• BMB Reports
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• v.54 no.5
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• pp.233-245
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• 2021

In eukaryotes, the genome is hierarchically packed inside the nucleus, which facilitates physical contact between cis-regulatory elements (CREs), such as enhancers and promoters. Accumulating evidence highlights the critical role of higher-order chromatin structure in precise regulation of spatiotemporal gene expression under diverse biological contexts including lineage commitment and cell activation by external stimulus. Genomics and imaging-based technologies, such as Hi-C and DNA fluorescence in situ hybridization (FISH), have revealed the key principles of genome folding, while newly developed tools focus on improvement in resolution, throughput and modality at single-cell and population levels, and challenge the knowledge obtained through conventional approaches. In this review, we discuss recent advances in our understanding of principles of higher-order chromosome conformation and technologies to investigate 4D chromatin interactions.

• International journal of advanced smart convergence
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• v.12 no.3
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• pp.233-243
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• 2023

In modern society, since the expansion of the e-commerce market and the spread of the pandemic, face-to-face business are gradually changing to non-face-to-face. In the logistics industry, the demand for unmanned courier storage is increasing due to lack of loading space from urbanization and courier theft accidents. As the demand for unmanned parcel lockers increases, improved functions such as food storage and efficient space loading are required. This study develops an integrated model-based evaluation procedure of product based on performance factors according to the IEC 61508 standard for newly unmanned parcel storage devices with active loading technology, and derive Critical Technology Element based on the product's core functions and performance goals. As proposing these research, We expect improve the safety and reliability of development targets by identifying and evaluating elements.

• Advances in concrete construction
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• v.9 no.3
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• pp.235-248
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• 2020

Progressive collapse in a structure occurs when load bearing members are failed and the adjoining structural elements cannot resist the redistributed forces and fails subsequently, that leads to complete collapse of structure. Recently, construction using precast concrete technology is adopted increasingly because it offers many advantages like faster construction, less requirement of skilled labours at site, reduced formwork and scaffolding, massive production with reduced amount of construction waste, better quality and better surface finishing as compared to conventional reinforced concrete construction. Connections are the critical elements for any precast structure, because in past, major collapse of precast structure took place because of connection failure. In this study, behavior of four different precast wet connections with U shaped reinforcement bars provided at different locations is evaluated. Reduced 1/3^rd scale precast beam column assemblies having two span beam and three columns with removed middle column are constructed and examined by performing experiments. The response of precast connections is compared with monolithic connection, under column removal scenario. The connection region of test specimens are filled by cast-in-place micro concrete with and without polypropylene fibers. Performance of specimen is evaluated on the basis of ultimate load carrying capacity, maximum deflection at the location of removed middle column, crack formation and failure propagation. Further, Finite element (FE) analysis is carried out for validation of experimental studies and understanding the performance of structural components. Monolithic and precast beam column assemblies are modeled using non-linear Finite Element (FE) analysis based software ABAQUS. Actual experimental conditions are simulated using appropriate boundary and loading conditions. Finite Element simulation results in terms of load versus deflection are compared with that of experimental study. The nonlinear FE analysis results shows good agreement with experimental results.

• Journal of Powder Materials
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• v.28 no.4
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• pp.317-324
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• 2021

High-strength low-alloy (HSLA) steels show excellent toughness when trace amounts of transition elements are added. In steels, prior austenite grain size (PAGS), which is often determined by the number of added elements, is a critical factor in determining the mechanical properties of the material. In this study, we used two etching methods to measure and compare the PAGS of specimens with bainitic HSLA steels having different Nb contents These two methods were nital etching and picric acid etching. Both methods confirmed that the sample with high Nb content exhibited smaller PAGS than its low Nb counterpart because of Nb's ability to hinder austenite recrystallization at high temperatures. Although both etching approaches are beneficial to PAGS estimation, the picric acid etching method has the advantage of enabling observation of the interface containing Nb precipitate. By contrast, the nital etching method has the advantage of a very short etching time (5 s) in determining the PAGS, with the picric acid etching method being considerably longer (5 h).

• Steel and Composite Structures
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• v.52 no.3
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• pp.327-341
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• 2024

This paper is the first in a series of articles dealing with the study and analysis of imperfections in thin-walled, cold-formed steel sections with modified cross-sectional shapes. A study was conducted, using 3D scanning techniques, to determine the most vulnerable geometric imperfections in the profiles. Based on a review of the literature, it has been determined that few researchers are studying thin-walled sections with modified cross-sectional shapes. Each additional bend in the section potentially generates geometric imperfections. Geometric imperfections significantly affect the resistance to loss of stability, which is crucial when analyzing thin-walled structures. In addition, the most critical locations along the length where these imperfections occur were determined. Based on the study, it was found that geometric imperfections cause a reduction in critical load. It should be noted that the tests performed are preliminary studies, based on which a program of further research will be developed. In addition, the article presents the current state of knowledge in the authors' field of interest. The future objective is to ascertain if these imperfections could potentially contribute positively to structural integrity. This enhanced understanding may pave the way for novel methodologies in structural engineering, wherein imperfections are viewed not solely as flaws but also as elements that could enhance the end product.

