• Biomolecules & Therapeutics
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• 제6권2호
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• pp.165-170
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• 1998

Antigenic potential of DW-116, a newly synthesized fluoroquinolone, was examined by conduc-ting active systemic anaphylaxis (ASA), passive cutaneous anaphylaxis (PCA) and passive hemagglutination (PHA) tests. In ASA test, mild to moderate signs of anaphylactic responses were observed in the groups sensitized with low (2 mg/body) and high (10 mg/body) doses of DW-116 alone and the group sensitized with DW-116 plus adjuvant. Some moderate to severe anaphylactic reactions were observed in the group sensitized with a DW-116-bovine serum albumin (BSA) conjugate plus adjuvant when challenged with a DW-116-guinea pig senHn albumin (GSA) conjugate. However these reactions were considered to be a cross-reaction between BSA and GSA since similar reactions were induced when challenged by GSA alone. In heterologous PCA test using mice and rats, positive responses were not detected in any of the experimental groups. In PHA test, positive responses were observed in the groups sensitized with low and high doses of DW-116 alone and the group sensitized with DW-116 plus adjuvant. However, these responses were not considered to be drug-specific because some positive responses were also seen in the negative control group. From these results, it was concluded that DW-116 is not likely to have specific antigenic potential in clinical use.

• Bulletin of the Korean Chemical Society
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• 제28권7호
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• pp.1159-1166
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• 2007

New unsymmetrical trans-stilbenes have been prepared by the sequential coupling reactions of bromobenzenesulfonate with formylarylboronic acids, benzylphosphonates and arylmagnesium bromides and characterized. The nickel-catalyzed reactions of stilbenesulfonates with aryl Grignard reagents produced the corresponding stilbenes via the nucleophilic aromatic substitution of the neopentyloxysulfonyl group by aryl nucleophiles. The great chemoselectivity of the alkyloxysulfonyl group allows the stepwise construction of unsymmetrical trans-stilbenes possessing terphenyl moieties. This procedure appears to be a promising and conceptually straightforward route for the parallel synthesis of various unsymmetrical stilbenes as well as other highly conjugated hydrocarbons.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1988년도 전기.전자공학 학술대회 논문집
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• pp.771-773
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• 1988

The Mechanical strength and the electrical insulation properties of the Epoxy Resin vary with the formation of chemical reactions between Epoxy and curing agent. Therefore, to study their reactions is important for understanding the properties of the cured Epoxy. In this paper, to get the cured Epoxy having good electrical insulation property, it is studied the effects of the surrounding temperature during the cure process on the property of the cured Epoxy. In the experiment, Epoxy is cured with the surrounding temperature varied between -5[$^{\circ}C$] to 50[$^{\circ}C$]. As the results, it follows that the higher the temperature is, the faster the cross-link process is.

• Bulletin of the Korean Chemical Society
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• 제34권12호
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• pp.3597-3601
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• 2013

The reactions of bis(Y-aryl) chlorothiophosphates (1) with substituted anilines and deuterated anilines are investigated kinetically in acetonitrile at $55.0^{\circ}C$. The Hammett plots for substituent Y variations in the substrates show biphasic concave upwards with a break point at Y = H. The cross-interaction constants (${\rho}_{XY}$) are positive for both electron-donating and electron-withdrawing Y substituents. The kinetic results of 1 are compared with those of Y-aryl phenyl chlorothiophosphates (2). The cross-interaction between Y and Y, due to additional substituent Y, is significant enough to result in the change of the sign of ${\rho}_{XY}$ from negative with 2 to positive with 1. The effect of the cross-interaction between Y and Y on the rate changes from negative role with electron-donating Y substituents to positive role with electron-withdrawing Y substituents, resulting in biphasic concave upward free energy correlation with Y. A stepwise mechanism with a rate-limiting leaving group departure from the intermediate involving a predominant frontside attack hydrogen bonded, four-center-type transition state is proposed based on the positive sign of ${\rho}_{XY}$ and primary normal deuterium kinetic isotope effects.

• Nuclear Engineering and Technology
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• 제28권1호
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• pp.72-78
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• 1996

단면적 평가를 위한 회귀분석 프로그램 COVAFIT를 개발하고 이를 실험 결과로서 보고되는 단면적을 평가하는데 적용하였다. 가중 최소제곱 선형 회귀 방법을 적용하였는데 이 때 새로 유도한 고차 다항식을 사용하였다. 점증하는 핵자료의 공분산에 대한 요구에 부응하여, 이 프로그램은 단면적 실험치와 함께 제공되는 분산-공분산 자료를 평가에 반영할 수 있다는 특징을 가지고 있다. MeV 에너지 영역에서 천연 산소 및 $O^{16}$의 중성자 전단면적과 세 가지 $C^{11}$ 생산 반응의 양성자 반응 단면적 평가를 통하여 사용방법론의 적절성과 COVAFIT의 유용성을 확인하였다.

