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Sperm-Associated Antigen 9 is a Promising marker for Early Diagnosis of Endometrial Cancer

  • Baser, Eralp;Togrul, Cihan;Ozgu, Emre;Ayhan, Sevgi;Caglar, Mete;Erkaya, Salim;Gungor, Tayfun
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7635-7638
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    • 2013
  • Background: Sperm-associated antigen 9 (SPAG9) has been recently proposed as a novel biomarker for early diagnosis of several human tumors, including ovarian, cervical and breast cancers. Its clinical value remains to be clarified for endometrial cancer (EC). In this study, we investigated the utility of serum SPAG9 levels in diagnosis of EC and its association with important clinicopathological parameters. Materials and Methods: This cross-sectional study was performed at a tertiary women's referral center in Ankara, Turkey. Preoperative serum samples were collected from patients surgically treated for endometrial cancer between June 2012-April 2013. Similar aged women with a biopsy proven benign endometrium were used as controls. Serum SPAG9 levels were measured with an enzyme-linked immunosorbent assay (ELISA) method and assessed for links with clinicopathological factors. Receiver operating characteristic (ROC) curve analysis was performed to assess power of SPAG9 levels for EC prediction. P values less than 0.05 were considered statistically significant. Results: A total of 63 women with EC and 27 with benign endometrium were included in the study. Mean age in the EC group was $58.7{\pm}1.1$. Median SPAG9 levels in the EC and control groups were 18.3 (range, 12.7-53.8) and 14.1 (range, 4.3-65.3), respectively (p<0.001). A cut-off value of 17 ng/ml for SPAG9 predicted presence of malignant endometrium with 74% sensitivity and 83% specificity [Area under curve (AUC)=0.82, p<0.001]. SPAG9 levels did not demonstrate any significant association with histological type, FIGO stage, tumor grade, size, myometrial invasion, lymphovascular space invasion, cervical involvement, adnexal involvement, peritoneal cytology or lymph node status (all p>0.05). Conclusions: Testing for SPAG9 may be useful for early detection of EC in asymptomatic high-risk women. Its role in post-treatment follow-up and early detection of recurrence should be assessed in future trials.

Comparison on marginal fitness and mechanical properties of copings with zirconia block and CAM type (지르코니아 블록과 CAM 종류에 따른 코핑의 변연적합도와 기계적 특성 비교)

  • Chung, In-Sung;Jeon, Byung-Wook;Kim, Won-Young;Kang, Jae-Min
    • Journal of Technologic Dentistry
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    • v.39 no.2
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    • pp.75-82
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    • 2017
  • Purpose: This study provided the basic data for selection the zirconia block and CAM by means of marginal fitness observations, flexural strength test and hardness test. Methods: Three dental zirconia blocks(ABCera, NaturaZ, ST98) and two dental milling machines(CAD/CAM MS, DWX-50) were used in this study. Metal abutment(diameter 10 mm, height 5 mm, inclined angle $3^{\circ}$ taper, 1 mm chamfer margin) was fabricated by Ti customized abutment, and then zirconia copings were fabricated for each ten specimens. Silicone replica technique was used to observe the marginal fitness of cross-sections with a stereomicroscope at ${\times}50$ magnification. The dental zirconia blocks was cut into 10 pieces each having a size of $25mm{\times}5mm{\times}1mm$, and fabricated according to the manufacturer's instructions, and flexural strength was measured using a universal testing machine. For hardness test, a micro Vickers hardness tester was used as it was in the flexural strength test. Statistical analysis was performed by one way ANOVA and post-test was performed by Scheffe test. Results: For marginal fitness of bucco-lingual axial, ZU group($59.7{\pm}10.3{\mu}m$) was the lowest, followed by RA, ZA, ZD, RD, RU. For marginal fitness of mesio-distal axial, ZU group($59.3{\pm}10.2{\mu}m$) was the lowest, followed by RA, ZA, RD, ZD, RU. One-way ANOVA showed statistically significant difference between groups(p<0.05). For flexural strength, ABCera block($718.0{\pm}57.2MPa$) was the highest, followed by NaturaZ, ST98. For hardness, ABCera block($1550.3{\pm}19.8Hv$) was the highest, followed by ST98, NaturaZ. There was no significant difference in flexural strength and hardness between blocks(p>0.05). Conclusion: Based on the results of this study, the type of dental zirconia block did influence the marginal fitness, and all dental zirconia blocks are expected to be suitable for clinical application. The highest flexural strength and hardness were ABCera block, and no statistically significant difference was observed.

