• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.392-392
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• 2022

세계적 규모의 팬데믹 감염병의 출현은 전 세계적으로 경제적, 문화적, 사회적 파급효과가 매우 강력하며 전 인류를 위협하고 있다. 최근에 발병한 중증급성 호흡기질환 코로나바이러스 2(Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2)는 2019년 12월 중국 우한에서 첫 보고 되었고 2022년 현재까지 종식되지 않고 있으며 바이러스의 전파력과 치명률이 높고 무증상 감염상태일 때에도 전염이 가능하여 현재 역학조사의 사후적 대응에 대한 한계가 있어 선제적 대응을 위한 수단이 필수 불가결해지고 있는 실정이다. 하수기반역학(Waste Based Epidemiology, WBE)이란 하수처리장으로 유입되기 전의 하수를 분석하여 하수 집수구역 내 도시민의 생활상을 예측하는 것으로 하수로 배출된 감염자의 분비물 및 배설물 속 바이러스를 하수관로에서 신속하게 검출함으로써 특정지역의 감염성 질환 전파 정도와 유행하는 타입(변이)등을 분석하고 기존 역학조사의 문제점을 극복할 수 있으며 선제적인 대응이 가능하다. 현재 COVID-19의 대유행과 관련하여 WBE를 기반으로 한 다양한 연구가 진행되고 있으며 실제 환자의 발생과 상관관계가 있음이 확인되고 있고 백신 접종과 새롭게 발생한 변이바이러스의 관계 속에서 발생하는 변수를 고려한 모델이 없다는 점을 들어 새로운 감염병 확산 예측 모델에 대한 필요성 또한 커지고 있다. 본 연구에서는 병원에서부터 하수처리장까지의 하수관거와 하수처리장에서의 SARS-CoV-2 검출농도 및 거동을 파악하는 것을 목적으로 하고 있으며 COVID-19의 감염규모 확산에 관한 방법론에서 수학적모델 (Euler Method, RK4 Method, Gillespie Algorithm)과 딥러닝 기반의 Nowcasting model과 Fore casting model을 살펴보고자 한다.

• Clinical and Experimental Vaccine Research
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• v.12 no.4
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• pp.337-345
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• 2023

Purpose: The global fight against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has led to widespread vaccination efforts, yet the optimal dosing schedule for SARS-CoV-2 vaccines remains a subject of ongoing research. This study aims to investigate the effectiveness of administering two booster doses as the third and fourth doses at different intervals to enhance vaccine protection. Materials and Methods: This study was conducted at a military regional hospital operated by the Ministry of National Defense in Taiwan. A cohort of vaccinated individuals was selected, and their vaccine potency was assessed at various time intervals following their initial vaccine administration. The study participants received booster doses as the third and fourth doses, with differing time intervals between them. The study monitored neutralizing antibody titers and other relevant parameters to assess vaccine efficacy. Results: Our findings revealed that the potency of the SARS-CoV-2 vaccine exhibited a significant decline 80 days after the initial vaccine administration. However, a longer interval of 175 days between booster injections resulted in significantly higher neutralizing antibody titers. The individuals who received the extended interval boosters exhibited a more robust immune response, suggesting that a vaccine schedule with a 175-day interval between injections may provide superior protection against SARS-CoV-2. Conclusion: This study underscores the importance of optimizing vaccine booster dosing schedules to maximize protection against SARS-CoV-2. The results indicate that a longer interval of 175 days between the third and fourth doses of the vaccine can significantly enhance the neutralizing antibody response, potentially offering improved protection against the virus. These findings have important implications for vaccine distribution and administration strategies in the ongoing battle against the SARS-CoV-2 pandemic. Further research and largescale trials are needed to confirm and extend these findings for broader public health implications.

• IMMUNE NETWORK
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• v.22 no.3
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• pp.21.1-21.21
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• 2022

As far the current severe coronavirus disease 2019 (COVID-19), respiratory disease is still the biggest threat to human health. In addition, infectious respiratory diseases are particularly prominent. In addition to killing and clearing the infection pathogen directly, regulating the immune responses against the pathogens is also an important therapeutic modality. Sirtuins belong to NAD+-dependent class III histone deacetylases. Among 7 types of sirtuins, silent information regulator type-1 (SIRT1) played a multitasking role in modulating a wide range of physiological processes, including oxidative stress, inflammation, cell apoptosis, autophagy, antibacterial and antiviral functions. It showed a critical effect in regulating immune responses by deacetylation modification, especially through high-mobility group box 1 (HMGB1), a core molecule regulating the immune system. SIRT1 was associated with many respiratory diseases, including COVID-19 infection, bacterial pneumonia, tuberculosis, and so on. Here, we reviewed the latest research progress regarding the effects of SIRT1 on immune system in respiratory diseases. First, the structure and catalytic characteristics of SIRT1 were introduced. Next, the roles of SIRT1, and the mechanisms underlying the immune regulatory effect through HMGB1, as well as the specific activators/inhibitors of SIRT1, were elaborated. Finally, the multitasking roles of SIRT1 in several respiratory diseases were discussed separately. Taken together, this review implied that SIRT1 could serve as a promising specific therapeutic target for the treatment of respiratory diseases.

