• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.13 no.9
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• pp.907-915
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• 2002

In this paper, a compact digital phase shifter to be used an active phased array antenna system for satellite communications was proposed. The even and odd mode analysis for a given reflection-type phase shifter, which uses a folded hybrid coupler as a base element, was performed and the design parameters were derived. Also, to verify experimentally the electrical performances of the proposed structure, X-band 4-bit digital phase shifter was designed and fabricated using Teflon soft substrate $({\varepsilon}_r; =\;2.17)$. Its circuit size was less than 3.5 cm $\times$ 3.0 cm, and it exhibited at least 50 % size reduction as compared with the conventional unfolded configuration. The experimental results of the fabricated phase shifter showed that the average insertion loss and insertion loss variation were less than 3.5 dB, $\pm$ 0.6 dB within the operating band, 7.9 ~ 8.4 GHz, respectively. And, input and output return loss were more than 10 dB, respectively. Also, the phase response of the phase shifter showed 4-bit operation with $\pm$3$^{\circ}$ rms phase error.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.10
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• pp.1521-1527
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• 2010

Since inkjet printing is being employed in production lines of electronics and display industries, the tack time for inspection of jetting failure has become very important because the throughput of the inkjet printing system can be extended to the maximum limit by adopting a shorter jetting inspection time. The most popular method for inspecting jetting failure involves the use of a linear stage, a high magnification lens, and a charge coupled devicecamera. However, this conventional approach requires approximately 60 s to complete the jetting inspection and might not be suitable for a high-speed reciprocating jetting inspection in endurance tests due to the unwanted mechanical vibration. In this study, a novel concept of an inkjet monitoring module is introduced, which has an overall inspection time of 18 s. For the shorter tack time of jetting inspection, the parameters affecting the tack time are discussed in this paper.

• Biomolecules & Therapeutics
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• v.28 no.3
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• pp.250-258
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• 2020

Emphysema, a major component of chronic obstructive pulmonary disease (COPD), is a leading cause of human death worldwide. The progressive deterioration of lung function that occurs in the disease is caused by chronic inflammation of the airway and destruction of the lung parenchyma. Despite the main impact of inflammation on the pathogenesis of emphysema, current therapeutic regimens mainly offer symptomatic relief and preservation of lung function with little therapeutic impact. In the present study, we aimed to discover novel therapeutics that suppress the pathogenesis of emphysema. Here, we show that LJ-2698, a novel and highly selective antagonist of the adenosine A₃ receptor, a G protein-coupled receptor involved in various inflammatory diseases, significantly reversed the elastase-induced destructive changes in murine lungs. We found that LJ-2698 significantly prevented elastase-induced airspace enlargement, resulting in restoration of pulmonary function without causing any obvious changes in body weight in mice. LJ-2698 was found to inhibit matrix metalloproteinase activity and pulmonary cell apoptosis in the murine lung. LJ-2698 treatment induced increases in anti-inflammatory cytokines in macrophages at doses that displayed no significant cytotoxicity in normal cell lines derived from various organs. Treatment with LJ-2698 significantly increased the number of anti-inflammatory M2 macrophages in the lungs. These results implicate the adenosine A₃ receptor in the pathogenesis of emphysema. Our findings also demonstrate the potential of LJ-2698 as a novel therapeutic/preventive agent in suppressing disease development with limited toxicity.

• Journal of KIISE:Software and Applications
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• v.36 no.5
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• pp.386-395
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• 2009

Business entities with which most service components interact are kind of cross-cutting concerns in a multi-layered distributed application architecture. When business entities are modified, service components related to them should also be modified, even though they implement common functions of the application framework. This paper proposes what we call DTT (Data Type-Tolerant) component model to process the variability of business entities, or externalized data, which feature modern application architectures. The DTT component model expresses the data variability of product lines at the implementation level by means of SCDTs (Self-Contained Data Types) and variation point interfaces. The model improves the efficiency of application engineering through data type converters which support type conversion between SCDTs and business entities of particular applications. The value of this model lies in that data and functions are coupled locally in each component again by allowing service components to deal with SCDTs only instead of externalized business eutities.

