• 한국임상약학회지
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• 제15권2호
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• pp.75-81
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• 2005

Community acquired pneumonia (CAP) remains a prevalent and potentially life threatening illness. American Thoracic Society and Infectious Disease Society America recommend combination therapies with ${\beta}-lactam$ plus a macrolide or a fluoroquinolone monotherapy for the empirical treatment of CAP. The aim of this study was to compare moxifloxacin monotherapy with cephalosporin plus azithromycin combination therapies. From January 2004 to March 2005, 18 patients in the moxifloxacin group(MG) and 21 patients in the cefuroxime or ceftriaxone plus azithromycin group(CAG) with CAP were retrospectively reviewed with regard to clinical, laboratory and microbiological data. Each patient was stratified into mild (risk class I-II), moderate (risk class III) and severe (risk class VI, V) group according to and PSI (Pneumonia Severity Index) score. Each group was compared for microbiological eradication, clinical assessment, the length of hospital stay. As results, Total 39 patients with CAP were reviewed. The appropriateness of admission was 83.3% in MC vs. 76.2% in CAC. The mean length of the hospital day was for 8.31 days vs. 7.39 days, days switching parenteral to oral antibiotics in 5.19 days vs. 5.28 days, clinical improvement in 2.43 days vs. 2.61 days in MG vs. CAC. Radiological improvement required 3.75 days vs 3.63 days in MG vs. CAG and bacteriological eradication rate at discharge was the same in the both groups. Mortality rate was 11.1% (2 of 18) vs 14.3% (3 of 21) in MG vs. CAG (p=0.77). Drug cost of the mean 5 hospital days requiring parenteral antibiotics was the most inexpensive in moxifloxacin group for the 147,045 won, and ceftriaxone 1g-azithromycin group for the 170,285 won, cefuroxime bid-azithromycin group for the 207,800 won, ceftriaxone 2g-azithromycin group far the 220,570 won, cefuroxime tid-azithromycin group for the 251,700 won. There was no significant statistical difference in clinical, bacterial, radiological cure and hospital days, and switch to oral days. In conclusion, that i.v. moxifloxacin monotherapy was as effective as azithromycin plus cefuroxime or ceftriaxone combination therapies fur the treatment of CAP. In drug cost analysis, moxifloxacin is less expensive than CAG.

• Journal of Preventive Veterinary Medicine
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• 제42권4호
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• pp.163-170
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• 2018

The cost-effectiveness of foot-and-mouth disease (FMD) control strategies was evaluated using a simulation model fitted to the 2010/11 FMD epidemic in the city of Andong, Republic of Korea. Seven FMD-control strategies were evaluated with respect to the direct cost of a FMD-control strategy, such as slaughtering, movement restriction, and vaccination. All the strategies included pre-emptive slaughtering, movement restriction, and vaccination, but the levels of each control option were different. The simulated median cost of the baseline FMD-control strategy (three kilometers of pre-emptive slaughtering area, 100 days of movement restriction and vaccination of all FMD-susceptible animals in the study area) was estimated to be USD 99.7 million. When a five kilometer vaccination area was applied (with the other control measures being the same as the baseline strategy), the simulated median cost was reduced to USD 81.1 million from USD 99.7. The simulated median costs were USD 107.6 million for a five kilometer radius slaughtering area and USD 168.8 million for 60 days of movement restriction. The FMD-control strategy cost decreased with increasing number of farms depopulated per day. The probability of passive surveillance being effective or the probability of the successful implementation of movement restrictions were increased. Cost-effectiveness analysis is a suitable tool for evaluating the financial consequences of FMD-control strategies by comparing the cost of control strategies for a specific area.

• Advances in concrete construction
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• 제11권2호
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• pp.99-109
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• 2021

Slag blended concrete is widely used as a mineral admixture in the modern concrete industry. This study shows an optimization process that determines the optimal mixture of air-entrained slag blended concrete considering carbonation durability, frost durability, CO2 emission, and materials cost. First, the aim of optimization is set as total cost, which equals material cost plus CO2 emission cost. The constraints of optimization consist of strength, workability, carbonation durability with climate change, frost durability, range of components and component ratio, and absolute volume. A genetic algorithm is used to determine optimal mixtures considering aim function and various constraints. Second, mixture design examples are shown considering four different cases, namely, mixtures without considering carbonation (Case 1), mixtures considering carbonation (Case 2), mixtures considering carbonation coupled with climate change (Case 3), and mixtures of high strength concrete (Case 4). The results show that the carbonization is the controlling factor of the mixture design of the concrete with ordinary strength (the designed strength is 30MPa). To meet the challenge of climate change, stronger concrete must be used. For high-strength slag blended concrete (design strength is 55MPa), strength is the control factor of mixture design.

