• 한국도로학회논문집
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• 제15권5호
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• pp.203-215
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• 2013

PURPOSES : This study deals with first traffic violations occurred by novice drivers, which may be associated with traffic accidents. The objective of this study is to identify what kinds of drivers' characteristics influence on duration till the first traffic violation. METHODS : For the study, Survival Analysis and Cox proportional hazard model, that are usually used in the medical field, were employed. Survival Analysis was conducted to investigate whether there exist differences in survival duration by each covariate, whereas Cox proportional hazard model was used to identify significant factors that affect survival duration till novice drivers violate traffic regulations for the first time after getting a driver license. RESULTS : The results of Survival Analysis indicate that female, age (less than 21), low-frequency examinee of written exam, and non-crash involved drivers have longer duration till the first violation compared to male, greater than 21 years old, high-frequency examinee of written exam, and crash involved drivers, respectively. For the Cox proportional hazard model, license class 1 acquisitor was found to increase the survival duration till the first traffic violation was made, while male, age of 21-24, age of 25-34, age of 45-54, and crash involved drivers were more likely to reduce the survival duration. CONCLUSIONS : Absolutely, traffic violation is closely related to traffic accidents and all of the drivers should keep the traffic regulations to enhance highway safety. The results of this study might provide some insights to construct safe road environments by controlling the factors that reduce the traffic violation duration of novice drivers.

• 한국통계학회:학술대회논문집
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• 한국통계학회 2005년도 춘계 학술발표회 논문집
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• pp.251-255
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• 2005

중도절단된 자료와 표본수가 적은 자료를 가지는 생존분석에서 생존율을 추정하거나 두 집단의 생존율을 비교할 때 정규분포 근사를 가정한 신뢰구간을 이용하는 데는 많은 어려움이 생긴다. 생존함수의 신뢰구간에 대한 중도절단을, 표본의 크기에 따른 다양한 상황의 모의실험을 통하여 Kaplan-Meier, Nelson, 적률 추정량 그리고 cox model의 ${\beta}$을 가지고 붓스트랩을 이용한 신뢰구간과 비모수 신뢰구간, 우도비 신뢰구간의 실제 포함 확률을 비교해보고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4453-4458
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• 2012

Angiogenesis plays a significant role in colorectal cancer (CRC) and cyclooxygenase-2 (COX-2) appears to be involved with multiple aspects of CRC angiogenesis. Our aim was to investigate the inhibitory effects of Tan II-A (Tanshinone II-A, Tan II-A) on tumor growth in mice, as well as alteration of expression of COX-2 and VEGF in CRC. We established the mice xenograft model of C26 CRC cell line, and injected 0.5, 1, 2mg/kg of Tan II-A and 1mg/kg of 5-FU in respectively in vivo. Then, we assayed tumor weight and volume, and evaluated microvascular density and expression of VEGF. COX-2 promoter and COX-2 plasmids were transfected into HCT-116 cells, followed by detection of COX-2 promoter activity by chemiluminescence, and detection of COX-2 mRNA expression by fluorescence quantitative PCR. Taken together, the results showed Tan II-A could inhibit tumor growth and suppress the VEGF level in vivo. HCT-116 cell experiments showed marked inhibitory effects of Tan II-A on COX-2 and VEGF in a dose-dependent manner. The results indicate that Tan II-A can effectively inhibit tumor growth and angiogenesis of human colorectal cancer via inhibiting the expression level of COX-2 and VEGF.

• Journal of the Korean Data and Information Science Society
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• 제12권1호
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• pp.103-125
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• 2001

The Box-Cox transformation is a well known family of power transformation that brings a set of data into agreement with the normality assumption of the residuals and hence the response variable of a postulated model in regression analysis. This paper proposes a new method for estimating the Box-Cox transformation using maximization of the Sample Entropy statistic which forces the data to get closer to normal as much as possible. A comparative study of the proposed procedure with the maximum likelihood procedure, the procedure via artificial regression estimation, and the recently introduced maximization of the Shapiro-Francia W' statistic procedure is given. In addition, we generate a table for the optimal spacings parameter in computing the Sample Entropy statistic.

• Journal of the Korean Data and Information Science Society
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• 제26권6호
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• pp.1225-1238
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• 2015

본 연구에서는 직장암 환자들의 수술 후 재발까지의 시간 데이터에 대해 집단 간 생존함수 양상에 차이가 있는지 로그 순위 검정 결과 유의수준 10%에서 포도당 단일수송체 (GLUT1)의 수준, 수술 전 병기 (cstage), 수술 후 병기 (ypstage)에 따른 차이가 유의하며, Cox 비례위험률 모형을 이용하여 검정한 결과 가장 유의한 공변량은 포도당 단일수송체와 수술 후 병기였다. 지수분포를 따른다고 가정할 경우, 우도함수를 기반한 여러 가지 위험률 변화점을 추정하였다.