DC ∼ 45 GHz CPW Wideband Distributed Amplifier Using MHEMT (MHEMT를 이용한 DC ∼ 45 GHz CPW 광대역 분산 증폭기 설계 및 제작)

  • Jin Jin-Man;Lee Bok-Hyung;Lim Byeong-Ok;An Dan;Lee Mun-Kyo;Lee Sang-Jin;Ko Du-Hyun;Beak Yong Hyun;Oh Jung-Hun;Chae Yeon-Sik;Park Hyung-Moo;Kim Sam-Dong;Rhee Jin-Koo
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.41 no.12
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    • pp.7-12
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    • 2004
  • In this paper, CPW wideband distributed amplifier was designed and fabricated using 0.1 $\mum$ InGaAs/InAlAs/GaAs Metamorphic HEMT(High Electron Mobility Transistor). The DC characteristics of MHEMT are 442 mA/mm of drain current density, 409 mS/mm of maximum transconductance. The current gain cut-off frequency(fT) is 140 GHz and the maximum oscillation frequency(fmax) is 447 GHz. The distributed amplifier was designed using 0.1 $\mum$ MHEMT and CPW technology. We designed the structure of CPW curve, tee and cross to analyze the discontinuity characteristics of the CPW line. The MIMIC circuit patterns were optimized electromagnetic field through momentum. The designed distributed amplifier was fabricated using our MIMIC standard process. The measured results show S21 gain of above 6 dB from DC to 45 GHz. Input reflection coefficient S11 of -10 dB, and output reflection coefficient S22 of -7 dB at 45 GHz, respectively. The chip size of the fabricated CPW distributed amplifier is 2.0 mm$\times$l.2 mm.

Studies of application of artificial ground freezing for a subsea tunnel under high water pressure - focused on case histories - (고수압 해저터널 건설을 위한 동결공법 적용성에 관한 연구 - 사례를 중심으로 -)

  • Son, Young-Jin;Lee, Kyu-Won;Ko, Tae Young
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.16 no.5
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    • pp.431-443
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    • 2014
  • In this paper case studies of artificial ground freezing, which have not been applied in Korea, have been investigated for the water cut-off in a subsea tunnel under high water pressure and the most commonly used cooling mediums of brine and liquid nitrogen are examined. Since sea water with pressure has the lower freezing point than pure water, the lower temperature cooling medium is required in the application of subsea tunnel. Also, the cooling medium must have refrigeration safety and is able to reduce executing time. Brine freezing system can reuse cooling medium and is safer than liquid nitrogen freezing. But it takes more time to freeze ground and needs complex circulation plants. On the other hand, liquid nitrogen freezing system can't recycle cooling medium and may cause breathing problems or asphyxiation through oxygen deficiency. But, freezing with liquid nitrogen is fast and requires simple refrigeration equipment. Principal elements of design for ground freezing in subsea tunnel have been extracted and these elements are needed further research.

A New Spray Chrysanthemum Cultivar, 'Dream Water' with Single Type for Cut Flower (홑꽃형 절화용 스프레이 국화 '드림워터' 육성)

  • Jung, Yun-Kyung;Lim, Jae-Wook;Kim, Sung-Kee;Lee, Young-Soon;Yu, Ye-Young
    • Horticultural Science & Technology
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    • v.30 no.2
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    • pp.220-223
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    • 2012
  • A new cultivar $Dendranthema$ $grandiflourm$ 'Dream Water' was developed at Gyeonggi-do Agricultural Research & Extension Services, Korea in 2009. The cultivar 'Dream Water' was initially derived from the cross in 2005 between 'Patra', a spray chrysanthemum cultivar with yellow single type, and 'Ruces', a spray chrysanthemum cultivar with white single type. The cultivar has single type with ivory petals. Trial evaluation was conducted from 2006 to 2009 for selection of this variety, including a shading culture in spring and a retarding culture in summer. The flowering time of 'Dream Water' was October 24th, and year-round flowering is possible by shading or lighting treatment. The diameter of the flower is 56.0 mm. Number of flowers per stem and petals per flower are 11.1 and 26.8, respectively. Its leaf color was green (Green Group 147A) and plant height was 89.7 cm. Days to flowering under the short day treatment is about 54 in spring, and diameter of flower center was 1.4 cm in the summer. The vase life was 16.7 days in autumn and consumer's preference of new spray chrysanthemum is high level than control.

