• The Korean Journal of Physiology
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• v.24 no.2
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• pp.389-402
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• 1990

The physiological characteristics of the neurons receiving the ventral root afferent inputs were investigated in the cat. A total of 70 cells were identified in the lumbosacral spinal cord. All these cells responded only to the C-strength stimulation of the distal stump of cut ventral root and the estimated conduction velocities of the VRA fibers were not faster than 4 m/sec. The majority of them were silent in resting state. For 49 cells, their peripheral receptive fields were characterized. Among them, 25 cells were exclusively excited by VRA inputs, 8 were inhibited and the remaining cells recevied both excitatory and inhibitory VRA inputs. According to the response pattern to the mechanical stimuli applied to their receptive fields, only a fourth of them were typical high threshold cell, a sixth, wide dynamic range cells, while remainings were a rather complex cells. Most of the cells receiving VRA inputs, received only the A ${\delta}-peripheral$ nerve inputs. Intravenous injection of morphine decreased the response of spinal cells to the VRA activation. The responses were abolished completely by counter irritation to the common peroneal nerve with C-strength-low frequency stimuli. These physiological properties of the spinal neurons receiving the VRA inputs are differ in some aspect from the spinal neurons receiving nociceptive inputs from the periphery, but still were consistent with the contention that VRA system might carry nociceptive informations arising from the spinal cord and/or neraby surrounding tissues.

• Korean Journal of Veterinary Research
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• v.39 no.4
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• pp.715-723
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• 1999

Bee venom (BV) has been traditionally applied to relieve pain and to cure inflammatory diseases such as rheumatoid arthritis (RA) and neuritis. While several investigators have evaluated the anti-inflammatory effect of BV treatment, the anti-nociceptive effect of BV treatment on inflammatory pain is not reported. Therefore, we decided to evaluate the analgesic effect of BV treatment using Freund's adjuvant induced chronic arthritis model. Freund's adjuvant-induced arthritis has been used as an experimental animal model for RA in humans to assess the efficacy of the anti-inflammatory/analgesic drugs. In this study, subcutaneous BV treatment (1mg/kg/day) produced significantly reductions of symptoms related to arthritic pain (i.e. mechanical hyperalgesia and thermal hyperalgesia). The anti-nociceptive effect of BV was observed from at least 12 days after BV treatment. Furthermore, BV treatment significantly suppressed adjuvant induced Fos expression in lumbar spinal cord. We also found that local injection of BV into near the inflammatory site (especially Zusanli-acupoint) showed more potent analgesic effect on arthritic pain rather than distant injection of BV from inflammatory site (arbitrary side of back). The present study demonstrates that BV treatment has anti-nociceptive effect on arthritis induced inflammatory pain. The analgesic effect of BV on RA is probably mediated by the effect of BV itself or possible other mechanism such as counter-irritation. Furthermore, it is possible that BV acupuncture is one of the promising candidates for long-term therapy of RA.

• Journal of Dental Rehabilitation and Applied Science
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• v.34 no.3
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• pp.175-185
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• 2018

Purpose: The aim of this clinical study was to evaluate the efficacy and safety of a self - applied paint - on whitening gel combined with wrap to increase the effect of a whitening gel and minimize gingival irritation. Materials and Methods: Ninety adult volunteers were randomly treated to a control group and two experimental groups using whitening gel containing 2.8% and 3.0% hydrogen peroxide for 30 persons each. They had used the wrap and whitening gel on maxillary 4 anterior teeth for 30 minutes per day during 2 weeks. Whitening tooth color response was measured by VITA shade guide and ShadeEye $NCC^{(R)}$. And side effects were assessed from interview and intraoral examination. The efficacy and safety evaluations were statistically analyzed. Results: In the evaluation with VITA shade guide, there was significantly the whitening effect in experimental groups compared with the control group. In the evaluation with ShadeEye $NCC^{(R)}$, the 3.0% experimental group showed significantly the whitening effect compared to the control group and the 2.8% experimental group (P < 0.05). There were some complaints of minor side effects, but there did not find abnormal symptoms of the gingival stimulation in all groups. Conclusion: A self - applied paint - on whitening gel combined with wrap can be used as a useful self-whitening material because the whitening effect increases as the concentration of hydrogen peroxide from 2.8% to 3.0% and also no significant side effects are observed.