• Pediatric Infection and Vaccine
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• v.31 no.1
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• pp.113-121
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• 2024

Purpose: In response to the surge in coronavirus disease 2019 (COVID-19) omicron variant cases, we have implemented preemptive testing for preschool and school. The purpose is to quickly detect COVID-19 cases using a rapid antigen test (RAT) kit so that normal school activities can continue. Methods: The results entered in The Healthcare Self-Test App were merged with the information on the status of confirmed cases in the COVID-19 Information Management System by Korea Disease Control and Prevention Agency (KDCA) for preschool and school of students and staffs March 2 to May 1, 2022 to analyze the RAT positive rate and positive predictive value of RAT. Results: In preschool and school 19,458,575 people were tested, weekly RAT positive rate ranged from 1.10% to 5.90%, positive predictive value of RAT ranged from 86.42% to 93.18%. By status, RAT positive rate ranged from 1.13% to 6.16% for students, 0.99% to 3.93% for staffs, positive predictive value of RAT ranged from 87.19% to 94.03% for students, 77.55% to 83.10% for staffs. RAT positive rate by symptoms ranged from 76.32% to 88.02% for those with symptoms and 0.34% to 1.11% for those without symptoms. As a result of preschool and school RAT, 943,342 confirmed cases were preemptively detected, before infection spread in preschool and school. Conclusions: RAT was well utilized to detect confirmed cases at an early stage, reducing the risk of transmission to minimize the educational gap in preschool and school. To compensate for the limitations of RAT, further research should continue to reevaluate the performance of RAT as new strains of viruses continue to emerge. We will have to come up with various ways to utilize it, such as performing periodic and repeated RAT and parallel polymerase chain reaction.

• The Journal of the Acoustical Society of Korea
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• v.42 no.2
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• pp.133-142
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• 2023

The office environment is changing according to work types, Information Technology (IT) advancements, and the Coronavirus disease (COVID)-19 situation. In order for office space users to perform their tasks comfortably and efficiently, it is necessary to secure individual privacy as well as easy communication among members. In Korea, the demand for improving the acoustic performance of office spaces is also increasing, but the related performance criteria and guidelines have not been established. In this study, standardization of office space acoustic performance measurement and evaluation methods and European countries' acoustic performance criteria were compared and reviewed. It is proposed to comprehensively review international standardization trends and acoustic performance standards in each country and to establish and utilize criteria for evaluating the acoustic performance and satisfaction of office spaces in Korea through our survey. Considering the international standardization direction and compatibility with communication and Public Address (PA) systems, it is appropriate to establish criteria using the speech transmission index or Speech Transmission Index (STI) application index. This criterion will be highly utilizable and compatible. In addition, since the office furniture industry is interested in improving the acoustic performance of office space, it is necessary to establish a labelling system for speech level reduction of office furniture.

• Journal of Information Technology Services
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• v.20 no.4
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• pp.23-33
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• 2021

The prolonged coronavirus 19 (COVID-19) has caused serious problems such as job losses and youth unemployment, but as the fourth industrial revolution and digital transformation accelerate, the importance of SW is highlighted and more qualified jobs are expected in the SW industry. However, domestic SW companies are having difficulties in not properly recognizing the value of SW products. Among many related issues, commercial SW maintenance-related issues are representative, and the main problem is the difference in the maintenance fee rates between domestic and foreign SW. In this study, the expected job creation effect when the SW maintenance rate is raised was analyzed using data related to the SW industry and commercial software. As a result of the analysis, the amount required to raise the commercial SW maintenance rate by 1% is 162 billion won. If all of these are used for employment, the expected new job creation effect is 3,240 jobs per year, and 15,451 jobs are created per year when calculated and estimated as the effect of increasing sales through the employment inducement coefficient. In addition, the amount required to raise the current average maintenance rate of 11.1% to 15% is 631.9 billion won, and it was possible to estimate the effect of creating jobs for 12,648 people based on the simple average wage and 60,259 people from the sales increase effect.

