• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.950-957
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• 2009

The purpose of this study was to develop generalized validity evaluation indexes for the Sasang type diagnostic test. As a generalized evaluation index for Sasang type diagnostic test, Generalized Squared Correlation (GC2), Mutual Information (I) and Mutual Information Coefficient (IC) as overall validity index, and Correlation Coefficient (C) and Mutual Information Contribution (ID) as type-specific validity index were suggested and the practicability of these indexes was assessed along with Percentage Correctly Predicted (PCP), adjusted PCP, type-specific sensitivity and type-specific specificity which was proposed previously. The usefulness of the nine validity indexes was examined using previously reported data and three mock Sasang type diagnosis results. We demonstrated here that the PCP is not adequate for the analysis of validity. We also showed that our validity index is recommendable for the comparison and improvement of Sasang type diagnosis. The generalized validity analysis of Sasang type diagnosis can provide a guideline for the development of new Sasang type diagnosis or pattern identification. The working sheet for calculating validity indexes can be acquired at http://www.sasangtypology.org/validity.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.48 no.4
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• pp.67-75
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• 2011

This paper presents a scale and rotation-invariant gait recognition method using R-transform, which is computed by projecting squared coefficients of Radon transform. Since R-transform is invariant to translation, rotation, and scaling, it particularly suitable for extracting object poses without camera calibration. Coefficients of R-transform are used to compute correlation, and the maximum correlation value determines the similarity between two gait images. The proposed method requires neither camera calibration nor geometric compensation, and as a result, it makes robust gait recognition possible without additional compensation for translation, rotation, and scaling.

• Journal of Periodontal and Implant Science
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• v.40 no.2
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• pp.61-68
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• 2010

Purpose: The present study was performed to clarify the relationship between periodontal disease severity and selected immunological parameters consisting of serum IgG titer against periodontopathogenic bacteria, the expression of the helper T-cell cytokine by gingival mononuclear cells, and patients' immunoreactivity to cross-reactive heat shock protein (HSP) epitope peptide from P. gingivalis HSP60. Methods: Twenty-five patients with moderate periodontitis had their gingival connective tissue harvested of gingival mononuclear cells during an open flap debridement procedure and peripheral blood was drawn by venipuncture to collect serum. The mean level of interproximal alveolar bone was calculated to be used as an index for periodontal disease severity for a given patient. Each of selected immunologic parameters was subject to statistical management to seek their correlations with the severity of periodontal disease. Results: A significant correlation could not be identified between serum IgG titers against specific bacteria (Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, and Streptococcus mutans) and the severity of periodontal disease. Expression of interleukin (IL)-10 by gingival mononuclear cells was statistically significant in the group of patients who had higher levels of alveolar bone height. However, a similar correlation could not be demonstrated in cases for IL-4 or interferon-$\gamma$. Patients' serum reactivity to cross-reactive epitope peptide showed a significant correlation with the amount of alveolar bone. Conclusions: It was concluded that expression of IL-10 by gingival mononuclear cells and patients' sero-reactivity to the cross-reactive HSP peptide of P. gingivalis HSP60 were significantly correlated with alveolar bone height.

• Tuberculosis and Respiratory Diseases
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• v.82 no.2
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• pp.126-132
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• 2019

Background: The development of lung cancer results from the interaction between genetic mutations and dynamic epigenetic alterations, although the exact mechanisms are not completely understood. Changes in DNA methylation may be a promising biomarker for early detection and prognosis of lung cancer. We evaluated the serial changes in genome-wide DNA methylation patterns in blood samples of lung cancer patients. Methods: Blood samples were obtained for three consecutive years from three patients (2 years before, 1 year before, and after lung cancer detection) and from three control subjects (without lung cancer). We used the MethylationEPIC BeadChip method, which covers the 850,000 bp cytosine-phosphate-guanine (CpG) site, to conduct an epigenome-wide analysis. Significant differentially methylated regions (DMRs) were identified using p-values <0.05 in a correlation test identifying serial methylation changes and serial increase or decrease in ${\beta}$ value above 0.1 for three consecutive years. Results: We found three significant CpG sites with differentially methylated ${\beta}$ values and 7,105 CpG sites with significant correlation from control patients without lung cancer. However, there were no significant DMRs. In contrast, we found 11 significant CpG sites with differentially methylated ${\beta}$ values and 10,562 CpG sites with significant correlation from patients with lung cancer. There were two significant DMRs: cg21126229 (RNF212) and cg27098574 (BCAR1). Conclusion: This study revealed DNA methylation changes that might be implicated in lung cancer development. The DNA methylation changes may be the possible candidate target regions for the early detection and prevention of lung cancer.

