• Title/Summary/Keyword: Coupled channel analysis

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Novel Genetic Variants Associated with Lumbar Spondylosis in Koreans : A Genome-Wide Association Study

  • Kim, Hyun Ah;Heo, Seong Gu;Park, Ji Wan;Jung, Young Ok
    • Journal of Korean Neurosurgical Society
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    • v.61 no.1
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    • pp.66-74
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    • 2018
  • Objective : The aim of this study was to identify the susceptibility genes responsible for lumbar spondylosis (LS) in Korean patients. Methods : Data from 1427 subjects were made available for radiographic grading and genome wide association studies (GWAS) analysis. Lateral lumbar spine radiographs were obtained and the various degrees of degenerative change were semi-quantitatively scored. A pilot GWAS was performed using the AffymetrixGenome-Wide Human single-nucleotide polymorphisms (SNPs), 500K array. A total of 352228 SNPs were analyzed and the association between the SNPs and case-control status was analyzed by stepwise logistic regression analyses. Results : The top 100 SNPs with a cutoff p-value of less than $3.7{\times}10^{-4}$ were selected for joint space narrowing, while a cutoff p-value of $6.0{\times}10^{-4}$ was applied to osteophytes and the Kellgren-Lawrence (K-L) osteoarthritis grade. The SNPs with the strongest effect on disc space narrowing, osteophytes, and K-L grade were serine incorporator 1 (rs155467, odds ratio [OR]=17.58, $p=1.6{\times}10^{-4}$), stromal interaction molecule 2 (STIM1, rs210781, OR=5.53, $p=5{\times}10^{-4}$), and transient receptor potential cation channel, subfamily C (rs11224760, OR=3.99, $p=4.8{\times}10^{-4}$), respectively. Leucine-rich repeat-containing G protein-coupled receptor 4 was significantly associated with both disc space narrowing and osteophytes (rs1979400, OR=2.01, $p=1.1{\times}10^{-4}$ for disc space narrowing, OR=1.79, $p=3{\times}10^{-4}$ for osteophytes), while zinc finger and BTB domain containing 7C was significantly and negatively associated with both osteophytes and a K-L grade >2 (rs12457004,OR=0.25, $p=5.8{\times}10^{-4}$ and OR=0.27, $p=5.3{\times}10^{-4}$, respectively). Conclusion : We identified SNPs that potentially contribute to the pathogenesis of LS. This is the first report of a GWAS in an Asian population.

An Experimental Study on Combustion Instability Characteristics of Various Fuel-Air Mixing Section Geometry in a Model Dump Shape Combustor (모형 덤프 연소기에서 혼합기 유입구 길이 변화에 따른 연소불안정 특성에 대한 실험적 연구)

  • Kim, Min-Ki;Yoon, Ji-Su;Hwang, Jeong-Jae;Yoon, Young-Bin
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2011.11a
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    • pp.187-199
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    • 2011
  • The main objective of this study was investigation of natural gas flames in a lean premixed swirl-stabilized dump combustor with an attention focused on the effect of the various fuel-air mixing section geometry on the combustion instability characteristics. The multi-channel dynamic pressure transducers were located on the combustor and inlet mixing section region to observe combustion pressure oscillation and difference phase at each dynamic pressure measurement results. Dynamic pressures were also measured to investigate characteristics of combustion at the same time. The combustor and mixing section length was varied in order to have different acoustic resonance characteristics from 800 to 1800 mm in combustor and 470, 550, 870 mm in mixing section. We observed two dominant instability frequencies in this study. Lower frequencies were obtained at lower equivalence ratio region and it was associated with a fundamental longitudinal mode of combustor length. Higher frequencies were observed in higher equivalence ratio conditions. It was related to secondary longitudinal mode of coupled with the combustor and mixing section. In this instability characteristics, pressure oscillation of mixing section part was larger than pressure oscillation of combustor. As a result, combustion instability was strongly affected by acoustic characteristics of combustor and mixing section geometry.

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History and Current Situation of River Management using Physical Habitat Models in the U.S. and Japan

  • Sekine, Masahiko
    • Korean Journal of Ecology and Environment
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    • v.46 no.1
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    • pp.10-17
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    • 2013
  • History of Instream Flow Incremental Methodology (IFIM) Following the large reservoir and water development era of the mid-twentieth century in North America, resource agencies became concerned over the loss of many miles of riverine fish and wildlife resources in the arid western United States. Consequently, several western states began issuing rules for protecting existing stream resources from future depletions caused by accelerated water development. Many assessment methods appeared during the 1960's and early 1970's. These techniques were based on hydrologic analysis of the water supply and hydraulic considerations of critical stream channel segments, coupled with empirical observations of habitat quality and an understanding of riverine fish ecology. Following enactment of the National Environmental Policy Act (NEPA) of 1970, attention was shifted from minimum flows to the evaluation of alternative designs and operations of federally funded water projects. Methods capable of quantifying the effect of incremental changes in stream flow to evaluate a series of possible alternative development schemes were needed. This need led to the development of habitat versus discharge functions developed from life stage-specific relations for selected species, that is, fish passage, spawning, and rearing habitat versus flow for trout or salmon. During the late 1970's and early 1980's, an era of small hydropower development began. Hundreds of proposed hydropower sites in the Pacific Northwest and New England regions of the United States came under intensive examination by state and federal fishery management interests. During this transition period from evaluating large federal reservoirs to evaluating license applications for small hydropower, the Instream Flow Incremental Methodology (IFIM) was developed under the guidance of the U.S. Fish and Wildlife Service (USFWS).

