• Korean Journal of Radiology
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• 제20권8호
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• pp.1266-1274
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• 2019

Objective: To determine whether radiologic extranodal extension (ENE) appearing on pretreatment CT and MRI could predict the prognosis in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC). Materials and Methods: The study population was obtained from a historical cohort diagnosed with HPV-related OPSCC. A total of 134 OPSCC patients who had a metastatic lymph node on pretreatment CT or MRI were included, and radiologic ENE was evaluated by two experienced head and neck radiologists. Kaplan-Meier and multivariate Cox regression analyses were performed to evaluate the impact of radiologic ENE on progression-free survival (PFS). The diagnostic performance of CT and MRI for the diagnosis of ENE was also evaluated in patients who underwent neck dissection. Results: Seventy patients (52.2%) showed radiologic ENE-positive findings. Although patients showing radiologic ENE had a worse 3-year PFS (83.7% vs. 95.3%, p = 0.023), the association between radiologic ENE and PFS was not statistically significant on multivariate analysis (p = 0.141; hazard ratio, 2.68; 95% confidence interval, 0.72-9.97). CT or MRI had a sensitivity of 62%, specificity of 77.8%, and accuracy of 71.9% for predicting pathologic ENE. Conclusion: Radiologic ENE on CT or MRI did not predict poor PFS in patients with HPV-related OPSCC, although there was a trend towards worse PFS. Further studies are warranted to determine whether radiologic ENE is a useful imaging biomarker to risk-stratify patients with HPV-related OPSCC.

• 한국의학물리학회지:의학물리
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• 제26권2호
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• pp.112-117
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• 2015

미국의학물리학회(AAPM) TG-100 위원회에서 제시하고 있는 가이드 라인에 준하여 환자 안전에 대한 정도관리를 수립하기 위하여 영남대학교병원 방사선종양학과에서 환자를 치료하는 중에 발생한 오류들을 중심으로 오류 유형을 분석하여, 환자중심의 방사선치료를 시행할 때 환자 안전을 위한 정도관리의 가이드 라인을 정립하고자 한다. 방사선종양학과에서 방사선 치료를 하는데 있어서 일으킬 수 있는 오류들을 분석하여 오류를 일으키는 빈도와 오류가 일어날 때 환자 에게 미치는 심각성과 오류가 일어났을 때 감지하지 못하고 지나치는 확률을 점수로 평가하고자 한다. 오류를 일으킬 수 있는 곳으로는 CT 모의치료실, 치료계획실, 치료실로 나누어 조사하였다. CT 모의치료실에서는 고정기구 사용의 오류가 위험중요지수의 값이 60으로 가장 높았고, 모의치료 정보입력의 오류가 6으로 가장 낮게 나타났다. 치료계획실에서는 선량계산 모델 선택의 오류가 위험중요지수의 값이 168로 가장 높았고, 환자의 치료 시작일 오류가 36으로 가장 낮게 나타났다. 치료실에서는 테이블 Bar 오류가 위험중요지수의 값이 252으로 가장 높았고, 체중변화 오류가 190을 나타내었으며, 배게 오류가 24로 가장 낮게 나타났다.

• 치과방사선
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• 제28권1호
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• pp.47-58
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• 1998

The purpose of this study was to investigate an influence of the change of central panoramic curves on the image reconstruction in the dental implant CT. The author designed three experimental groups according to the location of central panoramic curve. In group A, central panoramic curve was determined as the curve connecting the center of roots from the first premolar to the first molar. In group B, central panoramic curve was determined as the line connecting the lingual cortical plate at the level of the mesial aspect of the first premolar with the buccal cortical plate at the level of the mesial aspect of the first molar. In Group C, central panoramic curve was determined as the line connecting the buccal cortical plate at the level of the mesial aspect of the first premolar with the lingual cortical plate at the level of the mesial aspect of the first molar. Twenty four reformatted CT images was acquired from four mandibles embedded in the resin block and twenty four contact radiographs of dog specimens were acquired. Each Image was processed under Adobe Photoshop program analysed by MSPA(mandible/maxilla shape pattern analysis) variables such as MXVD, MXHD, UHD, MHD, and LHD. The obtained results were as follows ; 1. The mean of MXVD variable was 19.9, 20.2, and 20.0 in group A, B, and C, respectively, which were smaller than actual value 20.5. But, there was no significant difference among 3 groups (p>0.05). 2. The mean of MXHD, UHD, MHD, and LHD variables in group A, B, and C was 11.9, 12.2, and 12.3; 9.3, 9.5, and 9.6; 10.0, 10.3, and 10.3; 9.2, 9.3, and 9.4 respectively which were equal to or greater than the actual value 11.8, 9.3, 10.0, and 9.2. But, there was no significant difference among 3 groups (p>0.05). 3. The number of noneffective observations with difference over or under 1 mm with comparison to the actual value was 24(20％), 58(48.3％), and 52(43.3％), respectively, in group A, B, and C. 4. In group A, the number of observations over 1 mm and under 1 mm was 9 and 15, respectively, but in group Band C, the number of observations over 1 mm was more than under 1 mm.