• Phonetics and Speech Sciences
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• v.14 no.3
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• pp.1-9
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• 2022

The current study examined English-speaking adult learners' production and perception of L2 Korean stops (/t/ or /t'/ or /t^h/) to investigate whether the two modalities are linked in utilizing voice onset time (VOT) and fundamental frequency (F0) for the L2 sound distinction and how the learners' L2 proficiency mediates the relationship. Twenty-two English-speaking learners of Korean living in Seoul participated in the word-reading task of producing stop-initial words and the identification task of labelling CV stimuli synthesized to vary VOT and F0. Using logistic mixed-effects regression models, we quantified group- and individual-level weights of the VOT and F0 cues in differentiating the tense-lax, lax-aspirated, and tense-aspirated stops in Korean. The results showed that the learners as a group relied on VOT more than F0 both in production and perception (except the tense-lax pair), reflecting the dominant role of VOT in their L1 stop distinction. Individual-level analyses further revealed that the learners' L2 proficiency was related to their use of F0 in L2 production and their use of VOT in L2 perception. With this effect of L2 proficiency controlled in the partial correlation tests, we found a significant correlation between production and perception in using VOT and F0 for the lax-aspirated stop contrast. However, the same correlation was absent for the other stop pairs. We discuss a contrast-specific role of acoustic cues to address the non-uniform patterns of the production-perception link in the L2 sound learning context.

• International Journal of Computer Science & Network Security
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• v.24 no.3
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• pp.189-195
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• 2024

Road transport occupies the largest share in domestic and international transport. It is of key importance for the development of the economy, forasmuch as it provides the livelihood of the population, the development of the national economy, the possibility of establishing foreign economic relations. The purpose of the research is as follows: analysis of the current state of functioning of the road transport sector in Eastern Europe and identification of key problems and trends in its development. Research methods: Methods of grouping, comparison and generalization, correlation analisys have been used to identify the dynamics of the main indicators of road transport in Eastern Europe. The method of correlation-regression analysis has been applied to determine the impact of increasing the length of roads on the turnover of the road freight transport and the number of employed population in this area. Results. It has been found that the increase in the employed population by 96% and increase in revenues from transportation and storage of goods, postal and courier services (turnover of the road freight transport - in the original language) in the field of road transport by 82% is explained by the change in transport infrastructure capacity by increasing length of highways. According to the correlation analysis, it has been revealed that there is a high direct dependence between the length of roads and increased revenues from transportation and storage of goods in the field of road transport, as well as between the length of roads and increasing employment in this area.

• The Journal of Internal Korean Medicine
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• v.34 no.4
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• pp.428-437
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• 2013

Objectives : The aim of this study was to examine if there is a significant correlation between the changes of Fire- and Heat- related symptoms and motor function recovery in acute cerebral infarction patients. Methods : We studied inpatients within a month after the onset of cerebral infarction who were admitted at Kyunghee University Medical Center from May 2011 to January 2013. We executed correlation analysis between Fire-heat pattern score and motricity index score at visit 1 and visit 2, and checked if there was a significant correlation between the changes of Fire-heat pattern score and changes of motricity index score. Also, we compared the changes of both scores in patients taking Fire-heat and non Fire-heat pattern prescriptions. Results : There was a significant correlation between the Fire-heat pattern score and Motricity index score at visit 1 and visit 2, and changes of Fire-heat pattern score showed significant correlation with changes of motricity index score. Patients taking Fire-heat pattern prescriptions showed significant change in Fire-heat pattern score after herb-medication treatment while patients taking non-Fire-heat prescriptions showed insignificant change in Fire-heat pattern score. Conclusions : This study provides evidence that taking a Fire-heat pattern prescription could be considered as a first line herb-medication treatment in acute cerebral infarction patients.