• Nutritional Sciences
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• v.8 no.3
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• pp.159-168
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• 2005

Phytoestrogens, especially Yak-kong or soybean-derived isoflavones have been traditionally used as a supplement of estrogen for preventing postmemopausal osteoporosis in oriental folk medicine. In our previous study, the treatment of Yak-kong and soybean increased estrogen receptor-a (ERa) expression and proliferation of MG-63 osteoblastic cells. In contrast, the increase of estrogen receptor-$\beta$ (ER$\beta$) expression in proliferating MG-63 cells with Yak-kong and soybean treatment was less pronounced, which suggested that ER$\beta$ may play a role rather in the regulation of bone cell differentiation To determine the role of ER$\beta$ in Yak-kong or soybean mediated regulation of bone cell differentiation, we established MG-63 cell lines stably expressing either ER$\beta$ or antisense ER$\beta$ RNAs. Increased expression of ER$\beta$ did not affect ERa expression and proliferation of MG-63 cells. However, increased expression of ER$\beta$ in MG-63 cells (ER$\beta$-MG63 cells) selectively enhanced Yak-kong or soybean induced expression of osteoprotegerin (OPG), a novel soluble glycoprotein which is secreted from osteoblasts and mediates the signal for osteoclast differentiation. Inhibition of ER$\beta$ expression by antisense ER$\beta$ RNAs (As-ER$\beta$-MG63) caused these cells to insensitize Yak-kong or soybean induced expression of OPG but increased MG-63 cell proliferation. Furthermore, the comparable effects between Yak-kong and the combined treatment of genistein and daidzein at $0.5{\times}l0^{-8}$ M, which is a concentration of these two isoflavones similar to Yak-kong at 0.001 mg/mL, on OPG expression in ER$\beta$-MG63 cell demonstrate that the enhanced expression of OPG with Yak-kong treatment is mediated by the synergistic effect of low leveled isoflavones in the extracts. Together, coupled with low level of ER expression in osteoclasts, our data demonstrate that ER$\beta$ in osteoblasts plays an important role in Yak-kong and soybean mediated inhibition of osteoclast differentiation indirectly by enhancing the expression of OPG.

• Coupled systems mechanics
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• v.7 no.4
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• pp.485-507
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• 2018

The moving load causes the occurrence of vibrations in civil engineering structures such as bridges, railway lines, bridge cranes and others. A novel engineering method for separation of the variables in the differential equation of the elastic line of Bernoulli-Euler beam has been developed. The method can be utilized in engineering structures, leading to "a beam under moving load model" with generalized boundary conditions. This method has been implemented for analytical study of the dynamic response of the metal structure of a single girder bridge crane due to the telpher movement along the bridge girder. The modeled system includes: a crane bridge girder; a telpher, moving with a constant horizontal velocity; a load, elastically fixed to the telpher. The forced vibrations with their own frequencies and with a forced frequency, due to the telpher movement, have been analyzed. The loading resulting from the telpher uniform movement along the bridge girder is cyclical, which is a prerequisite for nucleation and propagation of fatigue cracks. The concept of "dynamic coefficient" has been introduced, which is defined as a ratio of the dynamic deflection of the bridge girder due to forced vibrations, to the static one. This ratio has been compared with the known from the literature empirical dynamic coefficient, which is due to the telpher track unevenness. The introduced dynamic coefficient shows larger values and has to be taken into account for engineering calculations of the bridge crane metal structure. In order to verify the degree of approximation, the obtained results have been compared with FEM outcomes. An additional comparison has been made with the exact solution, proposed by Timoshenko, for the case of simply supported beam subjected to a moving force. The comparisons show a good agreement.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.36 no.6
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• pp.506-512
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• 1991