• Convergence Security Journal
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• v.15 no.6_1
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• pp.69-78
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• 2015

Methods that industrial spies use to smuggle core technology out are becoming more intelligent, technological, and complex, thus resulting in more serious damages. In particular, defense industries in which involve national core technology as well as institutions including labor force are industries that are in a greater need of the convergence security. Defense Industry develops, experiments, and produces defense security supplies for national security protection. Defense industry involves a number of security elements such as military secret, industrial secret, core technology labor force, defense industry supply, critical national facility, and information communication system. Defense industry security is a complex of military security and industrial security which is convergence security that integrates all security elements of defense industry. Therefore, defense industry security is a typical ideal model for convergence security. Research on defense industry security is relatively insufficient compared to research of security in other industrial fields. In order to prevent core technology of denfese industry from leaking and to protect technical professionals and institutions, research and action on defense industry security from convergence security perspective are therefore essential at this point of time.

• Structural Engineering and Mechanics
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• v.87 no.1
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• pp.47-56
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• 2023

Any pre-existed delamination defect present during manufacturing or induce during service loading conditions in the wingskin adherend invariably shows a greater loss of structural integrity of the spar wingskin joint (SWJ). In the present study, inter-laminar delamination propagation at the critical location of the SWJ has been carried out using contact and multi-point constraint finite elements available with commercial FE software (ANSYS APDL). Strain energy release rates (SERR) based on virtual crack closure technique have been computed for evaluation of the opening (Mode-I), sliding (Mode-II) and cross sliding (Mode-III) modes of delamination by sequential release of multi point constraint elements. The variations of different modes of SERR are observed to be significant by considering varied delamination lengths, material properties of adherends and radius of curvature of the SWJ panel. The SERR rates are seen to be much different at the two pre-embedded delamination ends. This shows dissimilar delamination propagation rates. The maximum is seen to occur in the delamination front in the unstiffened region of the wingskin. The curvature geometry and material anisotropy of SWJ adherends significantly influences the SERR values. Increase in the SERR values are observed with decrease in the radius of curvature of wingskin panel, keeping its width unchanged. SWJs made with flat FRP composite adherends have superior resistance to delamination damage propagation than curved composite laminated SWJ panels. SWJ made with Boron/Epoxy (B/E) material shows greater resistance to the delamination propagation.

• Journal of Powder Materials
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• v.28 no.2
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• pp.91-96
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• 2021

Rare earth magnets with excellent magnetic properties are indispensable in the electric device, wind turbine, and e-mobility industries. The demand for the development of eco-friendly recycling techniques has increased to realize sustainable green technology, and the supply of rare earth resources, which are critical for the production of permanent magnets, are limited. Liquid metal extraction (LME), which is a type of pyrometallurgical recycling, is known to selectively extract the metal forms of rare earth elements. Although several studies have been carried out on the formation of intermetallic compounds and oxides, the effect of oxide formation on the extraction efficiency in the LME process remains unknown. In this study, microstructural and phase analyses are conducted to confirm the oxidation behavior of magnets pulverized by a jaw crusher. The LME process is performed with pulverized scrap, and extraction percentages are calculated to confirm the effect of the oxide phases on the extraction of Dy during the reaction. During the L ME process, Nd is completely extracted after 6 h, while Dy remains as Dy₂Fe₁₇ and Dy-oxide. Because the decomposition rate of Dy₂Fe₁₇ is faster than the reduction rate of Dy-oxide, the importance of controlling Dy-oxide on Dy extraction is confirmed.

• Structural Engineering and Mechanics
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• v.67 no.6
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• pp.629-641
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• 2018

The paper describes the development of a two-dimensional (2D) co-rotational nonlinear beam finite element that includes advanced path-following capabilities for detecting bifurcation instability in elasto-plasticity of steel elements subjected to fire without introducing imperfections. The advantage is twofold: i) no need to assume the magnitude of the imperfections and consequent reduction of the model complexity; ii) the presence of possible critical points is checked at each converged time step based on the actual load and stiffness distribution in the structure that is affected by the temperature field in the elements. In this way, the buckling modes at elevated temperature, that may be different from the ones at ambient temperature, can be properly taken into account. Moreover, an improved displacement predictor for estimating the displacement field allowed significant reduction of the computational cost. A co-rotational framework was exploited for describing the beam kinematic. In order to highlight the potential practical implications of the developed finite element, a parametric analysis was performed to investigate how the beam element compares both with the EN1993-1-2 buckling curve and with experimental tests on axially compressed steel members. Validation against experimental data and numerical outcomes obtained with commercial software is thoroughly described.

• Journal of Ocean Engineering and Technology
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• v.24 no.1
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• pp.172-177
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• 2010

This study presents an explicit dynamic analysis of an adhesively bonded single-lap joint under an impact load. The finite element software, ANSYS LS-DYNA, was used for the analysis and Von Mises stresses were obtained from the analysis. To model the adherents, solid elements were used and a rigid body was assumed for impactor modeling. Three impact heights (1 m, 5 m, and 10 m) were applied to consider different impact conditions and infinite boundary conditions were applied to the end-area of each adherent to save computational time in the analysis. In addition to investigating the stresses in the normal state, we also investigated the stresses in a damaged state (elasticity deterioration), simulated by a change in Young's modulus for 36 of the 3600 elements in the upper layer of the adhesive. The results showed that the location of damage is critical to the stress state of each layer (upper, middle, and lower).