• 한국식품영양학회지
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• 제22권2호
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• pp.261-271
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• 2009

Deep sea water exists at depths of over 200m under the sea. As no sunlight reaches it, photosynthesis does not take place within it, and it contains no organic matter. In addition, its temperature is maintained at a stable low level throughout the year, so it does not get mixed with the sea water on the surface. It contains a large amount of nutritious salts, whose cleanness is maintained. It is a marine resource that has matured for a long period of time. Research into deep sea water, which started in the 1970s, has been made around the whole world, including the USA and Japan. In Korea, research has been active in this area since 2000. As there has been a good amount of research into industrial applications for deep sea water, since 1993, patents for the relevant technologies have been applied. This paper intends to provide a resource to researchers of deep sea water, by summarizing of all domestic deep sea water-related patents applied with Korean Intellectual Property Office from 1993 to 2008. This research was conducted using a computer and KIPRIS Database owned by the Korea Institute of Patent Information. 'Deep sea water' was used as the search keyword. A total of 222 Korean patents relating to deep sea water have been registered on the basis of IPC. Of these, 126 patents relate to the manufacturing and the treatment of foods, foodstuffs, or non-alcoholic beverages(A23L), while 50 patents relate to the production for medical, dental, or cosmetic purposes(A61K). 38 patents relate to water purification, treatment of wastewater, sewage and sludge (C02F), while 8 patents relate to fishery and farming(A01K). In summary, it was found that studies for the practical use of deep sea water have been conducted in relation to the manufacturing and the treatment of foods, foodstuffs, beverages, and cosmetics.

• Bulletin of the Korean Chemical Society
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• 제32권6호
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• pp.2021-2026
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• 2011

AgNPs (silver nanoparticles) has been widely used for the commercial products, which have antimicrobial agent, medical devices, food industry and cosmetics. Despite, AgNPs have been reported as toxic to the mammalian cell, lung, liver, brain and other organs and many researchers have investigated the toxicity of AgNPs. In this study, we investigated toxicity of the AgNPs to the liver cell using metabolomics based on HRMAS NMR (High Resolution Magic Angle Spinning Nuclear Magnetic Resonance) technics, which could apply to the intact tissues or cells, to avoid the sample destruction. Target profiling and multivariative statistical analysis were performed to analyze the 1D $^1H$ spectrum. The results show that the concentrations of many metabolites were affected by the AgNPs in the liver cell. The concentrations of glutathione (GSH), lactate, taurine, and glycine were decreased and most of amino acids, choline analogues, and pyruvate were increased by the AgNPs. Moreover, the levels of the metabolites were recovered upto similar level of metabolites in the normal cell by the pre-treatment of NAC, external antioxidant. The results suggest that the depletion of the GSH by the AgNPs might induce the conversion of lactate and taurine to the pyruvate.

• 한국안전학회지
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• 제22권5호
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• pp.77-83
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• 2007

식물류에 다량으로 함유되어 있는 Cellulose는 인체에 무해할 뿐 아니라 연소시에 발생하는 유해가스가 적어서 친환경적인 에너지 자원으로 대두되고 있다. 특히 Cellulose의 유도체 중 하나인 Hydroxypropyl Methyl Cellulose(HMC)는 의약품의 코팅재료를 비롯하여, 고급용 건축자재, 염료, 화장품 등의 첨가제로 사용되면서, 사용량이 계속해서 증가하고 있다. 따라서 여러 가지 위험에 노출될 수 있으며, 열적 위험특성을 알기 위한 방법으로 일본에서 많이 사용되고 있는 단열자기발열실험장치(SIT-II)를 이용하여 HMC의 한계발화온도와 겉보기활성화에너지를 구하였다. 또한 국제적으로 널리 알려진 Frank-Kamenetskii의 무한평판을 기준으로 한 자연발화실험(IF-SIT)자료를 이용하여 자연발화온도와 활성화 에너지 값을 비교하였다. HMC의 자연발화온도와 겉보기 활성화 에너지는 SIT-II의 경우 $186^{\circ}C$의 한계발화온도와 104.5kJ/mol의 활성화 에너지를 구하였다. 기존에 구하여진 IF-SIT결과 값과 비교하였을 때 무한평판의 두께 3cm, 5cm, 7cm에 대해 각각 한계발화온도가 $199.5^{\circ}C,\;188.5^{\circ}C,\;180.5^{\circ}C$이고, 167.4kJ/mol의 활성화 에너지 값을 지니므로, SIT-II로 구하여진 겉보기 활성화 에너지는 IF-SIT로 구하여진 값 보다 낮게 나타났으며, 이 값은 일반 Cellulose의 활성화 에너지 값 보다 도 더 낮은 것으로 나타났다.

