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Nucleotide Sequence of Rat Transketolase and Liver-Specific Pretranslational Activation During Postnatal Development

  • Kim, Sung-Min F.;Kim, Byung-Moon;Jeng, Jingjau;Soh, Yun-Jo;Bak, Choong-Il;Huh, Jae-Wook;Song, Byoung-J.
    • BMB Reports
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    • 제29권2호
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    • pp.146-150
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    • 1996
  • A 2.1 kb cDNA clone for rat transketolase was isolated from rat liver ${\lambda}gt11$ cDNA library and its sequence was determined. The predicted rat transketolase (655 amino acids with $M_r$ 71,186) is highly similar (92%) to that of the human enzyme except that it contains an extra 32 amino acids at its N-terminus. Although it is less similar (<27%) to transketolases from non-mammalian species, the functional motifs such as the catalytic sites and thiamine binding domain are well conserved in the rat enzyme. Southern blot analysis of genomic DNA verified that transketolase appears to be derived from a single gene. Immunoblot and Northern blot analyses suggested that hepatic transketolase was activated pretranslationally by a 2.1-fold while little change was observed in brain enzyme, indicating a tissue-specific pretranslational activation during postnatal development.

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수상함의 동적 레이더 반사면적 해석 기법 연구 (A Study on a Dynamic Radar Cross Section Analysis Technique for a Surface Warship)

  • 김국현;김진형;최태묵;김윤환;조대승
    • 한국해양공학회지
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    • 제23권6호
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    • pp.77-81
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    • 2009
  • The radar cross section (RCS) of a warship is one of the most important design features in terms of her survivability in hostile environments. Ocean waves continuously changes the attitude of an objective warship to hostile radar and distorts the RCS as a result. This paper presents a dynamic RCS analysis technique and procedure that considers temporal ship motion. First, data sets are prepared for ship motions in 6 degrees of freedom, which are numerically simulated for an objective warship via frequency to time domain conversion with response amplitude operators and specified ocean wave spectra. Second, a series of RCS analysis models are transformed geometrically by referring to ship motion data sets. Finally, temporal RCS analyses are carried out with the RCS simulation code, SYSCOS. As an example, RCS analysis results are given for a virtual warship, which show that ship motions temporally change RCS values and cause RCS reduction compared with static value in terms of mean values.

퍼블릭 워터마킹에서 영상 블록의 유효성에 대한 연구 (A Study on the Validity of Image Block in a Public Watermarking)

  • 김효철;김현철;유기영
    • 대한전자공학회논문지SP
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    • 제38권4호
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    • pp.344-352
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    • 2001
  • 본 논문에서는 퍼블릭 워터마킹(public watermarking)에서 영상 블록의 유효성에 기반을 둔 상호연관성(cross-correlation property)과 관련기법을 제안하였다. 이 과정에서 워터마크의 비인식성(imperceptibility)과 깨지기 쉬운 워터마크(fragile watermark)를 보장하기 위하여 DCT(Discrete Cosine Transformation) 도메인의 고주파 영역을 사용하였다. 여러 가지 실험을 통하여 에러가 보정된 원본 영상(original image)들과 워터마크된 이미지(watermarked image)들 사이에 유효한 블록들이 동일함을 확인하였다. 그리고 이러한 상호연관성이 추후의 퍼블릭 워터마킹을 위한 응용들에 적용될 수 있음을 입증하였다.

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선형예측부호화 스펙트럼을 이용한 유발이음청 방재파의 잠시측정 (Mesurement of Evoked Otoacoustic Emission Latency Using Linear Prediction Coding Spectrum)

  • 안정일;최진영;이건일
    • 대한의용생체공학회:의공학회지
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    • 제12권3호
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    • pp.185-190
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    • 1991
  • An automatized latency calculation method of an e-OAE(evoked otacoustic emission) is proposed. The e-OAE signal measured from a normal adult is averaged 1000 times to remove noises. This averaged signal is converted to digital signal and that is processed by IBM-AT computer for latency calculation. we separate the stimulated and the emitted signal on the time domain by a modified LPC (linear prediction coding) spectrum, and the latency is calculated by cross-correlation method. By proposed latency calculation method the latency is 7.9[ms] for normal adult. The performance of the proposed method is also compared with that of the auto-correlation and cross performance of the proposed method is also compared with that of the auto-correlation and cross-correlation method. The result show that the proposed method has same precision with the conventional methods and can automatically calculate latency without subjective observation.

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Calculating the Threshold Energy of the Pulsed Laser Sintering of Silver and Copper Nanoparticles

  • Lee, Changmin;Hahn, Jae W.
    • Journal of the Optical Society of Korea
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    • 제20권5호
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    • pp.601-606
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    • 2016
  • In this study, in order to analyze the low-temperature sintering process of silver and copper nanoparticles, we calculate their melting temperatures and surface melting temperatures with respect to particle size. For this calculation, we introduce the concept of mean-squared displacement of the atom proposed by Shi (1994). Using a parameter defined by the vibrational component of melting entropy, we readily obtained the surface and bulk melting temperatures of copper and silver nanoparticles. We also calculated the absorption cross-section of nanoparticles for variation in the wavelength of light. By using the calculated absorption cross-section of the nanoparticles at the melting temperature, we obtained the laser threshold energy for the sintering process with respect to particle size and wavelength of laser. We found that the absorption cross-section of silver nanoparticles has a resonant peak at a wavelength of close to 350 nm, yielding the lowest threshold energy. We calculated the intensity distribution around the nanoparticles using the finite-difference time-domain method and confirmed the resonant excitation of silver nanoparticles near the wavelength of the resonant peak.