Manufacture of an Acousto-Optical Spectrometer for Radio Astronomical Observations (우주전파관측용 음향광학 전파분광기의 제작)

  • 임인성;최재현;오승엽
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.8 no.1
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    • pp.1-12
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    • 1997
  • The acousto-optical spectrometer as a new type backend of the receiver system for radio astronomical observations is manufactured for radio signal analysis. We studied on the effect of Acousto-Optic and Acousto-Optic devices and designed the optics system. We manufactured the optical mount and the CCD detector for deflected beam and interface card. This acousto-optical spectrometer consisted of a laser, optics, acousto-optic deflector, CCD detector and Interface card. This system use He-Ne laser as a light source and use optics to get parallel beam and to focus the deflected beam. Acousto-optic deflector converts IF signal to ultrasonic wave and deflect the laser beam according to the Bragg deflection. The ultra wide band acousto-optic deflector has 1 GHz bandwidth and a total of 2,048 channel Charge Coupled Device for signal detection. In this study, we discuss the theoretical description on the effect of Acousto-optics, the design of the optics, manufacture of optical mount, CCD detector, interface card and we presented the results of experiment. As a result of measurement, we have 1,000 channels bandwidth from CCD channels.

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A Study on TTX Traction Characteristics using Measurement System (계측시스템을 활용한 틸팅열차 추진장치 특성 연구)

  • Han, Young-Jae;Lee, Su-Gil;Park, Choon-Soo;Han, Seong-Ho;Lee, Jun-Seok;Jung, Kwon-Il
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.20 no.12
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    • pp.1093-1098
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    • 2007
  • Tilting trains are currently in operation in 13 countries around the world. With the advances in tilting technology, verification of economic efficiency, and changes in economic situations, the introduction of tilting trains will rapidly spread across the globe. The measurement system is composed of the industrial computers installed in the console and the measurement racks mounted on each car. It is utilized to accumulate the data by the communication card and the optical cable. The optical cable and power cable are coupled at the connector located in joint of train to make easy to disconnect car each other. The signal conditioner is designed to choose and to extend the channel for each sensor readily. The sensor measurement rack has adopted as decentralization method. It is installed in each car to minimize the cable length. In also, it is manufactured based on 19"rack and covered to protect the cable. In this study, the programs for measurement and analysis were also developed to understand the traction system characteristics of TTX. Using this measurement system, we studied that acceleration test, re-powering test, and gradually powering test. The acceleration performance of TTX is 1.735 km/h/s, and it is inner standard value. The notch test result from 1 to 7 steps, DC link voltage is under standard value, and the output electric current of inverter is controlled normally. From the test results, we saw the performances of the traction systems are normal.

Numerical Analysis of Runup and Wave Force Acting on Coastal Revetment and Onshore Structure due to Tsunami (해안안벽과 육상구조물에서 지진해일파의 처오름 및 작용파력에 관한 수치해석)

  • Lee, Kwang Ho;Kim, Chang Hoon;Kim, Do Sam;Yeh, Harry;Hwang, Young Tae
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.29 no.3B
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    • pp.289-301
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    • 2009
  • In this work, wave run-up heights and resultant wave forces on a vertical revetment due to tsunami (solitary wave) are investigated numerically using a numerical wave tank model called CADMAS-SURF (CDIT, 2001. Research and Development of Numerical Wave Channel (CADMAS-SURF). CDIT library, No. 12, Japan.), which is based on a 2-D Navier-Stokes solver, coupled to a volume of fluid (VOF) method. The third order approximate solution (Fenton, 1972. A ninth-order solution for the solitary wave. J. of Fluid Mech., Vol. 53, No.2, pp.257-271) is used to generate solitary waves and implemented in original CADMAS-SURF code. Numerical results of the wave profiles and forces are in good agreements with available experimental data. Using the numerical results, the regression curves determined from the least-square analysis are proposed, which can be used to determine the maximum wave run-up height and force on a vertical revetment due to tsunami. In addition, the capability of CADMAS-SURF is demonstrated for tsunami wave forces acting on an onshore structure using various configuration computations including the variations of the crown heights of the vertical wall and the position of the onshore structure. Based on the numerical results such as water level, velocity field and wave force, the direct effects of tsunami on an onshore structure are discussed.