• 벤처창업연구
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• 제9권6호
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• pp.153-161
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• 2014

본 연구는 Kano 모델을 이용하여 화장품 구매에 영향을 미치는 마케팅 믹스 요인을 분석하기 위해, 선행적 연구를 바탕으로 마케팅 믹스 요인 분류에 따라 긍정적 질문과 부정적 질문을 동시에 설문하여 매력적 품질, 일원적 품질, 당연적 품질을 규명하고자 하였다. Timko's Analysis 고객 만족과 불만족 계수를 이용한 화장품 구매에 영향을 미치는 마케팅 믹스 요인을 분석한 결과 촉진전략 중 가격할인 정책과 가족/ 주변인의 추천 전략이 매력적 품질로 나타났다. 제품 전략의 효능과 효과, 사용감, 피부적합성은 일원적 품질로 나와 고객의 요구를 충족시키면 선형적으로 그 만족도가 증가하는 것으로 파악되었다. 반면에 제품 측면의 용기, 포장 디자인, 색상, 브랜드 인지도와, 가격 측면의 낮은 가격, 중간가격 수준과 유통 측면의 구매경로, 촉진 측면의 매체 광고 에 대해서는 무관심 품질로 나타나서 이들 요인에 대하여는 과도한 예산을 집행하는 것은 투입대비 효과가 높지 않을 것으로 판단해 볼 수 있다.

• 한국미생물·생명공학회지
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• 제37권1호
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• pp.49-54
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• 2009

대황으로부터 추출한 rhapontin을 산업용 효소로 가수분해하여 rhapontigenin을 제조하고 kojic acid, hydroquinone 및 ascorbic acid를 비교물질로 한 tyrosinase 활성저해 실험과 S. bikiniensis를 이용한 멜라닌 생성 억제효과 실험을 통해 미백효과에 대한 가능성을 확인하였다. Rhapontin과 rhapontigenin의 결과를 비교해 보면 rhapontigenin의 경우 tyrosinase활성저해 및 멜라닌 생성 억제능이 증가하는 것으로 나타났다. 따라서 rhapontin을 효소 가수분해하여 생성된 rhapontigenin은 미백능이 월등히 증가된 천연 미백화장품소재로 개발될 수 있을 것으로 기대된다.

• 한국산학기술학회논문지
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• 제18권7호
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• pp.714-719
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• 2017

입자의 크기와 형상을 제어할 수 있는 무기물질의 제한된 제조방법은 나노입자와, 의료, 전자부품, 반도체, 의약품, 화장품 등과 같은 다양한 산업영역에서 신물질을 개발하는데 중요한 요소이다. 탄산칼슘은 수많은 활용성 때문에 산업에서 가장 많이 주목받고 있는 물질중 하나이다. 용액결정화는 용액으로부터 녹아 있는 용질을 순수한 고체 형태로 추출하는 분리 공정으로, 화학공업과 제약공업 등에 널리 적용되어, 사용되고 있는 분리공정 중에 하나이다. 입자의 평균입경과 입도분포, 형상은 연속식 결정화기에서 중요한 요소이다. 본 연구에서는 연속식 결정화기에서 염화칼슘 공정으로 탄산칼슘 입자를 제조할 때, 정상상태에서 탄산칼슘 입자의 입도분포와 입경변화에 대하여 연구하였다. 입자의 평균입경과 입도분포는 입도분석기를 이용하여 측정하였으며, 입자의 형상과 크기는 전자현미경(SEM)을 이용하여 변화를 관찰하였다. 정상상태에서, 주입되는 시료의 농도와 혼합속도가 증가 할수록 입자의 평균입경은 증가하고, 제조되는 입자는 aragonite 보다는 calcite 입자가 주로 생성된다.

• 복식문화연구
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• 제15권2호
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• pp.326-338
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• 2007

This paper examines the works produced from 2000, the first year of the new millenium, to the late 2006 with a focus on those of Jean Paul Gaultier, a representative designer of deconstruction, in an effort to determine the aesthetic characters of deconstructional fashion. In this context, this paper deals with the theoretical study on the concepts and features of deconstruction as a part of analysis into its fashion using the works of Gaultier as a major source viewed to typically demonstrate the deconstructional characters of fashion. For this purpose, a survey was conducted to 155 works of Gaultier featured from 2001 to 2006 mostly in Vogue, the popular and influencing magazine of the USA(39 pieces in 2001, 30 in 2002, 29 in 2003, 23 in 2004, 12 in 2005 and 22 in 2006, respectively). In particular, 106 fashion pictures were put to analysis as they seemed to represent deconstruction intensively. The deconstructional characters of his works were examined in the categories of difference, inter-meaning, inter-textuality and decomposition on the basis of preceding studies, which resulted in the following outcomes: First, difference was found in 38 works out of 106 images, accounting for 36%, the biggest frequency; Second, inter-meaning accounted for 33% with 35 pieces, most frequently next to difference; Third, inter-textuality followed inter-meaning with 17 images or 15% in terms of frequency; Fourth, decomposition was revealed in 16 images in the same ratio of 15% as inter-textuality.