• 대한화학회지
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• 제17권1호
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• pp.20-24
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• 1973

$^{93}Nb(n,\alpha)^{90}Y$, $^{90}Zr(n,p)^{90}Y$,$^{93}Nb(n,\alpha)^{90m}Y$및 $^{90}Zr(n,p)^{90m}Y$반응의 평균 핵분열 반응단면적을 결정하였다. $\alpha-$히드록시 이소부티르산을 용출제로한 양이온 교환 수지통을 사용하여 생성된 핵종을 정량적으로 분리하였다. $^{90m}Y$ 및 $^{90}Y$의 절대측정은 $\gamma-$선 분광법 및 보정된 $2\pi$계측기로 각각 $0.14\pm0.01mb$, $0.83\pm0.02mb$, $0.018\pm0.02mb$ 및 $0.33\pm0.02mb$이었다. $^{90}Y$ 대신 $^{90m}Y$ 를 사용하는 편이 니오브를 정량하기 위한 보다 좋은 분석방법이 될 수 있음을 알았으며 그 가능성에 대하여 검토하였다.

• 한국식품영양과학회지
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• 제24권5호
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• pp.816-828
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• 1995

식품의 가공처리나 저장 중에 단백질에 결합된 아미노산의 side chain이 상호간 또는 식품내 다른 분자들과 화학적으로 반응할 수 있다. 이 반응으로 아미노산의 구조적 파괴, recemization, 단백질의 상호작용들, 또한 환원성 당과, 산화제 및 polyphenol류와의 결합을 들 수 있다. 이들 중 Maillard 반응 (예 ; fructoselysinel과 아미노산 간의 cross-linking(예 ; lysinoalanine)에 의한 반응이 주를 이룬다. 이때 가장 영향을 받는 아미노산이 lysine으로, 이는 lysine이 기능성 유리 ${\varepsilon}-amino$ group을 갖고 있기 때문이다. 일반적으로 아미노산의 derivatives나 polypeptides내 cross-links는 단백질의 체내 이용율과 소화율을 감소시켜 단백질 식품의 품질을 떨어뜨린다. 본 논문에서는 식품낸의 lysinoalanine과 fructoselysine의 형성과 관련된 기술적, 분석적, 영양적 그리고 생리적인 문제들에 관하여 문헌고찰하였다. 결론적으로 식품내 이들의 존재가 여러가지 영향을 체내에서 미칠 수 있으나 정상 성인에게는 전혀 위험한 물질이 아님을 알 수 있었다. 그러나 제한된 formular foods를 주로 먹는 유아에게는 성장에 lysine이 필수적이므로 lysine 손상을 통한 단백질의 질 저하는 대단히 중요한 의미를 지닌다. 따라서 유아식의 가공처리와 저장에 주의를 해야할 필요가 있다고 본다.

• 약학회지
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• 제53권6호
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• pp.328-333
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• 2009

Contrast media are substances that are used to enhance the contrast of structures or fluids within the body in medical imaging. Those are commonly used to enhance the visibility of blood vessels and the gastrointestinal tract. The aim of this study is to evaluate patients who got injected iopamidol, developed as one of contrast medium regarding changes in cardiovascular system and especially, adverse drug reactions. This study were performed on randomly selected a total of 51 patients (range of 15~85 years old) who got injected contrast medium, Iopamidol at a P hospital in Gyeonggi province from September 22nd, 2008 to January 24th, 2009. Data were collected by questionnaire though person to person. We analyzed the data by SPSS (Version 12. for windows). Methods of analysis were frequency and cross analysis. In results, 19.6% (n=10) were founded for adverse drug reactions of contrast medium. 25.0% (n=4) of 10 patients who had adverse drug reactions of contrast medium had took abdomen contrast test. 2 patients of those took contrast test for chest. Also, 3.9% (n=2) patients felt vomiting and nausea after injection of contrast medium. In conclusion, 19.6% patients experienced adverse drug reaction of contrast medium. Therefore, when taking radiation test, we should make efforts to minimize adverse drug reactions to achieve suitable and effective treatment.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.221-221
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• 1994

The cross-coupling reaction of organo tin reagents with a variety of organic halides, catalyzed by palladium, provides a novel method for generating a carbon-carbon bond. We use this method for antibacterial agents, and synthesis of new quinolone derivatives which have carbon-carbon bond at C-7 position of general quinolone moieties. Aryl tin, quinolone moieties, and palladium catalyst were refluxed in DMF to afford new quinolone derivatives. This palladium catalyzed coupling reactions have capacity for further synthetic elaboration.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.65-66
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• 2003

The cause of Huntington's disease (HD) is a pathological expansion of the polyglutamine domain within the N-terminal region of huntingtin. Neuronal aggregates composed of mutant huntingtin within certain neuronal populations are a characteristic hallmark of HD. Because tissue transglutaminase (tTG) cross-links proteins into aggregates and polypeptide-bound glutamines are primary determining factors for tTG-catalyzed reactions, it has been hypothesized that tTG may contribute to the formation of aggregates. (omitted)