Closed Integral Form Expansion for the Highly Efficient Analysis of Fiber Raman Amplifier (라만증폭기의 효율적인 성능분석을 위한 라만방정식의 적분형 전개와 수치해석 알고리즘)

  • Choi, Lark-Kwon;Park, Jae-Hyoung;Kim, Pil-Han;Park, Jong-Han;Park, Nam-Kyoo
    • Korean Journal of Optics and Photonics
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    • v.16 no.3
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    • pp.182-190
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    • 2005
  • The fiber Raman amplifier(FRA) is a distinctly advantageous technology. Due to its wider, flexible gain bandwidth, and intrinsically lower noise characteristics, FRA has become an indispensable technology of today. Various FRA modeling methods, with different levels of convergence speed and accuracy, have been proposed in order to gain valuable insights for the FRA dynamics and optimum design before real implementation. Still, all these approaches share the common platform of coupled ordinary differential equations(ODE) for the Raman equation set that must be solved along the long length of fiber propagation axis. The ODE platform has classically set the bar for achievable convergence speed, resulting exhaustive calculation efforts. In this work, we propose an alternative, highly efficient framework for FRA analysis. In treating the Raman gain as the perturbation factor in an adiabatic process, we achieved implementation of the algorithm by deriving a recursive relation for the integrals of power inside fiber with the effective length and by constructing a matrix formalism for the solution of the given FRA problem. Finally, by adiabatically turning on the Raman process in the fiber as increasing the order of iterations, the FRA solution can be obtained along the iteration axis for the whole length of fiber rather than along the fiber propagation axis, enabling faster convergence speed, at the equivalent accuracy achievable with the methods based on coupled ODEs. Performance comparison in all co-, counter-, bi-directionally pumped multi-channel FRA shows more than 102 times faster with the convergence speed of the Average power method at the same level of accuracy(relative deviation < 0.03dB).

Recent Progress in Air-Conditioning and Refrigeration Research : A Review of Papers Published in the Korean Journal of Air-Conditioning and Refrigeration Engineering in 2012 (설비공학 분야의 최근 연구 동향 : 2012년 학회지 논문에 대한 종합적 고찰)

  • Han, Hwataik;Lee, Dae-Young;Kim, Sa Ryang;Kim, Hyun-Jung;Choi, Jong Min;Park, Jun-Seok;Kim, Sumin
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.25 no.6
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    • pp.346-361
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    • 2013
  • This article reviews the papers published in the Korean Journal of Air-Conditioning and Refrigeration Engineering during 2012. It is intended to understand the status of current research in the areas of heating, cooling, ventilation, sanitation, and indoor environments of buildings and plant facilities. The conclusions are as follows : (1) The research works on thermal and fluid engineering have been reviewed as groups of fluid machinery, pipes and valves, fuel cells and power plants, ground-coupled heat pumps, and general heat and mass transfer systems. Research issues are mainly focused on new and renewable energy systems, such as fuel cells, ocean thermal energy conversion power plants, and ground-coupled heat pump systems. (2) Research works on the heat transfer area have been reviewed in the categories of heat transfer characteristics, pool boiling and condensing heat transfer, and industrial heat exchangers. Researches on heat transfer characteristics included the results for natural convection in a square enclosure with two hot circular cylinders, non-uniform grooved tube considering tube expansion, single-tube annular baffle system, broadcasting LED light with ion wind generator, mechanical property and microstructure of SA213 P92 boiler pipe steel, and flat plate using multiple tripping wires. In the area of pool boiling and condensing heat transfer, researches on the design of a micro-channel heat exchanger for a heat pump, numerical simulation of a heat pump evaporator considering the pressure drop in the distributor and capillary tubes, critical heat flux on a thermoexcel-E enhanced surface, and the performance of a fin-and-tube condenser with non-uniform air distribution and different tube types were actively carried out. In the area of industrial heat exchangers, researches on a plate heat exchanger type dehumidifier, fin-tube heat exchanger, an electric circuit transient analogy model in a vertical closed loop ground heat exchanger, heat transfer characteristics of a double skin window for plant factory, a regenerative heat exchanger depending on its porous structure, and various types of plate heat exchangers were performed. (3) In the field of refrigeration, various studies were executed to improve refrigeration system performance, and to evaluate the applicability of alternative refrigerants and new components. Various topics were presented in the area of refrigeration cycle. Research issues mainly focused on the enhancement of the system performance. In the alternative refrigerant area, studies on CO2, R32/R152a mixture, and R1234yf were performed. Studies on the design and performance analysis of various compressors and evaporator were executed. (4) In building mechanical system research fields, twenty-nine studies were conducted to achieve effective design of mechanical systems, and also to maximize the energy efficiency of buildings. The topics of the studies included heating and cooling, HVAC system, ventilation, renewable energy systems, and lighting systems in buildings. New designs and performance tests using numerical methods and experiments provide useful information and key data, which can improve the energy efficiency of buildings. (5) In the fields of the architectural environment, studies for various purposes, such as indoor environment, building energy, and renewable energy were performed. In particular, building energy-related researches and renewable energy systems have been mainly studied, reflecting interests in global climate change, and efforts to reduce building energy consumption by government and architectural specialists. In addition, many researches have been conducted regarding indoor environments.