• 대한화학회지
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• 제57권4호
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• pp.483-488
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• 2013

$CuCl_2$로부터 용액합성법에 의해 CuO를 제조하였다. $CuCl_2$를 용액에 첨가하기 전에 용액내에 anatase형 $TiO_2$ 입자를 분산시켜 CuO가 형성되는 과정에서 $TiO_2$/CuO 결합입자를 합성하였다. 얻어진 $TiO_2$/CuO에 적당량의 글루코스를 가하여 반응시켜 CuO의 일부를 $Cu_2O$로 환원시켰다. 얻어진 시료 $TiO_2/Cu_xO$ (1$TiO_2/Cu_xO$ 복합체는 anatase와는 다르게 가시광선 전 영역에서 흡광이 발생했으며 당연한 결과로 태양광선에서 $TiO_2/Cu_xO$ 복합체의 광촉매 활성은 anatase $TiO_2$에 비하여 매우 뛰어난 것으로 나타났다. 또한 $TiO_2/Cu_xO$ 복합체의 항균성이 대단히 뛰어난 것으로 나타났다.

• 분석과학
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• 제11권5호
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• pp.341-346
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• 1998

$Cu^{2+}$을 2-피리딘카르복살데히드(PyTC)와 반응시켜 $[Cu(PyTC)H_2O)]SO_4$를 얻었다. 이화합물은 1:1 전해질이며 물과 극성 유기 용매에 아주 잘 녹았다. 이 착물의 원소분석, 전기전도도 및 분광학적 데이터에서 이화합물의 구조는 사각평면임을 제시하였다. PyTC를 이용한 Cu(II)의 정량 가능성에 대하여 연구하였다. 구리(II)의 PyTC용액은 pH 4에서 $2.9{\times}10^{-4}M$까지 Beer의 법칙에 따랐다.

• 분석과학
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• 제36권1호
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• pp.44-52
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• 2023

This protocol clarifies a simple and precise method for measuring the activity of xanthine oxidase (XO) enzyme inhibitor. XO enzyme, which accelerates oxidative stress-related disorders through its capacity to generate hydrogen peroxide and superoxide anion radicals (O₂^•-), has been found to be inhibited by several plant extracts. Enzyme samples were incubated with a suitable buffer containing adequate amounts of xanthine as a substrate to determine XO activity. The method depends on direct measurements of uric acid and hydrogen peroxide production to test XO with and without interference. The CUPRAC reagent (Cu(Nc)₂²⁺) was used to inhibit enzyme reaction after incubation was complete. The generated urate and peroxide reduced the Cu(II)-neocuproine complex (Cu(Nc)₂²⁺) to a brightly colored Cu(I)-neocuproine complex (Cu(Nc)₂⁺), which was assessed with a spectrophotometer at 450 nm. XO activity was found to be directly related to the increased absorbance of the colored Cu(I)-neocuproine complex (Cu(Nc)₂⁺). To eliminate catalase enzyme interference, the proposed method used sodium azide and was validated against XO activity using the UV method in matched samples with t-test analysis. The proposed assay can determine XO activity with high precision, as indicated by the correlation coefficient (R² = 0.9935) from comparison with the reference protocol.