• International Journal of Advanced Culture Technology
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• v.9 no.4
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• pp.188-193
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• 2021

This is a group pretest-posttest design study that aim to evaluate the effect of self-reflection promotion program of nursing students. The subjects of this study were 42 first-year nursing students. The data was collected from October 5 to November 2, 2020. A questionnaire was used to measure self-reflection and self-efficacy. The self-reflection promotion program was operated for a total of 8 hours in 4 sessions over 4 weeks. Online lectures were conducted using books, movies, and art recommended by expert. The subjects could take lectures using their smartphones, laptops, desktops, and tablet PC. As a result of the study, self-reflection was significantly improved after intervention than before intervention (t=-2.594, p=.013). In the sub-items, self-exploration and self-understanding were statistically significantly improved (t=-2.527, p=.015; t=-2.471, p=.018). However, other-exploration and other-understanding were not statistically significant (t=-1.226, p=.227; t=-.758, p=.453). The self-efficacy of the subjects was not statistically significant (t=-.170, p=.866). In future research, it will be necessary to develop and verify specific teaching and learning methods utilizing various contents that can improve self-reflection for nursing students.

• Korean Journal of Veterinary Service
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• v.46 no.1
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• pp.93-106
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• 2023

Emerging and re-emerging zoonotic viruses become critical public health, economic, societal, and cultural burdens. The Coronavirus disease-19 (COVID-19) pandemic reveals needs for effective preparedness and responsiveness against the emergence of variants and the next virus outbreak. The targeted next-generation sequencing (NGS) significantly contributes to the acquisition of viral genome sequences directly from clinical specimens. Using this advanced NGS technology, the genomic epidemiology and surveillance play a critical role in identifying of infectious source and origin, tracking of transmission chains and virus evolution, and characterizing the virulence and developing of vaccines during the outbreak. In this review, we highlight the platforms and preparation of targeted NGS for the viral genomics. We also demonstrate the application of this strategy to take advantage of the responsiveness and prevention of emerging zoonotic viruses. This article provides broad and deep insights into the preparedness and responsiveness for the next zoonotic virus outbreak.

• Korea Trade Review
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• v.45 no.3
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• pp.1-19
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• 2020

Recently, traditional trade in the global trade market has stagnated in the aftermath of the US-China trade war and the coronavirus (COVID-19) pandemic. However, the global e-commerce market is growing rapidly, presenting a new opportunity for exports. To examine the effect of an online matching and logistics system on reverse overseas direct purchase and the mediating effect of reliability, this study conducted a questionnaire survey on 320 employees in a Korean trade company from March 10 to April 30, 2018. The study model's goodness of fit was tested, and an analysis was performed using the AMOS statistical package. The online matching and logistics system were found to have a positive effect on reverse overseas direct purchase. Furthermore, results revealed that while a country's reliability mediated online matching and reverse overseas direct purchase, it did not mediate the logistics system. These results mean that online matching is affected by a country's reliability in overseas consumers' buying decision process. This study provides implications for the future directions of export companies and national policies to promote reverse overseas direct purchase. Future research including more countries and companies would be able to make further contributions toward the development of the Korean cross-border e-commerce industry.

• The Journal of the Convergence on Culture Technology
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• v.7 no.2
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• pp.317-324
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• 2021

The purpose of this study was to conduct pan play counseling that contains Korean cultural characteristics to see if it affects college students' anxiety reduction in coronavirus situations. Counseling was conducted for 40 minutes once a week. The associations of participants were recorded for each session. The score of anxiety test decreased in the participants' pre-and post-anxiety tests. The effectiveness of pan play counseling was verified. Case analysis applied phenomenological research method. Structural decisions through case analysis were in the order of regression, expression, differentiation, and integration. In the results of case analysis, participants feel confused through encounters in the early stages and regress unconsciously. Emotions of negativity that could not be erupted in the expression structure appear as consciousness, and the participants awaken. Participants expressed emotions such as fear, anxiety, loneliness, anger, and irritation. Consciousness of the unconscious causes a transformation of ego. The ego gains discernment as the great drama emerges from the differentiated structure. In other words, it builds confidence. The goal of counseling is to reinforce the ego, realizing the potential to overcome anxiety. In the last integration's structure, a wedding, a baby, and a old wise man appeared, showing that a transformation took place. In the results of this study, it was verified that pan play counseling has a healing effect. This study is expected to serve as an opportunity to develop Korean counseling techniques that incorporate Korean culture.