• 대한응급의학회지
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• 제29권6호
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• pp.679-686
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• 2018

Objective: The aim of this study was to identify the clinical characteristics and risk factors associated with the admission of patients in the emergency department (ED) within 30 days after discharge. Methods: A retrospective, observational study was conducted on adult patients presenting with abdominal pain to the ED of a single, urban, university hospital, between January 2014 and December 2015, who revisited the ED within 30 days after discharge. Data was collected on the emergency severity index level, time to contact doctors, physical examination, laboratory tests, use of computed tomography (CT), and patient disposition on revisitation. The primary outcome was hospital admission following an ED revisit in the 30-day period after the first visit. Results: During the study period, 19,480 patients visited the ED with the chief complaint of abdominal pain, and 13,577 were discharged. A total of 251 patients (1.29%) revisited the ED within 30 days, of which 89 were eligible for the study. The primary outcome was associated with not performing a CT scan on the initial visit and an increased C-reactive protein (CRP) value. Receiver operating characteristic curve analysis showed that a cut-off baseline CRP value of >0.35 mg/dL can predict the primary outcome with a sensitivity and specificity of 75% and 62.1%, respectively (area under the curve, 0.701; 95% confidence interval, 0.569-0.833; P=0.007). Conclusion: An increased CRP value and not performing abdominal CT were associated with a higher rate of admission following ED revisits of patients with abdominal pain. Future prospective studies on the role of abdominal CT imaging in patients presenting to the ED with abdominal pain will be needed.

• 한국식품영양과학회지
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• 제46권9호
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• pp.1097-1105
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• 2017

본 연구는 돼지고기로 제조된 소시지에 저가원료인 닭고기 혼합비율을 정량하기 위해 real-time PCR 법과 소량 함유된 닭의 정량의 정확도를 높이기 위해 닭의 내부 표준물질을 첨가하는 방법을 적용함으로써 소시지의 진위판별 가능성을 제시하였다. DNA 회수율과 PCR 증폭효율을 높이기 위해 QIAamp DNA Micro Kit을 사용하였고, 최종 PCR 반응액 $20{\mu}L$에 template DNA($5{\sim}10ng/{\mu}L$)는 $3.0{\sim}5.0{\mu}L$, primer 농도는 $0.5{\mu}L(10pmol)$, $2{\times}$ Cybrgreen buffer는 $10{\mu}L$로 조정하였을 때 가장 적합하였고, PCR 증폭조건은 annealing 온도를 $62^{\circ}C$, extension 온도를 $68^{\circ}C$, final extension 시간은 33초, 최종 PCR cycle은 40 cycle로 했을 때 가장 PCR 증폭효율이 좋은 것으로 평가되었다. 돼지와 닭의 DNA를 50 ng에서 0.05 ng으로 순차적으로 10배씩 희석한 template DNA를 이용해 민감도(최소 검출한계)를 확인한 결과 돼지와 닭 모두 0.05 ng 이상으로 각각 확인되었다. 표준곡선의 결정계수($R^2$)도 모두 0.995 이상으로 표준곡선의 linearity가 정량에 적합한 것으로 확인되었다. 돼지고기와 닭고기를 각각 70:30 비율로 혼합한 3점의 시료를 $70^{\circ}C$에서 10분간 열처리한 후 정량분석을 실시하여 기대치에 의한 측정치를 비교한 결과, 64.3:35.7의 비율로써 평균 5.7%의 차이를 나타내 생육(raw meat) 또는 가열처리된 시료의 상태에 따라 DNA에 영향을 주어 PCR 증폭효율 및 DNA 정량 값에 일부 영향을 주는 것으로 판단되었다. 소시지에 함유된 돼지고기와 닭고기의 함량을 분석한 결과 돼지고기에 비해 닭고기 함량이 적은 소시지에서는 닭고기(6%, 12%, 25%, 38%)의 검출이 어려웠고, Ct(threshold cycle) 값에 따른 DNA 정량값이 매우 낮아 배합비율을 환산이 어려웠다. 그러나 소시지에 닭의 표준물질 DNA(50 ng)를 첨가함으로써 배합비율이 증가할수록 Ct값도 점차 낮아져서 배합비율을 반영하고 있음에 따라 Ct값의 평균치${\pm}$오차범위 값으로 간접적으로 배합비율을 추정할 수 있을 것으로 생각되었다.