Pulsed CW 신호를 사용하는 수중 음원의 위치 추정을 위한 시간지연차 추정법 (Position Estimation of Underwater Acoustic Source Using Pulsed CW Signal)

  • 최영근;손권;도경철;김기만
    • 한국음향학회지
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    • 제23권7호
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    • pp.514-520
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    • 2004
  • 수중에서 음원의 위치 추정을 위해 적용되어지는 기법으로써 시간지연차 (TDOA : Time Difference Of Arrival) 추정, 빔 형성 기법, 고 분해능 기법 등이 있다. 본 논문에서는 상대적으로 적은 수의 센서를 사용하여 주파수 영역에서 시간 지연차 추정에 사용되는 MCPSP (Modified Cross Power Spectrum Phase) 함수를 이용하였다. 그러나 MCPSP 함수에 기반한 방법은 CW (Continuous Wate) 신호를 대상으로 할 경우 추정 성능이 크게 떨어진다. 이에 본 논문에서는 Pulsed CW신호를 사용하는 수중 음원의 위치를 추정하기 위해 단 구간 (short-time) 에너지 검출을 이용하여 핑(ping)의 경계 영역을 포함하는 세그먼트를 구성하고 이로부터 MCPSP 함수를 구하는 방법을 제안하였다. 제안된 방법의 성능에 대한 이론적인 접근과 함께 다양한 환경 하에서 분석이 이루어졌다.

Optimal cross-section and configuration design of cyclic loaded elastic-plastic structures

  • Valido, Anibal J.;Sousa, Luis G.;Cardoso, J. Barradas
    • Structural Engineering and Mechanics
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    • 제4권1호
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    • pp.25-35
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    • 1996
  • This paper describes a continuum variational formulation for design optimization of nonlinear structures in the elastic-plastic domain, where unloading and reloading of the structures are allowed to occur. The Total Lagrangian procedure is used for the description of the structural deformation. The direct differentiation approach is used to derive the sensitivities of the various structural response measures with respect to the design parameters. Since the material goes into the inelastic range and unloading and reloading of the structure are allowed to occur, the structural response is path dependent and an additional step is needed to integrate the constitutive equations. It can be shown, consequently, that design sensitivity analysis is also path-dependent. The theory has been discretized by the finite element technique and implemented in a structural analysis code. Mathematical programming approach is used for the optimization process. Numerical applications on trusses are performed, where cross-sectional areas and nodal point coordinates are treated as design variables. Optimal designs have been obtained and compared by using two different strategies: a two level strategy where the levels are defined accordingly the type of design variables, cross sectional areas or node coordinates, and optimizing simultaneously with respect to both types of design variables.

핵 연료집합체 부수로 해석을 위한 횡 방향 압력손실계수의 수치적 결정 (Numerical Determination of Lateral Loss Coefficients for Subchannel Analysis in Nuclear Fuel Bundles)

  • Kim, Sin;Park, Goon-Cherl
    • Nuclear Engineering and Technology
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    • 제27권4호
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    • pp.491-502
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    • 1995
  • 핵연료집합체 부수로 유동장에 대한 상세한 정보에 기초해 교차류를 정확히 예측하는 것은 핵연료의 성능을 해석하는데 중요한 요소이다. 본 연구에서는 저-Reynolds 수 k-$\varepsilon$ 난류모형을 채택하여 인접한 두 부수로 사이에 발생하는 교차류를 해석하였다 또한, 2차유동을 정확히 모사하기 위해서 비등방성 대수응력모형을 사용하였다. 이상의 난류 모형은 유한요소법을 통해 해석되었으며 가용한 실험자료와 비교하여 검증하였다. 그리고, 부수로 유동장에 대한 수치해석 결과를 이용하여 횡방향 합력손실계수의 상관식을 구성하였다. 상관식은 교차류를 제공하는 부수로의 축방향 속도에 대한 교차류의 속도비, 제공받는 부수로의 Reynolds 수 그리고 Pitch-to-diameter의 함수로 구성되었다.

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Therapeutic Intervention of Aggregate Formation in Huntington's Disease: A Potential Role of Tissue Transglutaminase (tTG)

  • Chun, Wan-Joo
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.65-66
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    • 2003
  • The cause of Huntington's disease (HD) is a pathological expansion of the polyglutamine domain within the N-terminal region of huntingtin. Neuronal aggregates composed of mutant huntingtin within certain neuronal populations are a characteristic hallmark of HD. Because tissue transglutaminase (tTG) cross-links proteins into aggregates and polypeptide-bound glutamines are primary determining factors for tTG-catalyzed reactions, it has been hypothesized that tTG may contribute to the formation of aggregates. (omitted)

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도파관 구조의 FDTD해석을 위한 새로운 흡수경계조건 (A new absorbing boundary condition for the FDTD simulation of waveguides)

  • 박면주;남상욱
    • 한국통신학회논문지
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    • 제21권12호
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    • pp.3227-3234
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    • 1996
  • This paper proposes a new absorbing boundary condition(ABC) for the FDTD simulation of waveguide problems. It is based on the exact analytic expression for the time domain EM wave propatation in the waveguide. The ABC derived from the expression has a convolution form whose kernel (the discrete Green's function) has a simple, closed form formula. Also, it is applicable to the wide variety of waveguide types with conducting boundaries and complex cross-sectional shapes.

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