Breeding of a New Spray Chrysanthemum Cultivar, 'Dream Round' with Dark Pink Petals and Thick Stem of Anemone Type for Cut-flower (줄기가 강건하고 진분홍색인 아네모네형 절화용 스프레이 국화 신품종 '드림라운드' 육성)

  • Jung, Yun Kyung;Kim, Sung Kee;Kim, Hee Dong;Lee, Young Soon
    • Horticultural Science & Technology
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    • v.31 no.4
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    • pp.517-521
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    • 2013
  • A new cultivar Dendranthema grandiflourm 'Dream Round' was developed at Gyeonggi-do Agricultural Research & Extension Services (GARES), Korea in 2010. The variety 'Dream Round' was initially derived from a cross in 2006 between 'Hebo' a seed parent, a spray chrysanthemum cultivar with white anemone type, and 'Samos' as a pollen parent, a spray chrysanthemum variety with white anemone type. The cultivar has anemone type with white petals. Trial evaluation was conducted from 2008 to 2010 for the selection of that cultivar, including a shading culture in spring and a retarding culture in summer. The flowering time of 'Dream Round' was October 24th, and year-round flowering was possible by shading or lighting treatment. The diameter of flower of 'Dream Round' was 34.1 mm. Numbers of flowers per stem and petals per flower of 'Dream Round' were 12.8 and 26.1, respectively. Its leaf color was green (Green Group 147A) and plant height was 92.4 cm. Days to flowering of 'Dream Round' under the short day treatment was about 54 in spring, and diameter of flower of 'Dream Round' was 34.2 mm in the summer. The vase life of 'Dream Round' was 21.7 days in autumn.

A Design Of Cross-Shpaed CMOS Hall Plate And Offset, 1/f Noise Cancelation Technique Based Hall Sensor Signal Process System (십자형 CMOS 홀 플레이트 및 오프셋, 1/f 잡음 제거 기술 기반 자기센서 신호처리시스템 설계)

  • Hur, Yong-Ki;Jung, Won-Jae;Lee, Ji-Hun;Nam, Kyu-Hyun;Yoo, Dong-Gyun;Yoon, Sang-Gu;Min, Chang-Gi;Park, Jun-Seok
    • Journal of the Institute of Electronics and Information Engineers
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    • v.53 no.5
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    • pp.152-159
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    • 2016
  • This paper describes an offset and 1/f noise cancellation technique based hall sensor signal processor. The hall sensor outputs a hall voltage from the input magnetic field, which direction is orthogonal to hall plate. The two major elements to complete the hall sensor operation are: the one is a hall sensor to generate hall voltage from input magentic field, and the other one is a hall signal process system to cancel the offset and 1/f noise of hall signal. The proposed hall sensor splits the hall signal and unwanted signals(i.e. offset and 1/f noise) using a spinning current biasing technique and chopper stabilizer. The hall signal converted to 100 kHz and unwanted signals stay around DC frequency pass through chopper stabilizer. The unwanted signals are bloked by highpass filter which, 60 kHz cut off freqyency. Therefore only pure hall signal is enter the ADC(analog to dogital converter) for digitalize. The hall signal and unwanted signal at the output of an amplifer and highpass filter, which increase the power level of hall signal and cancel the unwanted signals are -53.9 dBm @ 100 kHz and -101.3 dBm @ 10 kHz. The ADC output of hall sensor signal process system has -5.0 dBm hall signal at 100 kHz frequency and -55.0 dBm unwanted signals at 10 kHz frequency.