• Nuclear Medicine and Molecular Imaging
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• 제41권5호
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• pp.377-379
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• 2007

• Nuclear Medicine and Molecular Imaging
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• 제41권6호
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• pp.574-577
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• 2007

• 한국통신학회논문지
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• 제21권7호
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• pp.1803-1813
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• 1996

This paper describes an automatic threshold decision using a maximum mismatched correlation value in the direct sequence spread spectrum (DS-SS) system. For received PN codes with different single-to-noise ratio (SNR), this scheme is able to detect a desired threshold value in the search mode, i.e. a maximum mismstched correlation value, so that value is utilized as a threshold for the verification mode. Performance of the proposed scheme in both the additive white gaussian noise (AWGN) and frequency-selective Rayleigh fading channels is analyzed through the Monte Carlo simulation. And hardware implementation of this scheme using a DSP processor is demonstrated. The proposed acquisition shceme is compared to the conventional constant threshold (CT) scheme, and significant improvement of performance is shown. Analysis of system performance in the verification mode is presented, and key quantities such as the false alarm probability and the detection probability are derived in a AWGN channel.

• 핵의학기술
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• 제16권2호
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• pp.29-34
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• 2012

Siemens사의 CT 선량 감소 소프트웨어인 IRIS의 적용을 통하여 CT 선량 감소 시 노이즈 감소 효과와 해상력의 보존 그리고 ACCT에 IRIS 각 kernel의 적용 시 SUV 변화를 확인하는데 목적을 두었다. Biograph mCT 40 slice 스캐너를 이용하여 AAPM CT performance phantom, Anthropomorphic chest phantom을 관전압 120 kVp로 고정하고 100-10 mAs까지 15%감소하여 스캔 후 FBP, IRIS 각 kernel을 적용하여 재구성 하여 영상의 노이즈, 해상력, 영상 평가를 시행하였다. NEMA IEC body phantom을 이용하여 55.5 MBq를 background에 주입하고 열소와 배후 방사의 비를 8:1이 되도록 모형을 제작하였다. 120 kVp, 50 mAs 조건으로 1분, 2분, 3분, 4분 스캔하여 영상을 획득한 후 ACCT에 IRIS 각 kernel을 적용하여 기존 FBP 방식을 적용한 SUV와의 평가를 시행하였다. IRIS의 적용 시 기존 FBP 방식에 비하여 45% 선량을 감소하였음에도 불구하고 해상력 저하 없는 노이즈 감소 효과가 확인 되었으며 SUV 평가 실험에서 IRIS의 I70f kernel을 제외하고는 기존 FBP 방식을 통하여 획득된 SUV와 유의한 차이가 나타나지 않았다. 본 연구를 통하여 IRIS 적용 시 기존 FBP 방식에 비하여 CT 피폭선량 감소와 해상력 저하 없는 노이즈 감소 효과를 입증하였으며 IRIS kernel의 적절한 적용을 통하여 PET/CT 검사 시 환자 피폭선량 감소는 물론 FBP 방식에 비하여 우수한 영상의 획득이 가능할 것이라 사료된다.

• Computers and Concrete
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• 제11권2호
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• pp.123-148
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• 2013

The nonlinear finite element method with eight noded isoparametric quadrilateral element for concrete and two noded element for reinforcement is used for the prediction of the behavior of reinforcement concrete structures. The disturbed state concept (DSC) including the hierarchical single surface (HISS) plasticity model with associated flow rule with modifications is used to characterize the constitutive behavior of concrete both in compression and in tension which is named DSC/HISS-CT. The HISS model is applied to shows the plastic behavior of concrete, and DSC for microcracking, fracture and softening simulations of concrete. It should be noted that the DSC expresses the behavior of a material element as a mixture of two interacting components and can include both softening and stiffening, while the classical damage approach assumes that cracks (damage) induced in a material treated acts as a void, with no strength. The DSC/HISS-CT is a unified model with different mechanism, which expresses the observed behavior in terms of interacting behavior of components; thus the mechanism in the DSC is much different than that of the damage model, which is based on physical cracks which has no strength and interaction with the undamaged part. This is the first time the DSC/HISS-CT model, with the capacity to account for both compression and tension yields, is applied for concrete materials. The DSC model allows also for the characterization of non-associative behavior through the use of disturbance. Elastic perfectly plastic behavior is assumed for modeling of steel reinforcement. The DSC model is validated at two levels: (1) specimen and (2) practical boundary value problem. For the specimen level, the predictions are obtained by the integration of the incremental constitutive relations. The FE procedure with DSC/HISS-CT model is used to obtain predictions for practical boundary value problems. Based on the comparisons between DSC/HISS-CT predictions, test data and ANSYS software predictions, it is found that the model provides highly satisfactory predictions. The model allows computation of microcracking during deformation leading to the fracture and failure; in the model, the critical disturbance, Dc, identifies fracture and failure.