• 농촌지도와개발
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• 제20권2호
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• pp.315-339
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• 2013

이 연구의 목적은 산업연관표의 생산자가격평가표, 국내거래표, 도소매마진표, 화물운임표 등을 이용하여 충청남도의 농업생산부문 및 전 후방 농업관련산업의 농업관련 부가가치를 추계하는 방법을 제시하고, 2005년의 산업연관표를 이용하여 충청남도의 농업생산부문 및 농업관련산업의 농업관련 부가가치를 지역별, 산업별로 추계하는데 있다. 이 논문의 제언으로 충남지역에 취약한 의료보건 분야의 공공 복리시설, 수산물 위판장과 수산물 가공공장, 의약품, 화장품, 사료, 엽연초 가공공장, 도소매에 관련된 유통구조 혁신이 매우 취약하여 총체적이며 전 방위적인 정책적인 배려와 농림수산업의 성장과 경쟁력을 제고시키는 종합적이고도 전사적인 차원의 정책입안을 제언한다.

• KSBB Journal
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• 제28권5호
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• pp.295-302
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• 2013

Indigo is utilized in various industries including textile dyeing, cosmetics, printing and medicinal products and its reduced form, leuco-indigo, is mainly used in these process. Chemical reducing agent (sodium dithionite, sodium sulfide, etc.) is preferred to use for the formation of leucoindigo in industry. In traditional indigo fermentation process, microorganisms can participate in the reduction of indigo and thus it has been known to reduce environmental pollution and noxious byproducts. However, in fermentation method using microorganisms it is difficult to standardize large scale production process due to low yield and reproducibility. In this study, we attempted to develop the indigo reduction process using microbial flora which was isolated from naturally fermented indigo vat or deduced by metagenomic approach. From the results of library analyses of PCR-amplified 16S rRNA genes from the traditional indigo fermentation vat sample (metagenome), it was confirmed that Alkalibacteriums (71%) was distinctly dominant in population. Some strains were identified after confirming that they become pure culture in nutrient media modified slightly. Four strains were separated in this process and each strain showed obvious reducing ability toward indigo in dyeing test. It is expected that the analyzed results will provide important data for standardizing the natural fermentation of indigo and investigating the mechanism of indigo reduction.

• Molecular & Cellular Toxicology
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• 제3권1호
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• pp.23-30
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• 2007

The effects of high energy short wave solar radiation on human skin have received much publicity as the major cause of accelerated skin ageing and of skin cancers. To meet public demand, the cosmetic industry has developed sun protection factor products, which contain a variety of so-called "UV filters", among others benzophenone (BP) and its metabolites are the widely used UV filters. UV filters are also used to prevent UV light from damaging scents and colors in a variety of cosmetics products and to protect of plastic products against light-induced degradation. There are many variants of BP in use. In this respect, to regulate and to evaluate the hazardous effect of BP-type UV filters will be important to environment and human health. The genotoxicity of 7 BP-type UV filters was evaluated in L5178Y $(tk^{+/-})$ mouse lymphoma cells in vitro. BP, benzhydrol, 4-hydroxybenzophenone 2-hydroxy-4-methoxybenzophenone and 2, 4-dihydroxybenzophenone did not induce significant mutation frequencies both in the presence and absence of metabolic activation system. 2, 2'-Dihydroxy-4-methoxybenzophenone appeared the positive results at the highest dose, i.e. 120.4 ${\mu}g/mL$ only in the absence of metabolic activation system. And also, 2, 3, 4-trihydroxybenzophenone revealed a significant increase of mutation frequencies in the range of 138.1-207.2 ${\mu}g/mL$ in the absence of metabolic activation system and 118.3-354.8 ${\mu}g/mL$ in the presence of metabolic activation system. Through the results of MLA with 7 BP-type UV filters in L5178Y cells in vitro, we may provide the important clues on the genotoxic potentials of these BP-type UV filters.