Monoclonal antibodies (mAb) to indole-3-acetic acid (IAA) were produced and characterized. Spleen cells from mouse immunized with IAA coupled to bovine serum albumin were fused with SP2/0-Ag14 myeloma cells. Three clones secreted specific antibodies to IAA were established to hybridoma cell lines and designated WLI-G1, WLI-G3 and WLI-Ell. The antibodies produced were classified into IgG, types and revealed the high degree of specificity by cross-reaction in the IAA derivatives and its analogues. In the IAA-ELISA with mAb, the measuring range of the assay was 1-500 p mol, and Ka and binding capacity calculated from Scatchard plot were 6.7 X 10$^{-10}$ L/M and 6 x 10$^{-10}$ L/M respectively. The ELISA with mAb can be used to quantitate IAA directly in crude plant eatract. The results showed that the immunoassay was easy and sensitive method to perform and applicate for quantitative analysis of IAA in plant.

• Progress in Superconductivity
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• v.7 no.1
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• pp.6-10
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• 2005

We have studied feasibility of single-layer second-order $high-T_c$ SQUID gradiometers in magnetocardiography. We have measured human cardiomagnetic signals using a short-baseline (5.8 mm) single-layer second-order YBCO gradiometer in partially shielded environments. The gradiometer has an overall size of $17.6\;mm{\times}6\;mm$ and contains three parallel-connected pickup coils which are directly coupled to a step-edge junction SQUID. The gradiometer showed an unshielded gradient noise of $0.84\;pT/cm^2/Hz^{1/2}$ at 1 Hz, which corresponds to an equivalent field noise of $280\;fT/Hz^{1/2}$. The balancing factor was $10^3$. Based on the same design rules as the short-baseline devices, we have studied fabrication of 30 mm-long baseline gradiometers. The devices had an overall size of $70.2\;mm{\times}10.6\;mm$ with each pickup coil of $10\;mm{\times}10\;mm$ in outer size. As Josephson elements we made two types of submicron bridges, which are variable thickness bridge (VTB) and constant thickness bridge (CTB), from $3\;{\mu}m-wide$ and 300 nm-thick YBCO lines with a thin layer of Au on top by using a focused ion beam (FIB) patterning method. VTB was 300 nm wide, 200 nm thick, 30 nm long with Au removed and CTB 100 nm wide and 30 nm long. In temperature-dependent critical currents, $I_c(T)$, VTB showed an nonmetallic barrier-type behavior and CTB an SNS behavior. We believe that those characteristics are ascribed to naturally formed grain boundaries crossing the bridges.

• Journal of IKEEE
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• v.18 no.4
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• pp.559-565
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• 2014

A 3 dB coupler has been designed and implemented using the most commonly used double-sided FR4 boards. The coupling and the bandwidth of the coupler are enhanced with the enlarged overlapped area of the coupler. Major design parameters are plotted as a design guide and the parameters are verified by simulation and measurement. The size of the manufactured coupler is $30{\times}14mm^2$. Its measured insertion loss and phase difference are 0.6 dB and $90.5^{\circ}$ at center frequency of 2.5 GHz, respectively. The operating frequency range is 1.72 GHz to 3.08 GHz for $3.6{\pm}0.5dB$ insertion loss. The coupler has the performance similar to that of conventional Lange coupler, and implementation of the coupler is easy and cheap with wide metal width and spacing and no additional wire bonding process.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.10
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• pp.2269-2274
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• 2015

In this paper, the reduced size in horizontal sizes of the narrow band pass filter (BPF) with λg/4 short stub using S shaped folded coupling structure is presented. This BPF with narrow bandwidth show flexible bandwidth with variation of the position of the stubs using the Qe(external quality factor) without changing the impedance value. On the other hand, by replacing the horizontal quarter-wavelength transmission lines with the equivalent S shaped coupled line, the BPF with reduced the size of horizontal can be realized. The proposed BPF shows the insertion loss of 1.46 dB and the return loss of 16.5 dB with bandwidth of 3.4 % at the center frequency of 5.8 GHz, respectively.