• Communications for Statistical Applications and Methods
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• 제14권1호
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• pp.241-254
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• 2007

This paper propose a new short-term interest rate model having a different nonlinear drift function and the same diffusion coefficient with Chan et al. (1992) model. The fractional polynomial power of the drift function in our model is linked to the local volatility elasticity of the diffusion coefficient. While the nonlinear drift function estimated by $A\"{\i}t$-Sahalia (1996a) and others has a feature that higher interest rates tend to revert downward and low rates upward, the drift function estimated by our nonlinear model shows that higher interest rate mean-reverts strongly, but, medium rates has almost zero drift and low rates has a very small drift. This characteristic coincides the empirical result based on the nonparametric methodology by Stanton (1997) and the implication by the scatter plot of the short rate data.

• Journal of the Korean Data and Information Science Society
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• 제19권3호
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• pp.789-800
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• 2008

Current credit evaluation models based on financial data make use of smoothing estimated default ratios which are transformed from each financial variable. In this work, some problems of the credit evaluation models developed by financial experts are discussed and we propose improved credit evaluation models based on the stepwise variable selection method and Box-Cox transformed data whose distribution is much skewed to the right. After comparing goodness-of-fit tests of these models, the validation of the credit evaluation models using statistical methods such as the stepwise variable selection method and Box-Cox transformation function is explained.

• 대한한의학회지
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• 제23권4호
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• pp.32-44
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• 2002

Objective: In this study, we investigated the effects of Rhizoma Cimicifugae (RC) on the induction of nitric oxide (NO) in RAW 264.7 murine macrophages treated with lipopolysaccharide (LPS). Methods: We examined whether RC have an antipyretic effect by inhibition of COX and/or NOS in fever that is evoked by an intraperitoneal injection of LPS in rats. Results: 1. RC inhibited NO metabolites produced by activated murine macrophage in a dose-dependent manner. 2. RC had an antipyretic effect in a dose-dependent manner in LPS-induced fever. 3. RC inhibited levels of both COX-2 protein and iNOS protein increased by the treatment of LPS in brain tissues as well as brain blood vessels. 4. There were no changes in proteins of nNOS/COX-1. Conclusions: RC has an antipyretic effect by attenuating the level of iNOS and COX-2 protein.

• 산업진흥연구
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• 제5권1호
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• pp.1-11
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• 2020

본 연구에서는 정부정책이 효과가 있었는지 파악하기 위하여 과거 10년간의 산업재해 데이터를 살펴보았다. 이들 데이터로부터 중요한 두 개 또는 세 개의 변수간의 관계를 EDA 방법으로 살펴보았다. 근로자수(사업장규모)와 생존확률 간의 관계를 살펴본 결과 근로자수가 많을수록 시간이 지남에 따라 생존확률이 더욱 더 떨어짐(산업재해가 더 많이 일어남)을 알 수 있다. Cox의 비례위험모형을 적용해본 결과 사업장에서 발생한 총산업재해수가 많을수록 해당 사업장에서 산업재해가 발생할 위험성(hazard)이 높아지고, 근로자수가 적을수록 산업재해가 발생할 위험성이 높으며, 업종별로는 농업, 어업 및 임업이 건설업에 비해 산업재해를 당할 위험성이 더 크다. 공단, 민간 및 고용노동부의 역할은 고용노동부만 효과가 있고, 나머지 두 조직은 효과가 없는 것으로 나온다. recurrent event data를 Cox의 비례위험모델로 분석해본 결과 비슷한 결과가 나온다.

• 대한간호학회지
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• 제49권5호
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• pp.575-585
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• 2019

Purpose: The purpose of this study was to develop predictive models for pressure ulcer incidence using electronic health record (EHR) data and to compare their predictive validity performance indicators with that of the Braden Scale used in the study hospital. Methods: A retrospective case-control study was conducted in a tertiary teaching hospital in Korea. Data of 202 pressure ulcer patients and 14,705 non-pressure ulcer patients admitted between January 2015 and May 2016 were extracted from the EHRs. Three predictive models for pressure ulcer incidence were developed using logistic regression, Cox proportional hazards regression, and decision tree modeling. The predictive validity performance indicators of the three models were compared with those of the Braden Scale. Results: The logistic regression model was most efficient with a high area under the receiver operating characteristics curve (AUC) estimate of 0.97, followed by the decision tree model (AUC 0.95), Cox proportional hazards regression model (AUC 0.95), and the Braden Scale (AUC 0.82). Decreased mobility was the most significant factor in the logistic regression and Cox proportional hazards models, and the endotracheal tube was the most important factor in the decision tree model. Conclusion: Predictive validity performance indicators of the Braden Scale were lower than those of the logistic regression, Cox proportional hazards regression, and decision tree models. The models developed in this study can be used to develop a clinical decision support system that automatically assesses risk for pressure ulcers to aid nurses.