• 대한의용생체공학회:의공학회지
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• 제10권3호
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• pp.361-364
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• 1989

A PC-based motor nerve conduction velocity measuring system was designed and constructed. The system was composed with an EMG preamplifier, a stimulator, an Apple II plus microcomputer and an 8 bit AD converter. The system was primariliy intended to screen motor nerve difficulties of industrial workers. This system can acquire, store and display the waveforms of evoked potentials. The PC-based system is expected to increase the versatility and applicability as well as to reduce the system cost.

• Journal of the Korean Data and Information Science Society
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• 제20권5호
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• pp.887-894
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• 2009

The two-stage minimum risk point estimation of mean, the probability of success in a sequence of Bernoulli trials, is considered for the case where loss is taken to be symmetrized relative squared error of estimation, plus a fixed cost per observation. First order asymptotic expansions are obtained for large sample properties of two-stage procedure. Monte Carlo simulation is carried out to obtain the expected sample size that minimizes the risk and to examine its finite sample behavior.

• 설비공학논문집
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• 제28권3호
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• pp.110-114
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• 2016

Newly constructed multi-residential buildings with more than 500 households should be flushed out indoor contaminants using a mechanical ventilation system or large fans after the completion of construction and prior to occupancy by the Heath-friendly Housing Construction Standards since 2014. In addition, the standard recommends to maintain indoor temperature over $16^{\circ}C$ and relative humidity below 60% while performing the flush-out. However, it is difficult to maintain these recommended indoor conditions, especially during winter season because additional energy cost is needed for space heating. Therefore, in this study, additional energy cost including heating and ventilation energy cost in multi-residential household for flush-out during winter season was estimated using building energy simulation program called EnergyPlus. Additional energy cost according to various conditions for performing flush-out (such as performance period, ventilation rate, and heating set-point temperature) was analyzed. Based on the results of the energy simulation, the energy cost was estimated to be ranged from 14,625 to 29,452\/household in Incheon city and from 3,521 to 26,268\/household in Gwangju City. There was no significant change in energy cost according to the performing terms of flush-out between Incheon and Gwangju City.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회/대한산업공학회 2005년도 춘계공동학술대회 발표논문
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• pp.938-946
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• 2005

We study the firm's strategy to price its products and plan the spare parts manufacturing so as to maximize its profit and at the same time to fulfill its commitment to providing the customers with the key parts continuously over the relevant decision time horizon, i.e., the production plus warrantee period. To examine the research question, we developed and solved a two-stage optimal control theory model. Our analysis suggests that if the cost to produce the spare part during the warrantee period is more expensive than that during the production period, the firm should increase its sales price gradually throughout the production period to control its sales. In addition, during the production period it is optimal for the firm to produce the spare parts more than needed so that the overproduced spare parts can be used to partially meet the demand during the warrantee period. We conducted numerical analysis to investigate the sensitivity dynamics among key variables and parameters such as inventory holding cost, unit spare part production costs, part failure rate, and parameters in the demand function.

• Journal of Nutrition and Health
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• 제27권8호
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• pp.864-871
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• 1994

The productivity and 13 influencing variables in 14 conventional hospital foodservice systems the total direct and non-direct labor hours required to produce and serve the total number of patient meals plus the number of cafeteria meals. Human resource variable significantly influencing the productivity level was the labor cost. As this index decreased, the meals served per human hour worked increased. System resource variables correlating significantly with productivity were the length of cycle menu, the ratio of staff meals, and modified patient meal ratio. As the length of cycle menu and the ratio of modified patient meal decreased, more meals were produced per human hour. However, as staff meal ratio increased, the meals served per human hour worked increased. The stepwise regression analysis suggests that around 53% of the variance in productivity is explained by labor cost.

• 한국항행학회논문지
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• 제7권2호
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• pp.156-161
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• 2003

본 연구에서는 저가형 GPS 수신기와 자이로 및 속도계를 결합한 혼합항법시스템을 개발하여 그 정확도를 실험하였다. 본 혼합항법시스템에서는 기존의 강결합 방식이나 연결합 방식과 달리 변형된 결합방식을 채택하여 GPS 수신기나 자이로 혹은 속도계를 자유롭게 선택할 수 있도록 하였다. 실험 결과, 본 혼합항법시스템은 기존의 항법시스템보다 정확도가 향상되었으며 다중경로오차를 상당히 제거할 수 있음이 밝혀졌다. 또한 본 항법시스템은 후처리 지리정보자료획득의 측면에서 유리한 것으로 나타났다.

• 조명전기설비학회논문지
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• 제27권2호
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• pp.7-13
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• 2013

The portion of lighting power consumption for our country is up to 20~30% of the total amount. Currently, most of the DSM(Demand side management) of lighting power is delivered in supply of high efficient lighting to customers. On the contrary, applications of lighting power to power load leveling are still rare. In this paper, the simulations for various control types of lighting power for load leveling are tried, and we obtained the cost effective and optimal control method through that. This simulation was executed in test office with fluorescent light by us based on applying 8 control types(on, off & dimming), considering customers' satisfaction, for instance, minimum intensity of illumination allowed. According to the result of this test, we found that mixed type(chessboard(on-off) plus dimming control(10%)) is most effective.