Developing a Computer Model for Forest Road Design (임도설계(林道設計) 자동화(自動化)를 위한 전산(電算)모델의 개발(開發))

  • Chung, Joo Sang;Chung, Woo Dam
    • Journal of Korean Society of Forest Science
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    • v.84 no.3
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    • pp.333-342
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    • 1995
  • A user - oriented computer model to aid designing forest road is developed to release the burden by increasing efficiency of time - consuming and laborious road design works. In this paper, the structures and functions of the model are discussed. The model consists of functional modules : 1)input module to treat survey data and design criteria ; 2)road design module to generate preliminary road layout, horizontal and vertical curvatures and curve widening ; 3)earthwork analysis module to determine the economic mass movement ; 4)report writer module to produce hard copies of engineering drawings for plan views, cross - sections and profiles, earthwork calculation sheets and mass movement diagrams. In addition, the report writer also provides the information on earthwork disturbance along the cut and - fill slopes. The modules are designed to be fully - integrated to enable the users to perform engineering analyses and evaluate design alternatives in a series of road - design procedures.

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Anatomy of the Sural Nerve in the Foot and Ankle and Its Surgical Implications (족부 및 족관절 부위에서 비복 신경의 해부학 및 수술시의 의미)

  • Lee, Woo-Chun;Park, Hyun-Soo;Han, Young-Kil;Chang, Byeong-Chun;Rim, Jang-Woon;Rha, Jong-Deuk
    • Journal of Korean Foot and Ankle Society
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    • v.2 no.2
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    • pp.88-92
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    • 1998
  • The course of the sural nerve in the calf has been well documented, but there is a general lack of information concerning the distal course of the nerve. The purpose of this study was to describe the distal course of the sural nerve and its surgical implications. Seven fresh amputated specimens were dissected to show the anatomy of the sural nerve in the foot and ankle. At the level of about 10cm proximal to the plantar surface, the sural nerve coursed anteriorly and inferiorly away from the Achilles tendon. 2 to 4 lateral calcaneal branches arose. The first branch of the lateral calcaneal branches coursed along the lateral border of the Achilles tendon, and it arose at 8cm proximal to the plantar surface in 2 specimens, 12cm proximal to the plantar surface in 4 specimens, and at 12cm proximal to the plantar surface in one specimen. The main nerve trunk continued distally plantar to the peroneal tendons and divided into two terminal branches and crossed peroneus longus tendon at the level of the inferior border of the calcaneo-cuboid joint, at about 3cm(range, $2.5\sim3.0$)cm from the plantar surface. In conclusion, a longitudinal incision lateral to the Achilles tendon would cross the path of the sural nerve at about 10cm proximal to the plantar surface. When the first branch of them arise more than 10cm above the plantar surface, a logitudinal incision lateral to the Achilles tendon may be made without damage. The other lateral calcaneal branches will be cut when we make transverse incision paralled to the plantar surface. The terminal branch also may be in danger by the same transverse incision.

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Hand Gesture Recognition Regardless of Sensor Misplacement for Circular EMG Sensor Array System (원형 근전도 센서 어레이 시스템의 센서 틀어짐에 강인한 손 제스쳐 인식)

  • Joo, SeongSoo;Park, HoonKi;Kim, InYoung;Lee, JongShill
    • Journal of rehabilitation welfare engineering & assistive technology
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    • v.11 no.4
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    • pp.371-376
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    • 2017
  • In this paper, we propose an algorithm that can recognize the pattern regardless of the sensor position when performing EMG pattern recognition using circular EMG system equipment. Fourteen features were extracted by using the data obtained by measuring the eight channel EMG signals of six motions for 1 second. In addition, 112 features extracted from 8 channels were analyzed to perform principal component analysis, and only the data with high influence was cut out to 8 input signals. All experiments were performed using k-NN classifier and data was verified using 5-fold cross validation. When learning data in machine learning, the results vary greatly depending on what data is learned. EMG Accuracy of 99.3% was confirmed when using the learning data used in the previous studies. However, even if the position of the sensor was changed by only 22.5 degrees, it was clearly dropped to 67.28% accuracy. The accuracy of the proposed method is 98% and the accuracy of the proposed method is about 98% even if the sensor position is changed. Using these results, it is expected that the convenience of the users using the circular EMG system can be greatly increased.