• Toxicological Research
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• v.26 no.2
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• pp.157-162
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• 2010

In this study, we investigated the atmospheric heavy metal concentrations in the particulate matter inside the subway stations of Seoul. In particular, we examined the correlation between the heavy metals and studied the effect of the heavy metals on cell proliferation. In six selected subway stations in Seoul, particulate matter was captured at the platforms and 11 types of heavy metals were analyzed. The results showed that the mean concentration of iron was the highest out of the heavy metals in particulate matter, followed by copper, potassium, calcium, zinc, nickel, sodium, manganese, magnesium, chromium and cadmium in that order. The correlation analysis showed that the correlations between the heavy metals was highest in the following order: (Cu vs Zn), (Ca vs Na), (Ca vs Mn), (Ni vs Cr), (Na vs Mn), (Cr vs Cd), (Zn vs Cd), (Cu vs Cd), (Ni vs Cd), (Cu vs Ni), (K vs Zn), (Cu vs K), (Cu vs Cr), (K vs Cd), (Zn vs Cr), (K vs Ni), (Zn vs Ni), (K vs Cr), and (Fe vs Cu). The correlation coefficient between zinc and copper was 0.937, indicating the highest correlation. Copper, zinc, nickel, chromium and cadmium, which are generated from artificial sources in general, showed correlations with many of the other metals and the correlation coefficients were also relatively high. The effect of the heavy metals on cell proliferation was also investigated in this study. Cultured cell was exposed to 10 mg/l or 100 mg/l of iron, copper, calcium, zinc, nickel, manganese, magnesium, chromium and cadmium for 24 hours. The cell proliferation in all the heavy metal-treated groups was not inhibited at 10 mg/l of the heavy metal concentration. The only exception to this was with the cadmium-treated group which showed a strong cell proliferation inhibition. This study provides the fundamental data for the understanding of simultaneous heavy metal exposure tendency at the time of particulate matter exposure in subway stations and the identification of heavy metal sources. Moreover, this study can be used as the fundamental data for the cell toxicity study of the subway-oriented heavy metal-containing particulate matter.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.3
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• pp.32-39
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• 2018

Raman spectra exhibit differences in intensity depending on the measuring equipment and environmental conditions even for the same material. This restricts the pattern recognition approach of Raman spectroscopy and is an issue that must be solved for the sake of its practical application, so as to enable the reusability of the Raman database and interoperability between Raman devices. To this end, previous studies assumed the existence of a transfer function between the measurement devices to obtain a direct spectral correction. However, this method cannot cope with other conditions that cause various intensity distortions. Therefore, we propose a classification method using linear intensity calibration which can deal with various measurement conditions more flexibly. In order to evaluate the performance of the proposed method, a Raman library containing 14033 chemical substances was used for identification. Ten kinds of chemical Raman spectra measured using three different Raman spectroscopes were used as the experimental data. The experimental results show that the proposed method achieves 100% discrimination performance against the intensity-distorted spectra and shows a high correlation score for the identified material, thus making it a useful tool for the identification of chemical substances.

• The Journal of Internal Korean Medicine
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• v.40 no.4
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• pp.582-596
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• 2019

Objective: The aims of this study were to analyze the deficiency-excess pattern identification (虛實辨證) and compare it to the sputum cytokines of asthma patients. Method: 50 asthma patients who met the inclusion and exclusion criteria were included in this study. They were divided into two groups: deficiency and excess syndrome groups. Sputum examinations were performed including $TNF-{\alpha}$, Interleukin (IL)-4, IL-5, IL-10, and IL-13. The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), the Visual Analog Scale(VAS), and heart rate variability (HRV) were also measured. We also conducted laboratory tests, including the hematological indexes. Results: Based on the pattern identification, 50 asthma patients can be divided into two categories of groups: the deficiency syndrome group (N=24) and the excess syndrome group (N=26). In the analysis of sputum cytokines, although the $TNF-{\alpha}$, IL-4 and IL-13 were at a higher level in the deficient pattern group than in the excess pattern group, it was insignificantly different. There was a negative correlation in the analysis of QLQAKA and VAS. In the analysis of HRV, although the mean value of VLF, LF, and HF in the deficiency syndrome group was higher than in the excess syndrome group, it was insignificantly different. There was no significant difference in the hematological tests between the deficiency and the excess syndrome group. The mean value of the IgE in the blood tests was five times greater than the reference value. Conclusion: The cytokines of sputum including $TNF-{\alpha}$, IL-4, IL-5, IL-10, and IL-13 were indifferent statistically. Reinforcing the healthy and eliminating the pathogenic factors should be considered.